Estimated estimating equations: semiparametric inference for clustered and longitudinal data

Summary.  We introduce a flexible marginal modelling approach for statistical inference for clustered and longitudinal data under minimal assumptions. This estimated estimating equations approach is semiparametric and the proposed models are fitted by quasi-likelihood regression, where the unknown marginal means are a function of the fixed effects linear predictor with unknown smooth link, and variance–covariance is an unknown smooth function of the marginal means. We propose to estimate the nonparametric link and variance–covariance functions via smoothing methods, whereas the regression parameters are obtained via the estimated estimating equations. These are score equations that contain nonparametric function estimates. The proposed estimated estimating equations approach is motivated by its flexibility and easy implementation. Moreover, if data follow a generalized linear mixed model, with either a specified or an unspecified distribution of random effects and link function, the model proposed emerges as the corresponding marginal (population-average) version and can be used to obtain inference for the fixed effects in the underlying generalized linear mixed model, without the need to specify any other components of this generalized linear mixed model. Among marginal models, the estimated estimating equations approach provides a flexible alternative to modelling with generalized estimating equations. Applications of estimated estimating equations include diagnostics and link selection. The asymptotic distribution of the proposed estimators for the model parameters is derived, enabling statistical inference. Practical illustrations include Poisson modelling of repeated epileptic seizure counts and simulations for clustered binomial responses.     

Comparing Two Population Means and Variances: A Parametric Robust Way

Abstract

This article introduces a parametric robust way of comparing two population means and two population variances. With large samples the comparison of two means, under model misspecification, is lesser a problem, for, the validity of inference is protected by the central limit theorem. However, the assumption of normality is generally required, so that the inference for the ratio of two variances can be carried out by the familiar F statistic. A parametric robust approach that is insensitive to the distributional assumption will be proposed here. More specifically, it will be demonstrated that the normal likelihood function can be adjusted for asymptotically valid inferences for all underlying distributions with finite fourth moments. The normal likelihood function, on the other hand, is itself robust for the comparison of two means so that no adjustment is needed.     

Robust likelihood inferences for multivariate correlated data

Multivariate normal, due to its well-established theories, is commonly utilized to analyze correlated data of various types. However, the validity of the resultant inference is, more often than not, erroneous if the model assumption fails. We present a modification for making the multivariate normal likelihood acclimatize itself to general correlated data. The modified likelihood is asymptotically legitimate for any true underlying joint distributions so long as they have finite second moments. One can, hence, acquire full likelihood inference without knowing the true random mechanisms underlying the data. Simulations and real data analysis are provided to demonstrate the merit of our proposed parametric robust method.     

On the estimation of a binary response model in a selected population

A generalization of the Probit model is presented, with the extended skew-normal cumulative distribution as a link function, which can be used for modelling a binary response variable in the presence of selectivity bias. The estimate of the parameters via ML is addressed, and inference on the parameters expressing the degree of selection is discussed. The assumption underlying the model is that the selection mechanism influences the unmeasured factors and does not affect the explanatory variables. When this assumption is violated, but other conditional independencies hold, then the model proposed here is derived. In particular, the instrumental variable formula still applies and the model results at the second stage of the estimating procedure.     

Testing inference in variable dispersion beta regressions

The class of beta regression models proposed by Ferrari and Cribari-Neto [Beta regression for modelling rates and proportions, Journal of Applied Statistics 31 (2004), pp. 799–815] is useful for modelling data that assume values in the standard unit interval (0, 1). The dependent variable relates to a linear predictor that includes regressors and unknown parameters through a link function. The model is also indexed by a precision parameter, which is typically taken to be constant for all observations. Some authors have used, however, variable dispersion beta regression models, i.e., models that include a regression submodel for the precision parameter. In this paper, we show how to perform testing inference on the parameters that index the mean submodel without having to model the data precision. This strategy is useful as it is typically harder to model dispersion effects than mean effects. The proposed inference procedure is accurate even under variable dispersion. We present the results of extensive Monte Carlo simulations where our testing strategy is contrasted to that in which the practitioner models the underlying dispersion and then performs testing inference. An empirical application that uses real (not simulated) data is also presented and discussed.     

Semiparametric estimation in single index Poisson regression: a practical approach

In a single index Poisson regression model with unknown link function, the index parameter can be root- n consistently estimated by the method of pseudo maximum likelihood. In this paper, we study, by simulation arguments, the practical validity of the asymptotic behaviour of the pseudo maximum likelihood index estimator and of some associated cross-validation bandwidths. A robust practical rule for implementing the pseudo maximum likelihood estimation method is suggested, which uses the bootstrap for estimating the variance of the index estimator and a variant of bagging for numerically stabilizing its variance. Our method gives reasonable results even for moderate sized samples; thus, it can be used for doing statistical inference in practical situations. The procedure is illustrated through a real data example.     

ON PREDICTION OF TOTAL VALUE IN INCOMPLETELY SPECIFIED DOMAINS

This paper presents the problem of prediction of a domain total value based on the general linear model. In many methods presented in the survey sampling literature (e.g. Cassel, Särndal & Wretman, 1977 [Foundations of inference in survey sampling, New York: John Wiley & Sons]; Valliant, Dorfman & Royall, 2000 [Finite population sampling and inference. A prediction approach. New York: John Wiley & Sons]; Rao, 2003 [Small area estimation. New York; John Wiley & Sons]) a common assumption is that for each element of a population the domain to which it belongs is known. This assumption is especially important in the situation when a superpopulation model with auxiliary variables is considered. In this paper a method is proposed for prediction of the domain total when it is not known whether a unit belongs to a given domain or not, or when the information is available only for sampled elements of the population.     

Estimating the p-values of robust tests for the linear model

In this paper, we study the estimation of p-values for robust tests for the linear regression model. The asymptotic distribution of these tests has only been studied under the restrictive assumption of errors with known scale or symmetric distribution. Since these robust tests are based on robust regression estimates, Efron's bootstrap (1979) presents a number of problems. In particular, it is computationally very expensive, and it is not resistant to outliers in the data. In other words, the tails of the bootstrap distribution estimates obtained by re-sampling the data may be severely affected by outliers.We show how to adapt the Robust Bootstrap (Ann. Statist 30 (2002) 556; Bootstrapping MM-estimators for linear regression with fixed designs, http://mathstat.carleton.ca/~matias/pubs.html) to this problem. This method is very fast to compute, resistant to outliers in the data, and asymptotically correct under weak regularity assumptions. In this paper, we show that the Robust Bootstrap can be used to obtain asymptotically correct, computationally simple p-value estimates. A simulation study indicates that the tests whose p-values are estimated with the Robust Bootstrap have better finite sample significance levels than those obtained from the asymptotic theory based on the symmetry assumption.Although this paper is focussed on robust scores-type tests (in: Directions in Robust Statistics and Diagnostics, Part I, Springer, New York), our approach can be applied to other robust tests (for example, Wald- and dispersion-type also discussed in Markatou et al., 1991).     

Robust Inference in Conditionally Linear Nonlinear Regression Models

Abstract.  We consider robust methods of likelihood and frequentist inference for the nonlinear parameter, say α , in conditionally linear nonlinear regression models. We derive closed-form expressions for robust conditional, marginal, profile and modified profile likelihood functions for α under elliptically contoured data distributions. Next, we develop robust exact-F confidence intervals for α and consider robust Fieller intervals for ratios of regression parameters in linear models. Several well-known examples are considered and Monte Carlo simulation results are presented.     

Inference for the Dependent Competing Risks Model with Masked Causes of Failure

The competing risks model is useful in settings in which individuals/units may die/fail for different reasons. The cause specific hazard rates are taken to be piecewise constant functions. A complication arises when some of the failures are masked within a group of possible causes. Traditionally, statistical inference is performed under the assumption that the failure causes act independently on each item. In this paper we propose an EM-based approach which allows for dependent competing risks and produces estimators for the sub-distribution functions. We also discuss identifiability of parameters if none of the masked items have their cause of failure clarified in a second stage analysis (e.g. autopsy). The procedures proposed are illustrated with two datasets.     

Deletion diagnostics for generalized linear models using the adjusted Poisson likelihood function

In this article, we propose two novel diagnostic measures for the deletion of influential observations for regression parameters in the setting of generalized linear models. The proposed diagnostic methods are capable for detecting the influential observations under model misspecification, as long as the true underlying distributions have finite second moments.More specifically, it is demonstrated that the Poisson likelihood function can be properly adjusted to become asymptotically valid for practically all underlying discrete distributions. The adjusted Poisson regression model that achieves the robustness property is presented. Simulation studies and an illustration are performed to demonstrate the efficacy of the two novel diagnostic procedures.     

Data Dispersion: Now You See It… Now You Don't

Poisson regression is the most well-known method for modeling count data. When data display over-dispersion, thereby violating the underlying equi-dispersion assumption of Poisson regression, the common solution is to use negative-binomial regression. We show, however, that count data that appear to be equi- or over-dispersed may actually stem from a mixture of populations with different dispersion levels. To detect and model such a mixture, we introduce a generalization of the Conway-Maxwell-Poisson (COM-Poisson) regression model that allows for group-level dispersion. We illustrate mixed dispersion effects and the proposed methodology via semi-authentic data.     

Bayesian inference in a heteroscedastic replicated measurement error model using heavy-tailed distributions

We introduce a multivariate heteroscedastic measurement error model for replications under scale mixtures of normal distribution. The model can provide a robust analysis and can be viewed as a generalization of multiple linear regression from both model structure and distribution assumption. An efficient method based on Markov Chain Monte Carlo is developed for parameter estimation. The deviance information criterion and the conditional predictive ordinates are used as model selection criteria. Simulation studies show robust inference behaviours of the model against both misspecification of distributions and outliers. We work out an illustrative example with a real data set on measurements of plant root decomposition.     

Likelihood‐based and marginal inference methods for recurrent event data with covariate measurement error

Recurrent event data arise commonly in medical and public health studies. The analysis of such data has received extensive research attention and various methods have been developed in the literature. Depending on the focus of scientific interest, the methods may be broadly classified as intensity‐based counting process methods, mean function‐based estimating equation methods, and the analysis of times to events or times between events. These methods and models cover a wide variety of practical applications. However, there is a critical assumption underlying those methods–variables need to be correctly measured. Unfortunately, this assumption is frequently violated in practice. It is quite common that some covariates are subject to measurement error. It is well known that covariate measurement error can substantially distort inference results if it is not properly taken into account. In the literature, there has been extensive research concerning measurement error problems in various settings. However, with recurrent events, there is little discussion on this topic. It is the objective of this paper to address this important issue. In this paper, we develop inferential methods which account for measurement error in covariates for models with multiplicative intensity functions or rate functions. Both likelihood‐based inference and robust inference based on estimating equations are discussed. The Canadian Journal of Statistics 40: 530–549; 2012 © 2012 Statistical Society of Canada     

Bias in Small-Sample Inference With Count-Data Models

Abstract

Both Poisson and negative binomial regression can provide quasi-likelihood estimates for coefficients in exponential-mean models that are consistent in the presence of distributional misspecification. It has generally been recommended, however, that inference be carried out using asymptotically robust estimators for the parameter covariance matrix. As with linear models, such robust inference tends to lead to over-rejection of null hypotheses in small samples. Alternative methods for estimating coefficient estimator variances are considered. No one approach seems to remove all test bias, but the results do suggest that the use of the jackknife with Poisson regression tends to be least biased for inference.     

Efficient Bayesian analysis of multiple changepoint models with dependence across segments

We consider Bayesian analysis of a class of multiple changepoint models. While there are a variety of efficient ways to analyse these models if the parameters associated with each segment are independent, there are few general approaches for models where the parameters are dependent. Under the assumption that the dependence is Markov, we propose an efficient online algorithm for sampling from an approximation to the posterior distribution of the number and position of the changepoints. In a simulation study, we show that the approximation introduced is negligible. We illustrate the power of our approach through fitting piecewise polynomial models to data, under a model which allows for either continuity or discontinuity of the underlying curve at each changepoint. This method is competitive with, or outperform, other methods for inferring curves from noisy data; and uniquely it allows for inference of the locations of discontinuities in the underlying curve.     

Parametric simultaneous robust inferences for regression coefficient under generalized linear models

In this article, the parametric robust regression approaches are proposed for making inferences about regression parameters in the setting of generalized linear models (GLMs). The proposed methods are able to test hypotheses on the regression coefficients in the misspecified GLMs. More specifically, it is demonstrated that with large samples, the normal and gamma regression models can be properly adjusted to become asymptotically valid for inferences about regression parameters under model misspecification. These adjusted regression models can provide the correct type I and II error probabilities and the correct coverage probability for continuous data, as long as the true underlying distributions have finite second moments.     

Applying neural network Poisson regression to predict cognitive score changes

In this study, we combined a Poisson regression model with neural networks (neural network Poisson regression) to relax the traditional Poisson regression assumption of linearity of the Poisson mean as a function of covariates, while including it as a special case. In four simulated examples, we found that the neural network Poisson regression improved the performance of simple Poisson regression if the Poisson mean was nonlinearly related to covariates. We also illustrated the performance of the model in predicting five-year changes in cognitive scores, in association with age and education level; we found that the proposed approach had superior accuracy to conventional linear Poisson regression. As the interpretability of the neural networks is often difficult, its combination with conventional and more readily interpretable approaches under the generalized linear model can benefit applications in biomedicine.     

Statistical Inference for Damaged Poisson Distribution

Abstract

For non-negative integer-valued random variables, the concept of “damaged” observations was introduced, for the first time, by Rao and Rubin [Rao, C. R., Rubin, H. (1964). On a characterization of the Poisson distribution. Sankhya 26:295–298] in 1964 on a paper concerning the characterization of Poisson distribution. In 1965, Rao [Rao, C. R. (1965). On discrete distribution arising out of methods of ascertainment. Sankhya Ser. A. 27:311–324] discusses some results related with inferences for parameters of a Poisson Model when it has occurred partial destruction of observations. A random variable is said to be damaged if it is unobservable, due to a damage mechanism which randomly reduces its magnitude. In subsequent years, considerable attention has been given to characterizations of distributions of such random variables that satisfy the “Rao–Rubin” condition. This article presents some inference aspects of a damaged Poisson distribution, under reasonable assumption that, when an observation on the random variable is made, it is also possible to determine whether or not some damage has occurred. In other words, we do not know how many items are damaged, but we can identify the existence of damage. Particularly it is illustrated the situation in which it is possible to identify the occurrence of some damage although it is not possible to determine the amount of items damaged. Maximum likelihood estimators of the underlying parameters and their asymptotic covariance matrix are obtained. Convergence of the estimates of parameters to the asymptotic values are studied through Monte Carlo simulations.