Statistical inference for varying-coefficient partially linear errors-in-variables models with missing data

Abstract

The purpose of this paper is twofold. First, we investigate estimations in varying-coefficient partially linear errors-in-variables models with covariates missing at random. However, the estimators are often biased due to the existence of measurement errors, the bias-corrected profile least-squares estimator and local liner estimators for unknown parametric and coefficient functions are obtained based on inverse probability weighted method. The asymptotic properties of the proposed estimators both for the parameter and nonparametric parts are established. Second, we study asymptotic distributions of an empirical log-likelihood ratio statistic and maximum empirical likelihood estimator for the unknown parameter. Based on this, more accurate confidence regions of the unknown parameter can be constructed. The methods are examined through simulation studies and illustrated by a real data analysis.     

A note on predictive inference for multivariate elliptically contoured distributions

The prediction problem is considered for the multivariate regression model with an elliptically contoured error distribution. We show that the predictive distribution under elliptical errors assumption is the same as that obtained under normally distributed error in both the Bayesian approach using an im-proper prior and the classical approach. This gives inference robustness with respect to departures from the reference case of independent sampling from the normal distribution.     

Bayesian inference for joint location and scale nonlinear models with skew-normal errors

A regression model with skew-normal errors provides a useful extension for ordinary normal regression models when the dataset under consideration involves asymmetric outcomes. In this article, we explore the use of Markov Chain Monte Carlo (MCMC) methods to develop a Bayesian analysis for joint location and scale nonlinear models with skew-normal errors, which relax the normality assumption and include the normal one as a special case. The main advantage of these class of distributions is that they have a nice hierarchical representation that allows the implementation of MCMC methods to simulate samples from the joint posterior distribution. Finally, simulation studies and a real example are used to illustrate the proposed methodology.     

Pattern–mixture and selection models for analysing longitudinal data with monotone missing patterns

Summary. We examine three pattern–mixture models for making inference about parameters of the distribution of an outcome of interest Y that is to be measured at the end of a longitudinal study when this outcome is missing in some subjects. We show that these pattern–mixture models also have an interpretation as selection models. Because these models make unverifiable assumptions, we recommend that inference about the distribution of Y be repeated under a range of plausible assumptions. We argue that, of the three models considered, only one admits a parameterization that facilitates the examination of departures from the assumption of sequential ignorability. The three models are nonparametric in the sense that they do not impose restrictions on the class of observed data distributions. Owing to the curse of dimensionality, the assumptions that are encoded in these models are sufficient for identification but not for inference. We describe additional flexible and easily interpretable assumptions under which it is possible to construct estimators that are well behaved with moderate sample sizes. These assumptions define semiparametric models for the distribution of the observed data. We describe a class of estimators which, up to asymptotic equivalence, comprise all the consistent and asymptotically normal estimators of the parameters of interest under the postulated semiparametric models. We illustrate our methods with the analysis of data from a randomized clinical trial of contracepting women.     

Statistical inference in dynamic panel data models

Anderson and his collaborators have made seminal contributions to inference with instrumental variables and to dynamic panel data models. We review these contributions and the extensive economic and statistical literature that these contributions spawned. We describe our recent work in these two areas, presenting new approaches to (a) making valid inferences in the presence of weak instruments and (b) instrument and model selection for dynamic panel data models. Both approaches use empirical likelihood and resampling. For inference in the presence of weak instruments, our approach uses model averaging to achieve asymptotic efficiency with strong instruments but maintain valid inferences with weak instruments. For instrument and model selection, our approach aims at choosing valid instruments that are strong enough to be useful.     

Multiple imputation for ordinal longitudinal data with monotone missing data patterns

Missing data often complicate the analysis of scientific data. Multiple imputation is a general purpose technique for analysis of datasets with missing values. The approach is applicable to a variety of missing data patterns but often complicated by some restrictions like the type of variables to be imputed and the mechanism underlying the missing data. In this paper, the authors compare the performance of two multiple imputation methods, namely fully conditional specification and multivariate normal imputation in the presence of ordinal outcomes with monotone missing data patterns. Through a simulation study and an empirical example, the authors show that the two methods are indeed comparable meaning any of the two may be used when faced with scenarios, at least, as the ones presented here.     

Accurate inference for scale and location families

A great deal of inference in statistics is based on making the approximation that a statistic is normally distributed. The error in doing so is generally O(n^?1/2), where n is the sample size and can be considered when the distribution of the statistic is heavily biased or skewed. This note shows how one may reduce the error to O(n^?(j+1)/2), where j is a given integer. The case considered is when the statistic is the mean of the sample values of a continuous distribution with a scale or location change after the sample has undergone an initial transformation, which may depend on an unknown parameter. The transformation corresponding to Fisher's score function yields an asymptotically efficient procedure.     

Statistical inference for queueing models

The paper briefly describes methods and results in the statistical analysis of queueing systems     

Statistical inference for olfactometer data

Summary.  Olfactometer experiments are used to determine the effect of odours on the behaviour of organisms such as insects or nematodes, and typically result in data comprising many groups of small overdispersed counts. We develop a non-homogeneous Markov chain model for data from olfactometer experiments with parasitoid wasps and discuss a relation with the Dirichlet–multinomial distribution. We consider the asymptotic relative efficiencies of three different observation schemes and give an analysis of data intended to shed light on the effect of previous experience of odours in the wasps.     

Statistical inference for varying-coefficient models with error-prone covariates

Motivated by an application, we consider the statistical inference of varying-coefficient regression models in which some covariates are not observed, but ancillary variables are available to remit them. Due to the attenuation, the usual local polynomial estimation of the coefficient functions is not consistent. We propose a corrected local polynomial estimation for the unknown coefficient functions by calibrating the error-prone covariates. It is shown that the resulting estimators are consistent and asymptotically normal. In addition, we develop a wild bootstrap test for the goodness of fit of models. Some simulations are conducted to demonstrate the finite sample performances of the proposed estimation and test procedures. An example of application on a real data from Duchenne muscular dystrophy study is also illustrated.     

Robust location estimation with missing data

In a missing data setting, we have a sample in which a vector of explanatory variables ${\bf x}_i$ is observed for every subject i, while scalar responses $y_i$ are missing by happenstance on some individuals. In this work we propose robust estimators of the distribution of the responses assuming missing at random (MAR) data, under a semiparametric regression model. Our approach allows the consistent estimation of any weakly continuous functional of the response's distribution. In particular, strongly consistent estimators of any continuous location functional, such as the median, L‐functionals and M‐functionals, are proposed. A robust fit for the regression model combined with the robust properties of the location functional gives rise to a robust recipe for estimating the location parameter. Robustness is quantified through the breakdown point of the proposed procedure. The asymptotic distribution of the location estimators is also derived. The proofs of the theorems are presented in Supplementary Material available online. The Canadian Journal of Statistics 41: 111–132; 2013 © 2012 Statistical Society of Canada     

Statistical inference under imputation for proportional hazard model with missing covariates

Missing covariate data are common in biomedical studies. In this article, by using the non parametric kernel regression technique, a new imputation approach is developed for the Cox-proportional hazard regression model with missing covariates. This method achieves the same efficiency as the fully augmented weighted estimators (Qi et al. 2005. Journal of the American Statistical Association, 100:1250) and has a simpler form. The asymptotic properties of the proposed estimator are derived and analyzed. The comparisons between the proposed imputation method and several other existing methods are conducted via a number of simulation studies and a mouse leukemia data.     

Statistical inference for multiple change-point models

In this article, we propose a new technique for constructing confidence intervals for the mean of a noisy sequence with multiple change-points. We use the weighted bootstrap to generalize the bootstrap aggregating or bagging estimator. A standard deviation formula for the bagging estimator is introduced, based on which smoothed confidence intervals are constructed. To further improve the performance of the smoothed interval for weak signals, we suggest a strategy of adaptively choosing between the percentile intervals and the smoothed intervals. A new intensity plot is proposed to visualize the pattern of the change-points. We also propose a new change-point estimator based on the intensity plot, which has superior performance in comparison with the state-of-the-art segmentation methods. The finite sample performance of the confidence intervals and the change-point estimator are evaluated through Monte Carlo studies and illustrated with a real data example.     

The distribution of the Liu-type estimator of the biasing parameter in elliptically contoured models

We derive the density function of the stochastic shrinkage parameters of the Liu-type estimator in elliptical models. The correctness of derivation is checked by simulations. A real data application is also provided.     

Semi-empirical likelihood inference for the ROC curve with missing data

The receiver operating characteristic (ROC) curve is one of the most commonly used methods to compare the diagnostic performance of two or more laboratory or diagnostic tests. In this paper, we propose semi-empirical likelihood based confidence intervals for ROC curves of two populations, where one population is parametric and the other one is non-parametric and both have missing data. After imputing missing values, we derive the semi-empirical likelihood ratio statistic and the corresponding likelihood equations. It is shown that the log-semi-empirical likelihood ratio statistic is asymptotically scaled chi-squared. The estimating equations are solved simultaneously to obtain the estimated lower and upper bounds of semi-empirical likelihood confidence intervals. We conduct extensive simulation studies to evaluate the finite sample performance of the proposed empirical likelihood confidence intervals with various sample sizes and different missing probabilities.     

Maximum-likelihood estimates and likelihood-ratio criteria for multivariate elliptically contoured distributions

For a class of multivariate elliptically contoured distributions the maximum-likelihood estimators of the mean vector and covariance matrix are found under certain conditions. Likelihood-ratio criteria are obtained for a class of null hypotheses. These have the same form as in the normal case.     

Estimation of the covariance matrix with two-step monotone missing data

Abstract

We suggest shrinkage based technique for estimating covariance matrix in the high-dimensional normal model with missing data. Our approach is based on the monotone missing scheme assumption, meaning that missing values patterns occur completely at random. Our asymptotic framework allows the dimensionality p grow to infinity together with the sample size, N, and extends the methodology of Ledoit and Wolf (2004) Ledoit, O., Wolf, M. (2004). A well-conditioned estimator for large dimensional covariance matrices. J. Multivariate Anal. 88:365–411.[Crossref], [Web of Science ®] , [Google Scholar] to the case of two-step monotone missing data. Two new shrinkage-type estimators are derived and their dominance properties over the Ledoit and Wolf (2004) Ledoit, O., Wolf, M. (2004). A well-conditioned estimator for large dimensional covariance matrices. J. Multivariate Anal. 88:365–411.[Crossref], [Web of Science ®] , [Google Scholar] estimator are shown under the expected quadratic loss. We perform a simulation study and conclude that the proposed estimators are successful for a range of missing data scenarios.     

Statistical model and inference for pharmacokinetic data

In this paper, we consider a statistical model for the drug concentration–time profiles that are obtained in a pharmacokinetic (PK) study when the drug is orally administered. In the proposed statistical PK model, the subject-specific concentration–time curve is described by the one-compartment PK model with first-order absorption and elimination. Moreover, a multivariate generalized gamma distribution is developed for the joint distribution of the drug concentrations that are repeatedly measured from the same subject. We then construct confidence intervals for the subject–exposure parameters which provide a further insight into the individual exposure of the drug under study. The proposed statistical PK model and the associated inference are then applied to illustrate a real data set. A simulation study is also implemented to investigate the performances of the coverage probability and expected length of the proposed confidence intervals. Finally, we give conclusions and discussions on the application of the proposed procedures.     

Statistical inference for two Markov binomial models with applications

Disturbance models, involved in Engineering Process Control (EPC) and Statistical Process Control (SPC), take into consideration an additional parameter, the probability of a jump in the process parameter in any time period. Corrective actions are necessary to bring the process back on target. In a tuning procedure, one can deal with permanent corrective actions (settings), or with provisional ones (adjustments). Tuning r machines can be modeled through some binomial Markov chains, with the transition matrix depending on the probability that a disturbance occurs. Using two such models, we construct consistent estimators for the probability that a disturbance occurs at any period of time.     

Statistical inference for discrete middle-censored data

In this paper we consider the discrete middle censoring where lifetime, lower bound and length of censoring interval are variables with geometric distribution. We obtain the likelihood function of observed data and derive the MLE of the unknown parameter using EM algorithm. Also we obtain the Bayes estimator of the unknown parameter under squared error loss (SEL) function and credible interval of unknown parameter using Monte Carlo methods.