An evaluation of common methods for dichotomization of continuous variables to discriminate disease status

Dichotomization of continuous variables to discriminate a dichotomous outcome is often useful in statistical applications. If a true threshold for a continuous variable exists, the challenge is identifying it. This paper examines common methods for dichotomization to identify which ones recover a true threshold. We provide mathematical and numeric proofs demonstrating that maximizing the odds ratio, Youden’s statistic, Gini Index, chi-square statistic, relative risk and kappa statistic all theoretically recover a true threshold. A simulation study evaluating the ability of these statistics to recover a threshold when sampling from a population indicates that maximizing the chi-square statistic and Gini Index have the smallest bias and variability when the probability of being larger than the threshold is small while maximizing Kappa or Youden’s statistics is best when this probability is larger. Maximizing odds ratio is the most variable and biased of the methods.     

Sample Size Calculation for the Therapeutic Equivalence Problem

A method is proposed for the sample size calculation in the case of therapeutic equivalence of two pharmaceuticals, when the decision is based on post-treatment differences and the post-treatment values are dependent on the pretreatment ones. When the correlation coefficient is large (over 0.7), it is shown that sample size calculation (and the corresponding hypothesis test) based on the sample statistic formed by the mean difference of the post–pre differences of each group has smaller variance and hence leads to smaller sample sizes.     

On Using Linear Regressions in Welfare Economics

This article consists of two parts. The first part shows that the ordinary least squares regression coefficient is a weighted average of slopes between adjacent sample points. When applied to a linear regression, with income as the independent variable, the regression coefficient depends heavily on the slopes of high-income groups. The weight of the highest income decile may well exceed that of the other nine deciles. This may be undesirable, especially if the regression is used for welfare analysis, because the marginal propensities to consume attributed to the commodities are determined by the high-income groups. The second part of the article proposes alternative estimators, the extended Gini estimators, that enable investigators to control the weighting scheme and to incorporate their social views into the weighting scheme of the estimators     

城镇居民消费能力区域差异的基尼系数测度

建立中国居民消费能力综合评价指标体系,评价各地区综合消费能力大小,分析各地区居民消费能力的变异系数,并在此基础上构建消费能力的洛伦茨曲线,给出了基于人口不等分的消费基尼系数计算方法。对2008-2011年中国居民消费支出数据进行分析,并与多项式法计算消费基尼系数进行比较。结果表明:变异系数与消费基尼系数的相关系数达到0.993,消费基尼系数的设计是合理的;中国三个区域的消费差异有所不同,东部地区的消费基尼系数最大,中部地区的消费基尼系数最小,西部地区的消费基尼系数介于两者之间。     

从统计实施角度对基尼系数的再认识

文章从收集收入样本数据、到采用各种方法估算基尼系数、再到具体运用基尼系数进行收入差异评价的整个环节中,探讨了各个部分可能会出现的问题,以期能帮助我们如何用基尼系数客观地评判现实的经济生活。     

中国基尼系数警戒线的一个估计

 本文基于1978-2007年我国居民收入分配的分组数据测算了多个基尼系数,采用参数和非参数多种方法估计了基尼系数的分布服从渐近正态分布,最后基于大样本渐近特征给出了我国基尼系数警戒水平的估计值。     

Testing the Equality of Two Exponential Distributions

This paper proposes an overlapping-based test statistic for testing the equality of two exponential distributions with different scale and location parameters. The test statistic is defined as the maximum likelihood estimate of the Weitzman's overlapping coefficient, which estimates the agreement of two densities. The proposed test statistic is derived in closed form. Simulated critical points are generated for the proposed test statistic for various sample sizes and significance levels via Monte Carlo Simulations. Statistical powers of the proposed test are computed via simulation studies and compared to those of the existing Log likelihood ratio test.     

Strengthening the understanding of the relationship between survival designs and test statistics

In the planning of randomized survival trials, the role of follow‐up time of trial participants introduces a level of complexity not encountered in non‐survival trials. Of the two commonly used survival designs, one design fixes the follow‐up time whereas the other allows it to vary. When the follow‐up time is fixed the number of events varies. Conversely, when the number of events is fixed, the follow‐up time varies. These two designs influence test statistics in ways that have not been fully explored resulting in a misunderstanding of the design–test statistic relationship. We use examples from the literature to strengthen the understanding of this relationship. Group sequential trials are briefly discussed. When the number of events is fixed, we demonstrate why a two‐sample risk difference test statistic reduces to a one‐sample test statistic which is nearly equal to the risk ratio test statistic. Some aspects of fixed event designs that need further consideration are also discussed. Copyright © 2009 John Wiley & Sons, Ltd.     

Qualitative robustness of von Mises statistics based on strongly mixing data

In this article, the property of qualitative robustness is studied for von Mises statistics in the situation where the observations are not necessarily independent but are drawn from a strongly mixing sequence of identically distributed random variables. The notion of qualitative robustness is taken from “Zähle (2012, submitted)” where Huber’s version of Hampel’s original definition was adapted to the case of dependent observations. The main result is illustrated by means of several examples including the sample variance, the sample Gini’s mean difference and the Cramér–von Mises statistic.     

高校学生消费差异分析——基于基尼系数分解理论的实证研究

运用基尼系数分解方法，通过对北京市某高校325名学生抽样调查数据分析发现，以性别分组，组间差异构成是影响高校学生基尼系数的主要因素。以学生来自不同区域分组，差异主要来源于重叠项影响，但按两层分解基尼系数，性别内部来自不同区域的学生消费存在较为明显差异。学生消费支出主要用于基本生存消费。发展、享受、交往等开支增加起着扩大学生消费差异程度的作用，生存消费的增加起着缩小消费差异程度的作用。     

The power of the modified Wilcoxon rank-sum test for the one-sided alternative

When testing hypotheses in two-sample problems, the Wilcoxon rank-sum test is often used to test the location parameter, and this test has been discussed by many authors over the years. One modification of the Wilcoxon rank-sum test was proposed by Tamura [On a modification of certain rank tests. Ann Math Stat. 1963;34:1101–1103]. Deriving the exact critical value of the statistic is difficult when the sample sizes are increased. The normal approximation, the Edgeworth expansion, the saddlepoint approximation, and the permutation test were used to evaluate the upper tail probability for the modified Wilcoxon rank-sum test given finite sample sizes. The accuracy of various approximations to the probability of the modified Wilcoxon statistic was investigated. Simulations were used to investigate the power of the modified Wilcoxon rank-sum test for the one-sided alternative with various population distributions for small sample sizes. The method was illustrated by the analysis of real data.     

Asymptotic test statistics for coefficients of variation

A one-sample asymptotically normal test statistic Is derived for testing the hypothesis that the coefficient of variation of a normal population is equal to a specified value. Based on this derivation, an asymptotically noraml two-sample test statistic and an asymptotically chi-square k-sample test statistic are derived for testing the hypothesis that the coefficients of variation of k ≥2 normal populations are equal. The two and k-sample test statistics allow for unequal sample sizes. Results of a simulation study which evaluate the size and power of the test statistics and compare the test statistics to earlier ones developed by McKay (1932) and Bennett (1976) are presented.     

Applying skovgaard's modified directed likelihood statistic to mixed linear models

The introduction of software to calculate maximum likelihood estimates for mixed linear models has made likelihood estimation a practical alternative to methods based on sums of squares. Likelihood based tests and confidence intervals, however, may be misleading in problems with small sample sizes. This paper discusses an adjusted version of the directed log-likelihood statistic for mixed models that is highly accurate for testing one parameter hypotheses. Indroduced by Skovgaard (1996, Journal of the Bernoulli Society,2,145-165), we show in mixed models that the statistic has a simple conpact from that may be obtained from standard software. Simulation studies indicate that this statistic is more accurate than many of the specialized procedure that have been advocated.     

Posterior Distributions for the Gini Coefficient Using Grouped Data

When available data comprise a number of sampled households in each of a number of income classes, the likelihood function is obtained from a multinomial distribution with the income class population proportions as the unknown parameters. Two methods for going from this likelihood function to a posterior distribution on the Gini coefficient are investigated. In the first method, two alternative assumptions about the underlying income distribution are considered, namely a lognormal distribution and the Singh–Maddala (1976) income distribution. In these cases the likelihood function is reparameterized and the Gini coefficient is a nonlinear function of the income distribution parameters. The Metropolis algorithm is used to find the corresponding posterior distributions of the Gini coefficient from a sample of Bangkok households. The second method does not require an assumption about the nature of the income distribution, but uses (a) triangular prior distributions, and (b) beta prior distributions, on the location of mean income within each income class. By sampling from these distributions, and the Dirichlet posterior distribution of the income class proportions, alternative posterior distributions of the Gini coefficient are calculated.     

Optimal tests for carcinogenicity in a model with fatal and incidental tumours

In a recent paper Heimann and Neuhaus (Biometrika 88 (2001) 435) studied the combined test of Peto et al. (Long Term and Short Term Screening Assays for Carcinogens: A Critical Appraisal, IARC Monograph on the evaluation of the carcinogenic risk of chemicals to humans, Annex to supplement 2, WHO, Geneva, pp. 311–426) for the two sample testing problem. This test is an ad hoc test adding the log rank test statistic for the random censorship model and the Mantel Haenszel test statistic for the interval censored data model. Heimann and Neuhaus (Biometrika 88 (2001) 435) also introduced an appropriate statistical model combining randomly censored and interval censored data, to handle lethal and incidental tumours jointly.In the present paper we will derive asymptotically optimal tests for this model in a systematic way. The optimal test statistic is decomposed into two orthogonal parts, representing the fatal and incidental components. This will allow to use well known results from the literature for the fatal part, to estimate unknown quantities for the incidental part, and last but not least to compare with Peto's combined test.Moreover, we introduce conditional permutation versions of our tests which are finite sample distribution free under the null hypothesis with equal censoring and are asymptotically equivalent to their unconditional counterparts even under locally unequal censoring. Crucial for these results is a conditional limit theorem for the test statistics under local alternatives which follows from results of Strasser and Weber (Math. Methods Statist. 2 (1999) 220).     

理解区位基尼系数：局限性与基准分布的选择

 区位基尼系数虽然广泛用于度量产业的空间集聚,但很少有文献分析其应用的局限性和使用不同基准分布的影响。本文首先系统分析了区位基尼系数的三个主要缺陷：（1）受企业规模影响;（2）受地理单元设定的影响;（3）受产业分类影响。之后,本文分析了使用不同基准分布计算区位基尼系数所存在的经济意义上的差异,以及因此可能产生的理解偏差;同时,讨论了几种国内研究尚未使用过的比较有意义的基准分布形式。最后,本文以中国2004年制造业数据为例,解释了上述提出的问题。     

基尼系数的区间估计及其应用

 本文给出了收入为离散分布的三种计算基尼系数的新方法。利用收入份额法导出了基尼系数协方差算法的离散形式,并因此产生了计算基尼系数的回归系数法。文章重点讨论了基尼系数进行区间估计的两种方法,这些方法也适用于集中度指数,因而它们在测度社会经济领域的不平等中具有着十分广泛的用途。实际应用表明,新算法有效地简化了对基尼系数区间估计的标准差估算。     

EMPIRICAL LIKELIHOOD METHODS FOR THE GINI INDEX

The Gini index and its generalizations have been used extensively for measuring inequality and poverty in the social sciences. Recently, interval estimation based on nonparametric statistics has been proposed in the literature, for example the naive bootstrap method, the iterated bootstrap method and the bootstrap method via a pivotal statistic. In this paper, we propose empirical likelihood methods to construct confidence intervals for the Gini index or the difference of two Gini indices. Simulation studies show that the proposed empirical likelihood method performs slightly worse than the bootstrap method based on a pivotal statistic in terms of coverage accuracy, but it requires less computation. However, the bootstrap calibration of the empirical likelihood method performs better than the bootstrap method based on a pivotal statistic.     

Time-Varying Systemic Risk: Evidence From a Dynamic Copula Model of CDS Spreads

This article proposes a new class of copula-based dynamic models for high-dimensional conditional distributions, facilitating the estimation of a wide variety of measures of systemic risk. Our proposed models draw on successful ideas from the literature on modeling high-dimensional covariance matrices and on recent work on models for general time-varying distributions. Our use of copula-based models enables the estimation of the joint model in stages, greatly reducing the computational burden. We use the proposed new models to study a collection of daily credit default swap (CDS) spreads on 100 U.S. firms over the period 2006 to 2012. We find that while the probability of distress for individual firms has greatly reduced since the financial crisis of 2008–2009, the joint probability of distress (a measure of systemic risk) is substantially higher now than in the precrisis period. Supplementary materials for this article are available online.     

Contrasting the Gini and Zenga indices of economic inequality

The current financial turbulence in Europe inspires and perhaps requires researchers to rethink how to measure incomes, wealth, and other parameters of interest to policy-makers and others. The noticeable increase in disparities between less and more fortunate individuals suggests that measures based upon comparing the incomes of less fortunate with the mean of the entire population may not be adequate. The classical Gini and related indices of economic inequality, however, are based exactly on such comparisons. It is because of this reason that in this paper we explore and contrast the classical Gini index with a new Zenga index, the latter being based on comparisons of the means of less and more fortunate sub-populations, irrespectively of the threshold that might be used to delineate the two sub-populations. The empirical part of the paper is based on the 2001 wave of the European Community Household Panel data set provided by EuroStat. Even though sample sizes appear to be large, we supplement the estimated Gini and Zenga indices with measures of variability in the form of normal, t-bootstrap, and bootstrap bias-corrected and accelerated confidence intervals.