Quantile regression methods for left-truncated and right-censored data

Left-truncated and right-censored (LTRC) data are encountered frequently due to a prevalent cohort sampling in follow-up studies. Because of the skewness of the distribution of survival time, quantile regression is a useful alternative to the Cox's proportional hazards model and the accelerated failure time model for survival analysis. In this paper, we apply the quantile regression model to LTRC data and develops an unbiased estimating equation for regression coefficients. The proposed estimation methods use the inverse probabilities of truncation and censoring weighting technique. The resulting estimator is uniformly consistent and asymptotically normal. The finite-sample performance of the proposed estimation methods is also evaluated using extensive simulation studies. Finally, analysis of real data is presented to illustrate our proposed estimation methods.     

Proportional hazards regression with interval-censored and left-truncated data

This paper considers the estimation of the regression coefficients in the Cox proportional hazards model with left-truncated and interval-censored data. Using the approaches of Pan [A multiple imputation approach to Cox regression with interval-censored data, Biometrics 56 (2000), pp. 199–203] and Heller [Proportional hazards regression with interval censored data using an inverse probability weight, Lifetime Data Anal. 17 (2011), pp. 373–385], we propose two estimates of the regression coefficients. The first estimate is based on a multiple imputation methodology. The second estimate uses an inverse probability weight to select event time pairs where the ordering is unambiguous. A simulation study is conducted to investigate the performance of the proposed estimators. The proposed methods are illustrated using the Centers for Disease Control and Prevention (CDC) acquired immunodeficiency syndrome (AIDS) Blood Transfusion Data.     

Variable selection and weighted composite quantile estimation of regression parameters with left-truncated data

In this paper, we consider the weighted composite quantile regression for linear model with left-truncated data. The adaptive penalized procedure for variable selection is proposed. The asymptotic normality and oracle property of the resulting estimators are also established. Simulation studies are conducted to illustrate the finite sample performance of the proposed methods.     

Nonparametric tests for left-truncated and interval-censored data

This paper considers two-sample nonparametric comparison of survival function when data are subject to left truncation and interval censoring. We propose a class of rank-based tests, which are generalization of weighted log-rank tests for right-censored data. Simulation studies indicate that the proposed tests are appropriate for practical use.     

A semiparametric regression cure model for interval-censored and left-truncated data

Medical advancements have made it possible for patients to be cured of certain types of diseases. In follow-up studies, the disease event time can be subject to left truncation and interval censoring. In this article, we propose a semiparametric nonmixture cure model for the regression analysis of left-truncated and interval-censored (LTIC) data. We develop semiparametric maximum likelihood estimation for the nonmixture cure model with LTIC data. A simulation study is conducted to investigate the performance of the proposed estimators.     

A note on the efficiency of composite quantile regression

Composite quantile regression (CQR) is motivated by the desire to have an estimator for linear regression models that avoids the breakdown of the least-squares estimator when the error variance is infinite, while having high relative efficiency even when the least-squares estimator is fully efficient. Here, we study two weighting schemes to further improve the efficiency of CQR, motivated by Jiang et al. [Oracle model selection for nonlinear models based on weighted composite quantile regression. Statist Sin. 2012;22:1479–1506]. In theory the two weighting schemes are asymptotically equivalent to each other and always result in more efficient estimators compared with CQR. Although the first weighting scheme is hard to implement, it sheds light on in what situations the improvement is expected to be large. A main contribution is to theoretically and empirically identify that standard CQR has good performance compared with weighted CQR only when the error density is logistic or close to logistic in shape, which was not noted in the literature.     

Semiparametric analysis of transformation models with dependently left-truncated and right-censored data

In transplant studies, the patients must survive long enough to receive a transplant, which induces left-truncation. The assumption of independence between failure and truncation times may not hold since a longer transplant waiting time can be associated with a worse survivorship. To take dependence into consideration, we utilize a semiparametric transformation model, where the truncation time is both a truncated variable and a predictor of the time to failure. Using the inverse-probability-weighted (IPW) approach, we propose an IPW estimator of the marginal distribution of waiting time. Simulation studies are conducted to investigate finite sample performance of the proposed estimator. We also apply our methods to bone marrow and heart transplant data.     

Doubly robust weighted composite quantile regression based on SCAD-L2

In this article, a robust variable selection procedure based on the weighted composite quantile regression (WCQR) is proposed. Compared with the composite quantile regression (CQR), WCQR is robust to heavy-tailed errors and outliers in the explanatory variables. For the choice of the weights in the WCQR, we employ a weighting scheme based on the principal component method. To select variables with grouping effect, we consider WCQR with SCAD-L₂ penalization. Furthermore, under some suitable assumptions, the theoretical properties, including the consistency and oracle property of the estimator, are established with a diverging number of parameters. In addition, we study the numerical performance of the proposed method in the case of ultrahigh-dimensional data. Simulation studies and real examples are provided to demonstrate the superiority of our method over the CQR method when there are outliers in the explanatory variables and/or the random error is from a heavy-tailed distribution.     

The Cox-Aalen model for left-truncated and mixed interval-censored data

Scheike and Zhang [An additive-multiplicative Cox-Aalen regression model. Scand J Stat. 2002;29:75–88] proposed a flexible additive-multiplicative hazard model, called the Cox-Aalen model, by replacing the baseline hazard function in the well-known Cox model with a covariate-dependent Aalen model, which allows for both fixed and dynamic covariate effects. In this paper, based on left-truncated and mixed interval-censored (LT-MIC) data, we consider maximum likelihood estimation for the Cox-Aalen model with fixed covariates. We propose expectation-maximization (EM) algorithms for obtaining the conditional maximum likelihood estimators (cMLE) of the regression coefficients for the Cox-Aalen model. We establish the consistency of the cMLE. Numerical studies show that estimation via the EM algorithms performs well.     

A weighted linear quantile regression

In this article, we introduce a new weighted quantile regression method. Traditionally, the estimation of the parameters involved in quantile regression is obtained by minimizing a loss function based on absolute distances with weights independent of explanatory variables. Specifically, we study a new estimation method using a weighted loss function with the weights associated with explanatory variables so that the performance of the resulting estimation can be improved. In full generality, we derive the asymptotic distribution of the weighted quantile regression estimators for any uniformly bounded positive weight function independent of the response. Two practical weighting schemes are proposed, each for a certain type of data. Monte Carlo simulations are carried out for comparing our proposed methods with the classical approaches. We also demonstrate the proposed methods using two real-life data sets from the literature. Both our simulation study and the results from these examples show that our proposed method outperforms the classical approaches when the relative efficiency is measured by the mean-squared errors of the estimators.     

Copula-graphic estimation with left-truncated and right-censored data

In Survival Analysis and related fields of research right-censored and left-truncated data often appear. Usually, it is assumed that the right-censoring variable is independent of the lifetime of ultimate interest. However, in particular applications dependent censoring may be present; this is the case, for example, when there exist several competing risks acting on the same individual. In this paper we propose a copula-graphic estimator for such a situation. The estimator is based on a known Archimedean copula function which properly represents the dependence structure between the lifetime and the censoring time. Therefore, the current work extends the copula-graphic estimator in de Uña-Álvarez and Veraverbeke [Generalized copula-graphic estimator. Test. 2013;22:343–360] in the presence of left-truncation. An asymptotic representation of the estimator is derived. The performance of the estimator is investigated in an intensive Monte Carlo simulation study. An application to unemployment duration is included for illustration purposes.     

Bayesian quantile regression for ordinal longitudinal data

Since the pioneering work by Koenker and Bassett [27], quantile regression models and its applications have become increasingly popular and important for research in many areas. In this paper, a random effects ordinal quantile regression model is proposed for analysis of longitudinal data with ordinal outcome of interest. An efficient Gibbs sampling algorithm was derived for fitting the model to the data based on a location-scale mixture representation of the skewed double-exponential distribution. The proposed approach is illustrated using simulated data and a real data example. This is the first work to discuss quantile regression for analysis of longitudinal data with ordinal outcome.     

Quantile regression based on a weighted approach under semi-competing risks data

In this article, we investigate the quantile regression analysis for semi-competing risks data in which a non-terminal event may be dependently censored by a terminal event. Due to the dependent censoring, the estimation of quantile regression coefficients on the non-terminal event becomes difficult. In order to handle this problem, we assume Archimedean Copula to specify the dependence of the non-terminal event and the terminal event. Portnoy [Censored regression quantiles. J Amer Statist Assoc. 2003;98:1001–1012] considered the quantile regression model under right-censoring data. We extend his approach to construct a weight function, and then impose the weight function to estimate the quantile regression parameter for the non-terminal event under semi-competing risks data. We also prove the consistency and asymptotic properties for the proposed estimator. According to the simulation studies, the performance of our proposed method is good. We also apply our suggested approach to analyse a real data.     

A multi-index model for quantile regression with ordinal data

In this paper, we propose a quantile approach to the multi-index semiparametric model for an ordinal response variable. Permitting non-parametric transformation of the response, the proposed method achieves a root-n rate of convergence and has attractive robustness properties. Further, the proposed model allows additional indices to model the remaining correlations between covariates and the residuals from the single-index, considerably reducing the error variance and thus leading to more efficient prediction intervals (PIs). The utility of the model is demonstrated by estimating PIs for functional status of the elderly based on data from the second longitudinal study of aging. It is shown that the proposed multi-index model provides significantly narrower PIs than competing models. Our approach can be applied to other areas in which the distribution of future observations must be predicted from ordinal response data.     

On goodness-of-fit tests for Aalen's additive model based on left-truncated right-censored or doubly censored data

ABSTRACT

Gandy and Jensen (2005 Gandy, A., Jensen, U. (2005). On goodness-of-fit tests for Aalen's additive risk model. Scan. J. Stat. 32:425–445.[Crossref], [Web of Science ®] , [Google Scholar]) proposed goodness-of-fit tests for Aalen's additive risk model. In this article, we demonstrate that the approach of Gandy and Jensen (2005 Gandy, A., Jensen, U. (2005). On goodness-of-fit tests for Aalen's additive risk model. Scan. J. Stat. 32:425–445.[Crossref], [Web of Science ®] , [Google Scholar]) can be applied to left-truncated right-censored (LTRC) data and doubly censored data. A simulation study is conducted to investigate the performance of the proposed tests. The proposed tests are illustrated using heart transplant data.     

Empirical likelihood ratio confidence intervals in terms of cumulative hazard function for left-truncated and right-censored data

Abstract

Based on the approach of Pan and Zhou, we demonstrate that empirical likelihood ratios in terms of cumulative hazard function for left-truncated and right-censored (LTRC) data can be used to form confidence intervals for the parameters that are linear functionals of the cumulative hazard function. Simulation studies indicate that the empirical likelihood ratio based confidence intervals work well in finite samples.     

Penalized weighted composite quantile regression in the linear regression model with heavy-tailed autocorrelated errors

In this paper, a penalized weighted composite quantile regression estimation procedure is proposed to estimate unknown regression parameters and autoregression coefficients in the linear regression model with heavy-tailed autoregressive errors. Under some conditions, we show that the proposed estimator possesses the oracle properties. In addition, we introduce an iterative algorithm to achieve the proposed optimization problem, and use a data-driven method to choose the tuning parameters. Simulation studies demonstrate that the proposed new estimation method is robust and works much better than the least squares based method when there are outliers in the dataset or the autoregressive error distribution follows heavy-tailed distributions. Moreover, the proposed estimator works comparably to the least squares based estimator when there are no outliers and the error is normal. Finally, we apply the proposed methodology to analyze the electricity demand dataset.     

Nonstationary nonlinear quantile regression

This study examines estimation and inference based on quantile regression for parametric nonlinear models with an integrated time series covariate. We first derive the limiting distribution of the nonlinear quantile regression estimator and then consider testing for parameter restrictions, when the regression function is specified as an asymptotically homogeneous function. We also study linear-in-parameter regression models when the regression function is given by integrable regression functions as well as asymptotically homogeneous regression functions. We, furthermore, propose a fully modified estimator to reduce the bias in the original estimator under a certain set of conditions. Finally, simulation studies show that the estimators behave well, especially when the regression error term has a fat-tailed distribution.