Comment on ‘An improved score interval with a modified midpoint for a binomial proportion’

Yu et al. [An improved score interval with a modified midpoint for a binomial proportion. J Stat Comput Simul. 2014;84:1022–1038] propose a novel confidence interval (CI) for a binomial proportion by modifying the midpoint of the score interval. This CI is competitive with the various commonly used methods. At the same time, Martín and Álvarez [Two-tailed asymptotic inferences for a proportion. J Appl Stat. 2014;41:1516–1529] analyse the performance of 29 asymptotic two-tailed CI for a proportion. The CI they selected is based on the arcsin transformation (when this is applied to the data increased by 0.5), although they also refer to the good behaviour of the classical methods of score and Agresti and Coull (which may be preferred in certain circumstances). The aim of this commentary is to compare the four methods referred to previously. The conclusion (for the classic error α of 5%) is that with a small sample size (≤80) the method that should be used is that of Yu et al.; for a large sample size (n?≥?100), the four methods perform in a similar way, with a slight advantage for the Agresti and Coull method. In any case the Agresti and Coull method does not perform badly and tends to be conservative. The program which determines these four intervals are available from the address http://www.ugr.es/local/bioest/Z_LINEAR_K.EXEhttp://www.ugr.es/local/bioest/Z_LINEAR_K.EXE.     

A generalized score confidence interval for a binomial proportion

Constructing a confidence interval for a binomial proportion is one of the most basic problems in statistics. The score interval as well as the Wilson interval with some modified forms have been broadly investigated and suggested by many statisticians. In this paper, a generalized score interval CI_G(a) is proposed by replacing the coefficient 1/4 in the score interval with parameter a. Based on analyzing and comparing various confidence intervals, we recommend the generalized score interval CI_G(0.3) for the nominal confidence levels 0.90, 0.95 and 0.99, which improves the spike phenomenon of the score interval and behaves better and computes more easily than most of other approximate intervals such as the Agresti-Coull interval and the Jeffreys interval to estimate a binomial proportion.     

Confidence intervals for two sample binomial distribution

This paper considers confidence intervals for the difference of two binomial proportions. Some currently used approaches are discussed. A new approach is proposed. Under several generally used criteria, these approaches are thoroughly compared. The widely used Wald confidence interval (CI) is far from satisfactory, while the Newcombe's CI, new recentered CI and score CI have very good performance. Recommendations for which approach is applicable under different situations are given.     

Confidence Intervals in Regression That Utilize Uncertain Prior Information About a Vector Parameter

Consider a linear regression model with independent normally distributed errors. Suppose that the scalar parameter of interest is a specified linear combination of the components of the regression parameter vector. Also suppose that we have uncertain prior information that a parameter vector, consisting of specified distinct linear combinations of these components, takes a given value. Part of our evaluation of a frequentist confidence interval for the parameter of interest is the scaled expected length, defined to be the expected length of this confidence interval divided by the expected length of the standard confidence interval for this parameter, with the same confidence coefficient. We say that a confidence interval for the parameter of interest utilizes this uncertain prior information if (a) the scaled expected length of this interval is substantially less than one when the prior information is correct, (b) the maximum value of the scaled expected length is not too large and (c) this confidence interval reverts to the standard confidence interval, with the same confidence coefficient, when the data happen to strongly contradict the prior information. We present a new confidence interval for a scalar parameter of interest, with specified confidence coefficient, that utilizes this uncertain prior information. A factorial experiment with one replicate is used to illustrate the application of this new confidence interval.     

一种简单有效的二项分布比例参数似然比置信区间的求法

对二项分布比例参数p的似然比置信区间,提出一种简便求解方法。在平均覆盖率、平均区间长度及区间长度的95%置信区间准则下与WScore、Plus4、Jeffreys置信区间进行模拟比较。试验表明,在二项分布b(n,p)的参数n≥20且p∈(0.1,0.9)时,该方法获取的似然比置信区间性能优良。当点估计p值不是接近于0或1且n≥20时,推荐使用本方法获取p的置信区间。     

Inference for a binomial proportion in the presence of ties

We suppose a case is to be compared with controls on the basis of a test that gives a single discrete score. The score of the case may tie with the scores of one or more controls. However, scores relate to an underlying quantity of interest that is continuous and so an observed score can be treated as the rounded value of an underlying continuous score. This makes it reasonable to break ties. This paper addresses the problem of forming a confidence interval for the proportion of controls that have a lower underlying score than the case. In the absence of ties, this is the standard task of making inferences about a binomial proportion and many methods for forming confidence intervals have been proposed. We give a general procedure to extend these methods to handle ties, under the assumption that ties may be broken at random. Properties of the procedure are given and an example examines its performance when it is used to extend several methods. A real example shows that an estimated confidence interval can be much too small if the uncertainty associated with ties is not taken into account. Software implementing the procedure is freely available.     

Interval estimation for the breakpoint in segmented regression: a smoothed score‐based approach

This paper is concerned with interval estimation for the breakpoint parameter in segmented regression. We present score‐type confidence intervals derived from the score statistic itself and from the recently proposed gradient statistic. Due to lack of regularity conditions of the score, non‐smoothness and non‐monotonicity, naive application of the score‐based statistics is unfeasible and we propose to exploit the smoothed score obtained via induced smoothing. We compare our proposals with the traditional methods based on the Wald and the likelihood ratio statistics via simulations and an analysis of a real dataset: results show that the smoothed score‐like statistics perform in practice somewhat better than competitors, even when the model is not correctly specified.     

Robust confidence intervals for trend estimation in meta-analysis with publication bias

Confidence interval (CI) is very useful for trend estimation in meta-analysis. It provides a type of interval estimate of the regression slope as well as an indicator of the reliability of the estimate. Thus a precise calculation of confidence interval at an expected level is important. It is always difficult to explicitly quantify the CIs when there is publication bias in meta-analysis. Various CIs have been proposed, including the most widely used DerSimonian–Laird CI and the recently proposed Henmi–Copas CI. The latter provides a robust solution when there are non-ignorable missing data due to publication bias. In this paper we extended the idea into meta-analysis for trend estimation. We applied the method in different scenarios and showed that this type of CI is more robust than the others.     

Multiple Interval Mapping for Quantitative Trait Loci via EM Algorithm in the Presence of Crossover Interference

The rapid advance in molecular biology has made feasible systematic studies of mapping quantitative trait loci (QTL) in experiment organisms. The method of multiple interval mapping provides an appropriate way for mapping QTL using genetic makers. However, crossover interference has not been considered sufficiently in the current QTL mapping in which no crossover interference is assumed, and the length of maker interval is always kept fixed. In this article, we consider the issue of statistical inference in multiple interval mapping for QTL when crossover interference is present. The marker interval can be chosen appropriately in our method without keeping the maker interval lengths fixed in advance, and the asymptotic variance–covariance matrix of the MLEs is also derived. Two simulations are performed to evaluate the proposed method and show the impact of crossover interference to QTL mapping.     

Bayesian sample-size determination for one and two Poisson rate parameters with applications to quality control

We formulate Bayesian approaches to the problems of determining the required sample size for Bayesian interval estimators of a predetermined length for a single Poisson rate, for the difference between two Poisson rates, and for the ratio of two Poisson rates. We demonstrate the efficacy of our Bayesian-based sample-size determination method with two real-data quality-control examples and compare the results to frequentist sample-size determination methods.     

A confidence region with multiple intervals in multivariate bioassay

The exact confidence region for log relative potency resulting from likelihood score methods (Williams (1988) An exact confidence interval for the relative potency estimated from a multivariate bioassay, Biometrics, 44:861-868) will very likely consist of two disjoint confidence intervals. The two methods proposed by Williams which aim to select just one (the same) confidence interval from the confidence region are nearly – but not completely – consistent. The likelihood score interval and likelihood ratio interval are asymptotically equivalent. Williams's very strong claim concerning the confidence coefficient in the second selection method is still theoretically unproved; yet, simulations show that it is true for a wide range of practical experimental situations.     

Confidence intervals for estimating the population signal-to-noise ratio: a simulation study

This paper considered several confidence intervals for estimating the population signal-to-noise ratio based on parametric, non-parametric and modified methods. A simulation study has been conducted to compare the performance of the interval estimators under both symmetric and skewed distributions. We reported coverage probability and average width of the interval estimators. Based on the simulation study, we observed that some of our proposed interval estimators are performing better in the sense of smaller width and coverage probability and have been recommended for the researchers.     

Confidence intervals for coefficients of variation in two-parameter exponential distributions

This article examines confidence intervals for the single coefficient of variation and the difference of coefficients of variation in the two-parameter exponential distributions, using the method of variance of estimates recovery (MOVER), the generalized confidence interval (GCI), and the asymptotic confidence interval (ACI). In simulation, the results indicate that coverage probabilities of the GCI maintain the nominal level in general. The MOVER performs well in terms of coverage probability when data only consist of positive values, but it has wider expected length. The coverage probabilities of the ACI satisfy the target for large sample sizes. We also illustrate our confidence intervals using a real-world example in the area of medical science.     

Sample size needed to get given ratio of endpoints for confidence interval of standard deviation in a normal distribution

Confidence interval (CI) for a standard deviation in a normal distribution, based on pivotal quantity with a Chi-square distribution, is considered. As a measure of CI quality, the ratio of its endpoints is taken. There are given formulas for sample sizes so that this ratio does not exceed a fixed value. Both equally tailed and minimum ratio of endpoint CIs are considered.     

Sample size determination for quality control process using a multiple components tolerance interval

ABSTRACT

In the past, a tolerance interval was used for the statistical quality control process on raw materials and/or the final product. In the traditional concept of the tolerance interval, the variance from the measurements is a single component. However, we can find examples about several components that could vary in their measurements, so an approximate method must be found to modify the traditional tolerance interval. Now we employ a tolerance interval considering multiple components in the variance from the measurements to deal with quality control process. In our paper, the proposed method is used to solve the sample size determination for a two-sided tolerance interval approach considering multiple components on the variance of measurements.     

A Classroom Approach to the Construction of an Approximate Confidence Interval of a Poisson Mean Using One Observation

Even elementary statistical problems may give rise to a deeper and broader discussion of issues in probability and statistics. The construction of an approximate confidence interval for a Poisson mean turns out to be such a case. The simple standard two-sided Wald confidence interval by normal approximation is discussed and compared with the score interval. The discussion is partly in the form of an imaginary dialog between a teacher and a student, where the latter is supposed to have studied mathematical statistics for at least one semester.     

Calibrating the prior distribution for a normal model with conjugate prior

For a normal model with a conjugate prior, we provide an in-depth examination of the effects of the hyperparameters on the long-run frequentist properties of posterior point and interval estimates. Under an assumed sampling model for the data-generating mechanism, we examine how hyperparameter values affect the mean-squared error (MSE) of posterior means and the true coverage of credible intervals. We develop two types of hyperparameter optimality. MSE optimal hyperparameters minimize the MSE of posterior point estimates. Credible interval optimal hyperparameters result in credible intervals that have a minimum length while still retaining nominal coverage. A poor choice of hyperparameters has a worse consequence on the credible interval coverage than on the MSE of posterior point estimates. We give an example to demonstrate how our results can be used to evaluate the potential consequences of hyperparameter choices.     

Predicting a Future Median Life through a Power Transformation

A simple and unified prediction interval (PI) for the median of a future lifetime can be obtained through a power transformation. This interval usually possesses the correct coverage, at least asymptotically, when the transformation is known. However, when the transformation is unknown and is estimated from the data, a correction is required. A simple correction factor is derived based on large sample theory. Simulation shows that the unified PI after correction performs well. When compared with the existing frequentist PI's, it shows an equivalent or a better performance in terms of coverage probability and average length of the interval. Its nonparametric aspect and the ease of usage make it very attractive to practitioners. Real data examples are provided for illustration.     

Jackknife empirical likelihood for the error variance in linear models

Variance estimation is a fundamental yet important problem in statistical modelling. In this paper, we propose jackknife empirical likelihood (JEL) methods for the error variance in a linear regression model. We prove that the JEL ratio converges to the standard chi-squared distribution. The asymptotic chi-squared properties for the adjusted JEL and extended JEL estimators are also established. Extensive simulation studies to compare the new JEL methods with the standard method in terms of coverage probability and interval length are conducted, and the simulation results show that our proposed JEL methods perform better than the standard method. We also illustrate the proposed methods using two real data sets.     

Confidence intervals for the difference between independent binomial proportions: comparison using a graphical approach and moving averages

This paper uses graphical methods to illustrate and compare the coverage properties of a number of methods for calculating confidence intervals for the difference between two independent binomial proportions. We investigate both small‐sample and large‐sample properties of both two‐sided and one‐sided coverage, with an emphasis on asymptotic methods. In terms of aligning the smoothed coverage probability surface with the nominal confidence level, we find that the score‐based methods on the whole have the best two‐sided coverage, although they have slight deficiencies for confidence levels of 90% or lower. For an easily taught, hand‐calculated method, the Brown‐Li ‘Jeffreys’ method appears to perform reasonably well, and in most situations, it has better one‐sided coverage than the widely recommended alternatives. In general, we find that the one‐sided properties of many of the available methods are surprisingly poor. In fact, almost none of the existing asymptotic methods achieve equal coverage on both sides of the interval, even with large sample sizes, and consequently if used as a non‐inferiority test, the type I error rate (which is equal to the one‐sided non‐coverage probability) can be inflated. The only exception is the Gart‐Nam ‘skewness‐corrected’ method, which we express using modified notation in order to include a bias correction for improved small‐sample performance, and an optional continuity correction for those seeking more conservative coverage. Using a weighted average of two complementary methods, we also define a new hybrid method that almost matches the performance of the Gart‐Nam interval. Copyright © 2014 John Wiley & Sons, Ltd.