An asymptotic theory for semiparametric generalized least squares estimation in partially linear regression models

Consider a partially linear regression model with an unknown vector parameter β, an unknown functiong(·), and unknown heteroscedastic error variances. In this paper we develop an asymptotic semiparametric generalized least squares estimation theory under some weak moment conditions. These moment conditions are satisfied by many of the error distributions encountered in practice, and our theory does not require the number of replications to go to infinity.     

On testing proportionality in the Cox regression model by Andersen's plot

Andersen's plot, a graphical method for testing the proportionality assumption in the Cox Regression Model (Cox, 1972 Cox, D.R. (1972). Regression models and life tables (with discussion). J. Royal Stat. Soc. Ser. B 34:187–220. [Google Scholar]), first proposed by Kay (1977 Kay, R. (1977). Proportional hazard regression models and the analysis of censored survival data. Appl. Stat. 26(3):227–237.[Crossref] , [Google Scholar]) and popularized by Andersen (1982 Andersen, P.K. (1982). Testing goodness of fit of Cox's regression and life model. Biometrics 38:67–77.[Crossref], [Web of Science ®] , [Google Scholar]), has been used widely in biomedical research to check the validity of applying this popular regression model in survival analysis. Our theoretical derivation and examples show that the theoretical basis of this method is flawed. The graphical method should not be used in testing the proportionality. Instead, formal analytical methods based on residuals such as Cox–Snell residual and martingale residual should be used in practice.     

Assessing large sample bias in misspecified model scenarios with reference to exposure model misspecification in errors-in-variable regression: A new computational approach

In this paper, we develop a numerical method for evaluating the large sample bias in estimated regression coefficients arising due to exposure model misspecification while adjusting for measurement errors in errors-in-variable regression. The application of the proposed method has been demonstrated in the case of a logistic errors-in-variable regression model. The method is based on the combination of Monte-Carlo, numerical and, in some special cases, analytic integration techniques. The proposed method facilitates the investigation of the limiting bias in the estimated regression parameters based on a single data set rather than on repeated data sets as required by the conventional repeated sample method. Simulation studies demonstrate that the proposed method provides very similar estimates of bias in the estimated regression parameters under exposure model misspecification in logistic errors-in-variable regression with a higher degree of precision as compared to the conventional repeated sample method.     

Root-n-consistent Estimation in Partial Linear Models with Long-memory Errors

We consider estimation of β in the semiparametric regression model y ( i ) - x ^T( i )β + f ( i / n ) + ε( i ) where x ( i ) = g ( i )/ n ) + e ( i , f and g are unknown smooth functions and the processes ε( i ) and e ( i ) are stationary with short- or long-range dependence. For the case of i.i.d. errors, Speckman (1988) proposed a √ n –consistent estimator of β. In this paper it is shown that, under suitable regularity conditions, this estimator is asymptotically unbiased and √ n –consistent even if the errors exhibit long-range dependence. The orders of the finite sample bias and of the required bandwidth depend on the long-memory parameters. Simulations and a data example illustrate the method     

A generalized semiparametric regression and its efficient estimation

We investigate a generalized semiparametric regression. Such a model can avoid the risk of wrongly choosing the base measure function. We propose a profile likelihood to efficiently estimate both parameter and nonparametric function. The main difference from the classical profile likelihood is that the profile likelihood proposed is a functional of the base measure function, instead of a function of a real variable. By making the most of the structure information of the semiparametric exponential family, we get an explicit expression of the estimator of the least favorable curve. It ensures that the new profile likelihood is computationally simple. Due to the use of the least favorable curve, the semiparametric efficiency is achieved successfully and the estimation bias is reduced significantly. Simulation studies can illustrate that our proposal is much better than the existing methodologies for most cases under study, and is robust to the different model conditions.     

Plug-in bandwidth choice for estimation of nonparametric part in partial linear regression models with strong mixing errors

Consider a regression model where the regression function is the sum of a linear and a nonparametric component. Assuming that the errors of the model follow a stationary strong mixing process with mean zero, the problem of bandwidth selection for a kernel estimator of the nonparametric component is addressed here. We obtain an asymptotic expression for an optimal band-width and we propose to use a plug-in methodology in order to estimate this bandwidth through preliminary estimates of the unknown quantities. Asymptotic optimality for the plug-in bandwidth is established.     

Quantile regression in functional linear semiparametric model

This paper proposes nonparametric estimation methods for functional linear semiparametric quantile regression, where the conditional quantile of the scalar responses is modelled by both scalar and functional covariates and an additional unknown nonparametric function term. The slope function is estimated using the functional principal component basis and the nonparametric function is approximated by a piecewise polynomial function. The asymptotic distribution of the estimators of slope parameters is derived and the global convergence rate of the quantile estimator of unknown slope function is established under suitable norm. The asymptotic distribution of the estimator of the unknown nonparametric function is also established. Simulation studies are conducted to investigate the finite-sample performance of the proposed estimators. The proposed methodology is demonstrated by analysing a real data from ADHD-200 sample.     

A test for the linearity of the nonparametric part of a semiparametric logistic regression model

A semiparametric logistic regression model is proposed in which its nonparametric component is approximated with fixed-knot cubic B-splines. To assess the linearity of the nonparametric component, we construct a penalized likelihood ratio test statistic. When the number of knots is fixed, the null distribution of the test statistic is shown to be asymptotically the distribution of a linear combination of independent chi-squared random variables, each with one degree of freedom. We set the asymptotic null expectation of this test statistic equal to a value to determine the smoothing parameter value. Monte Carlo experiments are conducted to investigate the performance of the proposed test. Its practical use is illustrated with a real-life example.     

Evaluating functional covariate‐environment interactions in the Cox regression model

Children exposed to mixtures of endocrine disrupting compounds such as phthalates are at high risk of experiencing significant friction in their growth and sexual maturation. This article is primarily motivated by a study that aims to assess the toxicants‐modified effects of risk factors related to the hazards of early or delayed onset of puberty among children living in Mexico City. To address the hypothesis of potential nonlinear modification of covariate effects, we propose a new Cox regression model with multiple functional covariate‐environment interactions, which allows covariate effects to be altered nonlinearly by mixtures of exposed toxicants. This new class of models is rather flexible and includes many existing semiparametric Cox models as special cases. To achieve efficient estimation, we develop the global partial likelihood method of inference, in which we establish key large‐sample results, including estimation consistency, asymptotic normality, semiparametric efficiency and the generalized likelihood ratio test for both parameters and nonparametric functions. The proposed methodology is examined via simulation studies and applied to the analysis of the motivating data, where maternal exposures to phthalates during the third trimester of pregnancy are found to be important risk modifiers for the age of attaining the first stage of puberty. The Canadian Journal of Statistics 47: 204–221; 2019 © 2019 Statistical Society of Canada     

The exact properties of the lawless and wang operational ridge regression estimator in a misspecified regression equation

The exact properties of the Lawless and Wang Operational Ridge Regression estimator are derived in the context of a misspecified regression equation.     

Semiparametric regression estimation for longitudinal data in models with martingale difference error's structure

An inherent characteristic of longitudinal data is the dependence among the observations within the same subject. For exhibiting dependencies among the observations within the same subject, this paper considers a semiparametric partially linear regression model for longitudinal data based on martingale difference error's structure. We establish a strong consistency for the least squares estimator of a parametric component and the estimator of a non-parametric function under some mild conditions. A simulation study shows the performance of the proposed estimator in finite samples.     

Automatic and location-adaptive estimation in functional single-index regression

This paper develops a new automatic and location-adaptive procedure for estimating regression in a Functional Single-Index Model (FSIM). This procedure is based on k-Nearest Neighbours (kNN) ideas. The asymptotic study includes results for automatically data-driven selected number of neighbours, making the procedure directly usable in practice. The local feature of the kNN approach insures higher predictive power compared with usual kernel estimates, as illustrated in some finite sample analysis. As by-product, we state as preliminary tools some new uniform asymptotic results for kernel estimates in the FSIM model.     

Block empirical likelihood for longitudinal partially linear regression models

The authors propose a block empirical likelihood procedure to accommodate the within‐group correlation in longitudinal partially linear regression models. This leads them to prove a nonparametric version of the Wilks theorem. In comparison with normal approximations, their method does not require a consistent estimator for the asymptotic covariance matrix, which makes it easier to conduct inference on the parametric component of the model. An application to a longitudinal study on fluctuations of progesterone level in a menstrual cycle is used to illustrate the procedure developed here.     

Interval-valued data regression using partial linear model

Semi-parametric modelling of interval-valued data is of great practical importance, as exampled by applications in economic and financial data analysis. We propose a flexible semi-parametric modelling of interval-valued data by integrating the partial linear regression model based on the Center & Range method, and investigate its estimation procedure. Furthermore, we introduce a test statistic that allows one to decide between a parametric linear model and a semi-parametric model, and approximate its null asymptotic distribution based on wild Bootstrap method to obtain the critical values. Extensive simulation studies are carried out to evaluate the performance of the proposed methodology and the new test. Moreover, several empirical data sets are analysed to document its practical applications.     

Evaluating model misspecification in independent component analysis

Independent component analysis (ICA) is a popular blind source separation technique used in many scientific disciplines. Current ICA approaches have focused on developing efficient algorithms under specific ICA models, such as instantaneous or convolutive mixing conditions, intrinsically assuming temporal independence or autocorrelation of the sources. In practice, the true model is not known and different ICA algorithms can produce very different results. Although it is critical to choose an ICA model, there has not been enough research done on evaluating mixing models and assumptions, and how the associated algorithms may perform under different scenarios. In this paper, we investigate the performance of multiple ICA algorithms under various mixing conditions. We also propose a convolutive ICA algorithm for echoic mixing cases. Our simulation studies show that the performance of ICA algorithms is highly dependent on mixing conditions and temporal independence of the sources. Most instantaneous ICA algorithms fail to separate autocorrelated sources, while convolutive ICA algorithms depend highly on the model specification and approximation accuracy of unmixing filters.     

Properties of robust m-estimators for poisson and negative binomial data ∗

We investigate robust M-estimators of location and over-dispersion for independent and identically distributed samples from Poisson and Negative Binomial (NB)distributions. We focus on asymptotic and small-sample efficiencies, outlier-induced biases, and biases caused by model mis-specification. This is important information for assessing the practical utility of the estimation method. Our results demonstrate that resonably efficient estimation of location and over-dispersion parameters for count data is possible with samples sizes as small as n=25. The sensitivity of these stimators, especially when the amount of over-dispersion is small. We aslo conclude that serious biases result when using robust Poisson M-estimation with NB data. The biases are less serious when using robust NB M-estimation with Poisson data.     

Ridge regression methodology in partial linear models with correlated errors

In this article, a generalized restricted difference-based ridge estimator is defined for the vector parameter in a partial linear model when the errors are dependent. It is suspected that some additional linear constraints may hold on to the whole parameter space. The estimator is a generalization of the well-known restricted least-squares estimator and is confined to the (affine) subspace which is generated by the restrictions. The risk functions of the proposed estimators are derived under balanced loss function. Finally, the performance of the new estimators is evaluated by a simulated data set.     

A Better Alternative to Non-parametric Approaches for Adjusting for Covariate Measurement Errors in Logistic Regression

In this article, we propose a flexible parametric (FP) approach for adjusting for covariate measurement errors in regression that can accommodate replicated measurements on the surrogate (mismeasured) version of the unobserved true covariate on all the study subjects or on a sub-sample of the study subjects as error assessment data. We utilize the general framework of the FP approach proposed by Hossain and Gustafson in 2009 for adjusting for covariate measurement errors in regression. The FP approach is then compared with the existing non-parametric approaches when error assessment data are available on the entire sample of the study subjects (complete error assessment data) considering covariate measurement error in a multiple logistic regression model. We also developed the FP approach when error assessment data are available on a sub-sample of the study subjects (partial error assessment data) and investigated its performance using both simulated and real life data. Simulation results reveal that, in comparable situations, the FP approach performs as good as or better than the competing non-parametric approaches in eliminating the bias that arises in the estimated regression parameters due to covariate measurement errors. Also, it results in better efficiency of the estimated parameters. Finally, the FP approach is found to perform adequately well in terms of bias correction, confidence coverage, and in achieving appropriate statistical power under partial error assessment data.