A consistent estimator for logistic mixed effect models

We propose a consistent and locally efficient method of estimating the model parameters of a logistic mixed effect model with random slopes. Our approach relaxes two typical assumptions: the random effects being normally distributed, and the covariates and random effects being independent of each other. Adhering to these assumptions is particularly difficult in health studies where, in many cases, we have limited resources to design experiments and gather data in long‐term studies, while new findings from other fields might emerge, suggesting the violation of such assumptions. So it is crucial to have an estimator that is robust to such violations; then we could make better use of current data harvested using various valuable resources. Our method generalizes the framework presented in Garcia & Ma (2016) which also deals with a logistic mixed effect model but only considers a random intercept. A simulation study reveals that our proposed estimator remains consistent even when the independence and normality assumptions are violated. This contrasts favourably with the traditional maximum likelihood estimator which is likely to be inconsistent when there is dependence between the covariates and random effects. Application of this work to a study of Huntington's disease reveals that disease diagnosis can be enhanced using assessments of cognitive performance. The Canadian Journal of Statistics 47: 140–156; 2019 © 2019 Statistical Society of Canada     

Local influence for generalized linear mixed models

The authors describe a method for assessing model inadequacy in maximum likelihood estimation of a generalized linear mixed model. They treat the latent random effects in the model as missing data and develop the influence analysis on the basis of a Q‐function which is associated with the conditional expectation of the complete‐data log‐likelihood function in the EM algorithm. They propose a procedure to detect influential observations in six model perturbation schemes. They also illustrate their methodology in a hypothetical situation and in two real cases.     

A new stochastic mixed Liu estimator in linear regression model

Abstract

To overcome multicollinearity, a new stochastic mixed Liu estimator is presented and its efficiency is considered. We also compare the proposed estimators in the sense of matrix mean squared error criteria. Finally a numerical example and a simulation study are given to show the performance of the estimators.     

Estimation in a linear regression model with stochastic linear restrictions: a new two-parameter-weighted mixed estimator

The present paper considers the weighted mixed regression estimation of the coefficient vector in a linear regression model with stochastic linear restrictions binding the regression coefficients. We introduce a new two-parameter-weighted mixed estimator (TPWME) by unifying the weighted mixed estimator of Schaffrin and Toutenburg [1] and the two-parameter estimator (TPE) of Özkale and Kaç?ranlar [2]. This new estimator is a general estimator which includes the weighted mixed estimator, the TPE and the restricted two-parameter estimator (RTPE) proposed by Özkale and Kaç?ranlar [2] as special cases. Furthermore, we compare the TPWME with the weighted mixed estimator and the TPE with respect to the matrix mean square error criterion. A numerical example and a Monte Carlo simulation experiment are presented by using different estimators of the biasing parameters to illustrate some of the theoretical results.     

Robust estimation in generalized linear mixed models

Generalized linear mixed models (GLMMs) are widely used to analyse non-normal response data with extra-variation, but non-robust estimators are still routinely used. We propose robust methods for maximum quasi-likelihood and residual maximum quasi-likelihood estimation to limit the influence of outlying observations in GLMMs. The estimation procedure parallels the development of robust estimation methods in linear mixed models, but with adjustments in the dependent variable and the variance component. The methods proposed are applied to three data sets and a comparison is made with the nonparametric maximum likelihood approach. When applied to a set of epileptic seizure data, the methods proposed have the desired effect of limiting the influence of outlying observations on the parameter estimates. Simulation shows that one of the residual maximum quasi-likelihood proposals has a smaller bias than those of the other estimation methods. We further discuss the equivalence of two GLMM formulations when the response variable follows an exponential family. Their extensions to robust GLMMs and their comparative advantages in modelling are described. Some possible modifications of the robust GLMM estimation methods are given to provide further flexibility for applying the method.     

A generalized inverse regression estimator in multi-univariate linear calibration

A multivariate linear calibration problem, in which response variable is multivariate and explanatory variable is univariate, is considered. In this paper a class of generalized inverse regression estimators is proposed in multi-univariate linear calibration. It includes the classical estimator and the inverse regression one (or Krutchkoff estimator). For the proposed estimator we derive the expressions of bias and mean square error (MSE). Furthermore the behavior of these characteristics is investigated through an analytical method. In addition through a numerical study we confirm the existence of a generalized inverse regression estimator to improve both the classical and the inverse regression estimators on the MSE criterion.     

Efficiency of the generalized-difference-based weighted mixed almost unbiased two-parameter estimator in partially linear model

In this paper, a generalized difference-based estimator is introduced for the vector parameter β in partially linear model when the errors are correlated. A generalized-difference-based almost unbiased two-parameter estimator is defined for the vector parameter β. Under the linear stochastic constraint r = Rβ + e, we introduce a new generalized-difference-based weighted mixed almost unbiased two-parameter estimator. The performance of this new estimator over the generalized-difference-based estimator and generalized- difference-based almost unbiased two-parameter estimator in terms of the MSEM criterion is investigated. The efficiency properties of the new estimator is illustrated by a simulation study. Finally, the performance of the new estimator is evaluated for a real dataset.     

Improvement of generalized difference-based mixed Liu estimator in partially linear model

In this paper, a generalized difference-based mixed Liu estimator in partially linear model is presented, when it is supposed that the regression parameter may be restricted to a subspace and compare the proposed estimators in the sense of matrix mean squared error criteria. Finally a simulation study is presented to show the performance of the estimators.     

Robust quasi-likelihood inference in generalized linear mixed models with outliers

It is well known that in a traditional outlier-free situation, the generalized quasi-likelihood (GQL) approach [B.C. Sutradhar, On exact quasilikelihood inference in generalized linear mixed models, Sankhya: Indian J. Statist. 66 (2004), pp. 261–289] performs very well to obtain the consistent as well as the efficient estimates for the parameters involved in the generalized linear mixed models (GLMMs). In this paper, we first examine the effect of the presence of one or more outliers on the GQL estimation for the parameters in such GLMMs, especially in two important models such as count and binary mixed models. The outliers appear to cause serious biases and hence inconsistency in the estimation. As a remedy, we then propose a robust GQL (RGQL) approach in order to obtain the consistent estimates for the parameters in the GLMMs in the presence of one or more outliers. An extensive simulation study is conducted to examine the consistency performance of the proposed RGQL approach.     

Liu estimator in partly linear regression models with correlated errors

This article is concerned with the parameter estimation in partly linear regression models when the errors are dependent. To overcome the multicollinearity problem, a generalized Liu estimator is proposed. The theoretical properties of the proposed estimator and its relationship with some existing methods designed for partly linear models are investigated. Finally, a hypothetical data is conducted to illustrate some of the theoretical results.     

A comparison of mixed and minimax estimators of linear models

In this paper the stochastic properties of two estimators of linear models, mixed and minimax, based on different types of prior information, are compared using quadratic risk as the criterion for superiority. A necessary and sufficient condition for the minimax estimator to be superior to the comparable mixed estimator is derived as well as a simpler necessary but not sufficient condition.     

Mixed Liu estimator in linear measurement error models

In this paper, we introduce mixed Liu estimator (MLE) for the vector of parameters in linear measurement error models by unifying the sample and the prior information. The MLE is a generalization of the mixed estimator (ME) and Liu estimator (LE). In particular, asymptotic normality properties of the estimators are discussed, and the performance of the MLE over the LE and ME are compared based on mean squared error matrix (MSEM). Finally, a Monte Carlo simulation and a numerical example are also presented for analysis.     

A note on Stein-type shrinkage estimator in partial linear models

In this paper, an exact sufficient condition for the dominance of the Stein-type shrinkage estimator over the usual unbiased estimator in a partial linear model is exhibited. Comparison result is then done under the balanced loss function. It is assumed that the vector of disturbances is typically distributed according to the law belonging to the sub-class of elliptically contoured models. It is also shown that the dominance condition is robust. Furthermore, a nonparametric estimation after estimation of the linear part is added for detecting the efficiency of the obtained results.     

A simultaneous variable selection methodology for linear mixed models

Selecting an appropriate structure for a linear mixed model serves as an appealing problem in a number of applications such as in the modelling of longitudinal or clustered data. In this paper, we propose a variable selection procedure for simultaneously selecting and estimating the fixed and random effects. More specifically, a profile log-likelihood function, along with an adaptive penalty, is utilized for sparse selection. The Newton-Raphson optimization algorithm is performed to complete the parameter estimation. By jointly selecting the fixed and random effects, the proposed approach increases selection accuracy compared with two-stage procedures, and the usage of the profile log-likelihood can improve computational efficiency in one-stage procedures. We prove that the proposed procedure enjoys the model selection consistency. A simulation study and a real data application are conducted for demonstrating the effectiveness of the proposed method.     

Prediction in linear mixed models

Following estimation of effects from a linear mixed model, it is often useful to form predicted values for certain factor/variate combinations. The process has been well defined for linear models, but the introduction of random effects into the model means that a decision has to be made about the inclusion or exclusion of random model terms from the predictions. This paper discusses the interpretation of predictions formed including or excluding random terms. Four datasets are used to illustrate circumstances where different prediction strategies may be appropriate: in an orthogonal design, an unbalanced nested structure, a model with cubic smoothing spline terms and for kriging after spatial analysis. The examples also show the need for different weighting schemes that recognize nesting and aliasing during prediction, and the necessity of being able to detect inestimable predictions.     

Improvement of the Liu estimator in linear regression model

In the presence of stochastic prior information, in addition to the sample, Theil and Goldberger (1961) introduced a Mixed Estimator for the parameter vector β in the standard multiple linear regression model (T,Xβ,σ² I). Recently, the Liu estimator which is an alternative biased estimator for β has been proposed by Liu (1993). In this paper we introduce another new Liu type biased estimator called Stochastic restricted Liu estimator for β, and discuss its efficiency. The necessary and sufficient conditions for mean squared error matrix of the Stochastic restricted Liu estimator to exceed the mean squared error matrix of the mixed estimator will be derived for the two cases in which the parametric restrictions are correct and are not correct. In particular we show that this new biased estimator is superior in the mean squared error matrix sense to both the Mixed estimator and to the biased estimator introduced by Liu (1993).