Residuals for log-Burr XII regression models in survival analysis

In this paper, we compare three residuals to assess departures from the error assumptions as well as to detect outlying observations in log-Burr XII regression models with censored observations. These residuals can also be used for the log-logistic regression model, which is a special case of the log-Burr XII regression model. For different parameter settings, sample sizes and censoring percentages, various simulation studies are performed and the empirical distribution of each residual is displayed and compared with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be straightforwardly extended to the modified martingale-type residual in log-Burr XII regression models with censored data.     

The log-odd log-logistic Weibull regression model: modelling,estimation, influence diagnostics and residual analysis

In applications of survival analysis, the failure rate function may frequently present a unimodal shape. In such cases, the log-normal and log-logistic distributions are used. In this paper, we shall be concerned only with parametric forms, so a location-scale regression model based on the odd log-logistic Weibull distribution is proposed for modelling data with a decreasing, increasing, unimodal and bathtub failure rate function as an alternative to the log-Weibull regression model. For censored data, we consider a classic method to estimate the parameters of the proposed model. We derive the appropriate matrices for assessing local influences on the parameter estimates under different perturbation schemes and present some ways to assess global influences. Further, for different parameter settings, sample sizes and censoring percentages, various simulations are performed. In addition, the empirical distribution of some modified residuals is determined and compared with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be extended to a modified deviance residual in the new regression model applied to censored data. We analyse a real data set using the log-odd log-logistic Weibull regression model.     

Generalized log-gamma regression models with cure fraction

In this paper, the generalized log-gamma regression model is modified to allow the possibility that long-term survivors may be present in the data. This modification leads to a generalized log-gamma regression model with a cure rate, encompassing, as special cases, the log-exponential, log-Weibull and log-normal regression models with a cure rate typically used to model such data. The models attempt to simultaneously estimate the effects of explanatory variables on the timing acceleration/deceleration of a given event and the surviving fraction, that is, the proportion of the population for which the event never occurs. The normal curvatures of local influence are derived under some usual perturbation schemes and two martingale-type residuals are proposed to assess departures from the generalized log-gamma error assumption as well as to detect outlying observations. Finally, a data set from the medical area is analyzed.     

A log-linear regression model for the odd Weibull distribution with censored data

We introduce the log-odd Weibull regression model based on the odd Weibull distribution (Cooray, 2006). We derive some mathematical properties of the log-transformed distribution. The new regression model represents a parametric family of models that includes as sub-models some widely known regression models that can be applied to censored survival data. We employ a frequentist analysis and a parametric bootstrap for the parameters of the proposed model. We derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes and present some ways to assess global influence. Further, for different parameter settings, sample sizes and censoring percentages, some simulations are performed. In addition, the empirical distribution of some modified residuals are given and compared with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be extended to a modified deviance residual in the proposed regression model applied to censored data. We define martingale and deviance residuals to check the model assumptions. The extended regression model is very useful for the analysis of real data.     

Log-Weibull extended regression model: Estimation,sensitivity and residual analysis

The failure rate function commonly has a bathtub shape in practice. In this paper we discuss a regression model considering new Weibull extended distribution developed by Xie et al. (2002) that can be used to model this type of failure rate function. Assuming censored data, we discuss parameter estimation: maximum likelihood method and a Bayesian approach where Gibbs algorithms along with Metropolis steps are used to obtain the posterior summaries of interest. We derive the appropriate matrices for assessing the local influence on the parameter estimates under different perturbation schemes, and we also present some ways to perform global influence. Also, some discussions on case deletion influence diagnostics are developed for the joint posterior distribution based on the Kullback–Leibler divergence. Besides, for different parameter settings, sample sizes and censoring percentages, are performed various simulations and display and compare the empirical distribution of the Martingale-type residual with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be straightforwardly extended to the martingale-type residual in log-Weibull extended models with censored data. Finally, we analyze a real data set under a log-Weibull extended regression model. We perform diagnostic analysis and model check based on the martingale-type residual to select an appropriate model.     

Heteroscedastic log-exponentiated Weibull regression model

We introduce a new class of heteroscedastic log-exponentiated Weibull (LEW) regression models. The class of regression models can be applied to censored data and be used more effectively in survival analysis. Maximum likelihood estimation of the model parameters with censored data as well as influence diagnostics for the new regression model is investigated. For different parameter settings, sample sizes and censoring percentages, various simulation studies are performed and compared to the performance of the heteroscedastic LEW regression model. The normal curvatures for studying local influence are derived under various perturbation schemes. An empirical application to a real data set is provided to illustrate the usefulness of the new class of heteroscedastic regression models.     

Checking the linear transformation model for clustered failure time observations

The linear transformation model is a semiparametric model which contains the Cox proportional hazards model and the proportional odds model as special cases. Cai et al. (Biometrika 87:867-878, 2000) have proposed an inference procedure for the linear transformation model with correlated censored observations. In this article, we develop formal and graphical model checking techniques for the linear transformation models based on cumulative sums of martingale-type residuals. The proposed method is illustrated with a clinical trial data.     

The generalized log-gamma mixture model with covariates: local influence and residual analysis

In a sample of censored survival times, the presence of an immune proportion of individuals who are not subject to death, failure or relapse, may be indicated by a relatively high number of individuals with large censored survival times. In this paper the generalized log-gamma model is modified for the possibility that long-term survivors may be present in the data. The model attempts to separately estimate the effects of covariates on the surviving fraction, that is, the proportion of the population for which the event never occurs. The logistic function is used for the regression model of the surviving fraction. Inference for the model parameters is considered via maximum likelihood. Some influence methods, such as the local influence and total local influence of an individual are derived, analyzed and discussed. Finally, a data set from the medical area is analyzed under the log-gamma generalized mixture model. A residual analysis is performed in order to select an appropriate model. The authors would like to thank the editor and referees for their helpful comments. This work was supported by CNPq, Brazil.     

Empirical Likelihood Based Synthetic Data Method for Censored Regression Analysis

In this article, we propose a new empirical likelihood method for linear regression analysis with a right censored response variable. The method is based on the synthetic data approach for censored linear regression analysis. A log-empirical likelihood ratio test statistic for the entire regression coefficients vector is developed and we show that it converges to a standard chi-squared distribution. The proposed method can also be used to make inferences about linear combinations of the regression coefficients. Moreover, the proposed empirical likelihood ratio provides a way to combine different normal equations derived from various synthetic response variables. Maximizing this empirical likelihood ratio yields a maximum empirical likelihood estimator which is asymptotically equivalent to the solution of the estimating equation that are optimal linear combination of the original normal equations. It improves the estimation efficiency. The method is illustrated by some Monte Carlo simulation studies as well as a real example.     

A log-location-scale lifetime distribution with censored data: Regression modeling,residuals, and global influence

In survival analysis applications, the presence of failure rate functions with non monotone shapes is common. Therefore, models that can accommodate such different shapes are needed. In this article, we present a location regression model based on the complementary exponentiated exponential geometric distribution as an alternative to the usual bathtub, increasing, and decreasing failure rates in lifetime data. Assuming censored data, we consider the maximum likelihood inference for analysis, graphical verification for residuals, and test statistics for influential points.     

Nonparametric model checks in censored regression

Let M be a parametric model for an unknown regression function m. In order to check the validity of M, i.e., to test for m ∈ M, it is known that optinal tests should be based on the empirical process of the regressors marked by the residuals. In this paper we extend the methodology to censored regression. The asymptotic distribution of the underlying marked empirical process in provided. The Wild Bootstrap, appropriately modified to account for censhorship, provides distributional approximations. The method is applied to simulated data sets as well as tto the Stanford Heart Transplant Data.     

Deviance Residuals for an Angular Response

This paper discusses deviance residual approximations in von Mises regression models. By using a relationship between the von Mises and the wrapped normal distributions, the paper shows that the deviance component of the von Mises distribution is approximately a linear function of the standard normal distribution. Two standardized forms are proposed for the deviance residual, and a simulation study is performed to compare the approximation of the proposed residuals to the standard normal distribution. An illustrative example is given.     

A Log-Linear Regression Model for the Beta-Weibull Distribution

We introduce the log-beta Weibull regression model based on the beta Weibull distribution (Famoye et al., 2005 Famoye , F. , Lee , C. , Olumolade , O. ( 2005 ). The beta-Weibull distribution . Journal of Statistical Theory and Applications 4 : 121 – 136 . [Google Scholar]; Lee et al., 2007 Lee , C. , Famoye , F. , Olumolade , O. ( 2007 ). Beta-Weibull distribution: Some properties and applications to censored data . Journal of Modern Applied Statistical Methods 6 : 173 – 186 .[Crossref] , [Google Scholar]). We derive expansions for the moment generating function which do not depend on complicated functions. The new regression model represents a parametric family of models that includes as sub-models several widely known regression models that can be applied to censored survival data. We employ a frequentist analysis, a jackknife estimator, and a parametric bootstrap for the parameters of the proposed model. We derive the appropriate matrices for assessing local influences on the parameter estimates under different perturbation schemes and present some ways to assess global influences. Further, for different parameter settings, sample sizes, and censoring percentages, several simulations are performed. In addition, the empirical distribution of some modified residuals are displayed and compared with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be extended to a modified deviance residual in the proposed regression model applied to censored data. We define martingale and deviance residuals to evaluate the model assumptions. The extended regression model is very useful for the analysis of real data and could give more realistic fits than other special regression models.     

On quantile residuals in beta regression

Beta regression is often used to model the relationship between a dependent variable that assumes values on the open interval (0, 1) and a set of predictor variables. An important challenge in beta regression is to find residuals whose distribution is well approximated by the standard normal distribution. Two previous works compared residuals in beta regression, but the authors did not include the quantile residual. Using Monte Carlo simulation techniques, this article studies the behavior of certain residuals in beta regression in several scenarios. Overall, the results suggest that the distribution of the quantile residual is better approximated by the standard normal distribution than that of the other residuals in most scenarios. Three applications illustrate the effectiveness of the quantile residual.     

Residual analysis for parametric models fit to censored data

The focus of this paper is on residual analysis for the lognormal and extreme value or Weibull models, although the proposed methods can be applied to any parametric model. Residuals developed by Barlow and Prentice (1988) for the Cox proportional hazards model are extended to the parametric model setting. Three different residuals are proposed based on this approach with two residuals measuring the impact of survival time and one measuring the impact of the covariates included in the model. In addition, a residual derived from the deviations equality presented in Efron and Johnstone (1990) and the residual proposed by Joergensen (1984) for censored data models are discussed.     

New regression model with four regression structures and computational aspects

A new general class of exponentiated sinh Cauchy regression models for location, scale, and shape parameters is introduced and studied. It may be applied to censored data and used more effectively in survival analysis when compared with the usual models. For censored data, we employ a frequentist analysis for the parameters of the proposed model. Further, for different parameter settings, sample sizes, and censoring percentages, various simulations are performed. The extended regression model is very useful for the analysis of real data and could give more adequate fits than other special regression models.     

Model comparison of linear and nonlinear Bayesian structural equation models with dichotomous data

In this article, dichotomous variables are used to compare between linear and nonlinear Bayesian structural equation models. Gibbs sampling method is applied for estimation and model comparison. Statistical inferences that involve estimation of parameters and their standard deviations and residuals analysis for testing the selected model are discussed. Hidden continuous normal distribution (censored normal distribution) is used to solve the problem of dichotomous variables. The proposed procedure is illustrated by a simulation data obtained from R program. Analyses are done by using R2WinBUGS package in R-program.     

A new class of survival regression models with heavy-tailed errors: robustness and diagnostics

Birnbaum-Saunders models have largely been applied in material fatigue studies and reliability analyses to relate the total time until failure with some type of cumulative damage. In many problems related to the medical field, such as chronic cardiac diseases and different types of cancer, a cumulative damage caused by several risk factors might cause some degradation that leads to a fatigue process. In these cases, BS models can be suitable for describing the propagation lifetime. However, since the cumulative damage is assumed to be normally distributed in the BS distribution, the parameter estimates from this model can be sensitive to outlying observations. In order to attenuate this influence, we present in this paper BS models, in which a Student-t distribution is assumed to explain the cumulative damage. In particular, we show that the maximum likelihood estimates of the Student-t log-BS models attribute smaller weights to outlying observations, which produce robust parameter estimates. Also, some inferential results are presented. In addition, based on local influence and deviance component and martingale-type residuals, a diagnostics analysis is derived. Finally, a motivating example from the medical field is analyzed using log-BS regression models. Since the parameter estimates appear to be very sensitive to outlying and influential observations, the Student-t log-BS regression model should attenuate such influences. The model checking methodologies developed in this paper are used to compare the fitted models.     

Testing for normally in censored regressions

This paper derives a Lagrange Multiplier test for normality in censored regressions. The test is derived against the generalized log-gamma distribution, in which normal is a special case. The resulting test statistic coincides to some extent with previously suggested score and conditional moment tests. Estimation of the variance is performed by using the matrix of second order derivatives in order to get an easy to use test statistic. Small sample performance of the test is studied and compared to other tests by Monte Carlo experiments.     

Fitting linear regression models to censored data by least squares and maximum likelihood methods

Several approaches have been suggested for fitting linear regression models to censored data. These include Cox's propor­tional hazard models based on quasi-likelihoods. Methods of fitting based on least squares and maximum likelihoods have also been proposed. The methods proposed so far all require special purpose optimization routines. We describe an approach here which requires only a modified standard least squares routine.

We present methods for fitting a linear regression model to censored data by least squares and method of maximum likelihood. In the least squares method, the censored values are replaced by their expectations, and the residual sum of squares is minimized. Several variants are suggested in the ways in which the expect­ation is calculated. A parametric (assuming a normal error model) and two non-parametric approaches are described. We also present a method for solving the maximum likelihood equations in the estimation of the regression parameters in the censored regression situation. It is shown that the solutions can be obtained by a recursive algorithm which needs only a least squares routine for optimization. The suggested procesures gain considerably in computational officiency. The Stanford Heart Transplant data is used to illustrate the various methods.