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1.
Testing the reliability at a nominal stress level may lead to extensive test time. Estimations of reliability parameters can be obtained faster thanks to step-stress accelerated life tests (ALT). Usually, a transfer functional defined among a given class of parametric functions is required, but Bagdonavi?ius and Nikulin showed that ALT tests are still possible without any assumption about this functional. When shape and scale parameters of the lifetime distribution change with the stress level, they suggested an ALT method using a model called CHanging Shape and Scale (CHSS). They estimated the lifetime parameters at the nominal stress with maximum likelihood estimation (MLE). However, this method usually requires an initialization of lifetime parameters, which may be difficult when no similar product has been tested before. This paper aims to face this issue by using an iterating least square estimation (LSE) method. It will enable one to initialize the optimization required to carry out the MLE and it will give estimations that can sometimes be better than those given by MLE.  相似文献   

2.
Efficient industrial experiments for reliability analysis of manufactured goods may consist in subjecting the units to higher stress levels than those of the usual working conditions. This results in the so called "accelerated life tests" where, for each pre-fixed stress level, the experiment ends after the failure of a certain pre-fixed proportion of units or a certain test time is reached. The aim of this paper is to determine estimates of the mean lifetime of the units under usual working conditions from censored failure data obtained under stress conditions. This problem is approached through generalized linear modelling and related inferential techniques, considering a Weibull failure distribution and a log-linear stress-response relationship. The general framework considered has as particular cases, the Inverse Power Law model, the Eyring model, the Arrhenius model and the generalized Eyring model. In order to illustrate the proposed methodology, a numerical example is provided.  相似文献   

3.
Smoothed Gehan rank estimation methods are widely used in accelerated failure time (AFT) models with/without clusters. However, most methods are sensitive to outliers in the covariates. In order to solve this problem, we propose robust approaches based on the smoothed Gehan rank estimation methods for the AFT model, allowing for clusters by employing two different weight functions. Simulation studies show that the proposed methods outperform existing smoothed rank estimation methods regarding their biases and standard deviations when there are outliers in the covariates. The proposed methods are also applied to a real dataset from the “Major cardiovascular interventions” study.  相似文献   

4.
The accelerated failure time (AFT) model is an important regression tool to study the association between failure time and covariates. In this paper, we propose a robust weighted generalized M (GM) estimation for the AFT model with right-censored data by appropriately using the Kaplan–Meier weights in the GM–type objective function to estimate the regression coefficients and scale parameter simultaneously. This estimation method is computationally simple and can be implemented with existing software. Asymptotic properties including the root-n consistency and asymptotic normality are established for the resulting estimator under suitable conditions. We further show that the method can be readily extended to handle a class of nonlinear AFT models. Simulation results demonstrate satisfactory finite sample performance of the proposed estimator. The practical utility of the method is illustrated by a real data example.  相似文献   

5.
There are relatively few discussions about measurement error in the accelerated failure time (AFT) model, particularly for the semiparametric AFT model. In this article, we propose an adjusted estimation procedure for the semiparametric AFT model with covariates subject to measurement error, based on the profile likelihood approach and simulation and exploration (SIMEX) method. The simulation studies show that the proposed semiparametric SIMEX approach performs well. The proposed approach is applied to a coronary heart disease dataset from the Busselton Health study for illustration.  相似文献   

6.
Various types of failure, censored and accelerated life tests, are commonly employed for life testing in some manufacturing industries and products that are highly reliable. In this article, we consider the tampered failure rate model as one of such types that relate the distribution under use condition to the distribution under accelerated condition. It is assumed that the lifetimes of products under use condition have generalized Pareto distribution as a lifetime model. Some estimation methods such as graphical, moments, probability weighted moments, and maximum likelihood estimation methods for the parameters are discussed based on progressively type-I censored data. The determination of optimal stress change time is discussed under two different criteria of optimality. Finally, a Monte Carlo simulation study is carried out to examine the performance of the estimation methods and the optimality criteria.  相似文献   

7.
As a flexible alternative to the Cox model, the accelerated failure time (AFT) model assumes that the event time of interest depends on the covariates through a regression function. The AFT model with non‐parametric covariate effects is investigated, when variable selection is desired along with estimation. Formulated in the framework of the smoothing spline analysis of variance model, the proposed method based on the Stute estimate ( Stute, 1993 [Consistent estimation under random censorship when covariables are present, J. Multivariate Anal. 45 , 89–103]) can achieve a sparse representation of the functional decomposition, by utilizing a reproducing kernel Hilbert norm penalty. Computational algorithms and theoretical properties of the proposed method are investigated. The finite sample size performance of the proposed approach is assessed via simulation studies. The primary biliary cirrhosis data is analyzed for demonstration.  相似文献   

8.
The semiparametric accelerated failure time (AFT) model is not as widely used as the Cox relative risk model due to computational difficulties. Recent developments in least squares estimation and induced smoothing estimating equations for censored data provide promising tools to make the AFT models more attractive in practice. For multivariate AFT models, we propose a generalized estimating equations (GEE) approach, extending the GEE to censored data. The consistency of the regression coefficient estimator is robust to misspecification of working covariance, and the efficiency is higher when the working covariance structure is closer to the truth. The marginal error distributions and regression coefficients are allowed to be unique for each margin or partially shared across margins as needed. The initial estimator is a rank-based estimator with Gehan’s weight, but obtained from an induced smoothing approach with computational ease. The resulting estimator is consistent and asymptotically normal, with variance estimated through a multiplier resampling method. In a large scale simulation study, our estimator was up to three times as efficient as the estimateor that ignores the within-cluster dependence, especially when the within-cluster dependence was strong. The methods were applied to the bivariate failure times data from a diabetic retinopathy study.  相似文献   

9.
In accelerated life testing (ALT), products are exposed to stress levels higher than those at normal use in order to obtain information in a timely manner. Past work on planning ALT is predominantly on a single cause of failure. This article presents methods for planning ALT in the presence of k competing risks. Expressions for computing the Fisher information matrix are presented when risks are independently distributed lognormal. Optimal test plans are obtained under criteria that are based on determinants and maximum likelihood estimation. The proposed method is demonstrated on ALT of motor insulation.  相似文献   

10.
Recurrent event data are commonly encountered in longitudinal studies when events occur repeatedly over time for each study subject. An accelerated failure time (AFT) model on the sojourn time between recurrent events is considered in this article. This model assumes that the covariate effect and the subject-specific frailty are additive on the logarithm of sojourn time, and the covariate effect maintains the same over distinct episodes, while the distributions of the frailty and the random error in the model are unspecified. With the ordinal nature of recurrent events, two scale transformations of the sojourn times are derived to construct semiparametric methods of log-rank type for estimating the marginal covariate effects in the model. The proposed estimation approaches/inference procedures also can be extended to the bivariate events, which alternate themselves over time. Examples and comparisons are presented to illustrate the performance of the proposed methods.  相似文献   

11.
Traditionally, reliability assessment of devices has been based on life tests (LTs) or accelerated life tests (ALTs). However, these approaches are not practical for high-reliability devices which are not likely to fail in experiments of reasonable length. For these devices, LTs or ALTs will end up with a high censoring rate compromising the traditional estimation methods. An alternative approach is to monitor the devices for a period of time and assess their reliability from the changes in performance (degradation) observed during the experiment. In this paper, we present a model to evaluate the problem of train wheel degradation, which is related to the failure modes of train derailments. We first identify the most significant working conditions affecting the wheel wear using a nonlinear mixed-effects (NLME) model where the log-rate of wear is a linear function of some working conditions such as side, truck and axle positions. Next, we estimate the failure time distribution by working condition analytically. Point and interval estimates of reliability figures by working condition are also obtained. We compare the results of the analysis via an NLME to the ones obtained by an approximate degradation analysis.  相似文献   

12.
Modelling accelerated life test data by using a Bayesian approach   总被引:1,自引:0,他引:1  
Summary. Because of the high reliability of many modern products, accelerated life tests are becoming widely used to obtain timely information about their time-to-failure distributions. We propose a general class of accelerated life testing models which are motivated by the actual failure process of units from a limited failure population with a positive probability of not failing during the technological lifetime. We demonstrate a Bayesian approach to this problem, using a new class of models with non-monotone hazard rates, the hazard model with potential scope for use far beyond accelerated life testing. Our methods are illustrated with the modelling and analysis of a data set on lifetimes of printed circuit boards under humidity accelerated life testing.  相似文献   

13.
The cumulative exposure model (CEM) is a commonly used statistical model utilized to analyze data from a step-stress accelerated life testing which is a special class of accelerated life testing (ALT). In practice, researchers conduct ALT to: (1) determine the effects of extreme levels of stress factors (e.g., temperature) on the life distribution, and (2) to gain information on the parameters of the life distribution more rapidly than under normal operating (or environmental) conditions. In literature, researchers assume that the CEM is from well-known distributions, such as the Weibull family. This study, on the other hand, considers a p-step-stress model with q stress factors from the two-parameter Birnbaum-Saunders distribution when there is a time constraint on the duration of the experiment. In this comparison paper, we consider different frameworks to numerically compute the point estimation for the unknown parameters of the CEM using the maximum likelihood theory. Each framework implements at least one optimization method; therefore, numerical examples and extensive Monte Carlo simulations are considered to compare and numerically examine the performance of the considered estimation frameworks.  相似文献   

14.
We will discuss the reliability analysis of the constant stress accelerated life test on a series system connected with multiple components under independent Weibull lifetime distributions whose scale parameters are log-linear in the level of the stress variable. The system lifetimes are collected under Type I censoring but the components that cause the systems to fail may or may not be observed. The data are so called masked for the latter case. Maximum likelihood approach and the Bayesian method are considered when the data are masked. Statistical inference on the estimation of the underlying model parameters as well as the mean time to failure and the reliability function will be addressed. Simulation study for a three-component case shows that Bayesian analysis outperforms the maximum likelihood approach especially when the data are highly masked.  相似文献   

15.
Semiparametric accelerated failure time (AFT) models directly relate the expected failure times to covariates and are a useful alternative to models that work on the hazard function or the survival function. For case-cohort data, much less development has been done with AFT models. In addition to the missing covariates outside of the sub-cohort in controls, challenges from AFT model inferences with full cohort are retained. The regression parameter estimator is hard to compute because the most widely used rank-based estimating equations are not smooth. Further, its variance depends on the unspecified error distribution, and most methods rely on computationally intensive bootstrap to estimate it. We propose fast rank-based inference procedures for AFT models, applying recent methodological advances to the context of case-cohort data. Parameters are estimated with an induced smoothing approach that smooths the estimating functions and facilitates the numerical solution. Variance estimators are obtained through efficient resampling methods for nonsmooth estimating functions that avoids full blown bootstrap. Simulation studies suggest that the recommended procedure provides fast and valid inferences among several competing procedures. Application to a tumor study demonstrates the utility of the proposed method in routine data analysis.  相似文献   

16.
For the time-to-event outcome, current methods for sample determination are based on the proportional hazard model. However, if the proportionality assumption fails to capture the relationship between the hazard time and covariates, the proportional hazard model is not suitable to analyze survival data. The accelerated failure time (AFT) model is an alternative method to deal with survival data. In this paper, we address the issue that the relationship between the hazard time and the treatment effect is satisfied with the AFT model to design a multiregional trial. The log-rank test is employed to deal with the heterogeneous effect size among regions. The test statistic for the overall treatment effect is used to determine the total sample size for a multiregional trial, and the proposed criteria are used to rationalize partition sample size to each region.  相似文献   

17.
The step-stress model is a special case of accelerated life testing that allows for testing of units under different levels of stress with changes occurring at various intermediate stages of the experiment. Interest then lies on inference for the mean lifetime at each stress level. All step-stress models discussed so far in the literature are based on a single experiment. For the situation when data have been collected from different experiments wherein all the test units had been exposed to the same levels of stress but with possibly different points of change of stress, we introduce a model that combines the different experiments and facilitates a meta-analysis for the estimation of the mean lifetimes. We then discuss in detail the likelihood inference for the case of simple step-stress experiments under exponentially distributed lifetimes with Type-II censoring.  相似文献   

18.
Competing risks are common in clinical cancer research, as patients are subject to multiple potential failure outcomes, such as death from the cancer itself or from complications arising from the disease. In the analysis of competing risks, several regression methods are available for the evaluation of the relationship between covariates and cause-specific failures, many of which are based on Cox’s proportional hazards model. Although a great deal of research has been conducted on estimating competing risks, less attention has been devoted to linear regression modeling, which is often referred to as the accelerated failure time (AFT) model in survival literature. In this article, we address the use and interpretation of linear regression analysis with regard to the competing risks problem. We introduce two types of AFT modeling framework, where the influence of a covariate can be evaluated in relation to either a cause-specific hazard function, referred to as cause-specific AFT (CS-AFT) modeling in this study, or the cumulative incidence function of a particular failure type, referred to as crude-risk AFT (CR-AFT) modeling. Simulation studies illustrate that, as in hazard-based competing risks analysis, these two models can produce substantially different effects, depending on the relationship between the covariates and both the failure type of principal interest and competing failure types. We apply the AFT methods to data from non-Hodgkin lymphoma patients, where the dataset is characterized by two competing events, disease relapse and death without relapse, and non-proportionality. We demonstrate how the data can be analyzed and interpreted, using linear competing risks regression models.  相似文献   

19.
The analysis of survival endpoints subject to right-censoring is an important research area in statistics, particularly among econometricians and biostatisticians. The two most popular semiparametric models are the proportional hazards model and the accelerated failure time (AFT) model. Rank-based estimation in the AFT model is computationally challenging due to optimization of a non-smooth loss function. Previous work has shown that rank-based estimators may be written as solutions to linear programming (LP) problems. However, the size of the LP problem is O(n 2+p) subject to n 2 linear constraints, where n denotes sample size and p denotes the dimension of parameters. As n and/or p increases, the feasibility of such solution in practice becomes questionable. Among data mining and statistical learning enthusiasts, there is interest in extending ordinary regression coefficient estimators for low-dimensions into high-dimensional data mining tools through regularization. Applying this recipe to rank-based coefficient estimators leads to formidable optimization problems which may be avoided through smooth approximations to non-smooth functions. We review smooth approximations and quasi-Newton methods for rank-based estimation in AFT models. The computational cost of our method is substantially smaller than the corresponding LP problem and can be applied to small- or large-scale problems similarly. The algorithm described here allows one to couple rank-based estimation for censored data with virtually any regularization and is exemplified through four case studies.  相似文献   

20.
Accelerated life testing (ALT) provides a means of obtaining data on product lifetime and reliability relatively quickly by subjecting products to higher-than-usual levels of stress factors. We present methods for obtaining optimal designs for multiple-factor ALTs with time censoring and heteroscedasticity in order to estimate percentiles of product life at usage conditions. We assume a Weibull life distribution and log-linear life–stress relationships with non constant shape parameter for the ALT stress factors. The primary optimality criterion is the minimization of the asymptotic variance of maximum likelihood estimator of the percentile estimator at usage stress. We also consider a secondary criterion for our design optimization. The design construction methods are illustrated by two practical examples.  相似文献   

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