Modelling three-dimensional trajectories by using Bézier curves with application to hand motion

Summary.  A modelling approach for three-dimensional trajectories with particular application to hand reaching motions is described. Bézier curves are defined by control points which have a convenient geometrical interpretation. A fitting method for the control points to trajectory data is described. These fitted control points are then linked to covariates of interest by using a regression model. This allows the prediction of new trajectories and the ability to model the variability in trajectories. The methodology is illustrated with an application to hand trajectory modelling for ergonomics. Motion capture was used to collect a total of about 2000 hand trajectories performed by 20 subjects to a variety of targets. A simple model with strong predictive performance and interpretablility is developed. The use of hand trajectory models in the digital human models for virtual manufacturing applications is discussed.     

An adaptive sampling scheme guided by BART—with an application to predict processor performance

The evaluation of new processor designs is an important issue in electrical and computer engineering. Architects use simulations to evaluate designs and to understand trade‐offs and interactions among design parameters. However, due to the lengthy simulation time and limited resources, it is often practically impossible to simulate a full factorial design space. Effective sampling methods and predictive models are required. In this paper, the authors propose an automated performance predictive approach which employs an adaptive sampling scheme that interactively works with the predictive model to select samples for simulation. These samples are then used to build Bayesian additive regression trees, which in turn are used to predict the whole design space. Both real data analysis and simulation studies show that the method is effective in that, though sampling at very few design points, it generates highly accurate predictions on the unsampled points. Furthermore, the proposed model provides quantitative interpretation tools with which investigators can efficiently tune design parameters in order to improve processor performance. The Canadian Journal of Statistics 38: 136–152; 2010 © 2010 Statistical Society of Canada     

Alternatives to post‐processing posterior predictive p values

The posterior predictive p value (ppp) was invented as a Bayesian counterpart to classical p values. The methodology can be applied to discrepancy measures involving both data and parameters and can, hence, be targeted to check for various modeling assumptions. The interpretation can, however, be difficult since the distribution of the ppp value under modeling assumptions varies substantially between cases. A calibration procedure has been suggested, treating the ppp value as a test statistic in a prior predictive test. In this paper, we suggest that a prior predictive test may instead be based on the expected posterior discrepancy, which is somewhat simpler, both conceptually and computationally. Since both these methods require the simulation of a large posterior parameter sample for each of an equally large prior predictive data sample, we furthermore suggest to look for ways to match the given discrepancy by a computation‐saving conflict measure. This approach is also based on simulations but only requires sampling from two different distributions representing two contrasting information sources about a model parameter. The conflict measure methodology is also more flexible in that it handles non‐informative priors without difficulty. We compare the different approaches theoretically in some simple models and in a more complex applied example.     

Spatial Matérn Fields Driven by Non‐Gaussian Noise

The article studies non‐Gaussian extensions of a recently discovered link between certain Gaussian random fields, expressed as solutions to stochastic partial differential equations (SPDEs), and Gaussian Markov random fields. The focus is on non‐Gaussian random fields with Matérn covariance functions, and in particular, we show how the SPDE formulation of a Laplace moving‐average model can be used to obtain an efficient simulation method as well as an accurate parameter estimation technique for the model. This should be seen as a demonstration of how these techniques can be used, and generalizations to more general SPDEs are readily available.     

Discrete approximations to continuous univariate distributions—an alternative to simulation

A method to replace a continuous univariate distribution with a discrete distribution that takes MN different values is analysed. Both distributions share the same r th moments for r =0, . . ., 2 N −1 and their corresonding distribution functions coincide at least at M +1 points. Several statistical and engineering examples are considered in which the discrete approximation may be used to avoid a simulation study that would be much more demanding computationally.     

Semi‐parametric small‐area estimation by combining time‐series and cross‐sectional data methods

In survey sampling, policymaking regarding the allocation of resources to subgroups (called small areas) or the determination of subgroups with specific properties in a population should be based on reliable estimates. Information, however, is often collected at a different scale than that of these subgroups; hence, the estimation can only be obtained on finer scale data. Parametric mixed models are commonly used in small‐area estimation. The relationship between predictors and response, however, may not be linear in some real situations. Recently, small‐area estimation using a generalised linear mixed model (GLMM) with a penalised spline (P‐spline) regression model, for the fixed part of the model, has been proposed to analyse cross‐sectional responses, both normal and non‐normal. However, there are many situations in which the responses in small areas are serially dependent over time. Such a situation is exemplified by a data set on the annual number of visits to physicians by patients seeking treatment for asthma, in different areas of Manitoba, Canada. In cases where covariates that can possibly predict physician visits by asthma patients (e.g. age and genetic and environmental factors) may not have a linear relationship with the response, new models for analysing such data sets are required. In the current work, using both time‐series and cross‐sectional data methods, we propose P‐spline regression models for small‐area estimation under GLMMs. Our proposed model covers both normal and non‐normal responses. In particular, the empirical best predictors of small‐area parameters and their corresponding prediction intervals are studied with the maximum likelihood estimation approach being used to estimate the model parameters. The performance of the proposed approach is evaluated using some simulations and also by analysing two real data sets (precipitation and asthma).     

Sensitivity to censored‐at‐random assumption in the analysis of time‐to‐event endpoints

Over the past years, significant progress has been made in developing statistically rigorous methods to implement clinically interpretable sensitivity analyses for assumptions about the missingness mechanism in clinical trials for continuous and (to a lesser extent) for binary or categorical endpoints. Studies with time‐to‐event outcomes have received much less attention. However, such studies can be similarly challenged with respect to the robustness and integrity of primary analysis conclusions when a substantial number of subjects withdraw from treatment prematurely prior to experiencing an event of interest. We discuss how the methods that are widely used for primary analyses of time‐to‐event outcomes could be extended in a clinically meaningful and interpretable way to stress‐test the assumption of ignorable censoring. We focus on a ‘tipping point’ approach, the objective of which is to postulate sensitivity parameters with a clear clinical interpretation and to identify a setting of these parameters unfavorable enough towards the experimental treatment to nullify a conclusion that was favorable to that treatment. Robustness of primary analysis results can then be assessed based on clinical plausibility of the scenario represented by the tipping point. We study several approaches for conducting such analyses based on multiple imputation using parametric, semi‐parametric, and non‐parametric imputation models and evaluate their operating characteristics via simulation. We argue that these methods are valuable tools for sensitivity analyses of time‐to‐event data and conclude that the method based on piecewise exponential imputation model of survival has some advantages over other methods studied here. Copyright © 2016 John Wiley & Sons, Ltd.     

Measurement Error Correction by Exploiting Gene–Environment Independence in Family‐Based Case–Control Studies

Abstract. Family‐based case–control designs are commonly used in epidemiological studies for evaluating the role of genetic susceptibility and environmental exposure to risk factors in the etiology of rare diseases. Within this framework, it is often reasonable to assume genetic susceptibility and environmental exposure being conditionally independent of each other within families in the source population. We focus on this setting to explore the situation of measurement error affecting the assessment of the environmental exposure. We correct for measurement error through a likelihood‐based method. We exploit a conditional likelihood approach to relate the probability of disease to the genetic and the environmental risk factors. We show that this approach provides less biased and more efficient results than that based on logistic regression. Regression calibration, instead, provides severely biased estimators of the parameters. The comparison of the correction methods is performed through simulation, under common measurement error structures.