Local Box–Cox transformation on time-varying parametric models for smoothing estimation of conditional CDF with longitudinal data

Nonparametric estimation and inferences of conditional distribution functions with longitudinal data have important applications in biomedical studies, such as epidemiological studies and longitudinal clinical trials. Estimation approaches without any structural assumptions may lead to inadequate and numerically unstable estimators in practice. We propose in this paper a nonparametric approach based on time-varying parametric models for estimating the conditional distribution functions with a longitudinal sample. Our model assumes that the conditional distribution of the outcome variable at each given time point can be approximated by a parametric model after local Box–Cox transformation. Our estimation is based on a two-step smoothing method, in which we first obtain the raw estimators of the conditional distribution functions at a set of disjoint time points, and then compute the final estimators at any time by smoothing the raw estimators. Applications of our two-step estimation method have been demonstrated through a large epidemiological study of childhood growth and blood pressure. Finite sample properties of our procedures are investigated through a simulation study. Application and simulation results show that smoothing estimation from time-variant parametric models outperforms the existing kernel smoothing estimator by producing narrower pointwise bootstrap confidence band and smaller root mean squared error.     

On two-step estimation for varying coefficient models

In this note we discuss two-step kernel estimation of varying coefficient regression models that have a common smoothing variable. The method allows one to use different bandwidths for different coefficient functions. We consider local polynomial fitting and present explicit formulas for the asymptotic biases and variances of the estimators.     

Componentwise B-spline estimation for varying coefficient models with longitudinal data

A componentwise B-spline method is proposed for estimating the unknown functions in the varying-coefficient models with longitudinal data. Different amounts of smoothing are used for different individual coefficient functions and the estimators of different coefficient functions are obtained by different minimization operations. The local asymptotic bias and variance of the estimators are derived. It is shown that our estimators achieve the local and global optimal convergence rates even if the coefficient functions belong to different smoothness families. The asymptotic distributions of the estimators are also established and are used to construct approximate pointwise confidence intervals for coefficient functions. Finite sample properties of our procedures are studied through Monte Carlo simulations.     

On the Local Polynomial Estimators of the Counting Process Intensity Function and its Derivatives

Abstract. We consider the properties of the local polynomial estimators of a counting process intensity function and its derivatives. By expressing the local polynomial estimators in a kernel smoothing form via effective kernels, we show that the bias and variance of the estimators at boundary points are of the same magnitude as at interior points and therefore the local polynomial estimators in the context of intensity estimation also enjoy the automatic boundary correction property as they do in other contexts such as regression. The asymptotically optimal bandwidths and optimal kernel functions are obtained through the asymptotic expressions of the mean square error of the estimators. For practical purpose, we suggest an effective and easy‐to‐calculate data‐driven bandwidth selector. Simulation studies are carried out to assess the performance of the local polynomial estimators and the proposed bandwidth selector. The estimators and the bandwidth selector are applied to estimate the rate of aftershocks of the Sichuan earthquake and the rate of the Personal Emergency Link calls in Hong Kong.     

Efficient inference for parameters of unobservable periodic autoregressive time series

This paper considers estimating the model coefficients when the observed periodic autoregressive time series is contaminated by a trend. The proposed Yule–Walker estimators are obtained by a two-step procedure. In the first step, the trend is estimated by a weighted local polynomial, and the residuals are obtained by subtracting the trend estimates from the observations; in the second step, the model coefficients are estimated by the well-known Yule–Walker method via the residuals. It is shown that under certain conditions such Yule–Walker estimators are oracally efficient, i.e., they are asymptotically equivalent to those obtained from periodic autoregressive time series without a trend. An easy-to-use implementation procedure is provided. The performance of the estimators is illustrated by simulation studies and real data analysis. In particular, the simulation studies show that the proposed estimator outperforms that obtained from the residuals when the trend is estimated by kernel smoothing without taking the heteroscedasticity into consideration.     

A Unified View of Nonparametric Trend-Cycle Predictors Via Reproducing Kernel Hilbert Spaces

We provide a common approach for studying several nonparametric estimators used for smoothing functional time series data. Linear filters based on different building assumptions are transformed into kernel functions via reproducing kernel Hilbert spaces. For each estimator, we identify a density function or second order kernel, from which a hierarchy of higher order estimators is derived. These are shown to give excellent representations for the currently applied symmetric filters. In particular, we derive equivalent kernels of smoothing splines in Sobolev and polynomial spaces. The asymmetric weights are obtained by adapting the kernel functions to the length of the various filters, and a theoretical and empirical comparison is made with the classical estimators used in real time analysis. The former are shown to be superior in terms of signal passing, noise suppression and speed of convergence to the symmetric filter.     

Smoothing parameter selection in nonparametric regression using an improved Akaike information criterion

Many different methods have been proposed to construct nonparametric estimates of a smooth regression function, including local polynomial, (convolution) kernel and smoothing spline estimators. Each of these estimators uses a smoothing parameter to control the amount of smoothing performed on a given data set. In this paper an improved version of a criterion based on the Akaike information criterion (AIC), termed AIC_C, is derived and examined as a way to choose the smoothing parameter. Unlike plug-in methods, AIC_C can be used to choose smoothing parameters for any linear smoother, including local quadratic and smoothing spline estimators. The use of AIC_C avoids the large variability and tendency to undersmooth (compared with the actual minimizer of average squared error) seen when other 'classical' approaches (such as generalized cross-validation (GCV) or the AIC) are used to choose the smoothing parameter. Monte Carlo simulations demonstrate that the AIC_C-based smoothing parameter is competitive with a plug-in method (assuming that one exists) when the plug-in method works well but also performs well when the plug-in approach fails or is unavailable.     

Nonparametric estimation of varying coefficient error-in-variable models with validation sampling

In this paper, varying coefficient models are investigated with the response and covariate prone to measurement error. Without specifying any error structure equation, four estimators of the coefficient function vector are proposed by using the local linear kernel smoothing technique and also proved to be asymptotically normal. The data-driven bandwidth selection method is discussed. Simulation examples are conducted to evaluate the proposed estimation methods.     

Joint Mean-Covariance Models with Applications to Longitudinal Data in Partially Linear Model

Semiparametric regression models and estimating covariance functions are very useful in longitudinal study. Unfortunately, challenges arise in estimating the covariance function of longitudinal data collected at irregular time points. In this article, for mean term, a partially linear model is introduced and for covariance structure, a modified Cholesky decomposition approach is proposed to heed the positive-definiteness constraint. We estimate the regression function by using the local linear technique and propose quasi-likelihood estimating equations for both the mean and covariance structures. Moreover, asymptotic normality of the resulting estimators is established. Finally, simulation study and real data analysis are used to illustrate the proposed approach.     

Reducing component estimation for varying coefficient models

The estimation problem for varying coefficient models has been studied by many authors. We consider the problem in the case that the unknown functions admit different degrees of smoothness. In this paper we propose a reducing component local polynomial method to estimate the unknown functions. It is shown that all of our estimators achieve the optimal convergence rates. The asymptotic distributions of our estimators are also derived. The established asymptotic results and the simulation results show that our estimators outperform the the existing two-step estimators when the coefficient functions admit different degrees of smoothness. We also develop methods to speed up the estimation of the model and the selection of the bandwidths.     

Bayesian covariance estimation and inference in latent Gaussian process models

This paper describes inference methods for functional data under the assumption that the functional data of interest are smooth latent functions, characterized by a Gaussian process, which have been observed with noise over a finite set of time points. The methods we propose are completely specified in a Bayesian environment that allows for all inferences to be performed through a simple Gibbs sampler. Our main focus is in estimating and describing uncertainty in the covariance function. However, these models also encompass functional data estimation, functional regression where the predictors are latent functions, and an automatic approach to smoothing parameter selection. Furthermore, these models require minimal assumptions on the data structure as the time points for observations do not need to be equally spaced, the number and placement of observations are allowed to vary among functions, and special treatment is not required when the number of functional observations is less than the dimensionality of those observations. We illustrate the effectiveness of these models in estimating latent functional data, capturing variation in the functional covariance estimate, and in selecting appropriate smoothing parameters in both a simulation study and a regression analysis of medfly fertility data.     

Semiparametric inference for open populations using the Jolly–Seber model: a penalized spline approach

When there are frequent capture occasions, both semiparametric and nonparametric estimators for the size of an open population have been proposed using kernel smoothing methods. While kernel smoothing methods are mathematically tractable, fitting them to data is computationally intensive. Here, we use smoothing splines in the form of P-splines to provide an alternate less computationally intensive method of fitting these models to capture–recapture data from open populations with frequent capture occasions. We fit the model to capture data collected over 64 occasions and model the population size as a function of time, seasonal effects and an environmental covariate. A small simulation study is also conducted to examine the performance of the estimators and their standard errors.     

Robust estimation of multivariate regression model

This paper studies robust estimation of multivariate regression model using kernel weighted local linear regression. A robust estimation procedure is proposed for estimating the regression function and its partial derivatives. The proposed estimators are jointly asymptotically normal and attain nonparametric optimal convergence rate. One-step approximations to the robust estimators are introduced to reduce computational burden. The one-step local M-estimators are shown to achieve the same efficiency as the fully iterative local M-estimators as long as the initial estimators are good enough. The proposed estimators inherit the excellent edge-effect behavior of the local polynomial methods in the univariate case and at the same time overcome the disadvantages of the local least-squares based smoothers. Simulations are conducted to demonstrate the performance of the proposed estimators. Real data sets are analyzed to illustrate the practical utility of the proposed methodology. This work was supported by the National Natural Science Foundation of China (Grant No. 10471006).     

Unified Inference for Sparse and Dense Longitudinal Data in Time‐varying Coefficient Models

Time‐varying coefficient models are widely used in longitudinal data analysis. These models allow the effects of predictors on response to vary over time. In this article, we consider a mixed‐effects time‐varying coefficient model to account for the within subject correlation for longitudinal data. We show that when kernel smoothing is used to estimate the smooth functions in time‐varying coefficient models for sparse or dense longitudinal data, the asymptotic results of these two situations are essentially different. Therefore, a subjective choice between the sparse and dense cases might lead to erroneous conclusions for statistical inference. In order to solve this problem, we establish a unified self‐normalized central limit theorem, based on which a unified inference is proposed without deciding whether the data are sparse or dense. The effectiveness of the proposed unified inference is demonstrated through a simulation study and an analysis of Baltimore MACS data.     

Penalized Spline Estimation for Varying-Coefficient Models

Varying-coefficient models are useful extensions of classical linear models. They arise from multivariate nonparametric regression, nonlinear time series modeling and forecasting, longitudinal data analysis, and others. This article proposes the penalized spline estimation for the varying-coefficient models. Assuming a fixed but potentially large number of knots, the penalized spline estimators are shown to be strong consistency and asymptotic normality. A systematic optimization algorithm for the selection of multiple smoothing parameters is developed. One of the advantages of the penalized spline estimation is that it can accommodate varying degrees of smoothness among coefficient functions due to multiple smoothing parameters being used. Some simulation studies are presented to illustrate the proposed methods.     

Relative smoothing of discrete distributions with sparse observations

Quite often we are faced with a sparse number of observations over a finite number of cells and are interested in estimating the cell probabilities. Some local polynomial smoothers or local likelihood estimators have been proposed to improve on the histogram, which would produce too many zero values. We propose a relativized local polynomial smoothing for this problem, weighting heavier the estimating errors in small probability cells. A simulation study about the estimators that are proposed show a good behaviour with respect to natural error criteria, especially when dealing with sparse observations.     

Semiparametric Time-Varying Coefficients Regression Model for Longitudinal Data

Abstract.  In this paper, we consider a semiparametric time-varying coefficients regression model where the influences of some covariates vary non-parametrically with time while the effects of the remaining covariates follow certain parametric functions of time. The weighted least squares type estimators for the unknown parameters of the parametric coefficient functions as well as the estimators for the non-parametric coefficient functions are developed. We show that the kernel smoothing that avoids modelling of the sampling times is asymptotically more efficient than a single nearest neighbour smoothing that depends on the estimation of the sampling model. The asymptotic optimal bandwidth is also derived. A hypothesis testing procedure is proposed to test whether some covariate effects follow certain parametric forms. Simulation studies are conducted to compare the finite sample performances of the kernel neighbourhood smoothing and the single nearest neighbour smoothing and to check the empirical sizes and powers of the proposed testing procedures. An application to a data set from an AIDS clinical trial study is provided for illustration.     

Empirical likelihood for quantile regression models with longitudinal data

We develop two empirical likelihood-based inference procedures for longitudinal data under the framework of quantile regression. The proposed methods avoid estimating the unknown error density function and the intra-subject correlation involved in the asymptotic covariance matrix of the quantile estimators. By appropriately smoothing the quantile score function, the empirical likelihood approach is shown to have a higher-order accuracy through the Bartlett correction. The proposed methods exhibit finite-sample advantages over the normal approximation-based and bootstrap methods in a simulation study and the analysis of a longitudinal ophthalmology data set.     

Estimated estimating equations: semiparametric inference for clustered and longitudinal data

Summary.  We introduce a flexible marginal modelling approach for statistical inference for clustered and longitudinal data under minimal assumptions. This estimated estimating equations approach is semiparametric and the proposed models are fitted by quasi-likelihood regression, where the unknown marginal means are a function of the fixed effects linear predictor with unknown smooth link, and variance–covariance is an unknown smooth function of the marginal means. We propose to estimate the nonparametric link and variance–covariance functions via smoothing methods, whereas the regression parameters are obtained via the estimated estimating equations. These are score equations that contain nonparametric function estimates. The proposed estimated estimating equations approach is motivated by its flexibility and easy implementation. Moreover, if data follow a generalized linear mixed model, with either a specified or an unspecified distribution of random effects and link function, the model proposed emerges as the corresponding marginal (population-average) version and can be used to obtain inference for the fixed effects in the underlying generalized linear mixed model, without the need to specify any other components of this generalized linear mixed model. Among marginal models, the estimated estimating equations approach provides a flexible alternative to modelling with generalized estimating equations. Applications of estimated estimating equations include diagnostics and link selection. The asymptotic distribution of the proposed estimators for the model parameters is derived, enabling statistical inference. Practical illustrations include Poisson modelling of repeated epileptic seizure counts and simulations for clustered binomial responses.     

Wavelet estimation in time-varying coefficient time series models with measurement errors

The article studies a time-varying coefficient time series model in which some of the covariates are measured with additive errors. In order to overcome the bias of estimator of the coefficient functions when measurement errors are ignored, we propose a modified least squares estimator based on wavelet procedures. The advantage of the wavelet method is to avoid the restrictive smoothness requirement for varying-coefficient functions of the traditional smoothing approaches, such as kernel and local polynomial methods. The asymptotic properties of the proposed wavelet estimators are established under the α-mixing conditions and without specifying the error distribution. These results can be used to make asymptotically valid statistical inference.