Testing equality of proportions with incomplete correlated data

Let (ψ_i,φ_i) be independent, identically distributed pairs of zero-one random variables with (possible) dependence of ψ_i and φ_i within the pair. For n pairs, both variables are observed, but for m₁ additional pairs only ψ_i is observed and for m₂ others φ_i is observed. If π_1· = P{ψ_i = 1} and π_·1=P{φ_i, the problem is to test π_1·=π_·1. Maximum likelihood estimates of π_1· and π_·1 are obtained via the EM algorithm. A test statistic is developed whose null distribution is asymptotically chi-square with one degree of freedom (as n and either m₁ or m₂ tend to infinity). If m₁ = m₂ = 0 the statistic reduces to that of McNemar's test; if n = 0, it is equivalent to the statistic for testing equality of two independent proportions. This test is compared with other tests by means of Pitman efficiency. Examples are presented.     

Analysis of proportions for clustered binary data in the presence of unequal dispersions

This paper investigates the test procedures for testing the homogeneity of the proportions in the analysis of clustered binary data in the context of unequal dispersions across the treatment groups. We introduce a simple test procedure based on adjusted proportions using a sandwich estimator of the variance of the proportion estimators obtained by the generalized estimating equations approach of Zeger and Liang (1986) [Biometrics 42, 121-130]. We also extend the exiting test procedures of testing the hypothesis of proportions in this context. These test procedures are then compared, by simulations, in terms of size and power. Moreover, we derive the score test for testing the homogeneity of the dispersion parameters among several groups of clustered binary data. An illustrative application of the recommended test procedures is also presented.     

Local efficiency of moment estimators in beta-binomial model

In this paper, the beta-binomial model is introduced as a Markov chain. It is shown that the correlated binomial model of Kupper and Haseman (1978) is identical to the additive binomial model of AItham(1978) and both are a first order approximation of the beta-binomial model. For small γ, the local efficiency of the moment estimators for the mean ρ and the extra-binomial variation γ is examined analytically. It is shown that, locally, the moment estimator for p is efficient up to the second order of y. Exact formulae for the relative efficiency are obtained for both the cases with γ known and unknown. Generalization to the unequal sample size case is also carried out. In particular, the gain in efficiency by using the quasi-likelihood estimator instead of the ratio estimator for p is studied when γ is known. These results are in agreement with the Monte Carlo results of Kleinman(1973) and Crowder(1985).     

Testing equality of correlation coefficients for paired binary data from multiple groups

Paired binary data arise naturally when paired body parts are investigated in clinical trials. One of the widely used models for dealing with this kind of data is the equal correlation coefficients model. Before using this model, it is necessary to test whether the correlation coefficients in each group are actually equal. In this paper, three test statistics (likelihood ratio test, Wald-type test, and Score test) are derived for this purpose. The simulation results show that the Score test statistic maintains type I error rate and has satisfactory power, and therefore is recommended among the three methods. The likelihood ratio test is over conservative in most cases, and the Wald-type statistic is not robust with respect to empirical type I error. Three real examples, including a multi-centre Phase II double-blind placebo randomized controlled trial, are given to illustrate the three proposed test statistics.     

Testing equality of mean vectors in a one-way MANOVA with monotone missing data

In this study, testing the equality of mean vectors in a one-way multivariate analysis of variance (MANOVA) is considered when each dataset has a monotone pattern of missing observations. The likelihood ratio test (LRT) statistic in a one-way MANOVA with monotone missing data is given. Furthermore, the modified test (MT) statistic based on likelihood ratio (LR) and the modified LRT (MLRT) statistic with monotone missing data are proposed using the decomposition of the LR and an asymptotic expansion for each decomposed LR. The accuracy of the approximation for the Chi-square distribution is investigated using a Monte Carlo simulation. Finally, an example is given to illustrate the methods.     

Testing equality of location parameters of two exponential distributions from censored samples

A modification to Tiku's (1981) test, which may be seriously biased, is proposed. The modified test is only marginally biased if at all and is substantially more powerful. A ratio test based on Tiku’s (1967) modified likelihood function is also proposed, and shown to have power comparable to the power of the ratio test based on the likelihood function. The proposed ratio test is, however, much easier from a computational viewpoint.     

Estimation of the smaller and larger of two exponential location parameters

Assume independent random samples are drawn from two populations which are exponentially distributed with unknown location parameters and a common known scale parameter. We want to estimate the maximum and the minimum of the unknowo location paremeters. In this paper several estimators are proposed which are better than the natural estimations in terms of absolute bias and /or meaqn squared error.     

Testing the equality means of several log-normal distributions

Researches propose various methods for comparing the means of two log-normal distributions. Some of these methods have been recently extended to test the equality means of several log-normal populations. Investigations show that none of the established methods is satisfactory. In this article, we provide three methods based on the computational approach test, which is a parametric bootstrap approach, for testing the means of several log-normal distributions. Further, we compare our methods with the existing methods through Monte Carlo simulation. The numerical results show that the Type I errors of these procedures are satisfactory regardless of the sample size, number of populations, and the true parameters. Finally, we explain the considered methods by real examples.     

Estimation of the smaller and larger of two uniform scale parameters

Assume independent random samples are drawn from two populations which are uniformly distributed with unknown scale parameters. The problem is to estimate the minimum and the maximum of the two unknown scales. In this paper, several simple estimators are proposed which are better than the natural estimators in terms of standardized bias, risk under squared error loss and the Pitman nearness criterion.     

Sequential risk-efficient estimation for the ratio of two binomial proportions

A risk-efficient sequential point estimator is considered for the ratio of two independent binomial proportions based on maximum likelihood estimation under squared error loss and cost proportional to the observations. It is assumed that the cost per observation is constant. First-order asymptotic expansions are obtained for large-sample properties of the proposed procedure. Performance of the procedure is studied through the criteria of risk efficiency and regret analysis. Monte Carlo simulation is carried out to obtain the expected sample size that minimizes the risk and to examine its finite sample behavior. An example is provided to illustrate its use.     

Testing equality of two normal covariance matrices with monotone missing data

Abstract

The problem of testing equality of two multivariate normal covariance matrices is considered. Assuming that the incomplete data are of monotone pattern, a quantity similar to the Likelihood Ratio Test Statistic is proposed. A satisfactory approximation to the distribution of the quantity is derived. Hypothesis testing based on the approximate distribution is outlined. The merits of the test are investigated using Monte Carlo simulation. Monte Carlo studies indicate that the test is very satisfactory even for moderately small samples. The proposed methods are illustrated using an example.     

Exact tests for equality of two proportions: fisher v. bayes

Yates (1984) using theoretical and philosophical arguments claims to have proved that the Fisher exact test for comparing the proportions of two binomial experiments is the best exact test. The present article uses objective and practical arguments to confront the Fisher exact test with a Bayes exact test. Using simulated samples we claim to have proved here the inferiority of the Fisher exact test in relation to a Bayes exact test. The comparison is based on the quality concept of Dawid (1982).     

Testing for Heteroscedasticity and/or Autocorrelation in Longitudinal Mixed Effect Nonlinear Models with AR(1) Errors

The effect of influental observation son the parameter estimates of ordinary least squares regression models has received considerable a t t e n t i o n fn the last decade. However, very little attention has been given to the problem of influential observation sinthea naysis of variace . The purpose of this paper is to show by way of examples that in fluential observations can alter the conclusions of tests of hypotheses in the analysis of variance . Regression diagno stics for identifying both extreme points and out liers can be used toreveal potential data and design problems.     

Testing the equality of two independent regression models

In some situations, for example in agriculture, biology, hydrology, and psychology, researchers wish to determine whether the relationship between response variable and predictor variables differs in two populations. In other words, we are interested in comparing two regression models for two independent datasets. In this work, we will use the parametric and nonparametric methods to establish hypothesis testing for the equality of two independent regression models. Then the simulation study is provided to investigate the performance of the proposed method.     

A unified sequential test procedure for simultaneous testing the equality of several binomial proportions to a specified standard

In this article, we propose a unified sequentially rejective test procedure for testing simultaneously the equality of several independent binomial proportions to a specified standard. The proposed test procedure is general enough to include some well-known multiple testing procedures such as the Ordinary Bonferroni procedure, Hochberg procedure and Rom procedure. It involves multiple tests of significance based on the simple binomial tests (exact or approximate) which can be easily found in many elementary standard statistics textbooks. Unlike the traditional Chi-square test of the overall hypothesis, the procedure can identify the subset of the binomial proportions, which are different from the prespecified standard with the control of the familywise type I error rate. Moreover, the power computation of the procedure is provided and the procedure is illustrated by two real examples from an ecological study and a carcinogenicity study.     

Estimation in the presence of incidental parameters

This paper considers the estimation of “structural” parameters when the number of unknown parameters increases with the sample size. Neyman and Scott (1948) had demonstrated that maximum likelihood estimators (MLE) of structural parameters may be inconsistent in this case. Patefield (1977) further observed that the asymptotic covariance matrix of the MLE is not equal to the inverse of the information matrix. In this paper we establish asymptotic properties of estimators (which include in particular the MLE) obtained via the usual likelihood approach when the incidental parameters are first replaced by their estimates (which are allowed to depend on the structural parameters). Conditions for consistency and asymptotic normality together with a proper formula for the asymptotic covariance matrix are given. The results are illustrated and applied to the problem of estimating linear functional relationships, and mild conditions on the incidental parameters for the MLE (or an adjusted MLE) to be consistent and asymptotically normal are obtained. These conditions are weaker than those imposed by previous authors.     

Testing the Existence of Change-Point in NHPP Software Reliability Models

In the software testing process, the nature of the failure data is affected by many factors, such as the testing environment, testing strategy, and resource allocation. These factors are unlikely to all be kept stable during the entire process of software testing. As a result, the statistical structure of the failure data is likely to experience major changes. Recently, some useful non homogeneous Poisson process (NHPP) models with change-point are proposed. However, in many realistic situations, whether a change-point exists is unknown. Furthermore, some real data seem to have two or more change-points. In this article we propose test statistics to test the existence of change-point(s). The experimental results of real data show that our tests perform well.     

Testing for two states in a hidden Markov model

The authors consider hidden Markov models (HMMs) whose latent process has m ≥ 2 states and whose state‐dependent distributions arise from a general one‐parameter family. They propose a test of the hypothesis m = 2. Their procedure is an extension to HMMs of the modified likelihood ratio statistic proposed by Chen, Chen & Kalbfleisch (2004) for testing two states in a finite mixture. The authors determine the asymptotic distribution of their test under the hypothesis m = 2 and investigate its finite‐sample properties in a simulation study. Their test is based on inference for the marginal mixture distribution of the HMM. In order to illustrate the additional difficulties due to the dependence structure of the HMM, they show how to test general regular hypotheses on the marginal mixture of HMMs via a quasi‐modified likelihood ratio. They also discuss two applications.     

Multi - sample test of equal gamma distribution scale parameters in presence of unknown common shape parameter

Shiue and Bain proposed an approximate F statistic for testing equality of two gamma distribution scale parameters in presence of a common and unknown shape parameter. By generalizing Shiue and Bain's statistic we develop a new statistic for testing equality of L >= 2 gamma distribution scale parameters. We derive the distribution of the new statistic ESP for L = 2 and equal sample size situation. For other situations distribution of ESP is not known and test based on the ESP statistic has to be performed by using simulated critical values. We also derive a C(α) statistic CML and develop a likelihood ratio statistic, LR, two modified likelihood ratio statistics M and MLB and a quadratic statistic Q. The distribution of each of the statistics CML, LR, M, MLB and Q is asymptotically chi-square with L - 1 degrees of freedom. We then conducted a monte-carlo simulation study to compare the perfor- mance of the statistics ESP, LR, M, MLB, CML and Q in terms of size and power. The statistics LR, M, MLB and Q are in general liberal and do not show power advantage over other statistics. The statistic CML, based on its asymptotic chi-square distribution, in general, holds nominal level well. It is most powerful or nearly most powerful in most situations and is simple to use. Hence, we recommend the statistic CML for use in general. For better power the statistic ESP, based on its empirical distribution, is recommended for the special situation for which there is evidence in the data that λ₁ < … < λ_L and n₁ < … < n_L, where λ₁ …, λ_L are the scale parameters and n₁,…, n_L are the sample sizes.