Symmetry in mixture experiments

Two types of symmetry can arise when the proportions of mixture components are constrained by upper and lower bounds. These two types of symmetry are shown to be useful for blocking first-order designs, as well as for finding the centroid of the experimental region. Orthogonal blocking of first-order mixture designs provides a method of including process variables in the mixture experiment, with the mixture terms orthogonal to the process factors. Symmetric regions are used to develop spherical and rotatable response surface designs for mixtures. The central composite design and designs based on the icosahedron and the dodecahedron are given for four-component mixtures. The uniform shell designs are three-level designs when applied to mixture experiments.     

A new look on optimal foldover plans in terms of uniformity criteria

In this paper, we develop a new mechanism for finding the optimal foldover plans (OFPs) which is based on the uniformity criteria measured by Lee discrepancy, wrap-around L₂-discrepancy, and centered L₂-discrepancy. For three-level fractional factorials as the original designs, general foldover plans and combined designs are defined, and lower bounds of these three discrepancies of combined designs under general foldover plans are also obtained, which can be used as benchmarks for searching OFPs. Illustrative examples with a comparison study between the foldover plans under these discrepancies are provided. Our results provide a theoretical justification for OFPs of three-level designs in terms of uniformity criteria.     

A closer look at de-aliasing effects using an efficient foldover technique

Foldover techniques are used to reduce the confounding when some important effects (usually lower order effects) cannot be estimated independently. This article develops an efficient foldover mechanism for symmetric or asymmetric designs, whether regular or nonregular. In this paper, we take the uniformity criteria (UC) as the optimality measures to construct the optimal combined designs (initial design plus its corresponding foldover design) which have better capability of estimating lower order effects. The relationship between any initial design and its combined design is studied. A comparison study between the combined designs via different UC is provided. Equivalence between any combined design and its complementary combined design is investigated, which is a very useful constraint that reduce the search space. Using our results as benchmarks, we can implement a powerful algorithm for constructing optimal combined designs. Our work covers as well as gives results better than recent works of about 20 articles in the last few years as special cases. So this article is a good reference for constructing effective designs.     

Recursive techniques for the construction of experimental designs

The construction of experimental designs by recursive techniques is studied in this paper. Formulae for the recursive addition or deletion of data from a design are derived for a typical sub-hypothesis situation of a general experimental design. These results are used to consider the recursive construction of experimental designs with respect to different optimality criteria. This approach to the construction of designs is quite different to that of the well-established theory of optimal design.     

Lower bounds of the wrap-around -discrepancy and relationships between MLHD and uniform design with a large size

The wrap-around (WD) L₂-discrepancy has been commonly used in experimental designs. In this paper, some lower bounds of the WD L₂-discrepancy for asymmetrical U-type designs are given and the expectation and variance of midpoint Latin hypercube designs (LHD) are also obtained. Relationships between midpoint LHD and uniform designs for symmetrical and asymmetrical cases are discussed in the sense of comparing the lower bound and the expectation of squared wrap-around L₂-discrepancy of U-type designs. Some comparisons between simple random sampling and the lower bounds of U-type designs are given.     

Lee discrepancy on mixed two- and three-level uniform augmented designs

Follow-up experiment is widely applied to various fields such as science and engineering, since it is an indispensable strategy, especially when some additional resources or information become available after the initial design of experiment is carried out. Moreover, some extra factors may be added in the follow-up experiment. One may augment the number of runs and/or factors for the purpose of application. In this paper, the issue of the uniform row augmented designs and column augmented designs with mixed two- and three-level is investigated. The uniformity of augmented designs is discussed under the Lee discrepancy, some lower bounds of Lee discrepancy for the augmented designs are obtained. The construction algorithm of the uniform augmented designs is given. Some numerical examples indicate that uniform augmented designs can be constructed with high efficiency.     

Discussion

Control languages used to specify experimental designs to ANOVA programs must have syntax and semantics to express several different types of information about the data and their analysis. The languages associated with several widely distributed ANOVA programs are compared for their flexibility and legibility in expressing the set of designs encountered in design texts. The types of output of the programs are listed.     

On Second-Order A-, D- and E-Minimax Designs for Estimating Slopes in Extrapolation and Restricted Interpolation Regions

Summary

The concepts of D-, A- and E-minimax optimality criteria of designs for estimating the slopes of a response surface are considered for situations where the region of interest may not be identical to the experimental region. Optimal second-order designs are derived for the situation where the experimental region and the region of interest are both hyperspherical with a common centre. The dependence of the optimal design on the relative sizes of the regions is investigated. Further, the perfomance of designs optimal for one region in estimating slopes in other regions is also examined.     

A review of uniform cross-over designs

Uniform cross-over designs form an important family of experimental designs. They have been applied in many scientific disciplines including clinical trials, agricultural studies and psychological experiments. In this paper we consider the four types of uniform cross-over design, as given by Williams [1949. Experimental designs balanced for the estimation of residual effects of treatments. Aust. J. Sci. Res. 2, 149–168], Cheng and Wu [1980. Balanced repeated measurements designs. Ann. Statist. 8, 1272–1283. Corrigendum 11 (1983) 349], Bate and Jones [2006. The construction of nearly balanced and nearly strongly balanced uniform cross-over designs. J. Statist. Plann. Inference 136, 3248–3267] and Kunert [1983. Optimal design and refinement of the linear model with applications to repeated measurements designs. Ann. Statist. 11, 247–257]. The efficiency of these designs, existence criteria and methods of construction are described.     

An investigation of a quadratic design criterion for estimation of the hemodynamic response function

Optimal experimental design for estimation of the hemodynamic response function (HRF) is investigated using a nonlinear model with a quadratic mean squared error design criterion. This criterion is used, along with a genetic algorithm, to select locally optimal designs that are shown to be, in most cases, more efficient than designs selected with the more commonly used linear expansion criterion. These designs are also shown to result in lower overall asymptotic estimator variance and bias. The investigation focuses on a single stimulus type, but the criterion can also be used with multiple stimulus types.     

Optimal and efficient crossover designs for comparing test treatments to a control treatment under various models

We study the optimality, efficiency, and robustness of crossover designs for comparing several test treatments to a control treatment. Since A-optimality is a natural criterion in this context, we establish lower bounds for the trace of the inverse of the information matrix for the test treatments versus control comparisons under various models. These bounds are then used to obtain lower bounds for efficiencies of a design under these models. Two algorithms, both guided by these efficiencies and results from optimal design theory, are proposed for obtaining efficient designs under the various models.     

A relaxation procedure for calculating (G–)minimax optimal designs

Summary: In nonlinear statistical models, standard optimality functions for experimental designs depend on the unknown parameters of the model. An appealing and robust concept for choosing a design is the minimax criterion. However, so far, minimax optimal designs have been calculated efficiently under various restrictive conditions only. We extend an iterative relaxation scheme originally proposed by Shimizu and Aiyoshi (1980) and prove its convergence under very general assumptions which cover a variety of situations considered in experimental design. Application to different specific design criteria is discussed and issues of practical implementation are addressed. First numerical results suggest that the method may be very efficient with respect to the number of iterations required.*Supported by a grant from the Deutsche Forschungsgemeinschaft. We are grateful to a referee for his constructive suggestions.     

Robustness group divisible designs

Robustness of group divisible (GD) designs is investigated, when one block is lost, in terms of efficiency of the residual design. The exact evaluation of the efficiency can be made for singular GD and semi-regular GD designs as ell as regular GD designs with λ₁ = 0. In a regular GD design with λ₁ > 0, the efficiency may depend upon the lost block and sharp upper and lower bounds on the efficiency are presented. The investigation shows that GD designs are fairly robust in terms of efficiency. As a special case, we can also show the robustness of balanced incomplete block design when one block is lost.     

Optimal discrimination designs for exponential regression models

We investigate optimal designs for discriminating between exponential regression models of different complexity, which are widely used in the biological sciences; see, e.g., Landaw [1995. Robust sampling designs for compartmental models under large prior eigenvalue uncertainties. Math. Comput. Biomed. Appl. 181–187] or Gibaldi and Perrier [1982. Pharmacokinetics. Marcel Dekker, New York]. We discuss different approaches for the construction of appropriate optimality criteria, and find sharper upper bounds on the number of support points of locally optimal discrimination designs than those given by Caratheodory's Theorem. These results greatly facilitate the numerical construction of optimal designs. Various examples of optimal designs are then presented and compared to different other designs. Moreover, to protect the experiment against misspecifications of the nonlinear model parameters, we adapt the design criteria such that the resulting designs are robust with respect to such misspecifications and, again, provide several examples, which demonstrate the advantages of our approach.     

Some sufficient conditions for the type 1 optimality of block designs

In this paper, we investigate the problem of determining block designs which are optimal under type 1 optimality criteria within various classes of designs having υ treatments arranged in b blocks of size k. The solutions to two optimization problems are given which are related to a general result obtained by Cheng (1978) and which are useful in this investigation. As one application of the solutions obtained, the definition of a regular graph design given in Mitchell and John (1977) is extended to that of a semi-regular graph design and some sufficient conditions are derived for the existence of a semi-regular graph design which is optimal under a given type 1 criterion. A result is also given which shows how the sufficient conditions derived can be used to establish the optimality under a specific type 1 criterion of some particular types of semi- regular graph designs having both equal and unequal numbers of replicates. Finally,some sufficient conditions are obtained for the dual of an A- or D-optimal design to be A- or D-optimal within an appropriate class of dual designs.     

Lower Bounds for the Efficiency of Designs with Respect to the D-Criterion when the Observations are Correlated

In the general linear model consider the experimental design problem for the Gauß-Markov estimator or least squares estimator when the observations are correlated. We prove new formulas for the efficiency of an exact design with respect to the D-criterion. For models with intercept term, for example, these formulas are useful to derive better lower bounds for the efficiency than the bounds recently given for an arbitrary linear model. These bounds are applied in examples to symmetrical regular circulants as covariance matrices. A byproduct of the investigations is some insight as to what kinds of designs might retain their optimality or high efficiency (for the uncorrelated homoscedastic case) under correlated observations.     

On properties of efficiency-balanced designs

We consider a class of efficiency-balanced block designs which are design patterns for the analytical simplification of statistical analysis. This paper consists of eight sections which investigate various problems (such as, bounds on parameters, characterizations, existence and nonexistence, and dual designs) for efficiency-balanced block designs.     

Some new lower bounds to various discrepancies on combined designs

The foldover is a useful technique in construction of two-level factorial designs. A foldover design is the follow-up experiment generated by reversing the sign(s) of one or more factors in the initial design. The full design obtained by joining the runs in the foldover design to those of the initial design is called the combined design. In this article, some new lower bounds of various discrepancies of combined designs, such as the centered, symmetric, and wrap-around L₂-discrepancies, are obtained, which can be used as a better benchmark for searching optimal foldover plans. Our results provide a theoretical justification for optimal foldover plans in terms of uniformity criterion.     

On constructing general minimum lower order confounding two-level block designs

In practice, to reduce systematic variation and increase precision of effect estimation, a practical design strategy is then to partition the experimental units into homogeneous groups, known as blocks. It is an important issue to study the optimal way on blocking the experimental units. Blocked general minimum lower order confounding (B¹-GMC) is a new criterion for selecting optimal block designs. The paper considers the construction of optimal two-level block designs with respect to the B¹-GMC criterion. By utilizing doubling theory and MaxC2 design, some optimal block designs with respect to the B¹-GMC criterion are obtained.     

A NEW UPPER BOUND FOR THE EFFICIENCY FACTOR OF A BLOCK DESIGN

An upper bound for the efficiency factor of a block design, which in many cases is tighter than those reported by other authors, is derived. The bound is based on a lower bound for E(1/X) in terms of E(X) and var(X) for a random variable X on the unit interval. For the special case of resolvable designs, an improved bound is given which also competes with known bounds for resolvable designs in some cases.