A bayesian approach to the comparison of two means

A hierarchical Bayesian approach to the problem of comparison of two means is considered. Hypothesis testing, ranking and selection, and estimation (after selection) are treated. Under the hypothesis that two means are different, it is desired to select the population which has the larger mean. Expressions for the ranking probability of each mean being the larger and the corresponding estimate of each mean are given. For certain priors, it is possible to express the quantities of interest in closed form. A simulation study has been done to compare mean square errors of a hierarchical Bayesian estimator and some of the existing estimators of the selected mean. The case of comparing two means in the presence of block effects has also been considered and an example is presented to illustrate the methodology.     

Subset selection for normal means in multi-factor experiments

The procedure of Gupta [1956], [1965] for selecting a random sized subset of k ≧ 2 normal populations which contains the population with the largest population mean when the populations have a common variance is generalized to multi-factor experiments. Two-factor experiments with equal replication on each factor-level combination are discussed in detail. The cases of zero and non-zero interactions between factor levels are considered. For the two-factor, zero interaction case with a common number of observations at each factor-level combination, a table of constants necessary to implement the procedure is provided for experiments having selected levels per factor; the constants are equi-coordinate upper percentage points of a multivariate Student t distribution.     

Selecting the normal population with the largest mean when the variances are bounded

A multiple decision approach to the problem of selecting the population with the largest mean was formulated by Bechhofer (1954), where a single-sample solution was presented for the case of normal populations with known variances. In this paper the problem of selecting the normal population with the largest mean is considered when the population variances are unequal and unknown but are constrained only to be less than a specified upper bound. It is demonstrated that a slight modification of Bechhofer' s procedure will suffice to ensure the probability requirements under this simple constraint for cases of practical interest.     

Estimation of two ordered normal means when a covariance matrix is known

Estimation of two normal means with an order restriction is considered when a covariance matrix is known. It is shown that restricted maximum likelihood estimator (MLE) stochastically dominates both estimators proposed by Hwang and Peddada [Confidence interval estimation subject to order restrictions. Ann Statist. 1994;22(1):67–93] and Peddada et al. [Estimation of order-restricted means from correlated data. Biometrika. 2005;92:703–715]. The estimators are also compared under the Pitman nearness criterion and it is shown that the MLE is closer to ordered means than the other two estimators. Estimation of linear functions of ordered means is also considered and a necessary and sufficient condition on the coefficients is given for the MLE to dominate the other estimators in terms of mean squared error.     

Estimation of two order restricted normal means with unknown and possibly unequal variances

Estimation of each of and linear functions of two order restricted normal means is considered when variances are unknown and possibly unequal. We replace unknown variances with sample variances and construct isotonic regression estimators, which we call in our paper the plug-in estimators, to estimate ordered normal means. Under squared error loss, a necessary and sufficient condition is given for the plug-in estimators to improve upon the unrestricted maximum likelihood estimators uniformly. As for the estimation of linear functions of ordered normal means, we also show that when variances are known, the restricted maximum likelihood estimator always improves upon the unrestricted maximum likelihood estimator uniformly, but when variances are unknown, the plug-in estimator does not always improve upon the unrestricted maximum likelihood estimator uniformly.     

Selecting the normal population with largest (Smallest) value of mahalanobis distance from the origin

In this paper the problem of selecting the best of several normal populations in terms of Mahalanobis distance (MD) whenpopulation variance-covariance matrices are equal and unknown is discussed. The selection rule enunciated is shown to ap-proximately satisfy the usual requirement of a minimum guaranteed probability of correct selection. Methods of computing tables required for application of the rule are discussed.     

On the equivalence of two approaches to simplicity in the analysis of block designs and some related results

Two seemingly different approaches to simplicity in the analysis of connected block designs, and their relationship to the concepts of balance are discussed.     

A test statistic based on ranked set sampling for two normal means

In this study, we considered a hypothesis test for the difference of two population means using ranked set sampling. We proposed a test statistic for this hypothesis test with more than one cycle under normality. We also investigate the performance of this test statistic, when the assumptions hold and are violated. For this reason, we investigate the type I error and power rates of tests under normality with equal and unequal variances, non-normality with equal and unequal variances. We also examine the performance of this test under imperfect ranking case. The simulation results show that derived test performs quite well.     

A Hybrid Geometric Phase II/III Clinical Trial Design based on Treatment Failure Time and Toxicity

The problem of comparing several experimental treatments to a standard arises frequently in medical research. Various multi-stage randomized phase II/III designs have been proposed that select one or more promising experimental treatments and compare them to the standard while controlling overall Type I and Type II error rates. This paper addresses phase II/III settings where the joint goals are to increase the average time to treatment failure and control the probability of toxicity while accounting for patient heterogeneity. We are motivated by the desire to construct a feasible design for a trial of four chemotherapy combinations for treating a family of rare pediatric brain tumors. We present a hybrid two-stage design based on two-dimensional treatment effect parameters. A targeted parameter set is constructed from elicited parameter pairs considered to be equally desirable. Bayesian regression models for failure time and the probability of toxicity as functions of treatment and prognostic covariates are used to define two-dimensional covariate-adjusted treatment effect parameter sets. Decisions at each stage of the trial are based on the ratio of posterior probabilities of the alternative and null covariate-adjusted parameter sets. Design parameters are chosen to minimize expected sample size subject to frequentist error constraints. The design is illustrated by application to the brain tumor trial.     

A Two-stage minimax procedure with screening for selecting the largest normal mean

The problem of selecting the normal population with the largest population mean when the populations have a common known variance is considered. A two-stage procedure is proposed which guarantees the same probability requirement using the indifference-zone approach as does the single-stage procedure of Bechhofer (1954). The two-stage procedure has the highly desirable property that the expected total number of observations required by the procedure is always less than the total number of observations required by the corresponding single-stage procedure, regardless of the configuration of the population means. The saving in expected total number of observations can be substantial, particularly when the configuration of the population means is favorable to the experimenter. The saving is accomplished by screening out “non-contending” populations in the first stage, and concentrating sampling only on “contending” populations in the second stage.

The two-stage procedure can be regarded as a composite one which uses a screening subset-type approach (Gupta (1956), (1965)) in the first stage, and an indifference-zone approach (Bechhofer (1954)) applied to all populations retained in the selected sub-set in the second stage. Constants to implement the procedure for various k and P? are provided, as are calculations giving the saving in expected total sample size if the two-stage procedure is used in place of the corresponding single-stage procedure.     

Estimation and test of several multivariate normal means under an order restriction when the dimension is larger than two

Suppose that an order restriction is imposed among several p-variate normal mean vectors. We are interested in the problems of estimating these mean vectors and testing their homogeneity under this restriction. These problems are multivariate extensions of Bartholomew's (1959) ones. For the bivariate case, these problems have been studied by Sasabuchi et al. (1983) and (1998) and some others. In the present paper we examine the convergence of an iterative algorithm for computing the maximum likelihood estimator when p is larger than two. We also study some test procedures for testing homogeneity when p is larger than two.     

On rules based on sample medians for selection of the largest location parameter

The problem of selection of a subset containing the largest of several location parameters is considered, and a Gupta-type selection rule based on sample medians is investigated for normal and double exponential populations. Numerical comparisons between rules based on medians and means of small samples are made for normal and contaminated normal populations, assuming the popula-tion means to be equally spaced. It appears that the rule based on sample means loses its superiority over the rule based on sample medians in case the samples are heavily contaminated. The asymptotic relative efficiency (ARE) of the medians procedure relative to the means procedure is also computed, assuming the normal means to be in a slippage configuration. The means proce-dure is found to be superior to the median procedure in the sense of ARE. As in the small sample case, the situation is reversed if the normal populations are highly contaminate.     

Strategies for a sequential selection of the better of two trinomial populations

A sequential procedure for a selection of the better of two trinomial populations has been proposed by ?idók (1988). The present paper shows some Monte Carlo results for 4 different strategies of sequential experimentation in this procedure, on this basis compares the strategies, and gives some practical recommendations for choosing the strategy.     

Double sample tests for the equality of two means

A double sample (two stage) testing procedure is proposed as an alternative to the usual one stage     

The Estimation of Compensating Wage Differentials: Lessons From the Deadliest Catch

ABSTRACT

I use longitudinal survey data from commercial fishing deckhands in the Alaskan Bering Sea to provide new insights on empirical methods commonly used to estimate compensating wage differentials and the value of statistical life (VSL). The unique setting exploits intertemporal variation in fatality rates and wages within worker-vessel pairs caused by a combination of weather patterns and policy changes, allowing identification of parameters and biases that it has only been possible to speculate about in more general settings. I show that estimation strategies common in the literature produce biased estimates in this setting, and decompose the bias components due to latent worker, establishment, and job-match heterogeneity. The estimates also remove the confounding effects of endogenous job mobility and dynamic labor market search, narrowing a conceptual gap between search-based hedonic wage theory and its empirical applications. I find that workers’ marginal aversion to fatal risk falls as risk levels rise, which suggests complementarities in the benefits of public safety policies. Supplementary materials for this article are available online.     

Testing the equality of two normal percentiles

Two statistics are suggested for testing the equality of two normal percentiles where population means and variances are unknown. The first is based on the generalized likelihood ratio test (LRT), the second on Cochran's statistic used in the Behrens-Fisher problem. Size and power comparisons are made by using simulation and asympototic theory.     

Estimation of the common mean of two univariate normal populations

The problem of estimating the common mean μ of two univariate normal populations with unknown and unequal variances is considered from a decision-theoretic point of view. We restrict our attention to an appropriate class C and its three subclasses C_0C1C2of un-biased estimates of μ. We consider the usual estimate μ⁰ of μ which is the weighted linear combination of the sample means with weights as reciprocals of the sample variances. Its admissibility in C₀ and extended admissibility in C is proved. Admissible estimates in C₁ and C₂are also obtained.The loss is always assumed to be squared error. The question of admissibility of μ⁰ in the class of all estimators is still open.     

Adaptive blinded sample size adjustment for comparing two normal means—a mostly Bayesian approach

Adaptive sample size redetermination (SSR) for clinical trials consists of examining early subsets of on‐trial data to adjust prior estimates of statistical parameters and sample size requirements. Blinded SSR, in particular, while in use already, seems poised to proliferate even further because it obviates many logistical complications of unblinded methods and it generally introduces little or no statistical or operational bias. On the other hand, current blinded SSR methods offer little to no new information about the treatment effect (TE); the obvious resulting problem is that the TE estimate scientists might simply ‘plug in’ to the sample size formulae could be severely wrong. This paper proposes a blinded SSR method that formally synthesizes sample data with prior knowledge about the TE and the within‐treatment variance. It evaluates the method in terms of the type 1 error rate, the bias of the estimated TE, and the average deviation from the targeted power. The method is shown to reduce this average deviation, in comparison with another established method, over a range of situations. The paper illustrates the use of the proposed method with an example. Copyright © 2012 John Wiley & Sons, Ltd.     

Test of equality of normal means in the absence of independent estimator of variance

Let X_l,…,X_n be normally and independently distributed with means θ_l,…,θ_nand a cornmorl variance. Thus there are n observations and n+i unknwon parameters. A test of the null hypothesis that, the θ_i's are all zero and the alternative that the vector (θ_l,…,θ_n) lies in a convex cone with its vertex a.t the origin is connsidered in this paper. It is shown that under a mild condition the likelihood ratio test is possible. The ordinary one sided t - test belongs to the class of tests considered in this paper. The hypothesis of equality of means against the simple order alternative can be tested in certain cases .