Local Box–Cox transformation on time-varying parametric models for smoothing estimation of conditional CDF with longitudinal data

Nonparametric estimation and inferences of conditional distribution functions with longitudinal data have important applications in biomedical studies, such as epidemiological studies and longitudinal clinical trials. Estimation approaches without any structural assumptions may lead to inadequate and numerically unstable estimators in practice. We propose in this paper a nonparametric approach based on time-varying parametric models for estimating the conditional distribution functions with a longitudinal sample. Our model assumes that the conditional distribution of the outcome variable at each given time point can be approximated by a parametric model after local Box–Cox transformation. Our estimation is based on a two-step smoothing method, in which we first obtain the raw estimators of the conditional distribution functions at a set of disjoint time points, and then compute the final estimators at any time by smoothing the raw estimators. Applications of our two-step estimation method have been demonstrated through a large epidemiological study of childhood growth and blood pressure. Finite sample properties of our procedures are investigated through a simulation study. Application and simulation results show that smoothing estimation from time-variant parametric models outperforms the existing kernel smoothing estimator by producing narrower pointwise bootstrap confidence band and smaller root mean squared error.     

Semiparametric shape-invariant models for periodic data

This article presents a novel shape-invariant modeling approach to quasi-periodic data. We propose a dynamic semiparametric method that estimates the common cycle shape in a nonparametric way and the individual phase and amplitude variability in a parametric way. An efficient algorithm to compute the estimators is proposed. The behavior of the estimators is studied by simulation and by a real-data example.     

A comparison of dependence function estimators in multivariate extremes

Various nonparametric and parametric estimators of extremal dependence have been proposed in the literature. Nonparametric methods commonly suffer from the curse of dimensionality and have been mostly implemented in extreme-value studies up to three dimensions, whereas parametric models can tackle higher-dimensional settings. In this paper, we assess, through a vast and systematic simulation study, the performance of classical and recently proposed estimators in multivariate settings. In particular, we first investigate the performance of nonparametric methods and then compare them with classical parametric approaches under symmetric and asymmetric dependence structures within the commonly used logistic family. We also explore two different ways to make nonparametric estimators satisfy the necessary dependence function shape constraints, finding a general improvement in estimator performance either (i) by substituting the estimator with its greatest convex minorant, developing a computational tool to implement this method for dimensions \(D\ge 2\) or (ii) by projecting the estimator onto a subspace of dependence functions satisfying such constraints and taking advantage of Bernstein–Bézier polynomials. Implementing the convex minorant method leads to better estimator performance as the dimensionality increases.     

Semiparametric statistical inferences for longitudinal data with nonparametric covariance modelling

In this paper, semiparametric modelling for longitudinal data with an unstructured error process is considered. We propose a partially linear additive regression model for longitudinal data in which within-subject variances and covariances of the error process are described by unknown univariate and bivariate functions, respectively. We provide an estimating approach in which polynomial splines are used to approximate the additive nonparametric components and the within-subject variance and covariance functions are estimated nonparametrically. Both the asymptotic normality of the resulting parametric component estimators and optimal convergence rate of the resulting nonparametric component estimators are established. In addition, we develop a variable selection procedure to identify significant parametric and nonparametric components simultaneously. We show that the proposed SCAD penalty-based estimators of non-zero components have an oracle property. Some simulation studies are conducted to examine the finite-sample performance of the proposed estimation and variable selection procedures. A real data set is also analysed to demonstrate the usefulness of the proposed method.     

Frontier estimation using kernel smoothing estimators with data transformation

In economics, a production frontier function is a graph that shows the maximum output of production units such as firms, industries, or economies, as a function of their inputs. Practically, estimating production frontiers often requires imposition of constraints such as monotonicity or monotone concavity. However, few constrained estimators of production frontier have been proposed in the literature. They are based on simple envelopment techniques which often suffer from lack of precision and smoothness. Motivated by this observation, we propose a smooth constrained nonparametric frontier estimator respecting constraints by considering kernel smoothing estimators from a transformed data. It is particularly appealing to practitioners who would like to use smooth estimates that, in addition, satisfy theoretical axioms of production. The utility of this method is illustrated through application to one real dataset and simulation evidences are also presented to show its superiority over the most known methods.     

Random coefficient regressions: parametric goodness-of-fit tests

Random coefficient regression models have been applied in different fields during recent years and they are a unifying frame for many statistical models. Recently, Beran and Hall (Ann. Statist. 20 (1992) 1970) raised the question of the nonparametric study of the coefficients distribution. Nonparametric goodness-of-fit tests were considered in Delicado and Romo (Ann. Inst. Statist. Math. 51 (1999) 125). In this nonparametric framework, the study of parametric families for the coefficient distributions was started by Beran (Ann. Inst. Statist. Math. (1993) 639). Here we propose statistics for parametric goodness-of-fit tests and we obtain their asymptotic distributions. Moreover, we construct bootstrap approximations to these distributions, proving their validity. Finally, a simulation study illustrates our results.     

Interval estimation of the joint survival function for successive duration times under left truncation and right censoring

In incident cohort studies, survival data often include subjects who have had an initiate event at recruitment and may potentially experience two successive events (first and second) during the follow-up period. Since the second duration process becomes observable only if the first event has occurred, left truncation and dependent censoring arise if the two duration times are correlated. To confront the two potential sampling biases, we propose two inverse-probability-weighted (IPW) estimators for the estimation of the joint survival function of two successive duration times. One of them is similar to the estimator proposed by Chang and Tzeng [Nonparametric estimation of sojourn time distributions for truncated serial event data – a weight adjusted approach, Lifetime Data Anal. 12 (2006), pp. 53–67]. The other is the extension of the nonparametric estimator proposed by Wang and Wells [Nonparametric estimation of successive duration times under dependent censoring, Biometrika 85 (1998), pp. 561–572]. The weak convergence of both estimators are established. Furthermore, the delete-one jackknife and simple bootstrap methods are used to estimate standard deviations and construct interval estimators. A simulation study is conducted to compare the two IPW approaches.     

Nonparametric Regression with Sample Design Following a Random Process

Nonparametric regression is considered where the sample point placement is not fixed and equispaced, but generated by a random process with rate n. Conditions are found for the random processes that result in optimal rates of convergence for nonparametric regression when using a block thresholded wavelet estimator. Previous results on nonparametric regression via wavelets on both fixed and random sample point placement are shown to be special cases of the general result given here. The estimator is adaptive over a large range of Hölder function spaces and the convergence rate exhibited is an improvement over term-by-term wavelet estimators. Threshold selection is implemented in a data-adaptive fashion, rather than using a fixed threshold as is usually done in block thresholding. This estimator, BlockSure, is compared against fixed-threshold block estimators and the more traditional term-by-term threshold wavelet estimators on several random design schemes via simulations.     

Robust Mean Estimation Under a Possibly Incorrect Log-Normality Assumption

Nonparametric and parametric estimators are combined to minimize the mean squared error among their linear combinations. The combined estimator is consistent and for large sample sizes has a smaller mean squared error than the nonparametric estimator when the parametric assumption is violated. If the parametric assumption holds, the combined estimator has a smaller MSE than the parametric estimator. Our simulation examples focus on mean estimation when data may follow a lognormal distribution, or can be a mixture with an exponential or a uniform distribution. Motivating examples illustrate possible application areas.     

Semiparametric regression under long-range dependent errors

In this paper, we consider a semiparametric regression model under long-range dependent errors. By approximating the nonparametric component by a finite series sum, we construct consistent estimators for both parametric and nonparametric components. Meanwhile, convergence rates for the consistent estimators are also investigated. Additionally, an optimal truncation parameter selection procedure is proposed.     

Tail density estimation for exploratory data analysis using kernel methods

It is often critical to accurately model the upper tail behaviour of a random process. Nonparametric density estimation methods are commonly implemented as exploratory data analysis techniques for this purpose and can avoid model specification biases implied by using parametric estimators. In particular, kernel-based estimators place minimal assumptions on the data, and provide improved visualisation over scatterplots and histograms. However kernel density estimators can perform poorly when estimating tail behaviour above a threshold, and can over-emphasise bumps in the density for heavy tailed data. We develop a transformation kernel density estimator which is able to handle heavy tailed and bounded data, and is robust to threshold choice. We derive closed form expressions for its asymptotic bias and variance, which demonstrate its good performance in the tail region. Finite sample performance is illustrated in numerical studies, and in an expanded analysis of the performance of global climate models.     

Performance of coefficient of variation estimators in ranked set sampling

In this paper, we propose and evaluate the performance of different parametric and nonparametric estimators for the population coefficient of variation considering Ranked Set Sampling (RSS) under normal distribution. The performance of the proposed estimators was assessed based on the bias and relative efficiency provided by a Monte Carlo simulation study. An application in anthropometric measurements data from a human population is also presented. The results showed that the proposed estimators via RSS present an expressively lower mean squared error when compared to the usual estimator, obtained via Simple Random Sampling. Also, it was verified the superiority of the maximum likelihood estimator, given the necessary assumptions of normality and perfect ranking are met.     

Estimation of the Moment Generating Function

A number of statistical problems use the moment generating function (mgf) for purposes other than determining the moments of a distribution. If the distribution is not completely specified, then the mgf must be estimated from available data. The empirical mgf makes no assumptions concerning the underlying distribution except for the existence of the mgf. In contrast to the nonparametric approach provided by the empirical mgf, alternative estimators can be formed based on an assumed parametric model. Comparison of these approaches is considered for two parametric models; the normal and a one parameter gamma. Comparison criteria are efficiency and empirical confidence interval coverage. In general the parametric estimators outperform the empirical mgf when the model is correct. The comparisons are extended to underlying models which are two component mixtures from the distributional family assumed by the parametric estimators. Under the mixture models the superiority of the parametric estimator depends upon the model, value of the argument of the mgf, and the comparison criterion. The empirical mgf is the better estimator in some cases.     

Nonparametric estimation of transition probabilities in a non-Markov illness–death model

In this paper we consider nonparametric estimation of transition probabilities for multi-state models. Specifically, we focus on the illness-death or disability model. The main novelty of the proposed estimators is that they do not rely on the Markov assumption, typically assumed to hold in a multi-state model. We investigate the asymptotic properties of the introduced estimators, such as their consistency and their convergence to a normal law. Simulations demonstrate that the new estimators may outperform Aalen–Johansen estimators (the classical nonparametric tool for estimating the transition probabilities) in non-Markov situation. An illustration through real data analysis is included.     

Nonparametric estimation with recurrent competing risks data

Nonparametric estimators of component and system life distributions are developed and presented for situations where recurrent competing risks data from series systems are available. The use of recurrences of components’ failures leads to improved efficiencies in statistical inference, thereby leading to resource-efficient experimental or study designs or improved inferences about the distributions governing the event times. Finite and asymptotic properties of the estimators are obtained through simulation studies and analytically. The detrimental impact of parametric model misspecification is also vividly demonstrated, lending credence to the virtue of adopting nonparametric or semiparametric models, especially in biomedical settings. The estimators are illustrated by applying them to a data set pertaining to car repairs for vehicles that were under warranty.     

Quantile regression estimation of partially linear additive models

In this paper, we consider the estimation of partially linear additive quantile regression models where the conditional quantile function comprises a linear parametric component and a nonparametric additive component. We propose a two-step estimation approach: in the first step, we approximate the conditional quantile function using a series estimation method. In the second step, the nonparametric additive component is recovered using either a local polynomial estimator or a weighted Nadaraya–Watson estimator. Both consistency and asymptotic normality of the proposed estimators are established. Particularly, we show that the first-stage estimator for the finite-dimensional parameters attains the semiparametric efficiency bound under homoskedasticity, and that the second-stage estimators for the nonparametric additive component have an oracle efficiency property. Monte Carlo experiments are conducted to assess the finite sample performance of the proposed estimators. An application to a real data set is also illustrated.     

NEW EFFICIENT ESTIMATION AND VARIABLE SELECTION METHODS FOR SEMIPARAMETRIC VARYING-COEFFICIENT PARTIALLY LINEAR MODELS

The complexity of semiparametric models poses new challenges to statistical inference and model selection that frequently arise from real applications. In this work, we propose new estimation and variable selection procedures for the semiparametric varying-coefficient partially linear model. We first study quantile regression estimates for the nonparametric varying-coefficient functions and the parametric regression coefficients. To achieve nice efficiency properties, we further develop a semiparametric composite quantile regression procedure. We establish the asymptotic normality of proposed estimators for both the parametric and nonparametric parts and show that the estimators achieve the best convergence rate. Moreover, we show that the proposed method is much more efficient than the least-squares-based method for many non-normal errors and that it only loses a small amount of efficiency for normal errors. In addition, it is shown that the loss in efficiency is at most 11.1% for estimating varying coefficient functions and is no greater than 13.6% for estimating parametric components. To achieve sparsity with high-dimensional covariates, we propose adaptive penalization methods for variable selection in the semiparametric varying-coefficient partially linear model and prove that the methods possess the oracle property. Extensive Monte Carlo simulation studies are conducted to examine the finite-sample performance of the proposed procedures. Finally, we apply the new methods to analyze the plasma beta-carotene level data.     

Copulas checker-type approximations: Application to quantiles estimation of sums of dependent random variables

Abstract

Several approximations of copulas have been proposed in the literature. By using empirical versions of checker-type copulas approximations, we propose non parametric estimators of the copula. Under some conditions, the proposed estimators are copulas and their main advantage is that they can be sampled from easily. One possible application is the estimation of quantiles of sums of dependent random variables from a small sample of the multivariate law and a full knowledge of the marginal laws. We show that estimations may be improved by including in an easy way in the approximated copula some additional information on the law of a sub-vector for example. Our approach is illustrated by numerical examples.     

Nonparametric density estimation for multivariate bounded data

We propose a new nonparametric estimator for the density function of multivariate bounded data. As frequently observed in practice, the variables may be partially bounded (e.g. nonnegative) or completely bounded (e.g. in the unit interval). In addition, the variables may have a point mass. We reduce the conditions on the underlying density to a minimum by proposing a nonparametric approach. By using a gamma, a beta, or a local linear kernel (also called boundary kernels), in a product kernel, the suggested estimator becomes simple in implementation and robust to the well known boundary bias problem. We investigate the mean integrated squared error properties, including the rate of convergence, uniform strong consistency and asymptotic normality. We establish consistency of the least squares cross-validation method to select optimal bandwidth parameters. A detailed simulation study investigates the performance of the estimators. Applications using lottery and corporate finance data are provided.