Bayesian nonparametric survival analysis using mixture of Burr XII distributions

ABSTRACT

Recently, the Bayesian nonparametric approaches in survival studies attract much more attentions. Because of multimodality in survival data, the mixture models are very common. We introduce a Bayesian nonparametric mixture model with Burr distribution (Burr type XII) as the kernel. Since the Burr distribution shares good properties of common distributions on survival analysis, it has more flexibility than other distributions. By applying this model to simulated and real failure time datasets, we show the preference of this model and compare it with Dirichlet process mixture models with different kernels. The Markov chain Monte Carlo (MCMC) simulation methods to calculate the posterior distribution are used.     

Inference for Lévy‐Driven Stochastic Volatility Models via Adaptive Sequential Monte Carlo

Abstract. We investigate simulation methodology for Bayesian inference in Lévy‐driven stochastic volatility (SV) models. Typically, Bayesian inference from such models is performed using Markov chain Monte Carlo (MCMC); this is often a challenging task. Sequential Monte Carlo (SMC) samplers are methods that can improve over MCMC; however, there are many user‐set parameters to specify. We develop a fully automated SMC algorithm, which substantially improves over the standard MCMC methods in the literature. To illustrate our methodology, we look at a model comprised of a Heston model with an independent, additive, variance gamma process in the returns equation. The driving gamma process can capture the stylized behaviour of many financial time series and a discretized version, fit in a Bayesian manner, has been found to be very useful for modelling equity data. We demonstrate that it is possible to draw exact inference, in the sense of no time‐discretization error, from the Bayesian SV model.     

Shared frailty models with baseline generalized Pareto distribution

Abstract

In this article, we have considered three different shared frailty models under the assumption of generalized Pareto Distribution as baseline distribution. Frailty models have been used in the survival analysis to account for the unobserved heterogeneity in an individual risks to disease and death. These three frailty models are with gamma frailty, inverse Gaussian frailty and positive stable frailty. Then we introduce the Bayesian estimation procedure using Markov chain Monte Carlo (MCMC) technique to estimate the parameters. We applied these three models to a kidney infection data and find the best fitted model for kidney infection data. We present a simulation study to compare true value of the parameters with the estimated values. Model comparison is made using Bayesian model selection criterion and a well-fitted model is suggested for the kidney infection data.     

Markov chain Monte Carlo with the Integrated Nested Laplace Approximation

The Integrated Nested Laplace Approximation (INLA) has established itself as a widely used method for approximate inference on Bayesian hierarchical models which can be represented as a latent Gaussian model (LGM). INLA is based on producing an accurate approximation to the posterior marginal distributions of the parameters in the model and some other quantities of interest by using repeated approximations to intermediate distributions and integrals that appear in the computation of the posterior marginals. INLA focuses on models whose latent effects are a Gaussian Markov random field. For this reason, we have explored alternative ways of expanding the number of possible models that can be fitted using the INLA methodology. In this paper, we present a novel approach that combines INLA and Markov chain Monte Carlo (MCMC). The aim is to consider a wider range of models that can be fitted with INLA only when some of the parameters of the model have been fixed. We show how new values of these parameters can be drawn from their posterior by using conditional models fitted with INLA and standard MCMC algorithms, such as Metropolis–Hastings. Hence, this will extend the use of INLA to fit models that can be expressed as a conditional LGM. Also, this new approach can be used to build simpler MCMC samplers for complex models as it allows sampling only on a limited number of parameters in the model. We will demonstrate how our approach can extend the class of models that could benefit from INLA, and how the R-INLA package will ease its implementation. We will go through simple examples of this new approach before we discuss more advanced applications with datasets taken from the relevant literature. In particular, INLA within MCMC will be used to fit models with Laplace priors in a Bayesian Lasso model, imputation of missing covariates in linear models, fitting spatial econometrics models with complex nonlinear terms in the linear predictor and classification of data with mixture models. Furthermore, in some of the examples we could exploit INLA within MCMC to make joint inference on an ensemble of model parameters.     

Fully Bayesian logistic regression with hyper-LASSO priors for high-dimensional feature selection

Feature selection arises in many areas of modern science. For example, in genomic research, we want to find the genes that can be used to separate tissues of different classes (e.g. cancer and normal). One approach is to fit regression/classification models with certain penalization. In the past decade, hyper-LASSO penalization (priors) have received increasing attention in the literature. However, fully Bayesian methods that use Markov chain Monte Carlo (MCMC) for regression/classification with hyper-LASSO priors are still in lack of development. In this paper, we introduce an MCMC method for learning multinomial logistic regression with hyper-LASSO priors. Our MCMC algorithm uses Hamiltonian Monte Carlo in a restricted Gibbs sampling framework. We have used simulation studies and real data to demonstrate the superior performance of hyper-LASSO priors compared to LASSO, and to investigate the issues of choosing heaviness and scale of hyper-LASSO priors.     

Gamma shared frailty model based on reversed hazard rate

Abstract

Frailty models are used in survival analysis to account for unobserved heterogeneity in individual risks to disease and death. To analyze bivariate data on related survival times (e.g., matched pairs experiments, twin, or family data), shared frailty models were suggested. Shared frailty models are frequently used to model heterogeneity in survival analysis. The most common shared frailty model is a model in which hazard function is a product of random factor(frailty) and baseline hazard function which is common to all individuals. There are certain assumptions about the baseline distribution and distribution of frailty. In this paper, we introduce shared gamma frailty models with reversed hazard rate. We introduce Bayesian estimation procedure using Markov Chain Monte Carlo (MCMC) technique to estimate the parameters involved in the model. We present a simulation study to compare the true values of the parameters with the estimated values. Also, we apply the proposed model to the Australian twin data set.     

BINARY REGRESSION WITH A CLASS OF SKEWED t LINK MODELS

ABSTRACT

In this paper we propose a class of skewed t link models for analyzing binary response data with covariates. It is a class of asymmetric link models designed to improve the overall fit when commonly used symmetric links, such as the logit and probit links, do not provide the best fit available for a given binary response dataset. Introducing a skewed t distribution for the underlying latent variable, we develop the class of models. For the analysis of the models, a Bayesian and non-Bayesian methods are pursued using a Markov chain Monte Carlo (MCMC) sampling based approach. Necessary theories involved in modelling and computation are provided. Finally, a simulation study and a real data example are used to illustrate the proposed methodology.     

Bayesian analyses of an exponential-Poisson and related zero augmented type models

We consider several alternatives to the continuous exponential-Poisson distribution in order to accommodate the occurrence of zeros. Three of these are modifications of the exponential-Poisson model. One of these remains a fully continuous model. The other models we consider are all semi-continuous models, each with a discrete point mass at zero and a continuous density on the positive values. All of the models are applied to two environmental data sets concerning precipitation, and their Bayesian analyses using MCMC are discussed. This discussion covers convergence of the MCMC simulations and model selection procedures and considerations.     

Weibull multi-state models with misclassification

It is often important to allow multi-state models (MSMs) to accommodate misclassification of states. We introduce Bayesian parametric MSMs with unknown misclassification of states and Weibull distributed waiting times between states. This allows transitions between states to depend on the time spent in the current state, a feature lacking in commonly used exponential waiting times model. To fit the proposed model, a MCMC algorithm was employed. An example on the progression of bipolar disorder is presented along with simulation results. There was evidence that Weibull waiting times are an improvement over exponential in the study of bipolar disorder.     

A Stochastic Simulation Approach to Model Selection for Stochastic Volatility Models

Stochastic volatility models have been widely appreciated in empirical finance such as option pricing, risk management, etc. Recent advances of Markov chain Monte Carlo (MCMC) techniques made it possible to fit all kinds of stochastic volatility models of increasing complexity within Bayesian framework. In this article, we propose a new Bayesian model selection procedure based on Bayes factor and a classical thermodynamic integration technique named path sampling to select an appropriate stochastic volatility model. The performance of the developed procedure is illustrated with an application to the daily pound/dollar exchange rates data set.     

Stochastic volatility modelling in continuous time with general marginal distributions: Inference,prediction and model selection

We compare results for stochastic volatility models where the underlying volatility process having generalized inverse Gaussian (GIG) and tempered stable marginal laws. We use a continuous time stochastic volatility model where the volatility follows an Ornstein–Uhlenbeck stochastic differential equation driven by a Lévy process. A model for long-range dependence is also considered, its merit and practical relevance discussed. We find that the full GIG and a special case, the inverse gamma, marginal distributions accurately fit real data. Inference is carried out in a Bayesian framework, with computation using Markov chain Monte Carlo (MCMC). We develop an MCMC algorithm that can be used for a general marginal model.     

Forward Simulation Markov Chain Monte Carlo with Applications to Stochastic Epidemic Models

For many stochastic models, it is difficult to make inference about the model parameters because it is impossible to write down a tractable likelihood given the observed data. A common solution is data augmentation in a Markov chain Monte Carlo (MCMC) framework. However, there are statistical problems where this approach has proved infeasible but where simulation from the model is straightforward leading to the popularity of the approximate Bayesian computation algorithm. We introduce a forward simulation MCMC (fsMCMC) algorithm, which is primarily based upon simulation from the model. The fsMCMC algorithm formulates the simulation of the process explicitly as a data augmentation problem. By exploiting non‐centred parameterizations, an efficient MCMC updating schema for the parameters and augmented data is introduced, whilst maintaining straightforward simulation from the model. The fsMCMC algorithm is successfully applied to two distinct epidemic models including a birth–death–mutation model that has only previously been analysed using approximate Bayesian computation methods.     

Integer autoregressive models with structural breaks

Even though integer-valued time series are common in practice, the methods for their analysis have been developed only in recent past. Several models for stationary processes with discrete marginal distributions have been proposed in the literature. Such processes assume the parameters of the model to remain constant throughout the time period. However, this need not be true in practice. In this paper, we introduce non-stationary integer-valued autoregressive (INAR) models with structural breaks to model a situation, where the parameters of the INAR process do not remain constant over time. Such models are useful while modelling count data time series with structural breaks. The Bayesian and Markov Chain Monte Carlo (MCMC) procedures for the estimation of the parameters and break points of such models are discussed. We illustrate the model and estimation procedure with the help of a simulation study. The proposed model is applied to the two real biometrical data sets.     

INLA or MCMC? A tutorial and comparative evaluation for spatial prediction in log-Gaussian Cox processes

We investigate two options for performing Bayesian inference on spatial log-Gaussian Cox processes assuming a spatially continuous latent field: Markov chain Monte Carlo (MCMC) and the integrated nested Laplace approximation (INLA). We first describe the device of approximating a spatially continuous Gaussian field by a Gaussian Markov random field on a discrete lattice, and present a simulation study showing that, with careful choice of parameter values, small neighbourhood sizes can give excellent approximations. We then introduce the spatial log-Gaussian Cox process and describe MCMC and INLA methods for spatial prediction within this model class. We report the results of a simulation study in which we compare the Metropolis-adjusted Langevin Algorithm (MALA) and the technique of approximating the continuous latent field by a discrete one, followed by approximate Bayesian inference via INLA over a selection of 18 simulated scenarios. The results question the notion that the latter technique is both significantly faster and more robust than MCMC in this setting; 100,000 iterations of the MALA algorithm running in 20 min on a desktop PC delivered greater predictive accuracy than the default INLA strategy, which ran in 4 min and gave comparative performance to the full Laplace approximation which ran in 39 min.     

Bayesian multiple comparison of models for binary data with inequality constraints

In this paper we consider generalized linear models for binary data subject to inequality constraints on the regression coefficients, and propose a simple and efficient Bayesian method for parameter estimation and model selection by using Markov chain Monte Carlo (MCMC). In implementing MCMC, we introduce appropriate latent variables and use a simple approximation of a link function, to resolve computational difficulties and obtain convenient forms for full conditional posterior densities of elements of parameters. Bayes factors are computed via the Savage-Dickey density ratios and the method of Oh (Comput. Stat. Data Anal. 29:411–427, 1999), for which posterior samples from the full model with no degenerate parameter and the full conditional posterior densities of elements are needed. Since it uses one set of posterior samples from the full model for any model in consideration, it performs simultaneous comparison of all possible models and is very efficient compared with other model selection methods which require one to fit all candidate models. A simulation study shows that significant improvements can be made by taking the constraints into account. Real data on purchase intention of a product subject to order constraints is analyzed by using the proposed method. The analysis results show that there exist some price changes which significantly affect the consumer behavior. The results also show the importance of simultaneous comparison of models rather than separate pairwise comparisons of models since the latter may yield misleading results from ignoring possible correlations between parameters.     

Large Bayesian VARs: A Flexible Kronecker Error Covariance Structure

ABSTRACT

We introduce a class of large Bayesian vector autoregressions (BVARs) that allows for non-Gaussian, heteroscedastic, and serially dependent innovations. To make estimation computationally tractable, we exploit a certain Kronecker structure of the likelihood implied by this class of models. We propose a unified approach for estimating these models using Markov chain Monte Carlo (MCMC) methods. In an application that involves 20 macroeconomic variables, we find that these BVARs with more flexible covariance structures outperform the standard variant with independent, homoscedastic Gaussian innovations in both in-sample model-fit and out-of-sample forecast performance.     

A Sequential Point Process Model and Bayesian Inference for Spatial Point Patterns with Linear Structures

Abstract. We introduce a flexible spatial point process model for spatial point patterns exhibiting linear structures, without incorporating a latent line process. The model is given by an underlying sequential point process model. Under this model, the points can be of one of three types: a ‘background point’ an ‘independent cluster point’ or a ‘dependent cluster point’. The background and independent cluster points are thought to exhibit ‘complete spatial randomness’, whereas the dependent cluster points are likely to occur close to previous cluster points. We demonstrate the flexibility of the model for producing point patterns with linear structures and propose to use the model as the likelihood in a Bayesian setting when analysing a spatial point pattern exhibiting linear structures. We illustrate this methodology by analysing two spatial point pattern datasets (locations of bronze age graves in Denmark and locations of mountain tops in Spain).     

Parallel Markov chain Monte Carlo for Bayesian hierarchical models with big data,in two stages

Due to the escalating growth of big data sets in recent years, new Bayesian Markov chain Monte Carlo (MCMC) parallel computing methods have been developed. These methods partition large data sets by observations into subsets. However, for Bayesian nested hierarchical models, typically only a few parameters are common for the full data set, with most parameters being group specific. Thus, parallel Bayesian MCMC methods that take into account the structure of the model and split the full data set by groups rather than by observations are a more natural approach for analysis. Here, we adapt and extend a recently introduced two-stage Bayesian hierarchical modeling approach, and we partition complete data sets by groups. In stage 1, the group-specific parameters are estimated independently in parallel. The stage 1 posteriors are used as proposal distributions in stage 2, where the target distribution is the full model. Using three-level and four-level models, we show in both simulation and real data studies that results of our method agree closely with the full data analysis, with greatly increased MCMC efficiency and greatly reduced computation times. The advantages of our method versus existing parallel MCMC computing methods are also described.     

Bayesian Inference and Prediction in an M/G/1 with Optional Second Service

In this article, we exploit the Bayesian inference and prediction for an M/G/1 queuing model with optional second re-service. In this model, a service unit attends customers arriving following a Poisson process and demanding service according to a general distribution and some of customers need to re-service with probability “p”. First, we introduce a mixture of truncated Normal distributions on interval (? ∞, 0) to approximate the service and re-service time densities. Then, given observations of the system, we propose a Bayesian procedure based on birth-death MCMC methodology to estimate some performance measures. Finally, we apply the theories in practice by providing a numerical example based on real data which have been obtained from a hospital.     

Augmented mixed beta regression models with skew-normal independent distributions: Bayesian analysis of labor force data

Abstract

Augmented mixed beta regression models are suitable choices for modeling continuous response variables on the closed interval [0, 1]. The random eeceeects in these models are typically assumed to be normally distributed, but this assumption is frequently violated in some applied studies. In this paper, an augmented mixed beta regression model with skew-normal independent distribution for random effects are used. Next, we adopt a Bayesian approach for parameter estimation using the MCMC algorithm. The methods are then evaluated using some intensive simulation studies. Finally, the proposed models have applied to analyze a dataset from an Iranian Labor Force Survey.