NONPARAMETRIC ESTIMATION FOR COMPETING RISKS

This paper considers the estimation of the ratio of two scale parameters when the data are censored. It emphasises characteristics of the asymptotic variance under censoring from a practical point of view. The estimator proposed by Padgett & Wei (1982) for the two-sample scale model is extended to the competing risks model. Asymptotic properties of the estimator are studied via its influence function. The use of influence functions permits a unified treatment of both models. Examples show and illustrate that under both models the variance can become infinite under some circumstances.     

A Class of Non-parametric Tests in the Competing Risks Model for Comparing Two Samples

We consider a model when a process involving the production of elements is under inspection. The elements have possible failures due to competing risks. We assume the availability of a data set of failure times, D₁, obtained when the process is under control. Our main goal is to test if the failure rates in D₁ are equal to or less than the failure rates in another data set D₂, against undesirable neighbouring alternatives. A class of tests based on a two-dimensional vector statistic is obtained. Linear test statistics with weight functions giving optimal local asymptotic power are derived. Martingale techniques are used. An example illustrates the derivation of reasonable tests     

NONPARAMETRIC METHOD FOR ESTIMATING THE SIZE OF AN OPEN POPULATION USING MARGINAL DATA FROM REPEATED MULTIPLE LISTS

Kernel smoothing methods are used to extend the Poisson log‐linear approach to the estimation of the size of population using multiple lists to an open population when the multiple lists are recorded at each time point. The data is marginal as only the lists at each time point are available and the transitions of individuals between lists at different time points are not observable. Our analysis is motivated by and applied to data on the number of drug addicts in the Hong Kong Special Administrative Region.     

LIMIT THEOREMS FOR ASYMPTOTICALLY MINIMAX ESTIMATION OF A DISTRIBUTION WITH INCREASING FAILURE RATE UNDER A RANDOM MIXED CENSORSHIP/TRUNCATION MODEL

ABSTRACT

The search for optimal non-parametric estimates of the cumulative distribution and hazard functions under order constraints inspired at least two earlier classic papers in mathematical statistics: those of Kiefer and Wolfowitz[1] Kiefer, J. and Wolfowitz, J. 1976. Asymptotically Minimax Estimation of Concave and Convex Distribution Functions. Z. Wahrsch. Verw. Gebiete, 34: 73–85. [Crossref], [Web of Science ®] , [Google Scholar] and Grenander[2] Grenander, U. 1956. On the Theory of Mortality Measurement. Part II. Scand. Aktuarietidskrift J., 39: 125–153.  [Google Scholar] respectively. In both cases, either the greatest convex minorant or the least concave majorant played a fundamental role. Based on Kiefer and Wolfowitz's work, Wang3-4 Wang, J.L. 1986. Asymptotically Minimax Estimators for Distributions with Increasing Failure Rate. Ann. Statist., 14: 1113–1131. Wang, J.L. 1987. Estimators of a Distribution Function with Increasing Failure Rate Average. J. Statist. Plann. Inference, 16: 415–427.   found asymptotically minimax estimates of the distribution function F and its cumulative hazard function Λ in the class of all increasing failure rate (IFR) and all increasing failure rate average (IFRA) distributions. In this paper, we will prove limit theorems which extend Wang's asymptotic results to the mixed censorship/truncation model as well as provide some other relevant results. The methods are illustrated on the Channing House data, originally analysed by Hyde.5-6 Hyde, J. 1977. Testing Survival Under Right Censoring and Left Truncation. Biometrika, 64: 225–230. Hyde, J. 1980. “Survival Analysis with Incomplete Observations”. In Biostatistics Casebook 31–46. New York: Wiley Series in Probability and Mathematical Statistics: Applied Probability and Statistics.       

A SEMIPARAMETRIC MIXTURE MODEL FOR THE ANALYSIS OF COMPETING RISKS DATA

This paper deals with the regression analysis of failure time data when there are censoring and multiple types of failures. We propose a semiparametric generalization of a parametric mixture model of Larson & Dinse (1985), for which the marginal probabilities of the various failure types are logistic functions of the covariates. Given the type of failure, the conditional distribution of the time to failure follows a proportional hazards model. A marginal like lihood approach to estimating regression parameters is suggested, whereby the baseline hazard functions are eliminated as nuisance parameters. The Monte Carlo method is used to approximate the marginal likelihood; the resulting function is maximized easily using existing software. Some guidelines for choosing the number of Monte Carlo replications are given. Fixing the regression parameters at their estimated values, the full likelihood is maximized via an EM algorithm to estimate the baseline survivor functions. The methods suggested are illustrated using the Stanford heart transplant data.