Maximum likelihood estimation for outcome‐dependent samples

In outcome‐dependent sampling, the continuous or binary outcome variable in a regression model is available in advance to guide selection of a sample on which explanatory variables are then measured. Selection probabilities may either be a smooth function of the outcome variable or be based on a stratification of the outcome. In many cases, only data from the final sample is accessible to the analyst. A maximum likelihood approach for this data configuration is developed here for the first time. The likelihood for fully general outcome‐dependent designs is stated, then the special case of Poisson sampling is examined in more detail. The maximum likelihood estimator differs from the well‐known maximum sample likelihood estimator, and an information bound result shows that the former is asymptotically more efficient. A simulation study suggests that the efficiency difference is generally small. Maximum sample likelihood estimation is therefore recommended in practice when only sample data is available. Some new smooth sample designs show considerable promise.     

Robust Estimation for Zero‐Inflated Poisson Regression

Abstract. The zero‐inflated Poisson regression model is a special case of finite mixture models that is useful for count data containing many zeros. Typically, maximum likelihood (ML) estimation is used for fitting such models. However, it is well known that the ML estimator is highly sensitive to the presence of outliers and can become unstable when mixture components are poorly separated. In this paper, we propose an alternative robust estimation approach, robust expectation‐solution (RES) estimation. We compare the RES approach with an existing robust approach, minimum Hellinger distance (MHD) estimation. Simulation results indicate that both methods improve on ML when outliers are present and/or when the mixture components are poorly separated. However, the RES approach is more efficient in all the scenarios we considered. In addition, the RES method is shown to yield consistent and asymptotically normal estimators and, in contrast to MHD, can be applied quite generally.     

Inference for proportional hazard model with propensity score

Since the publication of the seminal paper by Cox (1972), proportional hazard model has become very popular in regression analysis for right censored data. In observational studies, treatment assignment may depend on observed covariates. If these confounding variables are not accounted for properly, the inference based on the Cox proportional hazard model may perform poorly. As shown in Rosenbaum and Rubin (1983), under the strongly ignorable treatment assignment assumption, conditioning on the propensity score yields valid causal effect estimates. Therefore we incorporate the propensity score into the Cox model for causal inference with survival data. We derive the asymptotic property of the maximum partial likelihood estimator when the model is correctly specified. Simulation results show that our method performs quite well for observational data. The approach is applied to a real dataset on the time of readmission of trauma patients. We also derive the asymptotic property of the maximum partial likelihood estimator with a robust variance estimator, when the model is incorrectly specified.     

Investigation of the performance of trimmed estimators of life time distributions with censoring

For the lifetime (or negative) exponential distribution, the trimmed likelihood estimator has been shown to be explicit in the form of a β‐trimmed mean which is representable as an estimating functional that is both weakly continuous and Fréchet differentiable and hence qualitatively robust at the parametric model. It also has high efficiency at the model. The robustness is in contrast to the maximum likelihood estimator (MLE) involving the usual mean which is not robust to contamination in the upper tail of the distribution. When there is known right censoring, it may be perceived that the MLE which is the most asymptotically efficient estimator may be protected from the effects of ‘outliers’ due to censoring. We demonstrate that this is not the case generally, and in fact, based on the functional form of the estimators, suggest a hybrid defined estimator that incorporates the best features of both the MLE and the β‐trimmed mean. Additionally, we study the pure trimmed likelihood estimator for censored data and show that it can be easily calculated and that the censored observations are not always trimmed. The different trimmed estimators are compared by a modest simulation study.     

Nonparametric likelihood and doubly robust estimating equations for marginal and nested structural models

This article considers Robins's marginal and nested structural models in the cross‐sectional setting and develops likelihood and regression estimators. First, a nonparametric likelihood method is proposed by retaining a finite subset of all inherent and modelling constraints on the joint distributions of potential outcomes and covariates under a correctly specified propensity score model. A profile likelihood is derived by maximizing the nonparametric likelihood over these joint distributions subject to the retained constraints. The maximum likelihood estimator is intrinsically efficient based on the retained constraints and weakly locally efficient. Second, two regression estimators, named hat and tilde, are derived as first‐order approximations to the likelihood estimator under the propensity score model. The tilde regression estimator is intrinsically and weakly locally efficient and doubly robust. The methods are illustrated by data analysis for an observational study on right heart catheterization. The Canadian Journal of Statistics 38: 609–632; 2010 © 2010 Statistical Society of Canada     

A Spline‐Based Semiparametric Maximum Likelihood Estimation Method for the Cox Model with Interval‐Censored Data

Abstract. We propose a spline‐based semiparametric maximum likelihood approach to analysing the Cox model with interval‐censored data. With this approach, the baseline cumulative hazard function is approximated by a monotone B‐spline function. We extend the generalized Rosen algorithm to compute the maximum likelihood estimate. We show that the estimator of the regression parameter is asymptotically normal and semiparametrically efficient, although the estimator of the baseline cumulative hazard function converges at a rate slower than root‐n. We also develop an easy‐to‐implement method for consistently estimating the standard error of the estimated regression parameter, which facilitates the proposed inference procedure for the Cox model with interval‐censored data. The proposed method is evaluated by simulation studies regarding its finite sample performance and is illustrated using data from a breast cosmesis study.     

High-correlated residuals improved estimation in the high-dimensional SUR model

This article focuses on estimating regression coefficients in the high-dimensional seemingly unrelated regression model. When the number of equations exceeds that of the observations, both the maximum likelihood estimator and Zellner’s two-stage estimator do not exist. As an alternative, we propose a two-stage conditional expectation improved estimator. The new estimator is further improved by the high-correlated residuals, and the high correlation is determined by hypothesis testings. Simulations show that the new estimator outperforms the ordinary least-squares estimator in terms of mean square errors, especially when high-correlated residuals exist between the equations.     

Estimation of two order restricted normal means with unknown and possibly unequal variances

Estimation of each of and linear functions of two order restricted normal means is considered when variances are unknown and possibly unequal. We replace unknown variances with sample variances and construct isotonic regression estimators, which we call in our paper the plug-in estimators, to estimate ordered normal means. Under squared error loss, a necessary and sufficient condition is given for the plug-in estimators to improve upon the unrestricted maximum likelihood estimators uniformly. As for the estimation of linear functions of ordered normal means, we also show that when variances are known, the restricted maximum likelihood estimator always improves upon the unrestricted maximum likelihood estimator uniformly, but when variances are unknown, the plug-in estimator does not always improve upon the unrestricted maximum likelihood estimator uniformly.     

Logistic discrimination using robust estimators: An influence function approach

Logistic regression is frequently used for classifying observations into two groups. Unfortunately there are often outlying observations in a data set and these might affect the estimated model and the associated classification error rate. In this paper, the authors study the effect of observations in the training sample on the error rate by deriving influence functions. They obtain a general expression for the influence function of the error rate, and they compute it for the maximum likelihood estimator as well as for several robust logistic discrimination procedures. Besides being of interest in their own right, the influence functions are also used to derive asymptotic classification efficiencies of different logistic discrimination rules. The authors also show how influential points can be detected by means of a diagnostic plot based on the values of the influence function     

Empirical likelihood inference for a common mean in the presence of heteroscedasticity

The authors develop empirical likelihood (EL) based methods of inference for a common mean using data from several independent but nonhomogeneous populations. For point estimation, they propose a maximum empirical likelihood (MEL) estimator and show that it is n‐consistent and asymptotically optimal. For confidence intervals, they consider two EL based methods and show that both intervals have approximately correct coverage probabilities under large samples. Finite‐sample performances of the MEL estimator and the EL based confidence intervals are evaluated through a simulation study. The results indicate that overall the MEL estimator and the weighted EL confidence interval are superior alternatives to the existing methods.     

Focused information criterion and model averaging based on weighted composite quantile regression

We study the focused information criterion and frequentist model averaging and their application to post‐model‐selection inference for weighted composite quantile regression (WCQR) in the context of the additive partial linear models. With the non‐parametric functions approximated by polynomial splines, we show that, under certain conditions, the asymptotic distribution of the frequentist model averaging WCQR‐estimator of a focused parameter is a non‐linear mixture of normal distributions. This asymptotic distribution is used to construct confidence intervals that achieve the nominal coverage probability. With properly chosen weights, the focused information criterion based WCQR estimators are not only robust to outliers and non‐normal residuals but also can achieve efficiency close to the maximum likelihood estimator, without assuming the true error distribution. Simulation studies and a real data analysis are used to illustrate the effectiveness of the proposed procedure.     

Tobit regression for modeling mean survival time using data subject to multiple sources of censoring

Mean survival time is often of inherent interest in medical and epidemiologic studies. In the presence of censoring and when covariate effects are of interest, Cox regression is the strong default, but mostly due to convenience and familiarity. When survival times are uncensored, covariate effects can be estimated as differences in mean survival through linear regression. Tobit regression can validly be performed through maximum likelihood when the censoring times are fixed (ie, known for each subject, even in cases where the outcome is observed). However, Tobit regression is generally inapplicable when the response is subject to random right censoring. We propose Tobit regression methods based on weighted maximum likelihood which are applicable to survival times subject to both fixed and random censoring times. Under the proposed approach, known right censoring is handled naturally through the Tobit model, with inverse probability of censoring weighting used to overcome random censoring. Essentially, the re‐weighting data are intended to represent those that would have been observed in the absence of random censoring. We develop methods for estimating the Tobit regression parameter, then the population mean survival time. A closed form large‐sample variance estimator is proposed for the regression parameter estimator, with a semiparametric bootstrap standard error estimator derived for the population mean. The proposed methods are easily implementable using standard software. Finite‐sample properties are assessed through simulation. The methods are applied to a large cohort of patients wait‐listed for kidney transplantation.     

Modeling nonlinear time series with local mixtures of generalized linear models

The authors consider a novel class of nonlinear time series models based on local mixtures of regressions of exponential family models, where the covariates include functions of lags of the dependent variable. They give conditions to guarantee consistency of the maximum likelihood estimator for correctly specified models, with stationary and nonstationary predictors. They show that consistency of the maximum likelihood estimator still holds under model misspecification. They also provide probabilistic results for the proposed model when the vector of predictors contains only lags of transformations of the modeled time series. They illustrate the consistency of the maximum likelihood estimator and the probabilistic properties via Monte Carlo simulations. Finally, they present an application using real data.     

Box‐Cox transformations in linear models: Large sample theory and tests of normality

The authors provide a rigorous large sample theory for linear models whose response variable has been subjected to the Box‐Cox transformation. They provide a continuous asymptotic approximation to the distribution of estimators of natural parameters of the model. They show, in particular, that the maximum likelihood estimator of the ratio of slope to residual standard deviation is consistent and relatively stable. The authors further show the importance for inference of normality of the errors and give tests for normality based on the estimated residuals. For non‐normal errors, they give adjustments to the log‐likelihood and to asymptotic standard errors.     

An Equivalence of Conditional and Unconditional Maximum Likelihood Estimators via Infinite Replication of Observations

Motivated by an application with complex survey data, we show that for logistic regression with a simple matched-pairs design, infinitely replicating observations and maximizing the conditional likelihood results in an estimator exactly identical to the unconditional maximum likelihood estimator based on the original sample, which is inconsistent. Therefore, applying conditional likelihood methods to a pseudosample with observations replicated a large number of times can lead to an inconsistent estimator; this casts doubt on one possible approach to conditional logistic regression with complex survey data. We speculate that for more general designs, an asymptotic equivalence holds.     

Estimation for Location-Scale Models with Censored Data

This article considers a class of estimators for the location and scale parameters in the location-scale model based on ‘synthetic data’ when the observations are randomly censored on the right. The asymptotic normality of the estimators is established using counting process and martingale techniques when the censoring distribution is known and unknown, respectively. In the case when the censoring distribution is known, we show that the asymptotic variances of this class of estimators depend on the data transformation and have a lower bound which is not achievable by this class of estimators. However, in the case that the censoring distribution is unknown and estimated by the Kaplan–Meier estimator, this class of estimators has the same asymptotic variance and attains the lower bound for variance for the case of known censoring distribution. This is different from censored regression analysis, where asymptotic variances depend on the data transformation. Our method has three valuable advantages over the method of maximum likelihood estimation. First, our estimators are available in a closed form and do not require an iterative algorithm. Second, simulation studies show that our estimators being moment-based are comparable to maximum likelihood estimators and outperform them when sample size is small and censoring rate is high. Third, our estimators are more robust to model misspecification than maximum likelihood estimators. Therefore, our method can serve as a competitive alternative to the method of maximum likelihood in estimation for location-scale models with censored data. A numerical example is presented to illustrate the proposed method.     

GMM Estimation of Count-Panel-Data Models With Fixed Effects and Predetermined Instruments

The “traditional” approach to the estimation of count-panel-data models with fixed effects is the conditional maximum likelihood estimator. The pseudo maximum likelihood principle can be used in these models to obtain orthogonality conditions that generate a robust estimator. This estimator is inconsistent, however, when the instruments are not strictly exogenous. This article proposes a generalized method of moments estimator for count-panel-data models with fixed effects, based on a transformation of the conditional mean specification, that is consistent even when the explanatory variables are predetermined. Two applications are discussed, the relationship between patents and research and development expenditures and the explanation of technology transfer.     

Statistical Engineering

This article compares the accuracy of the median unbiased estimator with that of the maximum likelihood estimator for a logistic regression model with two binary covariates. The former estimator is shown to be uniformly more accurate than the latter for small to moderately large sample sizes and a broad range of parameter values. In view of the recently developed efficient algorithms for generating exact distributions of sufficient statistics in binary-data problems, these results call for a serious consideration of median unbiased estimation as an alternative to maximum likelihood estimation, especially when the sample size is not large, or when the data structure is sparse.     

Variable selection via penalized minimum φ-divergence estimation in logistic regression

We propose penalized minimum φ-divergence estimator for parameter estimation and variable selection in logistic regression. Using an appropriate penalty function, we show that penalized φ-divergence estimator has oracle property. With probability tending to 1, penalized φ-divergence estimator identifies the true model and estimates nonzero coefficients as efficiently as if the sparsity of the true model was known in advance. The advantage of penalized φ-divergence estimator is that it produces estimates of nonzero parameters efficiently than penalized maximum likelihood estimator when sample size is small and is equivalent to it for large one. Numerical simulations confirm our findings.     

Second-order least squares estimation of censored regression models

This paper proposes the second-order least squares estimation, which is an extension of the ordinary least squares method, for censored regression models where the error term has a general parametric distribution (not necessarily normal). The strong consistency and asymptotic normality of the estimator are derived under fairly general regularity conditions. We also propose a computationally simpler estimator which is consistent and asymptotically normal under the same regularity conditions. Finite sample behavior of the proposed estimators under both correctly and misspecified models are investigated through Monte Carlo simulations. The simulation results show that the proposed estimator using optimal weighting matrix performs very similar to the maximum likelihood estimator, and the estimator with the identity weight is more robust against the misspecification.