A unified approach to estimation of nonlinear mixed effects and Berkson measurement error models

Mixed effects models and Berkson measurement error models are widely used. They share features which the author uses to develop a unified estimation framework. He deals with models in which the random effects (or measurement errors) have a general parametric distribution, whereas the random regression coefficients (or unobserved predictor variables) and error terms have nonparametric distributions. He proposes a second-order least squares estimator and a simulation-based estimator based on the first two moments of the conditional response variable given the observed covariates. He shows that both estimators are consistent and asymptotically normally distributed under fairly general conditions. The author also reports Monte Carlo simulation studies showing that the proposed estimators perform satisfactorily for relatively small sample sizes. Compared to the likelihood approach, the proposed methods are computationally feasible and do not rely on the normality assumption for random effects or other variables in the model.     

Nonparametric Kernel Methods with Errors‐in‐Variables: Constructing Estimators,Computing them,and Avoiding Common Mistakes

Estimating a curve nonparametrically from data measured with error is a difficult problem that has been studied by many authors. Constructing a consistent estimator in this context can sometimes be quite challenging, and in this paper we review some of the tools that have been developed in the literature for kernel‐based approaches, founded on the Fourier transform and a more general unbiased score technique. We use those tools to rederive some of the existing nonparametric density and regression estimators for data contaminated by classical or Berkson errors, and discuss how to compute these estimators in practice. We also review some mistakes made by those working in the area, and highlight a number of problems with an existing R package decon .     

Dependent Right Censorship in the MOMW Distribution

In this paper, we consider paired survival data, in which pair members are subject to the same right censoring time, but they are dependent on each other. Assuming the Marshall–Olkin Multivariate Weibull distribution for the joint distribution of the lifetimes (X₁, X₂) and the censoring time X₃, we derive the joint density of the actual observed data and obtain maximum likelihood estimators, Bayes estimators and posterior regret Gamma minimax estimators of the unknown parameters under squared error loss and weighted squared error loss functions. We compare the performances of the maximum likelihood estimators and Bayes estimators numerically in terms of biases and estimated Mean Squared Error Loss.     

Application of shrinkage estimation in linear regression models with autoregressive errors

In this paper, we consider the shrinkage and penalty estimation procedures in the linear regression model with autoregressive errors of order p when it is conjectured that some of the regression parameters are inactive. We develop the statistical properties of the shrinkage estimation method including asymptotic distributional biases and risks. We show that the shrinkage estimators have a significantly higher relative efficiency than the classical estimator. Furthermore, we consider the two penalty estimators: least absolute shrinkage and selection operator (LASSO) and adaptive LASSO estimators, and numerically compare their relative performance with that of the shrinkage estimators. A Monte Carlo simulation experiment is conducted for different combinations of inactive predictors and the performance of each estimator is evaluated in terms of the simulated mean-squared error. This study shows that the shrinkage estimators are comparable to the penalty estimators when the number of inactive predictors in the model is relatively large. The shrinkage and penalty methods are applied to a real data set to illustrate the usefulness of the procedures in practice.     

Robust Linear Calibration

We regard the simple linear calibration problem where only the response y of the regression line y = β₀ + β₁ t is observed with errors. The experimental conditions t are observed without error. For the errors of the observations y we assume that there may be some gross errors providing outlying observations. This situation can be modeled by a conditionally contaminated regression model. In this model the classical calibration estimator based on the least squares estimator has an unbounded asymptotic bias. Therefore we introduce calibration estimators based on robust one-step-M-estimators which have a bounded asymptotic bias. For this class of estimators we discuss two problems: The optimal estimators and their corresponding optimal designs. We derive the locally optimal solutions and show that the maximin efficient designs for non-robust estimation and robust estimation coincide.     

Analysis of short-term systematic measurement error variance for the difference of paired data without repetition of measurement

The variance of short-term systematic measurement errors for the difference of paired data is estimated. The difference of paired data is determined by subtracting the measurement results of two methods, which measure the same item only once without measurement repetition. The unbiased estimators for short-term systematic measurement error variances based on the one-way random effects model are not fit for practical purpose because they can be negative. The estimators, which are derived for balanced data as well as for unbalanced data, are always positive but biased. The basis of these positive estimators is the one-way random effects model. The biases, variances, and the mean squared errors of the positive estimators are derived as well as their estimators. The positive estimators are fit for practical purpose.     

Approximate estimations in capture–recapture model with heteroscedastic measurement errors

In a capture–recapture experiment, the number of measurements for individual covariates usually equals the number of captures. This creates a heteroscedastic measurement error problem and the usual surrogate condition does not hold in the context of a measurement error model. This study adopts a small measurement error assumption to approximate the conventional estimating functions and the population size estimator. This study also investigates the biases of the resulting estimators. In addition, modifications for two common approximation methods, regression calibration and simulation extrapolation, to accommodate heteroscedastic measurement error are also discussed. These estimation methods are examined through simulations and illustrated by analysing a capture–recapture data set.     

Locally efficient semiparametric estimators for a class of Poisson models with measurement error

The presence of measurement error may cause bias in parameter estimation and can lead to incorrect conclusions in data analyses. Despite a large body of literature on general measurement error problems, relatively few works exist to handle Poisson models. In this article we thoroughly study Poisson models with errors in covariates and propose consistent and locally efficient semiparametric estimators. We assess the finite sample performance of the estimators through extensive simulation studies and illustrate the proposed methodologies by analyzing data from the Stroke Recovery in Underserved Populations Study. The Canadian Journal of Statistics 47: 157–181; 2019 © 2019 Statistical Society of Canada     

A Class of Estimators Using Auxiliary Information for Estimating Finite Population Variance in Presence of Measurement Errors

This article addresses the problem of estimating the population variance using auxiliary information in the presence of measurement errors. When the measurement error variance associated with study variable is known, a class of estimators of the population variance using auxiliary information has been proposed. We obtain the bias and mean squared errors of the suggested class of estimators upto the terms of order n ^?1, and also optimum estimators in asymptotic sense of the class with approximate mean squared error formula.     

Adaptive Deconvolution on the Non‐negative Real Line

In this paper, we consider the problem of adaptive density or survival function estimation in an additive model defined by Z=X+Y with X independent of Y, when both random variables are non‐negative. This model is relevant, for instance, in reliability fields where we are interested in the failure time of a certain material that cannot be isolated from the system it belongs. Our goal is to recover the distribution of X (density or survival function) through n observations of Z, assuming that the distribution of Y is known. This issue can be seen as the classical statistical problem of deconvolution that has been tackled in many cases using Fourier‐type approaches. Nonetheless, in the present case, the random variables have the particularity to be supported. Knowing that, we propose a new angle of attack by building a projection estimator with an appropriate Laguerre basis. We present upper bounds on the mean squared integrated risk of our density and survival function estimators. We then describe a non‐parametric data‐driven strategy for selecting a relevant projection space. The procedures are illustrated with simulated data and compared with the performances of a more classical deconvolution setting using a Fourier approach. Our procedure achieves faster convergence rates than Fourier methods for estimating these functions.     

Asymptotic behaviour of the mean integrated squared error of kernel density estimators for dependent observations

Let X₁, X₂, … be a strictly stationary sequence of observations, and g be the joint density of (X₁, …, X_d) for some fixed d ? 1. We consider kernel estimators of the density g. The asymptotic behaviour of the mean integrated squared error of the kernel estimators is obtained under an assumption of weak dependence between the observations.     

On mitigating collinearity through mixtures

In linear models having near collinear columns of X, ridge and surrogate estimators often are used to mitigate collinearity. A new class of estimators is based on mixtures, either of X and a design minimal in an ordered class or of the Fisher information and a scalar matrix. Comparisons are drawn among choices for the mixing parameter, and the estimators are found to be admissible relative to ordinary least squares. Case studies demonstrate that selected mixture designs are perturbed from the original design to a lesser extent than are those of the surrogate method, while retaining reasonable efficiency characteristics.     

Wavelet estimators for the derivatives of the density function from data contaminated with heteroscedastic measurement errors

Measurement errors occur in many real data applications. In this paper, the linear and the non linear wavelet estimators of the derivatives of the density function are constructed in the case of data contaminated with heteroscedastic measurement errors. We establish L_p risk performance of the estimators and show that they achieve fast convergence rates under quite general conditions.     

A comparison of linear regression techniques in method comparison studies

In this study, the performances of linear regression techniques, which are especially used in clinical chemistry in method comparison studies, are compared via the Monte-Carlo simulation. The regression techniques that take the measurement errors of both dependent and independent variables into account are called Type II regression techniques. In this study, we also compare the performances of Type II and Type I (classical regression techniques that do not take the measurement errors of the independent variable into account) regression techniques for different sample sizes and different shape parameters of the Weibull distribution. The mean square error is used as a performance criterion of each technique. MATLAB 7.02 software is used in the simulation study. As a result, in all conditions, the ordinary least-square (OLS)-bisector regression technique, which bisects the OLS(Y | X) and the OLS(X | Y), shows the best performance.     

Estimation of the Population Size in the Classical Occupancy Problem

In the classical occupancy problem where the random variable X is the number of N elements selected by K individuals when each element is equally likely to be chosen by any of the individuals, it is desired to estimate N. Three estimators given in the literature are compared with three estimators derived in this article, two of which are based on Bayesian methods, utilizing a simulation study. One of the Bayes estimators appears to perform the best along with one proposed in the literature in 1968. The estimators are also compared using data obtained from a cemetery in Ohio.     

JAMES-STEIN RULE ESTIMATORS IN LINEAR REGRESSION MODELS WITH MULTIVARIATE-t DISTRIBUTED ERROR

This paper considers estimation of β in the regression model y =Xβ+μ, where the error components in μ have the jointly multivariate Student-t distribution. A family of James-Stein type estimators (characterised by nonstochastic scalars) is presented. Sufficient conditions involving only X are given, under which these estimators are better (with respect to the risk under a general quadratic loss function) than the usual minimum variance unbiased estimator (MVUE) of β. Approximate expressions for the bias, the risk, the mean square error matrix and the variance-covariance matrix for the estimators in this family are obtained. A necessary and sufficient condition for the dominance of this family over MVUE is also given.     

Immaculating the inconsistent estimator of slope parameter in measurement error model with replicated data

ABSTRACT

The measurement error model with replicated data on study as well as explanatory variables is considered. The measurement error variance associated with the explanatory variable is estimated using the complete data and the grouped data which is used for the construction of the consistent estimators of regression coefficient. These estimators are further used in constructing an almost unbiased estimator of regression coefficient. The large sample properties of these estimators are derived without assuming any distributional form of the measurement errors and the random error component under the setup of an ultrastructural model.     

Generalized minimum distance estimators of a linear model with correlated errors

R^p of a linear regression model of the type Y = Xθ + ɛ, where X is the design matrix, Y the vector of the response variable and ɛ the random error vector that follows an AR(1) correlation structure. These estimators are asymptotically analyzed, by proving their strong consistency, asymptotic normality and asymptotic efficiency. In a simulation study, a better behaviour of the Mean Squared Error of the proposed estimator with respect to that of the generalized least squares estimators is observed. Received: November 16, 1998; revised version: May 10, 2000     

Effect of Berkson measurement error on parameter estimates in Cox regression models

We study the effect of additive and multiplicative Berkson measurement error in Cox proportional hazard model. By plotting the true and the observed survivor function and the true and the observed hazard function dependent on the exposure one can get ideas about the effect of this type of error on the estimation of the slope parameter corresponding to the variable measured with error. As an example, we analyze the measurement error in the situation of the German Uranium Miners Cohort Study both with graphical methods and with a simulation study. We do not see a substantial bias in the presence of small measurement error and in the rare disease case. Even the effect of a Berkson measurement error with high variance, which is not unrealistic in our example, is a negligible attenuation of the observed effect. However, this effect is more pronounced for multiplicative measurement error.     

Consistent estimation of regression coefficients in ultrastructural measurement error model using stochastic prior information

The problem of consistent estimation of regression coefficients in a multivariate linear ultrastructural measurement error model is considered in this article when some additional information on regression coefficients is available a priori. Such additional information is expressible in the form of stochastic linear restrictions. Utilizing stochastic restrictions given a priori, some methodologies are presented to obtain the consistent estimators of regression coefficients under two types of additional information separately, viz., covariance matrix of measurement errors and reliability matrix associated with explanatory variables. The measurement errors are assumed to be not necessarily normally distributed. The asymptotic properties of the proposed estimators are derived and analyzed analytically as well as numerically through a Monte Carlo simulation experiment.