Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease?

The recent identification of genes (parkin, DJ-1, and PINK1) involved in recessive autosomal parkinsonism, and the indications that these proteins may have protective effects on the mitochondria, has led to the reemergence of the notion that mitochondrial dysfunction might play a central role in the etiology of sporadic Parkinson's disease (PD). This idea has previously been supported by biochemical analyses showing reduced mitochondrial activity in PD patients and in animal models of PD generated by the selective inhibition of mitochondria activity. However, the involvement of DJ-1 or PINK1 loss of function in classical idiopathic PD, characterized by pathological inclusions composed of aggregated alpha-synuclein protein, has still not been evaluated. More detailed studies of the possible interactions between parkin, DJ-1, PINK1, and alpha-synuclein and their effects on mitochondria are needed to more adequately define the biological pathways that may convergently or independently lead to parkinsonism.     

Murine models of life span extension

Mice are excellent experimental models for genetic research and are being used to investigate the genetic component of organismal aging. Several mutant mice are known to possess defects in the growth hormone/insulin-like growth factor 1 (GH/IGF-1) neurohormonal pathway and exhibit dwarfism together with extended life span. Their phenotypes resemble those of mice subjected to caloric restriction. Targeted mutations that affect components of this pathway, including the GH receptor, p66Shc, and the IGF-1 receptor (IGF-1R), also extend life span; mutations that affect IGF-1R or downstream components of the pathway decouple longevity effects from dwarfism. These effects on life span may result from an increased capacity to resist oxidative damage.     

Meeting report--44th Annual Drosophila Research Conference

The ability to compare the genetics of aging in multiple model organisms is a powerful tool to dissect the biology of aging. Although the fruit fly has only about half again as many genes as the nematode worm, its tissue organization is much more complex. The emerging importance of tissue specificity and endocrine signaling in aging makes the fly a natural choice for many researchers interested in unraveling the next level of complexity of the aging process. This Perspective provides an overview of research related to aging that was described at the annual Drosophila conference held in Chicago in March 2003.     

Functional foods for cardiovascular disease in women

Cardiovascular disease (CVD) is the leading cause of death in women. Functional food consumption can play an important role in the prevention and treatment of CVD. The purpose of this review is to establish recommendations for the intake of functional food ingredients in a healthy diet, such as soy proteins and isoflavone, omega-3 fatty acids (FAs) from fish oils (FOs) including eicosapentaenoic acid (EPA) and docoshexaenoic acid (DHA) and plant sterols-(PS) enriched foods - for prevention and treatment of CVD in postmenopausal women. First, controversial results exist on CVD risk factors after intake of soy protein and isoflavone that indicates that further clinical studies need to be done to better understand their role in maintaining and improving cholesterol levels. However, since soy contains polyunsaturated fats, replacing some higher fat meat protein sources with soy products may contribute to cardiovascular health. Secondly, FOs, including EPA and DHA, have shown promising effects for lowering triglyceride levels. In addition, emerging research appears to show that omega-3 FAs may have additional health effects with improved arterial health and a reduction in oxidative stress in postmenopausal women. Thirdly, foods and beverages supplemented with PS may reduce cholesterol; therefore, are a worthy addition to interventions aimed at lowering heart disease risk in women. Overall, incorporating functional foods into a healthy diet may be beneficial in helping to reduce lipids levels and thus the risk of CVD.     

Of worms, flies, dwarfs, and things that go bump in the night

Studies over the past several years have found that antagonism of the insulin/insulin-like growth factor 1 (IGF-1) signaling pathway increases life-span in Caenorhabditis elegans and Drosophila. However, a persistent problem in these studies is the fact that the genetic mutation has effects on the development of the organism as well as on reproductive function. These effects act as potential confounding variables that complicate the interpretation of results. Kenyon and colleagues circumvent these issues by suppressing the insulin/IGF-1-like daf-2 signaling pathway at specific stages in the life-span of C. elegans. The results of their investigation challenge our understanding of the evolution of aging and provide opportunities for future studies in mammalian models.     

Lithium treatment present and future

1. Lithium remains unmatched for long-term effectiveness against the morbidity and mortality associated with bipolar I and II disorders. 2. Lithium is the first choice for bipolar depression. 3. Recent studies suggest that long-term lithium treatment may have mortality-lowering and anti-suicidal effects. 4. Chronic lithium, or valproate, administration has been shown to have a neuroprotective effect on rat and human cultured neurons.     

Unearthing Loci that influence life span

It is known that certain hormones are involved in determining longevity (for example, insulin and insulin-like growth factor). Results presented in a paper published in this week's issue of Science allow us to add steroid hormones to this list. Anne Simon and colleagues show for the first time that a sterol hormone--ecdysone of the fly Drosophila melanogaster--regulates life span. In this Perspective, I discuss the implications of this result in the context of gene regulation and mechanisms of aging.     

Our common future: a rapidly growing and rapidly aging humankind

Abstract

Physical inactivity, diabetes, hypertension, dyslipidemia, smoking and obesity were associated with imbalance in oxidative stress, leading to endothelial dysfunction. Such dysfunction is present in both cardiovascular disease (CVD) and erectile dysfunction (ED). ED is the persistent inability to achieve or sustain an erection sufficient for satisfactory sexual performance and is one of the first manifestations of endothelial damage in men with CVD risk factors. The purpose of this article is to review the results of studies involving physical activity, CVD, endothelial dysfunction and ED in order to verify its applicability for improving the health and quality of life of men with such disorders. There is consistent evidence that endothelial damage is intimately linked to ED, and this manifestation seems to be associated with the appearance CVDs. On the other hand, physical activity has been pointed out as an important clinical strategy in the prevention and treatment of CVDs and ED mainly associated with improvement of endothelial function. However, further experimental and clinical prospective investigations are needed to test the role of physical exercises in the modulation of endothelial function and their implications on erectile function and the appearance of CVDs.     

Inside insulin signaling, communication is key to long life

In a recent Nature paper, Tatar and colleagues show that inhibition of insulin/insulin-like growth factor (IGF) signaling specifically in the adipose tissue of Drosophila melanogaster retards organismal aging, increases resistance to oxidative stress, augments lipid deposition, and restricts insulin signaling in peripheral tissues by a cell-non-autonomous mechanism. Consistent with recent work in the worm, these results suggest that insulin/IGF signaling itself may mediate communication among various tissues to influence organismal longevity.     

Mitigating the tithonus error: genetic analysis of mortality phenotypes

Summarizing an organism's age at death in terms of the mean or maximum life-span is the most popular way to describe genetic effects on aging. In this Perspective, the author describes a new study with the fly Drosophila melanogaster, in which another type of measure is also used: the age-dependent risk of death, or age-specific mortality. Changes in age-specific mortality reflect the underlying physiological deterioration of an organism as it ages. Thus, the author argues that these changes provide a phenotype that is ideal for the genetic analysis of aging.     

Oxidative mutagenesis, mismatch repair, and aging

A PubMed search for the term "oxidative stress" yields over 29,000 articles published on the subject over the past 10 years; more than 2000 of these articles also include the term "aging" in their title or abstract. Many theories of aging predict causal roles for oxidative stress in the myriad of pathological changes that occur as a function of age, including an increasing propensity to develop cancer. A possible link between aging and cancer is the induction and accumulation of somatic mutations caused by oxidative stress. This Review focuses on small mutational events that are induced by oxidative stress and the role of mismatch repair (MMR) in preventing their formation. It also discusses a possible inhibitory effect of oxidative stress on MMR. We speculate that a synergistic interaction between oxidative damage to DNA and reduced MMR levels will, in part, account for an accumulation of small mutational events, and hence cancer, with aging.     

The dual role of R&D expenditures in European Union’s member states: short- and long-term prospects

The objective of this article is to assess a potential dual role of public expenditures in R&D upon economic growth and employment, using these dimensions as partial representations of the socioeconomic state of affairs in European Union’s Member States. First, we look into direct, short-term impacts arising from R&D expenditures, much in the sense of a multiplier effect. Second, we analyse impacts from the stage of development of National Innovation Systems (NIS) upon the macroeconomic conditions of interest, assuming that current stages of development are products of previous commitment to innovation, that is, a structural, long-term outcome of innovation-oriented investments. In order to empirically test our propositions, we have analysed 28 EU Member States (1990–2013) through three sets of econometric (static and dynamic panel data) models. Results highlight that EU countries’ governmental commitment to their respective innovation systems catalyses current and prospective economic growth and employment levels, suggesting a complementarity between Neo-Schumpeterian and Neo-Keynesian perceptions over governmental R&D involvement. This can bring innovation efforts closer to the macroeconomic debate on monetary and fiscal policies and function as a criticism to austerity measures, as this may not only affect the present socioeconomic situation, but also generate the cornerstone for a perennial state of divergence among EU Member States.     

THE FATALISTIC IMAGINATION AND THE CONTINUED SALIENCE OF RELIGION IN THE MODERN WORLD: A TEST OF RESOURCE COMPENSATION/RESOURCE AMPLIFICATION HYPOTHESES USING CROSSNATIONAL DATA

The resource compensation hypothesis predicts that religiosity will serve as a cognitive buffer against structural constraints whereby more religious individuals will exhibit lower levels of fatalism than their less religious counterparts. The resource amplification perspective, on the other hand, predicts that religiosity will foster a sense that otherworldly forces control life's outcomes, leading to higher levels of fatalism. Using a precise measure of fatalism from the two most recent waves of the World Values Survey, a comparative examination of three Latin American countries, South Africa, and the United States is carried out. With Mexico as the sole exception, findings from ordered logistic regression models suggest that higher levels of religiosity are associated with lower levels of fatalism, supporting the resource compensation hypothesis. Implications for longstanding debates over the salience of modern religion are considered. An important and underappreciated cognitive function provided by thriving religious denominations and institutions may be to provide a catalyst for personal empowerment that comes through the rejection of a fatalistic mentality.     

Variation in Associations Between Family Dinners and Adolescent Well‐Being

Empirical evidence and conventional wisdom suggest that family dinners are associated with positive outcomes for youth. Recent research using fixed‐effects models as a more stringent test of causality suggests a more limited role of family meals in protecting children from risk. Estimates of average effects, however, may mask important variation in the link between family meals and well‐being; in particular, family meals may be more or less helpful based on the quality of family relationships. Using 2 waves of the National Longitudinal Study of Adolescent Health (N = 17,977), this study extended recent work to find that family dinners have little benefit when parent–child relationships are weak but contribute to fewer depressive symptoms and less delinquency among adolescents when family relationships are strong. The findings highlight the importance of attending to variation when assessing what helps and what hurts in families.     

The role of a mission leader within a large Catholic health system

This reflective narrative is intended as a "Letter to the Editor" of sorts, to highlight my personal and professional growth in the role of mission leader for a large academic health centre in South Western Ontario, Canada. This story takes the reader through my lived experience, my beliefs and views of the role of mission leader, against a backdrop of the work of Mary Kathryn Grant, a pioneer in this area of mission and leadership.     

Care fit for children

SUMMARY. Following on from articles in Children and Society (3.1), this article discusses issues raised by recent research on foster and residential care practices, and centres on the question of whether children's homes should seek to provide child oriented day-to-day care. The role performed by children's homes in substitute child care is considered in order to highlight the dangers inherent in the notion that it may be appropriate to trade off child oriented care for the rather abstract notion of the ‘wider function’ of children's homes     

Paradigm shift: implementing MEGA, a new tool proposed to define and assess sexually abusive dynamics in youth ages 19 and under

Previous definitions of sexually abusive behavior in children and adolescents were deficient in failing to (1) highlight salient neuropsychological elements and antisocial behaviors that may contribute to a youth's functioning; (2) discriminate among possible types of coercion (e.g., manipulation, threats, physical force, and use of weapons); and (3) include predatory elements of sexual abuse against strangers or casual acquaintances. This article discusses a new comprehensive assessment tool that assists in defining sexually abusive youth. This tool, the Multiplex Empirically Guided Inventory of Ecological Aggregates for Assessing Sexually Abusive Children and Adolescents (Ages 19 and under) (MEGA; Miccio-Fonseca, 2006b), encompasses neuropsychological elements, coercive aspects, and predatory elements as essential factors to consider in comprehensive assessments of sexually abusive youth.     

THE "PSYCHOSOMATIC FAMILY" RECONSIDERED: DIABETES IN CONTEXT

Minuchin, Rosman and Baker's (1978) Psychosomatic Families is widely cited as a demonstration that the physiological disturbance of some diabetic patients serves a function in their families. We found that the original data did not provide such a demonstration. We examined the psychosomatic family model in light of recent developments in the study and treatment of diabetes. We concluded that the model decontextualizes the family and assigns to it characteristics that are more appropriately seen as reflections of the disease process, the family coping tasks this entails, and the nature of the family's relationship with the health care system. The need for new open-systems models of the family's role in diabetes is discussed .     

Empathic people have more friends: Empathic abilities predict social network size and position in social network predicts empathic efforts

Living in large groups and maintaining extensive social relationships, as humans do, requires special social capabilities. Past research has shown that social cognitive abilities predict people’s social network size. To extend these findings we explored the role of a social emotional ability, and investigated how empathic abilities shape people’s social network. In line with the social brain hypothesis the findings show that dispositional empathic abilities (IRI), and empathic concern specifically, predict how many close relationships people maintain. The study also found that emphatic abilities are strategically used in people’s social network, with more empathy exercised in the support group with closer relationships. The findings further demonstrate the social function of empathy and highlight the importance of understanding empathy in terms of its strategic exercise among various social relationships.     

Accommodating Emotion and Affect in Political Discussions in Classrooms

Abstract

This article calls for greater attention to the role of emotion and affect in classroom discussions where theoretical models of discussion and deliberation tend to emphasize the rationalistic elements called for in such pedagogical strategies. Using two examples drawn from secondary classrooms, the authors highlight the role of emotion and affect in student exchanges about controversial public issues. Given the contemporary climate of national political discourse, being prepared for and accommodating these elements will be essential to taking up these strategies as a form of inquiry-oriented teaching and learning that seeks to address public issues with students across the curriculum.