Adaptive lifting for nonparametric regression

Many wavelet shrinkage methods assume that the data are observed on an equally spaced grid of length of the form 2^J for some J. These methods require serious modification or preprocessed data to cope with irregularly spaced data. The lifting scheme is a recent mathematical innovation that obtains a multiscale analysis for irregularly spaced data. A key lifting component is the “predict” step where a prediction of a data point is made. The residual from the prediction is stored and can be thought of as a wavelet coefficient. This article exploits the flexibility of lifting by adaptively choosing the kind of prediction according to a criterion. In this way the smoothness of the underlying ‘wavelet’ can be adapted to the local properties of the function. Multiple observations at a point can readily be handled by lifting through a suitable choice of prediction. We adapt existing shrinkage rules to work with our adaptive lifting methods. We use simulation to demonstrate the improved sparsity of our techniques and improved regression performance when compared to both wavelet and non-wavelet methods suitable for irregular data. We also exhibit the benefits of our adaptive lifting on the real inductance plethysmography and motorcycle data.     

A ‘nondecimated’ lifting transform

Classical nondecimated wavelet transforms are attractive for many applications. When the data comes from complex or irregular designs, the use of second generation wavelets in nonparametric regression has proved superior to that of classical wavelets. However, the construction of a nondecimated second generation wavelet transform is not obvious. In this paper we propose a new ‘nondecimated’ lifting transform, based on the lifting algorithm which removes one coefficient at a time, and explore its behavior. Our approach also allows for embedding adaptivity in the transform, i.e. wavelet functions can be constructed such that their smoothness adjusts to the local properties of the signal. We address the problem of nonparametric regression and propose an (averaged) estimator obtained by using our nondecimated lifting technique teamed with empirical Bayes shrinkage. Simulations show that our proposed method has higher performance than competing techniques able to work on irregular data. Our construction also opens avenues for generating a ‘best’ representation, which we shall explore.     

Real nonparametric regression using complex wavelets

Summary.  Wavelet shrinkage is an effective nonparametric regression technique, especially when the underlying curve has irregular features such as spikes or discontinuities. The basic idea is simple: take the discrete wavelet transform of data consisting of a signal corrupted by noise; shrink or remove the wavelet coefficients to remove the noise; then invert the discrete wavelet transform to form an estimate of the true underlying curve. Various researchers have proposed increasingly sophisticated methods of doing this by using real-valued wavelets. Complex-valued wavelets exist but are rarely used. We propose two new complex-valued wavelet shrinkage techniques: one based on multiwavelet style shrinkage and the other using Bayesian methods. Extensive simulations show that our methods almost always give significantly more accurate estimates than methods based on real-valued wavelets. Further, our multiwavelet style shrinkage method is both simpler and dramatically faster than its competitors. To understand the excellent performance of this method we present a new risk bound on its hard thresholded coefficients.     

New Ridge Regression Estimator in Semiparametric Regression Models

In the context of ridge regression, the estimation of shrinkage parameter plays an important role in analyzing data. Many efforts have been put to develop the computation of risk function in different full-parametric ridge regression approaches using eigenvalues and then bringing an efficient estimator of shrinkage parameter based on them. In this respect, the estimation of shrinkage parameter is neglected for semiparametric regression model. Not restricted, but the main focus of this approach is to develop necessary tools for computing the risk function of regression coefficient based on the eigenvalues of design matrix in semiparametric regression. For this purpose the differencing methodology is applied. We also propose a new estimator for shrinkage parameter which is of harmonic type mean of ridge estimators. It is shown that this estimator performs better than all the existing ones for the regression coefficient. For our proposal, a Monte Carlo simulation study and a real dataset analysis related to housing attributes are conducted to illustrate the efficiency of shrinkage estimators based on the minimum risk and mean squared error criteria.     

Asymptotic properties of the estimators of the semi-parametric spatial regression model

Spatial data and non parametric methods arise frequently in studies of different areas and it is a common practice to analyze such data with semi-parametric spatial autoregressive (SPSAR) models. We propose the estimations of SPSAR models based on maximum likelihood estimation (MLE) and kernel estimation. The estimation of spatial regression coefficient ρ was done by optimizing the concentrated log-likelihood function with respect to ρ. Furthermore, under appropriate conditions, we derive the limiting distributions of our estimators for both the parametric and non parametric components in the model.     

A weighted linear quantile regression

In this article, we introduce a new weighted quantile regression method. Traditionally, the estimation of the parameters involved in quantile regression is obtained by minimizing a loss function based on absolute distances with weights independent of explanatory variables. Specifically, we study a new estimation method using a weighted loss function with the weights associated with explanatory variables so that the performance of the resulting estimation can be improved. In full generality, we derive the asymptotic distribution of the weighted quantile regression estimators for any uniformly bounded positive weight function independent of the response. Two practical weighting schemes are proposed, each for a certain type of data. Monte Carlo simulations are carried out for comparing our proposed methods with the classical approaches. We also demonstrate the proposed methods using two real-life data sets from the literature. Both our simulation study and the results from these examples show that our proposed method outperforms the classical approaches when the relative efficiency is measured by the mean-squared errors of the estimators.     

Wavelet shrinkage for unequally spaced data

Wavelet shrinkage (WaveShrink) is a relatively new technique for nonparametric function estimation that has been shown to have asymptotic near-optimality properties over a wide class of functions. As originally formulated by Donoho and Johnstone, WaveShrink assumes equally spaced data. Because so many statistical applications (e.g., scatterplot smoothing) naturally involve unequally spaced data, we investigate in this paper how WaveShrink can be adapted to handle such data. Focusing on the Haar wavelet, we propose four approaches that extend the Haar wavelet transform to the unequally spaced case. Each approach is formulated in terms of continuous wavelet basis functions applied to a piecewise constant interpolation of the observed data, and each approach leads to wavelet coefficients that can be computed via a matrix transform of the original data. For each approach, we propose a practical way of adapting WaveShrink. We compare the four approaches in a Monte Carlo study and find them to be quite comparable in performance. The computationally simplest approach (isometric wavelets) has an appealing justification in terms of a weighted mean square error criterion and readily generalizes to wavelets of higher order than the Haar.     

A wavelet lifting approach to long-memory estimation

Reliable estimation of long-range dependence parameters is vital in time series. For example, in environmental and climate science such estimation is often key to understanding climate dynamics, variability and often prediction. The challenge of data collection in such disciplines means that, in practice, the sampling pattern is either irregular or blighted by missing observations. Unfortunately, virtually all existing Hurst parameter estimation methods assume regularly sampled time series and require modification to cope with irregularity or missing data. However, such interventions come at the price of inducing higher estimator bias and variation, often worryingly ignored. This article proposes a new Hurst exponent estimation method which naturally copes with data sampling irregularity. The new method is based on a multiscale lifting transform exploiting its ability to produce wavelet-like coefficients on irregular data and, simultaneously, to effect a necessary powerful decorrelation of those coefficients. Simulations show that our method is accurate and effective, performing well against competitors even in regular data settings. Armed with this evidence our method sheds new light on long-memory intensity results in environmental and climate science applications, sometimes suggesting that different scientific conclusions may need to be drawn.     

VARIABLE SELECTION AND REGRESSION ANALYSIS FOR GRAPH-STRUCTURED COVARIATES WITH AN APPLICATION TO GENOMICS

Graphs and networks are common ways of depicting information. In biology, many different biological processes are represented by graphs, such as regulatory networks, metabolic pathways and protein-protein interaction networks. This kind of a priori use of graphs is a useful supplement to the standard numerical data such as microarray gene expression data. In this paper, we consider the problem of regression analysis and variable selection when the covariates are linked on a graph. We study a graph-constrained regularization procedure and its theoretical properties for regression analysis to take into account the neighborhood information of the variables measured on a graph, where a smoothness penalty on the coefficients is defined as a quadratic form of the Laplacian matrix associated with the graph. We establish estimation and model selection consistency results and provide estimation bounds for both fixed and diverging numbers of parameters in regression models. We demonstrate by simulations and a real dataset that the proposed procedure can lead to better variable selection and prediction than existing methods that ignore the graph information associated with the covariates.     

Image processing through multiscale analysis and measurement noise modeling

We describe a range of powerful multiscale analysis methods. We also focus on the pivotal issue of measurement noise in the physical sciences. From multiscale analysis and noise modeling, we develop a comprehensive methodology for data analysis of 2D images, 1D signals (or spectra), and point pattern data. Noise modeling is based on the following: (i) multiscale transforms, including wavelet transforms; (ii) a data structure termed the multiresolution support; and (iii) multiple scale significance testing. The latter two aspects serve to characterize signal with respect to noise. The data analysis objectives we deal with include noise filtering and scale decomposition for visualization or feature detection.     

A modified generalized lasso algorithm to detect local spatial clusters for count data

Detecting local spatial clusters for count data is an important task in spatial epidemiology. Two broad approaches—moving window and disease mapping methods—have been suggested in some of the literature to find clusters. However, the existing methods employ somewhat arbitrarily chosen tuning parameters, and the local clustering results are sensitive to the choices. In this paper, we propose a penalized likelihood method to overcome the limitations of existing local spatial clustering approaches for count data. We start with a Poisson regression model to accommodate any type of covariates, and formulate the clustering problem as a penalized likelihood estimation problem to find change points of intercepts in two-dimensional space. The cost of developing a new algorithm is minimized by modifying an existing least absolute shrinkage and selection operator algorithm. The computational details on the modifications are shown, and the proposed method is illustrated with Seoul tuberculosis data.     

Application of shrinkage estimation in linear regression models with autoregressive errors

In this paper, we consider the shrinkage and penalty estimation procedures in the linear regression model with autoregressive errors of order p when it is conjectured that some of the regression parameters are inactive. We develop the statistical properties of the shrinkage estimation method including asymptotic distributional biases and risks. We show that the shrinkage estimators have a significantly higher relative efficiency than the classical estimator. Furthermore, we consider the two penalty estimators: least absolute shrinkage and selection operator (LASSO) and adaptive LASSO estimators, and numerically compare their relative performance with that of the shrinkage estimators. A Monte Carlo simulation experiment is conducted for different combinations of inactive predictors and the performance of each estimator is evaluated in terms of the simulated mean-squared error. This study shows that the shrinkage estimators are comparable to the penalty estimators when the number of inactive predictors in the model is relatively large. The shrinkage and penalty methods are applied to a real data set to illustrate the usefulness of the procedures in practice.     

An Improved Estimation in Regression Parameter Matrix in Multivariate Regression Model

We consider shrinkage and preliminary test estimation strategies for the matrix of regression parameters in multivariate multiple regression model in the presence of a natural linear constraint. We suggest a shrinkage and preliminary test estimation strategies for the parameter matrix. The goal of this article is to critically examine the relative performances of these estimators in the direction of the subspace and candidate subspace restricted type estimators. Our analytical and numerical results show that the proposed shrinkage and preliminary test estimators perform better than the benchmark estimator under candidate subspace and beyond. The methods are also applied on a real data set for illustrative purposes.     

Bayesian covariance estimation and inference in latent Gaussian process models

This paper describes inference methods for functional data under the assumption that the functional data of interest are smooth latent functions, characterized by a Gaussian process, which have been observed with noise over a finite set of time points. The methods we propose are completely specified in a Bayesian environment that allows for all inferences to be performed through a simple Gibbs sampler. Our main focus is in estimating and describing uncertainty in the covariance function. However, these models also encompass functional data estimation, functional regression where the predictors are latent functions, and an automatic approach to smoothing parameter selection. Furthermore, these models require minimal assumptions on the data structure as the time points for observations do not need to be equally spaced, the number and placement of observations are allowed to vary among functions, and special treatment is not required when the number of functional observations is less than the dimensionality of those observations. We illustrate the effectiveness of these models in estimating latent functional data, capturing variation in the functional covariance estimate, and in selecting appropriate smoothing parameters in both a simulation study and a regression analysis of medfly fertility data.     

Shrinkage estimation in lognormal regression model for censored data

We introduce in this paper, the shrinkage estimation method in the lognormal regression model for censored data involving many predictors, some of which may not have any influence on the response of interest. We develop the asymptotic properties of the shrinkage estimators (SEs) using the notion of asymptotic distributional biases and risks. We show that if the shrinkage dimension exceeds two, the asymptotic risk of the SEs is strictly less than the corresponding classical estimators. Furthermore, we study the penalty (LASSO and adaptive LASSO) estimation methods and compare their relative performance with the SEs. A simulation study for various combinations of the inactive predictors and censoring percentages shows that the SEs perform better than the penalty estimators in certain parts of the parameter space, especially when there are many inactive predictors in the model. It also shows that the shrinkage and penalty estimators outperform the classical estimators. A real-life data example using Worcester heart attack study is used to illustrate the performance of the suggested estimators.     

Maximum likelihood estimation of linear continuous time long memory processes with discrete time data

Summary.  We develop a new class of time continuous autoregressive fractionally integrated moving average (CARFIMA) models which are useful for modelling regularly spaced and irregu-larly spaced discrete time long memory data. We derive the autocovariance function of a stationary CARFIMA model and study maximum likelihood estimation of a regression model with CARFIMA errors, based on discrete time data and via the innovations algorithm. It is shown that the maximum likelihood estimator is asymptotically normal, and its finite sample properties are studied through simulation. The efficacy of the approach proposed is demonstrated with a data set from an environmental study.     

Non-penalty shrinkage estimation of random effect models for longitudinal data with AR(1) errors

In this paper, we consider the non-penalty shrinkage estimation method of random effect models with autoregressive errors for longitudinal data when there are many covariates and some of them may not be active for the response variable. In observational studies, subjects are followed over equally or unequally spaced visits to determine the continuous response and whether the response is associated with the risk factors/covariates. Measurements from the same subject are usually more similar to each other and thus are correlated with each other but not with observations of other subjects. To analyse this data, we consider a linear model that contains both random effects across subjects and within-subject errors that follows autoregressive structure of order 1 (AR(1)). Considering the subject-specific random effect as a nuisance parameter, we use two competing models, one includes all the covariates and the other restricts the coefficients based on the auxiliary information. We consider the non-penalty shrinkage estimation strategy that shrinks the unrestricted estimator in the direction of the restricted estimator. We discuss the asymptotic properties of the shrinkage estimators using the notion of asymptotic biases and risks. A Monte Carlo simulation study is conducted to examine the relative performance of the shrinkage estimators with the unrestricted estimator when the shrinkage dimension exceeds two. We also numerically compare the performance of the shrinkage estimators to that of the LASSO estimator. A longitudinal CD4 cell count data set will be used to illustrate the usefulness of shrinkage and LASSO estimators.     

The Dantzig Selector in Cox's Proportional Hazards Model

Abstract. The Dantzig selector (DS) is a recent approach of estimation in high‐dimensional linear regression models with a large number of explanatory variables and a relatively small number of observations. As in the least absolute shrinkage and selection operator (LASSO), this approach sets certain regression coefficients exactly to zero, thus performing variable selection. However, such a framework, contrary to the LASSO, has never been used in regression models for survival data with censoring. A key motivation of this article is to study the estimation problem for Cox's proportional hazards (PH) function regression models using a framework that extends the theory, the computational advantages and the optimal asymptotic rate properties of the DS to the class of Cox's PH under appropriate sparsity scenarios. We perform a detailed simulation study to compare our approach with other methods and illustrate it on a well‐known microarray gene expression data set for predicting survival from gene expressions.     

Multiscale interpretation of taut string estimation and its connection to Unbalanced Haar wavelets

We compare two state-of-the-art non-linear techniques for nonparametric function estimation via piecewise constant approximation: the taut string and the Unbalanced Haar methods. While it is well-known that the latter is multiscale, it is not obvious that the former can also be interpreted as multiscale. We provide a unified multiscale representation for both methods, which offers an insight into the relationship between them as well as suggesting lessons both methods can learn from each other.     

Estimating Individual-Level Risk in Spatial Epidemiology Using Spatially Aggregated Information on the Population at Risk

We propose a novel alternative to case-control sampling for the estimation of individual-level risk in spatial epidemiology. Our approach uses weighted estimating equations to estimate regression parameters in the intensity function of an inhomogeneous spatial point process, when information on risk-factors is available at the individual level for cases, but only at a spatially aggregated level for the population at risk. We develop data-driven methods to select the weights used in the estimating equations and show through simulation that the choice of weights can have a major impact on efficiency of estimation. We develop a formal test to detect non-Poisson behavior in the underlying point process and assess the performance of the test using simulations of Poisson and Poisson cluster point processes. We apply our methods to data on the spatial distribution of childhood meningococcal disease cases in Merseyside, U.K. between 1981 and 2007.