Designs for cropping systems research

The present article establishes equivalence between extended group divisible (EGD) designs and designs for crop sequence experiments. This equivalence has encouraged the agricultural experimenters to use EGD designs for their experimentation. Some real life applications of EGD designs have been given. It has also been shown that several existing association schemes are special cases of EGD association scheme. Some methods of construction of EGD designs are also given. A catalogue of EGD designs obtainable through methods of construction along with efficiency factors of various factorial effects is also presented. In some crop sequence experiments that are conducted to develop suitable integrated nutrient supply system of a crop sequence, the treatments do not comprise of a complete factorial structure. The experimenter is interested in estimating the residual and direct effect of the treatments along with their cumulative effects. For such experimental settings block designs with two sets of treatments applied in succession are the appropriate designs. The correspondence established between row–column designs and block designs for two stage experiments by Parsad et al. [2003. Structurally incomplete row–column designs. Comm. Statist. Theory Methods 32(1), 239–261] has been exploited in obtaining designs for such experimental situations. Some open problems related to designing of crop sequence experiments are also given.     

Optimum covariate designs in partially balanced incomplete block (PBIB) design set-ups

The use of covariates in block designs is necessary when the covariates cannot be controlled like the blocking factor in the experiment. In this paper, we consider the situation where there is some flexibility for selection in the values of the covariates. The choice of values of the covariates for a given block design attaining minimum variance for estimation of each of the parameters has attracted attention in recent times. Optimum covariate designs in simple set-ups such as completely randomised design (CRD), randomised block design (RBD) and some series of balanced incomplete block design (BIBD) have already been considered. In this paper, optimum covariate designs have been considered for the more complex set-ups of different partially balanced incomplete block (PBIB) designs, which are popular among practitioners. The optimum covariate designs depend much on the methods of construction of the basic PBIB designs. Different combinatorial arrangements and tools such as orthogonal arrays, Hadamard matrices and different kinds of products of matrices viz. Khatri–Rao product, Kronecker product have been conveniently used to construct optimum covariate designs with as many covariates as possible.     

Optimal discrimination designs for exponential regression models

We investigate optimal designs for discriminating between exponential regression models of different complexity, which are widely used in the biological sciences; see, e.g., Landaw [1995. Robust sampling designs for compartmental models under large prior eigenvalue uncertainties. Math. Comput. Biomed. Appl. 181–187] or Gibaldi and Perrier [1982. Pharmacokinetics. Marcel Dekker, New York]. We discuss different approaches for the construction of appropriate optimality criteria, and find sharper upper bounds on the number of support points of locally optimal discrimination designs than those given by Caratheodory's Theorem. These results greatly facilitate the numerical construction of optimal designs. Various examples of optimal designs are then presented and compared to different other designs. Moreover, to protect the experiment against misspecifications of the nonlinear model parameters, we adapt the design criteria such that the resulting designs are robust with respect to such misspecifications and, again, provide several examples, which demonstrate the advantages of our approach.     

Robust designs for misspecified logistic models

We develop criteria that generate robust designs and use such criteria for the construction of designs that insure against possible misspecifications in logistic regression models. The design criteria we propose are different from the classical in that we do not focus on sampling error alone. Instead we use design criteria that account as well for error due to bias engendered by the model misspecification. Our robust designs optimize the average of a function of the sampling error and bias error over a specified misspecification neighbourhood. Examples of robust designs for logistic models are presented, including a case study implementing the methodologies using beetle mortality data.     

Some methods for constructing efficiency-balanced block designs

Three methods are presented for constructing connected efficiency-balanced block designs from other block designs with the same properties. The resulting designs differ from the original ones in the number of blocks and/or in the number of experimental units and their arrangement, while the number of treatments remains unaltered. Some remarks on the proposed methods of construction refer also to variance-balanced block designs.     

A unified theory for generalized cyclic designs

Properties of abelian groups are used to unify the construction of cyclic and generalized cyclic designs. Necessary and sufficient conditions are obtained for the generation of fractional sets of blocks, and also for the generation of resolvable designs. It is shown how to apply these results in conjunction with efficiency arguments to obtain useful designs.     

Robust prediction and extrapolation designs for censored data

In this paper we present the construction of robust designs for a possibly misspecified generalized linear regression model when the data are censored. The minimax designs and unbiased designs are found for maximum likelihood estimation in the context of both prediction and extrapolation problems. This paper extends preceding work of robust designs for complete data by incorporating censoring and maximum likelihood estimation. It also broadens former work of robust designs for censored data from others by considering both nonlinearity and much more arbitrary uncertainty in the fitted regression response and by dropping all restrictions on the structure of the regressors. Solutions are derived by a nonsmooth optimization technique analytically and given in full generality. A typical example in accelerated life testing is also demonstrated. We also investigate implementation schemes which are utilized to approximate a robust design having a density. Some exact designs are obtained using an optimal implementation scheme.     

Addition of runs to a two-level supersaturated design

The purpose of this article is to introduce a new class of extended E(s²)-optimal two level supersaturated designs obtained by adding runs to an existing E(s²)-optimal two level supersaturated design. The extended design is a union of two optimal SSDs belonging to different classes. New lower bound to E(s²) has been obtained for the extended supersaturated designs. Some examples and a small catalogue of E(s²)-optimal SSDs are also included.     

Confounded row–column designs

Confounded row–column designs for factorial experiments are considered and a simple method of construction using the classical method of confounding is described. Partially confounded designs are also studied and a method for generating Rao's (1946) designs is presented.     

Robust designs for one-point extrapolation

We consider the construction of designs for the extrapolation of a regression response to one point outside of the design space. The response function is an only approximately known function of a specified linear function. As well, we allow for variance heterogeneity. We find minimax designs and corresponding optimal regression weights in the context of the following problems: (P1) for nonlinear least squares estimation with homoscedasticity, determine a design to minimize the maximum value of the mean squared extrapolation error (MSEE), with the maximum being evaluated over the possible departures from the response function; (P2) for nonlinear least squares estimation with heteroscedasticity, determine a design to minimize the maximum value of MSEE, with the maximum being evaluated over both types of departures; (P3) for nonlinear weighted least squares estimation, determine both weights and a design to minimize the maximum MSEE; (P4) choose weights and design points to minimize the maximum MSEE, subject to a side condition of unbiasedness. Solutions to (P1)–(P4) are given in complete generality. Numerical comparisons indicate that our designs and weights perform well in combining robustness and efficiency. Applications to accelerated life testing are highlighted.     

Minimum projection uniformity for computer experiment with quantitative factors

Computer experiments involving quantitative factors at high levels are becoming more and more important in the study of complex experiments arising in the area of science and engineering. Uniform designs are found to be widely applicable in computer experiments in the form of space-filling designs. In this paper, the projection uniformity for quantitative designs is studied under wrap-around $L_2$-discrepancy. A lower bound of uniformity pattern for general asymmetric designs is provided, which can be used to serve as a benchmark for both comparing different designs and also to determine the optimal design. As a byproduct, a lower bound of wrap-around $L_2$-discrepancy measure for the asymmetric design is also obtained. Some illustrative examples and numerical comparisons are also provided for supporting our theoretical results.     

Lower Bounds for the Efficiency of Designs with Respect to the D-Criterion when the Observations are Correlated

In the general linear model consider the experimental design problem for the Gauß-Markov estimator or least squares estimator when the observations are correlated. We prove new formulas for the efficiency of an exact design with respect to the D-criterion. For models with intercept term, for example, these formulas are useful to derive better lower bounds for the efficiency than the bounds recently given for an arbitrary linear model. These bounds are applied in examples to symmetrical regular circulants as covariance matrices. A byproduct of the investigations is some insight as to what kinds of designs might retain their optimality or high efficiency (for the uncorrelated homoscedastic case) under correlated observations.     

Characterization of minimum aberration mixed factorials in terms of consulting designs

In this paper, by introducing a concept of consulting design and based on the connection between factorial design theory and coding theory, we obtain combinatorial identities that relate the wordlength pattern of a regular mixed factorial design to that of its consulting design. According to these identities, we further-more establish the general and unified rules for identifying minimum aberration mixed factorial designs through their consulting designs. It is an improvement and generalization of the results in Mukerjee and Wu (2001). This paper is supported by NNSF of China grant No. 10171051 and RFDP grant No. 1999005512.     

MV-optimality standardized through the coefficient of variation

Many of the usual criteria for optimal experimental designs do not take into account the different scale of the variance of the parameters. Dette [1997. Designing experiments with respect to “standardized” optimality criteria. J. Roy. Statist. Soc. Ser. B Stat. Methodol. 59(1), 97–110] provided a standardization based on the efficiencies for estimating each of the parameters. This approach provides designs with similar efficiencies for all of the parameters.     

Interaction balance for symmetrical factorial designs with generalized minimum aberration

There are two different systems of contrast parameterization when analyzing the interaction effects among the factors with more than two levels, i.e., linear-quadratic system and orthogonal components system. Based on the former system and an ANOVA model, Xu and Wu (2001) introduced the generalized wordlength pattern for general factorial designs. This paper shows that the generalized wordlength pattern exactly measures the balance pattern of interaction columns of a symmetrical design ground on the orthogonal components system, and thus an alternative angle to look at the generalized minimum aberration criterion is given. This work is partially supported by NNSF of China grant No. 10231030.     

Considerations on group-wise identical designs for linear mixed models

We consider a general class of mixed models, where the individual parameter vector is composed of a linear function of the population parameter vector plus an individual random effects vector. The linear function can vary for the different individuals. We show that the search for optimal designs for the estimation of the population parameter vector can be restricted to the class of group-wise identical designs, i.e., for each of the groups defined by the different linear functions only one individual elementary design has to be optimized. A way to apply the result to non-linear mixed models is described.     

D-optimal minimax regression designs on discrete design space

One classical design criterion is to minimize the determinant of the covariance matrix of the regression estimates, and the designs are called D-optimal designs. To reflect the nature that the proposed models are only approximately true, we propose a robust design criterion to study response surface designs. Both the variance and bias are considered in the criterion. In particular, D-optimal minimax designs are investigated and constructed. Examples are given to compare D-optimal minimax designs with classical D-optimal designs.     

Some sufficient conditions for establishing (M,S)-optimality

Two sufficient conditions are given for an incomplete block design to be (M,S- optimal. For binary designs the conditions are (i) that the elements in each row, excluding the diagonal element, of the association matrix differ by at most one, and (ii) that the off-diagonal elements of the block characteristic matrix differ by at most one. It is also shown how the conditions can be utilized for nonbinary designs and that for blocks of size two the sufficient condition in terms of the association matrix can be attained.     

Optimal crossover designs when carryover effects are proportional to direct effects

Crossover designs are used for a variety of different applications. While these designs have a number of attractive features, they also induce a number of special problems and concerns. One of these is the possible presence of carryover effects. Even with the use of washout periods, which are for many applications widely accepted as an indispensable component, the effect of a treatment from a previous period may not be completely eliminated. A model that has recently received renewed attention in the literature is the model in which first-order carryover effects are assumed to be proportional to direct treatment effects. Under this model, assuming that the constant of proportionality is known, we identify optimal and efficient designs for the direct effects for different values of the constant of proportionality. We also consider the implication of these results for the case that the constant of proportionality is not known.     

Efficient experimental designs for sigmoidal growth models

For the Weibull- and Richards-regression model robust designs are determined by maximizing a minimum of D  - or _D1$D_1$-efficiencies, taken over a certain range of the non-linear parameters. It is demonstrated that the derived designs yield a satisfactory solution of the optimal design problem for this type of model in the sense that these designs are efficient and robust with respect to misspecification of the unknown parameters. Moreover, the designs can also be used for testing the postulated form of the regression model against a simplified sub-model.