Space‐time cluster identification in point processes

The authors propose a new type of scan statistic to test for the presence of space‐time clusters in point processes data, when the goal is to identify and evaluate the statistical significance of localized clusters. Their method is based only on point patterns for cases; it does not require any specific knowledge of the underlying population. The authors propose to scan the three‐dimensional space with a score test statistic under the null hypothesis that the underlying point process is an inhomogeneous Poisson point process with space and time separable intensity. The alternative is that there are one or more localized space‐time clusters. Their method has been implemented in a computationally efficient way so that it can be applied routinely. They illustrate their method with space‐time crime data from Belo Horizonte, a Brazilian city, in addition to presenting a Monte Carlo study to analyze the power of their new test.     

Tests of serial independence based on Kendall's process

The authors propose new rank statistics for testing the white noise hypothesis in a time series. These statistics are Cramér‐von Mises and Kolmogorov‐Smirnov functionals of an empirical distribution function whose mean is related to a serial version of Kendall's tau through a linear transform. The authors determine the asymptotic behaviour of the underlying serial process and the large‐sample distribution of the proposed statistics under the null hypothesis of white noise. They also present simulation results showing the power of their tests.     

Modelling map positional error to infer true feature location

The authors consider the issue of map positional error, or the difference between location as represented in a spatial database (i.e., a map) and the corresponding unobservable true location. They propose a fully model‐based approach that incorporates aspects of the map registration process commonly performed by users of geographic informations systems, including rubber‐sheeting. They explain how estimates of positional error can be obtained, hence estimates of true location. They show that with multiple maps of varying accuracy along with ground truthing data, suitable model averaging offers a strategy for using all of the maps to learn about true location.     

Parameter Estimation for Inhomogeneous Space‐Time Shot‐Noise Cox Point Processes

We consider the problem of parameter estimation for inhomogeneous space‐time shot‐noise Cox point processes. We explore the possibility of using a stepwise estimation method and dimensionality‐reducing techniques to estimate different parts of the model separately. We discuss the estimation method using projection processes and propose a refined method that avoids projection to the temporal domain. This remedies the main flaw of the method using projection processes – possible overlapping in the projection process of clusters, which are clearly separated in the original space‐time process. This issue is more prominent in the temporal projection process where the amount of information lost by projection is higher than in the spatial projection process. For the refined method, we derive consistency and asymptotic normality results under the increasing domain asymptotics and appropriate moment and mixing assumptions. We also present a simulation study that suggests that cluster overlapping is successfully overcome by the refined method.     

Estimation with right‐censored observations under a semi‐Markov model

The semi‐Markov process often provides a better framework than the classical Markov process for the analysis of events with multiple states. The purpose of this paper is twofold. First, we show that in the presence of right censoring, when the right end‐point of the support of the censoring time is strictly less than the right end‐point of the support of the semi‐Markov kernel, the transition probability of the semi‐Markov process is nonidentifiable, and the estimators proposed in the literature are inconsistent in general. We derive the set of all attainable values for the transition probability based on the censored data, and we propose a nonparametric inference procedure for the transition probability using this set. Second, the conventional approach to constructing confidence bands is not applicable for the semi‐Markov kernel and the sojourn time distribution. We propose new perturbation resampling methods to construct these confidence bands. Different weights and transformations are explored in the construction. We use simulation to examine our proposals and illustrate them with hospitalization data from a recent cancer survivor study. The Canadian Journal of Statistics 41: 237–256; 2013 © 2013 Statistical Society of Canada     

Stationary state space models for longitudinal data

The authors consider a class of state space models for the analysis of non‐normal longitudinal data whose latent process follows a stationary AR(1) model with exponential dispersion model margins. They propose to estimate parameters through an estimating equation approach based on the Kalman smoother. This allows them to carry out a straightforward analysis of a wide range of non‐normal data. They illustrate their approach via a simulation study and through analyses of Brazilian precipitation and US polio infection data.     

Longitudinal data analysis for generalized linear models with follow‐up dependent on outcome‐related variables

In longitudinal studies, observation times are often irregular and subject‐specific. Frequently they are related to the outcome measure or other variables that are associated with the outcome measure but undesirable to condition upon in the model for outcome. Regression analyses that are unadjusted for outcome‐dependent follow‐up then yield biased estimates. The authors propose a class of inverse‐intensity rate‐ratio weighted estimators in generalized linear models that adjust for outcome‐dependent follow‐up. The estimators, based on estimating equations, are very simple and easily computed; they can be used under mixtures of continuous and discrete observation times. The predictors of observation times can be past observed outcomes, cumulative values of outcome‐model covariates and other factors associated with the outcome. The authors validate their approach through simulations and they illustrate it using data from a supported housing program from the US federal government.     

A UNIFIED FRAMEWORK FOR MODELLING WILDLIFE POPULATION DYNAMICS†

This paper proposes a unified framework for defining and fitting stochastic, discrete‐time, discrete‐stage population dynamics models. The biological system is described by a state‐space model, where the true but unknown state of the population is modelled by a state process, and this is linked to survey data by an observation process. All sources of uncertainty in the inputs, including uncertainty about model specification, are readily incorporated. The paper shows how the state process can be represented as a generalization of the standard Leslie or Lefkovitch matrix. By dividing the state process into subprocesses, complex models can be constructed from manageable building blocks. The paper illustrates the approach with a model of the British grey seal metapopulation, using sequential importance sampling with kernel smoothing to fit the model.     

Forecasting mortality rates via density ratio modeling

The authors propose a semiparametric approach to modeling and forecasting age‐specific mortality in the United States. Their method is based on an extension of a class of semiparametric models to time series. It combines information from several time series and estimates the predictive distribution conditional on past data. The conditional expectation, which is the most commonly used predictor in practice, is the first moment of this distribution. The authors compare their method to that of Lee and Carter.     

Estimating the Period of a Cyclic Non‐Homogeneous Poisson Process

Abstract. Motivated by applications of Poisson processes for modelling periodic time‐varying phenomena, we study a semi‐parametric estimator of the period of cyclic intensity function of a non‐homogeneous Poisson process. There are no parametric assumptions on the intensity function which is treated as an infinite dimensional nuisance parameter. We propose a new family of estimators for the period of the intensity function, address the identifiability and consistency issues and present simulations which demonstrate good performance of the proposed estimation procedure in practice. We compare our method to competing methods on synthetic data and apply it to a real data set from a call center.     

Exact and approximate sum representations for the Dirichlet process

The Dirichlet process can be regarded as a random probability measure for which the authors examine various sum representations. They consider in particular the gamma process construction of Ferguson (1973) and the “stick‐breaking” construction of Sethuraman (1994). They propose a Dirichlet finite sum representation that strongly approximates the Dirichlet process. They assess the accuracy of this approximation and characterize the posterior that this new prior leads to in the context of Bayesian nonpara‐metric hierarchical models.     

A generalisation of T‐optimality for discriminating between competing models with an application to pharmacokinetic studies

The T‐optimality criterion is used in optimal design to derive designs for model selection. To set up the method, it is required that one of the models is considered to be true. We term this local T‐optimality. In this work, we propose a generalisation of T‐optimality (termed robust T‐optimality) that relaxes the requirement that one of the candidate models is set as true. We then show an application to a nonlinear mixed effects model with two candidate non‐nested models and combine robust T‐optimality with robust D‐optimality. Optimal design under local T‐optimality was found to provide adequate power when the a priori assumed true model was the true model but poor power if the a priori assumed true model was not the true model. The robust T‐optimality method provided adequate power irrespective of which model was true. The robust T‐optimality method appears to have useful properties for nonlinear models, where both the parameter values and model structure are required to be known a priori, and the most likely model that would be applied to any new experiment is not known with certainty. Copyright © 2012 John Wiley & Sons, Ltd.     

A Semiparametric Regression Model for Longitudinal Data with Non‐stationary Errors

Motivated by the need to analyze the National Longitudinal Surveys data, we propose a new semiparametric longitudinal mean‐covariance model in which the effects on dependent variable of some explanatory variables are linear and others are non‐linear, while the within‐subject correlations are modelled by a non‐stationary autoregressive error structure. We develop an estimation machinery based on least squares technique by approximating non‐parametric functions via B‐spline expansions and establish the asymptotic normality of parametric estimators as well as the rate of convergence for the non‐parametric estimators. We further advocate a new model selection strategy in the varying‐coefficient model framework, for distinguishing whether a component is significant and subsequently whether it is linear or non‐linear. Besides, the proposed method can also be employed for identifying the true order of lagged terms consistently. Monte Carlo studies are conducted to examine the finite sample performance of our approach, and an application of real data is also illustrated.     

A Semi‐parametric Transformation Frailty Model for Semi‐competing Risks Survival Data

In the analysis of semi‐competing risks data interest lies in estimation and inference with respect to a so‐called non‐terminal event, the observation of which is subject to a terminal event. Multi‐state models are commonly used to analyse such data, with covariate effects on the transition/intensity functions typically specified via the Cox model and dependence between the non‐terminal and terminal events specified, in part, by a unit‐specific shared frailty term. To ensure identifiability, the frailties are typically assumed to arise from a parametric distribution, specifically a Gamma distribution with mean 1.0 and variance, say, σ². When the frailty distribution is misspecified, however, the resulting estimator is not guaranteed to be consistent, with the extent of asymptotic bias depending on the discrepancy between the assumed and true frailty distributions. In this paper, we propose a novel class of transformation models for semi‐competing risks analysis that permit the non‐parametric specification of the frailty distribution. To ensure identifiability, the class restricts to parametric specifications of the transformation and the error distribution; the latter are flexible, however, and cover a broad range of possible specifications. We also derive the semi‐parametric efficient score under the complete data setting and propose a non‐parametric score imputation method to handle right censoring; consistency and asymptotic normality of the resulting estimators is derived and small‐sample operating characteristics evaluated via simulation. Although the proposed semi‐parametric transformation model and non‐parametric score imputation method are motivated by the analysis of semi‐competing risks data, they are broadly applicable to any analysis of multivariate time‐to‐event outcomes in which a unit‐specific shared frailty is used to account for correlation. Finally, the proposed model and estimation procedures are applied to a study of hospital readmission among patients diagnosed with pancreatic cancer.     

On inference for a semiparametric partially linear regression model with serially correlated errors

The authors consider a semiparametric partially linear regression model with serially correlated errors. They propose a new way of estimating the error structure which has the advantage that it does not involve any nonparametric estimation. This allows them to develop an inference procedure consisting of a bandwidth selection method, an efficient semiparametric generalized least squares estimator of the parametric component, a goodness‐of‐fit test based on the bootstrap, and a technique for selecting significant covariates in the parametric component. They assess their approach through simulation studies and illustrate it with a concrete application.     

Testing for two states in a hidden Markov model

The authors consider hidden Markov models (HMMs) whose latent process has m ≥ 2 states and whose state‐dependent distributions arise from a general one‐parameter family. They propose a test of the hypothesis m = 2. Their procedure is an extension to HMMs of the modified likelihood ratio statistic proposed by Chen, Chen & Kalbfleisch (2004) for testing two states in a finite mixture. The authors determine the asymptotic distribution of their test under the hypothesis m = 2 and investigate its finite‐sample properties in a simulation study. Their test is based on inference for the marginal mixture distribution of the HMM. In order to illustrate the additional difficulties due to the dependence structure of the HMM, they show how to test general regular hypotheses on the marginal mixture of HMMs via a quasi‐modified likelihood ratio. They also discuss two applications.     

A J‐function for Inhomogeneous Spatio‐temporal Point Processes

We propose a new summary statistic for inhomogeneous intensity‐reweighted moment stationarity spatio‐temporal point processes. The statistic is defined in terms of the n‐point correlation functions of the point process, and it generalizes the J‐function when stationarity is assumed. We show that our statistic can be represented in terms of the generating functional and that it is related to the spatio‐temporal K‐function. We further discuss its explicit form under some specific model assumptions and derive ratio‐unbiased estimators. We finally illustrate the use of our statistic in practice. © 2014 Board of the Foundation of the Scandinavian Journal of Statistics     

Bayesian Analysis of the Proportional Hazards Model with Time‐Varying Coefficients

We study a Bayesian analysis of the proportional hazards model with time‐varying coefficients. We consider two priors for time‐varying coefficients – one based on B‐spline basis functions and the other based on Gamma processes – and we use a beta process prior for the baseline hazard functions. We show that the two priors provide optimal posterior convergence rates (up to the term) and that the Bayes factor is consistent for testing the assumption of the proportional hazards when the two priors are used for an alternative hypothesis. In addition, adaptive priors are considered for theoretical investigation, in which the smoothness of the true function is assumed to be unknown, and prior distributions are assigned based on B‐splines.     

Self‐modelling regression for longitudinal data with time‐invariant covariates

The authors propose the use of self‐modelling regression to analyze longitudinal data with time invariant covariates. They model the population time curve with a penalized regression spline and use a linear mixed model for transformation of the time and response scales to fit the individual curves. Fitting is done by an iterative algorithm using off‐the‐shelf linear and nonlinear mixed model software. Their method is demonstrated in a simulation study and in the analysis of tree swallow nestling growth from an experiment that includes an experimentally controlled treatment, an observational covariate and multi‐level sampling.     

Cure rate models: A unified approach

The authors propose a novel class of cure rate models for right‐censored failure time data. The class is formulated through a transformation on the unknown population survival function. It includes the mixture cure model and the promotion time cure model as two special cases. The authors propose a general form of the covariate structure which automatically satisfies an inherent parameter constraint and includes the corresponding binomial and exponential covariate structures in the two main formulations of cure models. The proposed class provides a natural link between the mixture and the promotion time cure models, and it offers a wide variety of new modelling structures as well. Within the Bayesian paradigm, a Markov chain Monte Carlo computational scheme is implemented for sampling from the full conditional distributions of the parameters. Model selection is based on the conditional predictive ordinate criterion. The use of the new class of models is illustrated with a set of real data involving a melanoma clinical trial.