Progressive censoring with fixed censoring times

In this paper, we revisit the progressive Type-I censoring scheme as it has originally been introduced by Cohen [Progressively censored samples in life testing. Technometrics. 1963;5(3):327–339]. In fact, original progressive Type-I censoring proceeds as progressive Type-II censoring but with fixed censoring times instead of failure time based censoring times. Apparently, a time truncation has been added to this censoring scheme by interpreting the final censoring time as a termination time. Therefore, not much work has been done on Cohens's original progressive censoring scheme with fixed censoring times. Thus, we discuss distributional results for this scheme and establish exact distributional results in likelihood inference for exponentially distributed lifetimes. In particular, we obtain the exact distribution of the maximum likelihood estimator (MLE). Further, the stochastic monotonicity of the MLE is verified in order to construct exact confidence intervals for both the scale parameter and the reliability.     

Restricted optimal progressive censoring

Unlike traditional Type I and II censoring, progressive censoring allows for removal of surviving units throughout the life test. This feature has several benefits and in the literature, much work has been done on inference based on progressively censored samples and identifying optimal progressive censoring schemes. In this paper, we introduce restricted progressive censoring and within this class, the problem of identifying optimal schemes under different minimum variance criteria. We explore these plans geometrically as well as provide some useful properties. In particular, we look at the vertices of the set of admissible plans and their role in approximating optimal plans. We also provide computational results for illustrative purposes.     

Inverse censoring weighted median regression

We implement semiparametric random censorship model aided inference for censored median regression models. This is based on the idea that, when the censoring is specified by a common distribution, a semiparametric survival function estimator acts as an improved weight in the so-called inverse censoring weighted estimating function. We show that the proposed method will always produce estimates of the model parameters that are as good as or better than an existing estimator based on the traditional Kaplan–Meier weights. We also provide an illustration of the method through an analysis of a lung cancer data set.     

An asymptotic approach to progressive censoring

Progressive Type-II censoring was introduced by Cohen (Technometrics 5(1963) 327) and has been the topic of much research. The question stands whether it is sensible to use this sampling plan by design, instead of regular Type-II right censoring. We introduce an asymptotic progressive censoring model, and find optimal censoring schemes for location-scale families. Our optimality criterion is the determinant of the 2×2 covariance matrix of the asymptotic best linear unbiased estimators. We present an explicit expression for this criterion, and conditions for its boundedness. By means of numerical optimization, we determine optimal censoring schemes for the extreme value, the Weibull and the normal distributions. In many situations, it is shown that these progressive schemes significantly improve upon regular Type-II right censoring.     

Tests for symmetry with right censoring

Permutation tests for symmetry are suggested using data that are subject to right censoring. Such tests are directly relevant to the assumptions that underlie the generalized Wilcoxon test since the symmetric logistic distribution for log-errors has been used to motivate Wilcoxon scores in the censored accelerated failure time model. Its principal competitor is the log-rank (LGR) test motivated by an extreme value error distribution that is positively skewed. The proposed one-sided tests for symmetry against the alternative of positive skewness are directly relevant to the choice between usage of these two tests.

The permutation tests use statistics from the weighted LGR class normally used for making two-sample comparisons. From this class, the test using LGR weights (all weights equal) showed the greatest discriminatory power in simulations that compared the possibility of logistic errors versus extreme value errors.

In the test construction, a median estimate, determined by inverting the Kaplan–Meier estimator, is used to divide the data into a “control” group to its left that is compared with a “treatment” group to its right. As an unavoidable consequence of testing symmetry, data in the control group that have been censored become uninformative in performing this two-sample test. Thus, early heavy censoring of data can reduce the effective sample size of the control group and result in diminished power for discriminating symmetry in the population distribution.     

Adjusting win statistics for dependent censoring

For composite outcomes whose components can be prioritized on clinical importance, the win ratio, the net benefit and the win odds apply that order in comparing patients pairwise to produce wins and subsequently win proportions. Because these three statistics are derived using the same win proportions and they test the same hypothesis of equal win probabilities in the two treatment groups, we refer to them as win statistics. These methods, particularly the win ratio and the net benefit, have received increasing attention in methodological research and in design and analysis of clinical trials. For time-to-event outcomes, however, censoring may introduce bias. Previous work has shown that inverse-probability-of-censoring weighting (IPCW) can correct the win ratio for bias from independent censoring. The present article uses the IPCW approach to adjust win statistics for dependent censoring that can be predicted by baseline covariates and/or time-dependent covariates (producing the CovIPCW-adjusted win statistics). Theoretically and with examples and simulations, we show that the CovIPCW-adjusted win statistics are unbiased estimators of treatment effect in the presence of dependent censoring.     

Fisher information in progressive hybrid censoring schemes

The hybrid censoring scheme, which is a mixture of Type-I and Type-II censoring schemes, has been extended to the case of progressive censoring schemes by Kundu and Joarder [Analysis of Type-II progressively hybrid censored data, Comput. Stat. Data Anal. 50 (2006), pp. 2509–2528] and Childs et al. [Exact likelihood inference for an exponential parameter under progressive hybrid censoring schemes, in Statistical Models and Methods for Biomedical and Technical Systems, F. Vonta, M. Nikulin, N. Limnios, and C. Huber-Carol, eds., Birkhäuser, Boston, MA, 2007, pp. 323–334]. In this paper, we derive a simple expression for the Fisher information contained in Type-I and Type-II progressively hybrid censored data. An illustrative example is provided applicable to a scaled-exponential distribution to demonstrate our methodologies.     

A modified kernel quantile estimator under censoring

Based on right-censored data from a lifetime distribution F₀, a modification of the kernel quantile estimator is proposed. The advantage of this estimator is that the data play a role in the degree of smoothing of the estimator while retaining the desirable features of the kernel estimator. Convergence in probability and almost sure convergence of the estimator are discussed. Also, asymptotic normality and confidence bands are presented and some examples are given.     

Generalized inverted exponential distribution under hybrid censoring

The hybrid censoring scheme is a mixture of Type-I and Type-II censoring schemes. Based on hybrid censored samples, we first derive the maximum likelihood estimators of the unknown parameters and the expected Fisher’s information matrix of the generalized inverted exponential distribution (GIED). Monte Carlo simulations are performed to study the performance of the maximum likelihood estimators. Next we consider Bayes estimation under the squared error loss function. These Bayes estimates are evaluated by applying Lindley’s approximation method, the importance sampling procedure and Metropolis–Hastings algorithm. The importance sampling technique is used to compute the highest posterior density credible intervals. Two data sets are analyzed for illustrative purposes. Finally, we discuss a method of obtaining the optimum hybrid censoring scheme.     

A general censoring scheme for circular data

A generalized censoring scheme in the survival analysis context was introduced by the authors in Jammalamadaka and Mangalam [S. Rao Jammalamadaka, V. Mangalam, Nonparametric estimation for middle censored data, J. Nonparametr. Stat. 15 (2003) 253–265]. In this article we discuss how such a censoring scheme applies to circular data and in particular when the original data is assumed to come from a parametric model such as the von Mises. Maximum likelihood estimation of the parameters as well as their large-sample properties are considered under this censoring scheme. We also consider nonparametric estimation of the circular probability distribution under such a general censoring scheme and use Monte Carlo methods to investigate its effects on the estimation of the mean direction and concentration.     

A consistency result in general censoring models

In this paper we prove a consistency result for sieved maximum likelihood estimators of the density in general random censoring models with covariates. The proof is based on the method of functional estimation. The estimation error is decomposed in a deterministic approximation error and the stochastic estimation error. The main part of the proof is to establish a uniform law of large numbers for the conditional log-likelihood functional, by using results and techniques from empirical process theory.     

Bayesian inference under progressive type-I interval censoring

Bayesian estimation for population parameter under progressive type-I interval censoring is studied via Markov Chain Monte Carlo (MCMC) simulation. Two competitive statistical models, generalized exponential and Weibull distributions for modeling a real data set containing 112 patients with plasma cell myeloma, are studied for illustration. In model selection, a novel Bayesian procedure which involves a mixture model is proposed. Then the mix proportion is estimated through MCMC and used as the model selection criterion.     

Multi-treatment covariate-adjusted adaptive design under informative censoring

In the present work, we find a set of reliability functionals to fix up an allocation strategy among K(≥2) treatments when the response distributions, conditionally dependent on some continuous prognostic variable, are exponential with unknown linear regression functions as the means of the respective conditional distributions. Targeting such reliability functionals, we propose a covariate-adjusted response-adaptive randomization procedure for the multi-treatment single-period clinical trial under the Koziol–Green model for informative censoring. We compare the proposed procedure with its competitive covariate-eliminated procedure.     

Hybrid censoring schemes with exponential failure distribution

The mixture of Type I and Type I1 censoring schemes, called the hybrid censoring, is quite important in life–testing experiments. Epstein(1954, 1960) introduced this testing scheme and proposed a two–sided confidence interval to estimate the mean lifetime, θ, when the underlying lifetime distribution is assumed to be exponential. There are some two–sided confidence intervals and credible intervals proposed by Fairbanks et al. (1982) and Draper and Guttman (1987) respectively. In this paper we obtain the exact two–sided confidence interval of θ following the approach of Chen and Bhattacharya (1988). We also obtain the asymptotic confidence intervals in the Hybrid censoring case. It is important to observe that the results for Type I and Type II censoring schemes can be obtained as particular cases of the Hybrid censoring scheme. We analyze one data set and compare different methods by Monte Carlo simulations.     

Cure-rate estimation under Case-1 interval censoring

We consider nonparametric estimation of cure-rate based on mixture model under Case-1 interval censoring. We show that the nonparametric maximum-likelihood estimator (NPMLE) of cure-rate is non-unique as well as inconsistent, and propose two estimators based on the NPMLE of the distribution function under this censoring model. We present a cross-validation method for choosing a ‘cut-off’ point needed for the estimators. The limiting distributions of the latter are obtained using extreme-value theory. Graphical illustration of the procedures based on simulated data is provided.