On power and sample size calculations for Wald tests in generalized linear models

A Wald test-based approach for power and sample size calculations has been presented recently for logistic and Poisson regression models using the asymptotic normal distribution of the maximum likelihood estimator, which is applicable to tests of a single parameter. Unlike the previous procedures involving the use of score and likelihood ratio statistics, there is no simple and direct extension of this approach for tests of more than a single parameter. In this article, we present a method for computing sample size and statistical power employing the discrepancy between the noncentral and central chi-square approximations to the distribution of the Wald statistic with unrestricted and restricted parameter estimates, respectively. The distinguishing features of the proposed approach are the accommodation of tests about multiple parameters, the flexibility of covariate configurations and the generality of overall response levels within the framework of generalized linear models. The general procedure is illustrated with some special situations that have motivated this research. Monte Carlo simulation studies are conducted to assess and compare its accuracy with existing approaches under several model specifications and covariate distributions.     

Guaranteed Local Maximum Likelihood Detection of a Change Point in Nonparametric Logistic Regression

We consider nonparametric logistic regression and propose a generalized likelihood test for detecting a threshold effect that indicates a relationship between some risk factor and a defined outcome above the threshold but none below it. One important field of application is occupational medicine and in particular, epidemiological studies. In epidemiological studies, segmented fully parametric logistic regression models are often threshold models, where it is assumed that the exposure has no influence on a response up to a possible unknown threshold, and has an effect beyond that threshold. Finding efficient methods for detection and estimation of a threshold is a very important task in these studies. This article proposes such methods in a context of nonparametric logistic regression. We use a local version of unknown likelihood functions and show that under rather common assumptions the asymptotic power of our test is one. We present a guaranteed non asymptotic upper bound for the significance level of the proposed test. If applying the test yields the acceptance of the conclusion that there was a change point (and hence a threshold limit value), we suggest using the local maximum likelihood estimator of the change point and consider the asymptotic properties of this estimator.     

Combining information from multiple surveys through the empirical likelihood method

It is often desirable to combine information collected in compatible multiple surveys in order to improve estimation and meet consistency requirements. Zieschang (1990) and Renssen & Nieuwenbroek (1997) suggested to this end the use of the generalized regression estimator with enlarged number of auxiliary variables. Unfortunately, adjusted weights associated with their approach can be negative. The author uses the notion of pseudo empirical likelihood to construct new estimators that are consistent, efficient and possess other attractive properties. The proposed approach is asymptotically equivalent to the earlier one, but it has clear maximum likelihood interpretations and its adjusted weights are always positive. The author also provides efficient algorithms for computing his estimators.     

Logistic Regression and Discriminant Analysis by Ordinary Least Squares

If the observations for fitting a polytomous logistic regression model satisfy certain normality assumptions, the maximum likelihood estimates of the regression coefficients are the discriminant function estimates. This article shows that these estimates, their unbiased counterparts, and associated test statistics for variable selection can be calculated using ordinary least squares regression techniques, thereby providing a convenient method for fitting logistic regression models in the normal case. Evidence is given indicating that the discriminant function estimates and test statistics merit wider use in nonnormal cases, especially in exploratory work on large data sets.     

On the Restricted Liu Estimator in the Logistic Regression Model

The logistic regression model is used when the response variables are dichotomous. In the presence of multicollinearity, the variance of the maximum likelihood estimator (MLE) becomes inflated. The Liu estimator for the linear regression model is proposed by Liu to remedy this problem. Urgan and Tez and Mansson et al. examined the Liu estimator (LE) for the logistic regression model. We introduced the restricted Liu estimator (RLE) for the logistic regression model. Moreover, a Monte Carlo simulation study is conducted for comparing the performances of the MLE, restricted maximum likelihood estimator (RMLE), LE, and RLE for the logistic regression model.     

On extending bock's model of logistic regression in the analysis of categorical data

A general class of multiple logistic regression models is reviewed and an extension is proposed which leads to restricted maximum likelihood estimates of model parameters. Examples of thegeneral model are given, with an emphasis placed on the interpretation of the parameters in each case.     

Estimation and diagnostics for heteroscedastic nonlinear regression models based on scale mixtures of skew-normal distributions

An extension of some standard likelihood based procedures to heteroscedastic nonlinear regression models under scale mixtures of skew-normal (SMSN) distributions is developed. This novel class of models provides a useful generalization of the heteroscedastic symmetrical nonlinear regression models (Cysneiros et al., 2010), since the random term distributions cover both symmetric as well as asymmetric and heavy-tailed distributions such as skew-t, skew-slash, skew-contaminated normal, among others. A simple EM-type algorithm for iteratively computing maximum likelihood estimates of the parameters is presented and the observed information matrix is derived analytically. In order to examine the performance of the proposed methods, some simulation studies are presented to show the robust aspect of this flexible class against outlying and influential observations and that the maximum likelihood estimates based on the EM-type algorithm do provide good asymptotic properties. Furthermore, local influence measures and the one-step approximations of the estimates in the case-deletion model are obtained. Finally, an illustration of the methodology is given considering a data set previously analyzed under the homoscedastic skew-t nonlinear regression model.     

A comparison of two approaches for power and sample size calculations in logistic regression models

Whittemore (1981) proposed an approach for calculating the sample size needed to test hypotheses with specified significance and power against a given alternative for logistic regression with small response probability. Based on the distribution of covariate, which could be either discrete or continuous, this approach first provides a simple closed-form approximation to the asymptotic covariance matrix of the maximum likelihood estimates, and then uses it to calculate the sample size needed to test a hypothesis about the parameter. Self et al. (1992) described a general approach for power and sample size calculations within the framework of generalized linear models, which include logistic regression as a special case. Their approach is based on an approximation to the distribution of the likelihood ratio statistic. Unlike the Whittemore approach, their approach is not limited to situations of small response probability. However, it is restricted to models with a finite number of covariate configurations. This study compares these two approaches to see how accurate they would be for the calculations of power and sample size in logistic regression models with various response probabilities and covariate distributions. The results indicate that the Whittemore approach has a slight advantage in achieving the nominal power only for one case with small response probability. It is outperformed for all other cases with larger response probabilities. In general, the approach proposed in Self et al. (1992) is recommended for all values of the response probability. However, its extension for logistic regression models with an infinite number of covariate configurations involves an arbitrary decision for categorization and leads to a discrete approximation. As shown in this paper, the examined discrete approximations appear to be sufficiently accurate for practical purpose.     

Efficient Estimation of the Partly Linear Additive Hazards Model with Current Status Data

This paper focuses on efficient estimation, optimal rates of convergence and effective algorithms in the partly linear additive hazards regression model with current status data. We use polynomial splines to estimate both cumulative baseline hazard function with monotonicity constraint and nonparametric regression functions with no such constraint. We propose a simultaneous sieve maximum likelihood estimation for regression parameters and nuisance parameters and show that the resultant estimator of regression parameter vector is asymptotically normal and achieves the semiparametric information bound. In addition, we show that rates of convergence for the estimators of nonparametric functions are optimal. We implement the proposed estimation through a backfitting algorithm on generalized linear models. We conduct simulation studies to examine the finite‐sample performance of the proposed estimation method and present an analysis of renal function recovery data for illustration.     

Varying coefficient transformation cure models for failure time data

This article discusses regression analysis of right-censored failure time data where there may exist a cured subgroup, and also covariate effects may be varying with time, a phenomena that often occurs in many medical studies. To address the problem, we discuss a class of varying coefficient transformation models along with a logistic model for the cured subgroup. For inference, a sieve maximum likelihood approach is developed with the use of spline functions, and the asymptotic properties of the proposed estimators are established. The proposed method can be easily implemented, and the conducted simulation study suggests that the proposed method works well in practical situations. An illustrative example is provided.

     

Corrected likelihood-ratio tests in logistic regression using small-sample data

Likelihood-ratio tests (LRTs) are often used for inferences on one or more logistic regression coefficients. Conventionally, for given parameters of interest, the nuisance parameters of the likelihood function are replaced by their maximum likelihood estimates. The new function created is called the profile likelihood function, and is used for inference from LRT. In small samples, LRT based on the profile likelihood does not follow χ² distribution. Several corrections have been proposed to improve LRT when used with small-sample data. Additionally, complete or quasi-complete separation is a common geometric feature for small-sample binary data. In this article, for small-sample binary data, we have derived explicitly the correction factors of LRT for models with and without separation, and proposed an algorithm to construct confidence intervals. We have investigated the performances of different LRT corrections, and the corresponding confidence intervals through simulations. Based on the simulation results, we propose an empirical rule of thumb on the use of these methods. Our simulation findings are also supported by real-world data.     

Target estimation for the logistic regression model

The method of target estimation developed by Cabrera and Fernholz [(1999). Target estimation for bias and mean square error reduction. The Annals of Statistics, 27(3), 1080–1104.] to reduce bias and variance is applied to logistic regression models of several parameters. The expectation functions of the maximum likelihood estimators for the coefficients in the logistic regression models of one and two parameters are analyzed and simulations are given to show a reduction in both bias and variability after targeting the maximum likelihood estimators. In addition to bias and variance reduction, it is found that targeting can also correct the skewness of the original statistic. An example based on real data is given to show the advantage of using target estimators for obtaining better confidence intervals of the corresponding parameters. The notion of the target median is also presented with some applications to the logistic models.     

Errors-in-variables beta regression models

Beta regression models provide an adequate approach for modeling continuous outcomes limited to the interval (0, 1). This paper deals with an extension of beta regression models that allow for explanatory variables to be measured with error. The structural approach, in which the covariates measured with error are assumed to be random variables, is employed. Three estimation methods are presented, namely maximum likelihood, maximum pseudo-likelihood and regression calibration. Monte Carlo simulations are used to evaluate the performance of the proposed estimators and the naïve estimator. Also, a residual analysis for beta regression models with measurement errors is proposed. The results are illustrated in a real data set.     

On the small sample properties of norm-restricted maximum likelihood estimators for logistic regression models

This paper develops alternatives to maximum likelihood estimators (MLE) for logistic regression models and compares the mean squared error (MSE) of the estimators. The MLE for the vector of underlying success probabilities has low MSE only when the true probabilities are extreme (i.e., near 0 or 1). Extreme probabilities correspond to logistic regression parameter vectors which are large in norm. A competing “restricted” MLE and an empirical version of it are suggested as estimators with better performance than the MLE for central probabilities. An approximate EM-algorithm for estimating the restriction is described. As in the case of normal theory ridge estimators, the proposed estimators are shown to be formally derivable by Bayes and empirical Bayes arguments. The small sample operating characteristics of the proposed estimators are compared to the MLE via a simulation study; both the estimation of individual probabilities and of logistic parameters are considered.     

Estimation of parameters in incomplete data models defined by dynamical systems

Parametric incomplete data models defined by ordinary differential equations (ODEs) are widely used in biostatistics to describe biological processes accurately. Their parameters are estimated on approximate models, whose regression functions are evaluated by a numerical integration method. Accurate and efficient estimations of these parameters are critical issues. This paper proposes parameter estimation methods involving either a stochastic approximation EM algorithm (SAEM) in the maximum likelihood estimation, or a Gibbs sampler in the Bayesian approach. Both algorithms involve the simulation of non-observed data with conditional distributions using Hastings–Metropolis (H–M) algorithms. A modified H–M algorithm, including an original local linearization scheme to solve the ODEs, is proposed to reduce the computational time significantly. The convergence on the approximate model of all these algorithms is proved. The errors induced by the numerical solving method on the conditional distribution, the likelihood and the posterior distribution are bounded. The Bayesian and maximum likelihood estimation methods are illustrated on a simulated pharmacokinetic nonlinear mixed-effects model defined by an ODE. Simulation results illustrate the ability of these algorithms to provide accurate estimates.     

Computational algorithms for the factor model

Algorithms for computing the maximum likelihood estimators and the estimated covariance matrix of the estimators of the factor model are derived. The algorithms are particularly suitable for large matrices and for samples that give zero estimates of some error variances. A method of constructing estimators for reduced models is presented. The algorithms can also be used for the multivariate errors-in-variables model with known error covariance matrix.     

Testing Inference from Logistic Regression Models in Data with Unobserved Heterogeneity at Cluster Levels

Clustering due to unobserved heterogeneity may seriously impact on inference from binary regression models. We examined the performance of the logistic, and the logistic-normal models for data with such clustering. The total variance of unobserved heterogeneity rather than the level of clustering determines the size of bias of the maximum likelihood (ML) estimator, for the logistic model. Incorrect specification of clustering as level 2, using the logistic-normal model, provides biased estimates of the structural and random parameters, while specifying level 1, provides unbiased estimates for the former, and adequately estimates the latter. The proposed procedure appeals to many research areas.     

Mixtures of Linear Regression with Measurement Errors

Existing research on mixtures of regression models are limited to directly observed predictors. The estimation of mixtures of regression for measurement error data imposes challenges for statisticians. For linear regression models with measurement error data, the naive ordinary least squares method, which directly substitutes the observed surrogates for the unobserved error-prone variables, yields an inconsistent estimate for the regression coefficients. The same inconsistency also happens to the naive mixtures of regression estimate, which is based on the traditional maximum likelihood estimator and simply ignores the measurement error. To solve this inconsistency, we propose to use the deconvolution method to estimate the mixture likelihood of the observed surrogates. Then our proposed estimate is found by maximizing the estimated mixture likelihood. In addition, a generalized EM algorithm is also developed to find the estimate. The simulation results demonstrate that the proposed estimation procedures work well and perform much better than the naive estimates.     

On a hybrid data cloning method and its application in generalized linear mixed models

The data cloning method is a new computational tool for computing maximum likelihood estimates in complex statistical models such as mixed models. This method is synthesized with integrated nested Laplace approximation to compute maximum likelihood estimates efficiently via a fast implementation in generalized linear mixed models. Asymptotic behavior of the hybrid data cloning method is discussed. The performance of the proposed method is illustrated through a simulation study and real examples. It is shown that the proposed method performs well and rightly justifies the theory. Supplemental materials for this article are available online.     

Statistical Engineering

This article compares the accuracy of the median unbiased estimator with that of the maximum likelihood estimator for a logistic regression model with two binary covariates. The former estimator is shown to be uniformly more accurate than the latter for small to moderately large sample sizes and a broad range of parameter values. In view of the recently developed efficient algorithms for generating exact distributions of sufficient statistics in binary-data problems, these results call for a serious consideration of median unbiased estimation as an alternative to maximum likelihood estimation, especially when the sample size is not large, or when the data structure is sparse.