Determination of sample size for selecting the smallest of k poisson population means

A procedure for selecting a Poisson population with smallest mean is considered using an indifference zone approach. The objective is to determine the smallest sample size n required from k ≥ 2 populations in order to attain the desired probability of correct selection. Since the means procedure is not consistent with respect to the difference or ratio alone, two distance measures are used simultaneously to overcome the difficulty in obtaining the smallest probability of correct selection that is greater than some specified limit. The constants required to determine n are computed and tabulated. The asymptotic results are derived using a normal approximation. A comparison with the exact results indicates that the proposed approximation works well. Only in the extreme cases small increases in n are observed. An example of industrial accident data is used to illustrate this procedure.     

ON A SHARED ALLELE TEST OF RANDOM MATING

A simple random sample is observed from a population with a large number‘K’ of alleles, to test for random mating. Of n couples, n_ijkl have female genotype ij and male genotype kl (i, j, k, l{1,…, A‘}). The large contingency table is collapsed into three counts, n₀, n₁ and n₂ where n_p is the number of couples with s alleles in common (s = 0,1, 2). The counts are estimated by np?_o where n₀, is the estimated probability of a couple having s alleles in common under the hypothesis of random mating. The usual chi-square goodness of fit statistic X² compares observed (n_s) with expected (np?) over the three categories, s = 0,1,2. An empirical observation has suggested that X² is close to having a chi-square distribution with two degrees of freedom (X) despite a large number of parameters implicitly estimated in _e. This paper gives two theorems which show that x is indeed the approximate distribution of X² for large n and K₁“, provided that no allele type over-dominates the others.     

A Nonrandomized,Nonconservative Version of the Fisher Exact Test

The Fisher exact test has been unjustly dismissed by some as ‘only conditional,’ whereas it is unconditionally the uniform most powerful test among all unbiased tests, tests of size α and with power greater than its nominal level of significance α. The problem with this truly optimal test is that it requires randomization at the critical value(s) to be of size α. Obviously, in practice, one does not want to conclude that ‘with probability x the we have a statistical significant result.’ Usually, the hypothesis is rejected only if the test statistic's outcome is more extreme than the critical value, reducing the actual size considerably.

The randomized unconditional Fisher exact is constructed (using Neyman–structure arguments) by deriving a conditional randomized test randomizing at critical values c(t) by probabilities γ(t), that both depend on the total number of successes T (the complete-sufficient statistic for the nuisance parameter—the common success probability) conditioned upon.

In this paper, the Fisher exact is approximated by deriving nonrandomized conditional tests with critical region including the critical value only if γ (t) > γ₀, for a fixed threshold value γ₀, such that the size of the unconditional modified test is for all value of the nuisance parameter—the common success probability—smaller, but as close as possible to α. It will be seen that this greatly improves the size of the test as compared with the conservative nonrandomized Fisher exact test.

Size, power, and p value comparison with the (virtual) randomized Fisher exact test, and the conservative nonrandomized Fisher exact, Pearson's chi-square test, with the more competitive mid-p value, the McDonald's modification, and Boschloo's modifications are performed under the assumption of two binomial samples.     

The distribution of random determinants

The exact distribution of |Δn| where Δn is a random determinant with independent and identically distributed exponential elements is given for the cases n = 2 and 3. From the investigation of the behaviour of the density functions for these cases it is conjectured that for any fixed n, the probability density of |Δn| for large values of the argument is the same as the density of (Y/n)ⁿ, where Y is a gamma random variable.     

Classification Error of the Thresholded Independence Rule

We consider classification in the situation of two groups with normally distributed data in the ‘large p small n’ framework. To counterbalance the high number of variables, we consider the thresholded independence rule. An upper bound on the classification error is established that is taylored to a mean value of interest in biological applications.     

Relation of modified power series distributions to lagrangian probability distributions

The class of Lagrangian probability distributions ‘LPD’, given by the expansion of a probability generating function f‘t’ under the transformation u = t/g‘t’ where g ‘t’ is also a p.g.f., has been substantially widened by removing the restriction that the defining functions g ‘t’ and f‘t’ be probability generating functions. The class of modified power series distributions defined by Gupta ‘1974’ has been shown to be a sub-class of the wider class of LPDs     

ON THE NUMBER OF RECORDS NEAR THE MAXIMUM

Recent work has considered properties of the number of observations X_j, independently drawn from a discrete law, which equal the sample maximum X_(n) The natural analogue for continuous laws is the number K_n(a) of observations in the interval (X_(n)–a, X_(n)], where a > 0. This paper derives general expressions for the law, first moment, and probability generating function of K_n(a), mentioning examples where evaluations can be given. It seeks limit laws for n→ and finds a central limit result when a is fixed and the population law has a finite right extremity. Whenever the population law is attracted to an extremal law, a limit theorem can be found by letting a depend on n in an appropriate manner; thus the limit law is geometric when the extremal law is the Gumbel type. With these results, the paper obtains limit laws for ‘top end’ spacings X_(n) - X_(n-j) with j fixed.     

On approximating point spread distributions

We discuss some properties of the point spread distribution, defined as the distribution of the difference of two independent binomial random variables with the same parameter n including exact and approximate probabilities and related optimization issues. We use various approximation techniques for different distributions, special functions, and analytic, combinatorial and symbolic methods, such as multi-summation techniques. We prove that in case of unequal success rates, if these rates change with their difference kept fixed and small, and n is appropriately bounded, then the point spread distribution only slightly changes for small point differences. We also prove that for equal success rates p, the probability of a tie is minimized if p=1/2. Numerical examples are included for the case with n=12.     

A Note on Dirichlet One-Armed Bandits

One of the two independent stochastic processes (or ‘arms’) is selected and observed sequentially at each of n(≤ ∝) stages. Arm 1 yields observations identically distributed with unknown probability measure P with a Dirichlet process prior whereas observations from arm 2 have known probability measure Q. Future observations are discounted and at stage m, the payoff is a _m(≥0) times the observation Z _m at that stage. The objective is to maximize the total expected payoff. Clayton and Berry (1985) consider this problem when a _m equals 1 for m ≤ n and 0 for m > n(< ∝) In this paper, the Clayton and Berry (1985) results are extended to the case of regular discount sequences of horizon n, which may also be infinite. The results are illustrated with numerical examples. In case of geometric discounting, the results apply to a bandit with many independent unknown Dirichlet arms.     

Bayesian tests for matched proportions

A sample of n subjects is observed in each of two states, S₁-and S₂. In each state, a subject is in one of two conditions, X or Y. Thus, a subject may be recorded as showing a change if its condition in the two states is ‘Y,X’ or ‘X,Y’ and, otherwise, the condition is unchanged. We consider a Bayesian test of the null hypothesis that the probability of an ‘X,Y’ change exceeds that of a ‘Y,X’ change by amount k_O. That is, we develop the posterior distribution of k_O, the difference between the two probabilities and reject the null hypothesis if k lies outside the appropriate posterior probability interval. The performance of the method is assessed by Monte Carlo and other numerical studies and brief tables of exact critical values are presented     

Asymptotics of the Finite-time Ruin Probability for the Sparre Andersen Risk Model Perturbed by an Inflated Stationary Chi-process

In this article, we consider the Sparre Andersen risk model that is perturbed by an inflated chi-process with non-negative random inflator R. Under some conditions on the perturbation and the random inflator, which allow for both small and large fluctuations, exact asymptotic behaviour of the finite-time ruin probability is obtained when initial reserve tends to infinity.     

A Proposed Hybrid Effect Size Plus p-Value Criterion: Empirical Evidence Supporting its Use

ABSTRACT

When the editors of Basic and Applied Social Psychology effectively banned the use of null hypothesis significance testing (NHST) from articles published in their journal, it set off a fire-storm of discussions both supporting the decision and defending the utility of NHST in scientific research. At the heart of NHST is the p-value which is the probability of obtaining an effect equal to or more extreme than the one observed in the sample data, given the null hypothesis and other model assumptions. Although this is conceptually different from the probability of the null hypothesis being true, given the sample, p-values nonetheless can provide evidential information, toward making an inference about a parameter. Applying a 10,000-case simulation described in this article, the authors found that p-values’ inferential signals to either reject or not reject a null hypothesis about the mean (α?=?0.05) were consistent for almost 70% of the cases with the parameter’s true location for the sampled-from population. Success increases if a hybrid decision criterion, minimum effect size plus p-value (MESP), is used. Here, rejecting the null also requires the difference of the observed statistic from the exact null to be meaningfully large or practically significant, in the researcher’s judgment and experience. The simulation compares performances of several methods: from p-value and/or effect size-based, to confidence-interval based, under various conditions of true location of the mean, test power, and comparative sizes of the meaningful distance and population variability. For any inference procedure that outputs a binary indicator, like flagging whether a p-value is significant, the output of one single experiment is not sufficient evidence for a definitive conclusion. Yet, if a tool like MESP generates a relatively reliable signal and is used knowledgeably as part of a research process, it can provide useful information.     

Quantile regression via iterative least squares computations

We present an estimating framework for quantile regression where the usual L ₁-norm objective function is replaced by its smooth parametric approximation. An exact path-following algorithm is derived, leading to the well-known ‘basic’ solutions interpolating exactly a number of observations equal to the number of parameters being estimated. We discuss briefly possible practical implications of the proposed approach, such as early stopping for large data sets, confidence intervals, and additional topics for future research.     

Continuity and Analysis of Sequences of Principal Components

Double arrays of n rows and p columns can be regarded as n drawings from some p-dimensional population. A sequence of such arrays is considered. Principal component analysis for each array forms sequences of sample principal components and eigenvalues. The continuity of these sequences, in the sense of convergence with probability one and convergence in probability, is investigated, that appears to be informative for pattern study and prediction of principal components. Various features of paths of sequences of population principal components are highlighted through an example.     

A modified one-sample test for goodness-of-fit

This paper introduces a modified one-sample test of goodness-of-fit based on the cumulative distribution function. Damico [A new one-sample test for goodness-of-fit. Commun Stat – Theory Methods. 2004;33:181–193] proposed a test for testing goodness-of-fit of univariate distribution that uses the concept of partitioning the probability range into n intervals of equal probability mass 1/n and verifies that the hypothesized distribution evaluated at the observed data would place one case into each interval. The present paper extends this notion by allowing for m intervals of probability mass r/n, where r≥1 and n=m×r. A simulation study for small and moderate sample sizes demonstrates that the proposed test for two observations per interval under various alternatives is more powerful than the test proposed by Damico (2004).     

A Simple Test Procedure When Data are Given by n Indepenent Blocks

In this article we consider a test procedure which is useful in the situations where data are given by n independent blocks and the experimental conditions differ between blocks. The basic idea is very simple. The significance of the sample for each block is calculated and then standardized by its null mean and variance. The sum of standardized significances is proposed as a test statistic. The normal approximation for large n and the exact method for small n are applied in the continuous case. For the discrete case, some devices are also proposed. Several examples are given in order to explain how to apply the procedure.     

Bad Probability,Good Statistics,and Group Testing for Binomial Estimation

This article examines some improperly stated but often used textbook probability problems. Moving from a probabilistic to a statistical setting provides insight into group testing (i.e., observing only whether one or more of a group responds and not the response of each individual). Exact methods are used to construct tables showing (i) that group testing n times to estimate p can be more efficient than n individual tests even for small n and large p, (ii) optimal grouping strategies for various (n, p) combinations, and (iii) the efficiencies and biases achieved.     

A proposal for plotting positions in probability plots

Probability plots allow us to determine whether a set of sample observations is distributed according to a theoretical distribution. Plotting positions are fundamental elements in statistics and, in particular, for the construction of probability plots. In this paper, a new plotting position to construct different probability plots, such as Q–Q Plot, P–P Plot and S–P Plot, is proposed. The proposed definition is based on the median of the ith order statistic of the theoretical distribution considered. The main feature of this plotting position formula is that it is independent of the theoretical distribution selected. Moreover, the procedure developed is ‘almost’ exact, reaching, without a high cost of time, an accuracy as great as we want, which avoids using approximations (proposed by other authors).     

A Bayesian non‐inferiority test for two independent binomial proportions

In drug development, non‐inferiority tests are often employed to determine the difference between two independent binomial proportions. Many test statistics for non‐inferiority are based on the frequentist framework. However, research on non‐inferiority in the Bayesian framework is limited. In this paper, we suggest a new Bayesian index τ = P(π₁ > π₂ ? Δ₀ | X₁,X₂), where X₁ and X₂ denote binomial random variables for trials n₁ and n₂, and parameters π₁ and π₂, respectively, and the non‐inferiority margin is Δ₀ > 0. We show two calculation methods for τ, an approximate method that uses normal approximation and an exact method that uses an exact posterior PDF. We compare the approximate probability with the exact probability for τ. Finally, we present the results of actual clinical trials to show the utility of index τ. Copyright © 2013 John Wiley & Sons, Ltd.     

Comparison of exact tests for association in unordered contingency tables using standard,mid-p,and randomized test versions

Pearson’s chi-square (Pe), likelihood ratio (LR), and Fisher (Fi)–Freeman–Halton test statistics are commonly used to test the association of an unordered r×c contingency table. Asymptotically, these test statistics follow a chi-square distribution. For small sample cases, the asymptotic chi-square approximations are unreliable. Therefore, the exact p-value is frequently computed conditional on the row- and column-sums. One drawback of the exact p-value is that it is conservative. Different adjustments have been suggested, such as Lancaster’s mid-p version and randomized tests. In this paper, we have considered 3×2, 2×3, and 3×3 tables and compared the exact power and significance level of these test’s standard, mid-p, and randomized versions. The mid-p and randomized test versions have approximately the same power and higher power than that of the standard test versions. The mid-p type-I error probability seldom exceeds the nominal level. For a given set of parameters, the power of Pe, LR, and Fi differs approximately the same way for standard, mid-p, and randomized test versions. Although there is no general ranking of these tests, in some situations, especially when averaged over the parameter space, Pe and Fi have the same power and slightly higher power than LR. When the sample sizes (i.e., the row sums) are equal, the differences are small, otherwise the observed differences can be 10% or more. In some cases, perhaps characterized by poorly balanced designs, LR has the highest power.