Conditional tests in a competing risks model

Testing for equality of competing risks based on their cumulative incidence functions (CIFs) or their cause specific hazard rates (CSHRs) has been considered by many authors. The finite sample distributions of the existing test statistics are in general complicated and the use of their asymptotic distributions can lead to conservative tests. In this paper we show how to perform some of these tests using the conditional distributions of their corresponding test statistics instead (conditional on the observed data). The resulting conditional tests are initially developed for the case of k = 2 and are then extended to k > 2 by performing a sequence of two sample tests and by combining several risks into one. A simulation study to compare the powers of several tests based on their conditional and asymptotic distributions shows that using conditional tests leads to a gain in power. A real life example is also discussed to show how to implement such conditional tests.     

Conditional maximum likelihood estimation in negative binomial INGARCH processes with known number of successes when the true parameter is at the boundary of the parameter space

The paper establishes the asymptotic distribution of the conditional maximum likelihood estimator for integer-valued generalized autoregressive conditional heteroskedastic (INGARCH) processes of conditional negative binomial distributions, with the number of successes in the definition of the negative binomial distribution being assumed to be known, when the true parameter is at the boundary of the parameter space. Based on the result, coefficient nullity tests are developed for model simplification. The proposed tests are investigated through a simulation study.     

A class of exact UMP unbiased tests for conditional symmetry in small-sample square contingency tables

Testing conditional symmetry against various alternative diagonals-parameter symmetry models often provides a point of departure in studies of square contingency tables with ordered categories. Typically, chi-square or likelihood-ratio tests are used for such purposes. Since these tests depend on the validity of asymptotic approximation, they may be inappropriate in small-sample situations where exact tests are required. In this paper, we apply the theory of UMP unbiased tests to develop a class of exact tests for conditional symmetry in small samples. Oesophageal cancer and longitudinal income data are used to illustrate the approach.     

Conditional and unconditional tests with historical controls

Score statistics utilizing historical control data have been proposed to test for increasing trend in tumour occurrence rates in laboratory carcinogenicity studies. Novel invariance arguments are used to confirm, under slightly weaker conditions, previously established asymptotic distributions (mixtures of normal distributions) of tests unconditional on the tumor response rate in the concurrent control group. Conditioning on the control response rate, an ancillary statistic, leads to a new conditional limit theorem in which the test statistic converges to an unknown random variable. Because of this, a subasymptotic approximation to the conditional limiting distribution is also considered. The adequacy of these large-sample approximations in finite samples is evaluated using computer simulation. Bootstrap methods for use in finite samples are also proposed. The application of the conditional and unconditional tests is illustrated using bioassay data taken from the literature. The results presented in this paper are used to formulate recommendations for the use of tests for trend with historical controls in practice.     

Detecting parameter shift in garch models

This paper applies recent theories of testing for parameter constancy to the conditional variance in a GARCH model. The supremum Lagrange multiplier test for conditional Gaussian GARCH models and its robustified variants are discussed. The asymptotic null distribution of the test statistics are derived from the weak convergence of the scores, and the critical values from the hitting probability of squared Bessel process.

Monte Carlo studies on the finite sample size and power performance of the supremum LM tests are conducted. Applications of these tests to S&P 500 indicate that the hypothesis of stable conditional variance parameters can be rejected.     

Tests for Equality of Parameters of Two Exponential Distributions with Common Known Coefficient of Variation

ABSTRACT

This article considers the problem of testing equality of parameters of two exponential distributions having common known coefficient of variation, both under unconditional and conditional setup. Unconditional tests based on BLUE'S and LRT are considered. Using the Conditionality Principle of Fisher, an UMP conditional test for one-sided alternative is derived by conditioning on an ancillary. This test is seen to be uniformly more powerful than unconditional tests in certain given ranges of ancillary. Simulation studies on the power functions of the tests are done for this purpose.     

Detecting parameter shift in garch models

This paper applies recent theories of testing for parameter constancy to the conditional variance in a GARCH model. The supremum Lagrange multiplier test for conditional Gaussian GARCH models and its robustified variants are discussed. The asymptotic null distribution of the test statistics are derived from the weak convergence of the scores, and the critical values from the hitting probability of squared Bessel process.

Monte Carlo studies on the finite sample size and power performance of the supremum LM tests are conducted. Applications of these tests to S&P 500 indicate that the hypothesis of stable conditional variance parameters can be rejected.     

Evaluating Multivariate GARCH Models in the Nordic Electricity Markets

ABSTRACT

This article considers a variety of specification tests for multivariate GARCH models that are used for dynamic hedging in electricity markets. The test statistics include the robust conditional moments tests for sign-size bias along with the recently introduced copula tests for an appropriate dependence structure. We consider this effort worthwhile, since quite often the tests of multivariate GARCH models are omitted and the models become selected ad hoc depending on the results they generate. Hedging performance comparisons, in terms of unconditional and conditional ex-post variance portfolio reduction, are conducted.     

The effect of conditional heteroskedasticity on common statistical procedures for means and variances

Summary: Commonly used standard statistical procedures for means and variances (such as the t–test for means or the F–test for variances and related confidence procedures) require observations from independent and identically normally distributed variables. These procedures are often routinely applied to financial data, such as asset or currency returns, which do not share these properties. Instead, they are nonnormal and show conditional heteroskedasticity, hence they are dependent. We investigate the effect of conditional heteroskedasticity (as modelled by GARCH(1,1)) on the level of these tests and the coverage probability of the related confidence procedures. It can be seen that conditional heteroskedasticity has no effect on procedures for means (at least in large samples). There is, however, a strong effect of conditional heteroskedasticity on procedures for variances. These procedures should therefore not be used if conditional heteroskedasticity is prevalent in the data.*We are grateful to the referees for their useful and constructive comments.     

A comparison of some conditional and unconditional exact tests for 2x2 contingency tables

In 1935, R.A. Fisher published his well-known “exact” test for 2x2 contingency tables. This test is based on the conditional distribution of a cell entry when the rows and columns marginal totals are held fixed. Tocher (1950) and Lehmann (1959) showed that Fisher s test, when supplemented by randomization, is uniformly most powerful among all the unbiased tests UMPU). However, since all the practical tests for 2x2 tables are nonrandomized - and therefore biased the UMPU test is not necessarily more powerful than other tests of the same or lower size. Inthis work, the two-sided Fisher exact test and the UMPU test are compared with six nonrandomized unconditional exact tests with respect to their power. In both the two-binomial and double dichotomy models, the UMPU test is often less powerful than some of the unconditional tests of the same (or even lower) size. Thus, the assertion that the Tocher-Lehmann modification of Fisher's conditional test is the optimal test for 2x2 tables is unjustified.     

Exact inference for multivariate ordered alternatives

In this paper we discuss three types of ordered alternatives ordered location, stochastic ordering and quadrant dependence. We prove that quadrant dependence is the more general among the three. Then we consider a conditional tests for the equality of c distributions against quadrant dependence in a multivariate setup. An exact simultaneous testing procedure based on dependent conditional tests is presented. Two applications to real data are also given.     

Correlation-adjusted estimation of sensitivity and specificity of two diagnostic tests

Summary. Models for multiple-test screening data generally require the assumption that the tests are independent conditional on disease state. This assumption may be unreasonable, especially when the biological basis of the tests is the same. We propose a model that allows for correlation between two diagnostic test results. Since models that incorporate test correlation involve more parameters than can be estimated with the available data, posterior inferences will depend more heavily on prior distributions, even with large sample sizes. If we have reasonably accurate information about one of the two screening tests (perhaps the standard currently used test) or the prevalences of the populations tested, accurate inferences about all the parameters, including the test correlation, are possible. We present a model for evaluating dependent diagnostic tests and analyse real and simulated data sets. Our analysis shows that, when the tests are correlated, a model that assumes conditional independence can perform very poorly. We recommend that, if the tests are only moderately accurate and measure the same biological responses, researchers use the dependence model for their analyses.     

On Testing Dependence between Time to Failure and Cause of Failure via Conditional Probabilities

Abstract.  Dependence structures between the failure time and the cause of failure are expressed in terms of the monotonicity properties of the conditional probabilities involving the cause of failure and the failure time. These properties of the conditional probabilities are used for testing four types of departures from the independence of the failure time and the cause of failure and tests based on U -statistics are proposed. In the process, a concept of concordance and discordance between a continuous and a binary variable is introduced to propose a statistical test. The proposed tests are applied to two illustrative applications.     

Comparing two independent incidence rates using conditional and unconditional exact tests

Several unconditional exact tests, which are constructed to control the Type I error rate at the nominal level, for comparing two independent Poisson rates are proposed and compared to the conditional exact test using a binomial distribution. The unconditional exact test using binomial p-value, likelihood ratio, or efficient score as the test statistic improves the power in general, and are therefore recommended. Unconditional exact tests using Wald statistics, whether on the original or square-root scale, may be substantially less powerful than the conditional exact test, and is not recommended. An example is provided from a cardiovascular trial.     

Nonparametric testing for no covariate effects in conditional copulas

In dependence modelling using conditional copulas, one often imposes the working assumption that the covariate influences the conditional copula solely through the marginal distributions. This so-called (pairwise) simplifying assumption is almost standardly made in vine copula constructions. However, in recent literature evidence was provided that such an assumption might not be justified. Among the first issues is thus to test for its appropriateness. In this paper nonparametric tests for the null hypothesis of the simplifying assumption are proposed, and their asymptotic behaviours, under the null hypothesis and under some local alternatives, are established. The tests are fully nonparametric in nature: not requiring choices of copula families nor knowledge of the marginals. In a simulation study, the finite-sample size and power performances of the tests are investigated, and compared with these of the few available tests. A real data application illustrates the use of the tests.     

A resampling procedure for nonparametric combination of several dependent tests

Summary This paper deals with nonparametric methods for combining dependent permutation or randomization tests. Particularly, they are nonparametric with respect to the underlying dependence structure. The methods are based on a without replacement resampling procedure (WRRP) conditional on the observed data, also called conditional simulation, which provide suitable estimates, as good as computing time permits, of the permutational distribution of any statistic. A class C of combining functions is characterized in such a way that all its members, under suitable and reasonable conditions, are found to be consistent and unbiased. Moreover, for some of its members, their almost sure asymptotic equivalence with respect to best tests, in particular cases, is shown. An applicational example to a multivariate permutationalt-paired test is also discussed.     

Comparing two poisson parameters: what to do when the optimal isn't done

Suppose two Poisson processes with rates γ₁ and γ₂ are observed for fixed times t_l and t₂. This paper considers hypothesis tests and confidence intervals for the parameter ρ = γ₂/γ₁. Uniformly most powerful unbiased tests and uniformly most accurate unbiased confidence intervals exist for ρ, but they require randomization and so are not used in practice. Several alternative procedures have been proposed. In the context of one-sided hypothesis tests these procedures are reviewed and compared on numerical grounds and by use of the conditionality and repeated sampling principles. It is argued that a conditional binomial test which rejects with conditional level closest to but not necessarily less than, the nominal a is the most reasonable. This test is different from the usual conditional binomial test which rejects with conditional level closeset to but less than or equal to the nominal α Numerical results indicate that an approximate procedure based on the Poisson variance stabilizing transformation has properties similar to the preferred conditional binomial test. Values for λ₁ = t₁λ₁ required to achieve a specified power are considered. These results are also discussed in terms of test inversion to obtain confidence intervals.     

Analysis of reliability characteristics in the acceptance sampling tests

Until now, various acceptance reliability sampling plans have been developed based on different life tests of items. However, the statistical effect of the acceptance sampling tests on the reliability characteristic of the lots accepted in the test has not been appropriately addressed. In this paper, we deal with an acceptance reliability sampling plan under a ‘general framework’ and discuss the corresponding statistical effect of the acceptance sampling tests. The lifetime of the population before the acceptance test and that of population ‘conditional on the acceptance’ in the sampling test are stochastically compared. The improvement of reliability characteristics of the population conditional on the acceptance in the sampling test is precisely analyzed.     

A review and some new results on permutation testing for multivariate problems

In recent years permutation testing methods have increased both in number of applications and in solving complex multivariate problems. When available permutation tests are essentially of an exact nonparametric nature in a conditional context, where conditioning is on the pooled observed data set which is often a set of sufficient statistics in the null hypothesis. Whereas, the reference null distribution of most parametric tests is only known asymptotically. Thus, for most sample sizes of practical interest, the possible lack of efficiency of permutation solutions may be compensated by the lack of approximation of parametric counterparts. There are many complex multivariate problems, quite common in empirical sciences, which are difficult to solve outside the conditional framework and in particular outside the method of nonparametric combination (NPC) of dependent permutation tests. In this paper we review such a method and its main properties along with some new results in experimental and observational situations (robust testing, multi-sided alternatives and testing for survival functions).