Asymptotic equivalence between two empirical mean residual life processes

There are two mean residual life estimates for right censored data. One is based on the Kaplan-Meier estimate, the other, based on the Susarla-Van Ryzin estimate for survival function. In this paper, we define the empirical mean residual life process for right censored data and show that the two empirical mean residual life processes based on the Kaplan-Meier and Susarla-Van Ryzin estimates are asymptotically equivalent uniformly on an interval under some conditions. Also we discuss the case which the asymptotic equivalence might fail.     

Inference based on progressive Type I interval censored data from log-normal distribution

This article considers inference for the log-normal distribution based on progressive Type I interval censored data by both frequentist and Bayesian methods. First, the maximum likelihood estimates (MLEs) of the unknown model parameters are computed by expectation-maximization (EM) algorithm. The asymptotic standard errors (ASEs) of the MLEs are obtained by applying the missing information principle. Next, the Bayes’ estimates of the model parameters are obtained by Gibbs sampling method under both symmetric and asymmetric loss functions. The Gibbs sampling scheme is facilitated by adopting a similar data augmentation scheme as in EM algorithm. The performance of the MLEs and various Bayesian point estimates is judged via a simulation study. A real dataset is analyzed for the purpose of illustration.     

Selection of suitable prior for the Bayesian mixture of a class of lifetime distributions under type-I censored datasets

This paper explores the study on mixture of a class of probability density functions under type-I censoring scheme. In this paper, we mold a heterogeneous population by means of a two-component mixture of the class of probability density functions. The parameters of the class of mixture density functions are estimated and compared using the Bayes estimates under the squared-error and precautionary loss functions. A censored mixture dataset is simulated by probabilistic mixing for the computational purpose considering particular case of the Maxwell distribution. Closed-form expressions for the Bayes estimators along with their posterior risks are derived for censored as well as complete samples. Some stimulating comparisons and properties of the estimates are presented here. A factual dataset has also been for illustration.     

Bayesian and maximum likelihood estimations of the inverted exponentiated half logistic distribution under progressive Type II censoring

In this paper, the estimation of parameters, reliability and hazard functions of a inverted exponentiated half logistic distribution (IEHLD) from progressive Type II censored data has been considered. The Bayes estimates for progressive Type II censored IEHLD under asymmetric and symmetric loss functions such as squared error, general entropy and linex loss function are provided. The Bayes estimates for progressive Type II censored IEHLD parameters, reliability and hazard functions are also obtained under the balanced loss functions. However, the Bayes estimates cannot be obtained explicitly, Lindley approximation method and importance sampling procedure are considered to obtain the Bayes estimates. Furthermore, the asymptotic normality of the maximum likelihood estimates is used to obtain the approximate confidence intervals. The highest posterior density credible intervals of the parameters based on importance sampling procedure are computed. Simulations are performed to see the performance of the proposed estimates. For illustrative purposes, two data sets have been analyzed.     

Bayesian prediction of unobserved values for Type-II censored data

In this paper, we consider posterior predictive distributions of Type-II censored data for an inverse Weibull distribution. These functions are given by using conditional density functions and conditional survival functions. Although the conditional survival functions were expressed by integral forms in previous studies, we derive the conditional survival functions in closed forms and thereby reduce the computation cost. In addition, we calculate the predictive confidence intervals of unobserved values and coverage probabilities of unobserved values by using the posterior predictive survival functions.     

A Quantile Survival Model for Censored Data

In this paper we propose a quantile survival model to analyze censored data. This approach provides a very effective way to construct a proper model for the survival time conditional on some covariates. Once a quantile survival model for the censored data is established, the survival density, survival or hazard functions of the survival time can be obtained easily. For illustration purposes, we focus on a model that is based on the generalized lambda distribution (GLD). The GLD and many other quantile function models are defined only through their quantile functions, no closed‐form expressions are available for other equivalent functions. We also develop a Bayesian Markov Chain Monte Carlo (MCMC) method for parameter estimation. Extensive simulation studies have been conducted. Both simulation study and application results show that the proposed quantile survival models can be very useful in practice.     

Simultaneous estimation for non-crossing multiple quantile regression with right censored data

In this paper, we consider the estimation problem of multiple conditional quantile functions with right censored survival data. To account for censoring in estimating a quantile function, weighted quantile regression (WQR) has been developed by using inverse-censoring-probability weights. However, the estimated quantile functions from the WQR often cross each other and consequently violate the basic properties of quantiles. To avoid quantile crossing, we propose non-crossing weighted multiple quantile regression (NWQR), which estimates multiple conditional quantile functions simultaneously. We further propose the adaptive sup-norm regularized NWQR (ANWQR) to perform simultaneous estimation and variable selection. The large sample properties of the NWQR and ANWQR estimators are established under certain regularity conditions. The proposed methods are evaluated through simulation studies and analysis of a real data set.     

Comparisons of methods of estimation for a pareto distribution of the first kind

This paper compares methods of estimation for the parameters of a Pareto distribution of the first kind to determine which method provides the better estimates when the observations are censored, The unweighted least squares (LS) and the maximum likelihood estimates (MLE) are presented for both censored and uncensored data. The MLE's are obtained using two methods, In the first, called the ML method, it is shown that log-likelihood is maximized when the scale parameter is the minimum sample value. In the second method, called the modified ML (MML) method, the estimates are found by utilizing the maximum likelihood value of the shape parameter in terms of the scale parameter and the equation for the mean of the first order statistic as a function of both parameters. Since censored data often occur in applications, we study two types of censoring for their effects on the methods of estimation: Type II censoring and multiple random censoring. In this study we consider different sample sizes and several values of the true shape and scale parameters.

Comparisons are made in terms of bias and the mean squared error of the estimates. We propose that the LS method be generally preferred over the ML and MML methods for estimating the Pareto parameter γ for all sample sizes, all values of the parameter and for both complete and censored samples. In many cases, however, the ML estimates are comparable in their efficiency, so that either estimator can effectively be used. For estimating the parameter α, the LS method is also generally preferred for smaller values of the parameter (α ≤4). For the larger values of the parameter, and for censored samples, the MML method appears superior to the other methods with a slight advantage over the LS method. For larger values of the parameter α, for censored samples and all methods, underestimation can be a problem.     

Inference for mixed generalized exponential distribution under progressively type-II censored samples

In industrial life tests, reliability analysis and clinical trials, the type-II progressive censoring methodology, which allows for random removals of the remaining survival units at each failure time, has become quite popular for analyzing lifetime data. Parameter estimation under progressively type-II censored samples for many common lifetime distributions has been investigated extensively. However, how to estimate unknown parameters of the mixed distribution models under progressive type-II censoring schemes is still a challenging and interesting problem. Based on progressively type-II censored samples, this paper addresses the estimation problem of mixed generalized exponential distributions. In addition, it is observed that the maximum-likelihood estimates (MLEs) cannot be easily obtained in closed form due to the complexity of the likelihood function. Thus, we make good use of the expectation-maximization algorithm to obtain the MLEs. Finally, some simulations are implemented in order to show the performance of the proposed method under finite samples and a case analysis is illustrated.     

Inference for Burr XII distribution under Type I progressive hybrid censoring

We consider estimation of unknown parameters of a Burr XII distribution based on progressively Type I hybrid censored data. The maximum likelihood estimates are obtained using an expectation maximization algorithm. Asymptotic interval estimates are constructed from the Fisher information matrix. We obtain Bayes estimates under the squared error loss function using the Lindley method and Metropolis–Hastings algorithm. The predictive estimates of censored observations are obtained and the corresponding prediction intervals are also constructed. We compare the performance of the different methods using simulations. Two real datasets have been analyzed for illustrative purposes.     

The competing risks analysis for parallel and series systems using Type-II progressive censoring

Abstract

Recently, the study of the lifetime of systems in reliability and survival analysis in the presence of several causes of failure (competing risks) has attracted attention in the literature. In this paper, series and parallel systems with exponential lifetime for each item of the system are considered. Several causes of failure independently affect lifetime distributions and observations of failure times of the systems are considered under progressive Type-II censored scheme. For series systems, the maximum likelihood estimates of parameters are computed and confidence intervals for parameters of the model are obtained using Fisher information matrix. For parallel systems, the generalized EM algorithm which uses the Newton-Raphson algorithm inside the EM algorithm is used to compute the maximum likelihood estimates of parameters. Also, the standard errors of the maximum likelihood estimates are computed by using the supplemented EM algorithm. The simulation study confirms the good performance of the introduced approach.     

Multiple imputation of censored survival data in the presence of missing covariates using restricted mean survival time

Missing covariates data with censored outcomes put a challenge in the analysis of clinical data especially in small sample settings. Multiple imputation (MI) techniques are popularly used to impute missing covariates and the data are then analyzed through methods that can handle censoring. However, techniques based on MI are available to impute censored data also but they are not much in practice. In the present study, we applied a method based on multiple imputation by chained equations to impute missing values of covariates and also to impute censored outcomes using restricted survival time in small sample settings. The complete data were then analyzed using linear regression models. Simulation studies and a real example of CHD data show that the present method produced better estimates and lower standard errors when applied on the data having missing covariate values and censored outcomes than the analysis of the data having censored outcome but excluding cases with missing covariates or the analysis when cases with missing covariate values and censored outcomes were excluded from the data (complete case analysis).     

Estimation for an inverted exponentiated Rayleigh distribution under type II progressive censoring

In this paper, we consider estimation of unknown parameters of an inverted exponentiated Rayleigh distribution under type II progressive censored samples. Estimation of reliability and hazard functions is also considered. Maximum likelihood estimators are obtained using the Expectation–Maximization (EM) algorithm. Further, we obtain expected Fisher information matrix using the missing value principle. Bayes estimators are derived under squared error and linex loss functions. We have used Lindley, and Tiernery and Kadane methods to compute these estimates. In addition, Bayes estimators are computed using importance sampling scheme as well. Samples generated from this scheme are further utilized for constructing highest posterior density intervals for unknown parameters. For comparison purposes asymptotic intervals are also obtained. A numerical comparison is made between proposed estimators using simulations and observations are given. A real-life data set is analyzed for illustrative purposes.     

Estimation for the generalized half-normal distribution based on progressive type-II censoring

Based on progressively type-II censored data, the problem of estimating unknown parameters and reliability function of a two-parameter generalized half-normal distribution is considered. Maximum likelihood estimates are obtained by applying expectation-maximization algorithm. Since they do not have closed forms, approximate maximum likelihood estimators are proposed. Several Bayesian estimates with respect to different symmetric and asymmetric loss functions such as squared error, LINEX and general entropy are calculated. The Lindley approximation method is applied to determine Bayesian estimates. Monte Carlo simulations are performed to compare the performances of the different methods. Finally, one real data set is analysed.     

Cure rate survival models with missing covariates: a simulation study

In this paper we study the cure rate survival model involving a competitive risk structure with missing categorical covariates. A parametric distribution that can be written as a sequence of one-dimensional conditional distributions is specified for the missing covariates. We consider the missing data at random situation so that the missing covariates may depend only on the observed ones. Parameter estimates are obtained by using the EM algorithm via the method of weights. Extensive simulation studies are conducted and reported to compare estimates efficiency with and without missing data. As expected, the estimation approach taking into consideration the missing covariates presents much better efficiency in terms of mean square errors than the complete case situation. Effects of increasing cured fraction and censored observations are also reported. We demonstrate the proposed methodology with two real data sets. One involved the length of time to obtain a BS degree in Statistics, and another about the time to breast cancer recurrence.     

Robust inference for generalized partially linear mixed models that account for censored responses and missing covariates – an application to Arctic data analysis

In this article, we propose a family of bounded influence robust estimates for the parametric and non-parametric components of a generalized partially linear mixed model that are subject to censored responses and missing covariates. The asymptotic properties of the proposed estimates have been looked into. The estimates are obtained by using Monte Carlo expectation–maximization algorithm. An approximate method which reduces the computational time to a great extent is also proposed. A simulation study shows that performances of the two approaches are similar in terms of bias and mean square error. The analysis is illustrated through a study on the effect of environmental factors on the phytoplankton cell count.     

On the Bayesian inference of Kumaraswamy distributions based on censored samples

In this article we discuss Bayesian estimation of Kumaraswamy distributions based on three different types of censored samples. We obtain Bayes estimates of the model parameters using two different types of loss functions (LINEX and Quadratic) under each censoring scheme (left censoring, singly type-II censoring, and doubly type-II censoring) using Monte Carlo simulation study with posterior risk plots for each different choices of the model parameters. Also, detailed discussion regarding elicitation of the hyperparameters under the dependent prior setup is discussed. If one of the shape parameters is known then closed form expressions of the Bayes estimates corresponding to posterior risk under both the loss functions are available. To provide the efficacy of the proposed method, a simulation study is conducted and the performance of the estimation is quite interesting. For illustrative purpose, real-life data are considered.     

Bivariate modelling of longitudinal measurements of two human immunodeficiency type 1 disease progression markers in the presence of informative drop-outs

Summary.  The main statistical problem in many epidemiological studies which involve repeated measurements of surrogate markers is the frequent occurrence of missing data. Standard likelihood-based approaches like the linear random-effects model fail to give unbiased estimates when data are non-ignorably missing. In human immunodeficiency virus (HIV) type 1 infection, two markers which have been widely used to track progression of the disease are CD4 cell counts and HIV–ribonucleic acid (RNA) viral load levels. Repeated measurements of these markers tend to be informatively censored, which is a special case of non-ignorable missingness. In such cases, we need to apply methods that jointly model the observed data and the missingness process. Despite their high correlation, longitudinal data of these markers have been analysed independently by using mainly random-effects models. Touloumi and co-workers have proposed a model termed the joint multivariate random-effects model which combines a linear random-effects model for the underlying pattern of the marker with a log-normal survival model for the drop-out process. We extend the joint multivariate random-effects model to model simultaneously the CD4 cell and viral load data while adjusting for informative drop-outs due to disease progression or death. Estimates of all the model's parameters are obtained by using the restricted iterative generalized least squares method or a modified version of it using the EM algorithm as a nested algorithm in the case of censored survival data taking also into account non-linearity in the HIV–RNA trend. The method proposed is evaluated and compared with simpler approaches in a simulation study. Finally the method is applied to a subset of the data from the 'Concerted action on seroconversion to AIDS and death in Europe' study.     

On self-consistent estimators and kernel density estimators with doubly censored data

We study the detailed structure (in a large sample) of the self-consistent estimators of the survival functions with doubly censored data. We also introduce the kernel-type density estimators based on the self-consistent estimators, and using our results on the structure of the self-consistent estimators, we establish the strong uniform consistency and the asymptotic normality of the kernel density estimators for doubly censored data. From these, the strong uniform consistency and the asymptotic normality of the failure rate estimators for doubly censored data are derived.