Third-order likelihood-based inference for the log-normal regression model

This paper examines the general third-order theory to the log-normal regression model. The interest parameter is its conditional mean. For inference, traditional first-order approximations need large sample sizes and normal-like distributions. Some specific third-order methods need the explicit forms of the nuisance parameter and ancillary statistic, which are quite complicated. Note that this general third-order theory can be applied to any continuous models with standard asymptotic properties. It only needs the log-likelihood function. With small sample settings, the simulation studies for confidence intervals of the conditional mean illustrate that the general third-order theory is much superior to the traditional first-order methods.     

Simultaneous inferences for variance ratios of some mixed linear models

Earlier investigations used a one-sided inequality to consltuct confidence regions for the variance ratios or balanced randoiu models. In this study, confidence regions are based on a two-sided generalisation of this inequality and the results are illustrated by estimating the parameters of some elementary random models.     

Generalized confidence intervals for proportions of total variance in mixed linear models

Exact confidence intervals for a proportion of total variance, based on pivotal quantities, only exist for mixed linear models having two variance components. Generalized confidence intervals (GCIs) introduced by Weerahandi [1993. Generalized confidence intervals (Corr: 94V89 p726). J. Am. Statist. Assoc. 88, 899–905] are based on generalized pivotal quantities (GPQs) and can be constructed for a much wider range of models. In this paper, the author investigates the coverage probabilities, as well as the utility of GCIs, for a proportion of total variance in mixed linear models having more than two variance components. Particular attention is given to the formation of GPQs and GCIs in mixed linear models having three variance components in situations where the data exhibit complete balance, partial balance, and partial imbalance. The GCI procedure is quite general and provides a useful method to construct confidence intervals in a variety of applications.     

Likelihood ratio tests for variance components in linear mixed models

Although the asymptotic distributions of the likelihood ratio for testing hypotheses of null variance components in linear mixed models derived by Stram and Lee [1994. Variance components testing in longitudinal mixed effects model. Biometrics 50, 1171–1177] are valid, their proof is based on the work of Self and Liang [1987. Asymptotic properties of maximum likelihood estimators and likelihood tests under nonstandard conditions. J. Amer. Statist. Assoc. 82, 605–610] which requires identically distributed random variables, an assumption not always valid in longitudinal data problems. We use the less restrictive results of Vu and Zhou [1997. Generalization of likelihood ratio tests under nonstandard conditions. Ann. Statist. 25, 897–916] to prove that the proposed mixture of chi-squared distributions is the actual asymptotic distribution of such likelihood ratios used as test statistics for null variance components in models with one or two random effects. We also consider a limited simulation study to evaluate the appropriateness of the asymptotic distribution of such likelihood ratios in moderately sized samples.     

A note on inference for P(X < Y) for right truncated exponentially distributed data

In this paper, a likelihood based analysis is developed and applied to obtain confidence intervals and p values for the stress-strength reliability R  =  P(X  <  Y) with right truncated exponentially distributed data. The proposed method is based on theory given in Fraser et al. (Biometrika 86:249–264, 1999) which involves implicit but appropriate conditioning and marginalization. Monte Carlo simulations are used to illustrate the accuracy of the proposed method.     

Likelihood ratio tests in linear mixed models with one variance component

Summary.  We consider the problem of testing null hypotheses that include restrictions on the variance component in a linear mixed model with one variance component and we derive the finite sample and asymptotic distribution of the likelihood ratio test and the restricted likelihood ratio test. The spectral representations of the likelihood ratio test and the restricted likelihood ratio test statistics are used as the basis of efficient simulation algorithms of their null distributions. The large sample χ ² mixture approximations using the usual asymptotic theory for a null hypothesis on the boundary of the parameter space have been shown to be poor in simulation studies. Our asymptotic calculations explain these empirical results. The theory of Self and Liang applies only to linear mixed models for which the data vector can be partitioned into a large number of independent and identically distributed subvectors. One-way analysis of variance and penalized splines models illustrate the results.     

Confidence intervals for variance components in unbalanced one-way random effects model using non-normal distributions

In scenarios where the variance of a response variable can be attributed to two sources of variation, a confidence interval for a ratio of variance components gives information about the relative importance of the two sources. For example, if measurements taken from different laboratories are nine times more variable than the measurements taken from within the laboratories, then 90% of the variance in the responses is due to the variability amongst the laboratories and 10% of the variance in the responses is due to the variability within the laboratories. Assuming normally distributed sources of variation, confidence intervals for variance components are readily available. In this paper, however, simulation studies are conducted to evaluate the performance of confidence intervals under non-normal distribution assumptions. Confidence intervals based on the pivotal quantity method, fiducial inference, and the large-sample properties of the restricted maximum likelihood (REML) estimator are considered. Simulation results and an empirical example suggest that the REML-based confidence interval is favored over the other two procedures in unbalanced one-way random effects model.     

Sums of squares and products matrices for a non-full ranks hypothesis in the model of potthoff and roy

Formulae for sums of squares and products matrices, useful in testing a general linear hypothesis in the model of POTTHOFF and ROY, are given, Contrary to the customary approach, these formulae are expressed in original terms of the design matrices and the matrices formulating the hypothesis. They are applicable regardless of the ranks of the matrices involved, which allows to avoid a transformation of the hypothesis and a repara-metrization of the model.     

A simultaneous variable selection methodology for linear mixed models

Selecting an appropriate structure for a linear mixed model serves as an appealing problem in a number of applications such as in the modelling of longitudinal or clustered data. In this paper, we propose a variable selection procedure for simultaneously selecting and estimating the fixed and random effects. More specifically, a profile log-likelihood function, along with an adaptive penalty, is utilized for sparse selection. The Newton-Raphson optimization algorithm is performed to complete the parameter estimation. By jointly selecting the fixed and random effects, the proposed approach increases selection accuracy compared with two-stage procedures, and the usage of the profile log-likelihood can improve computational efficiency in one-stage procedures. We prove that the proposed procedure enjoys the model selection consistency. A simulation study and a real data application are conducted for demonstrating the effectiveness of the proposed method.     

Bootstrap tests for variance components in generalized linear mixed models

In many applications of generalized linear mixed models to clustered correlated or longitudinal data, often we are interested in testing whether a random effects variance component is zero. The usual asymptotic mixture of chi‐square distributions of the score statistic for testing constrained variance components does not necessarily hold. In this article, the author proposes and explores a parametric bootstrap test that appears to be valid based on its estimated level of significance under the null hypothesis. Results from a simulation study indicate that the bootstrap test has a level much closer to the nominal one while the asymptotic test is conservative, and is more powerful than the usual asymptotic score test based on a mixture of chi‐squares. The proposed bootstrap test is illustrated using two sets of real‐life data obtained from clinical trials. The Canadian Journal of Statistics © 2009 Statistical Society of Canada     

Confidence intervals for the between group variance in the unbalanced one-way random effects model of anaylsis of variance

A confidence interval for the between group variance is proposed which is deduced from Wald'sexact confidence interval for the rtio of the two variance components in the one-way random effects model and the exact confidence interval for the error variance resp.an unbiased estimator of the error variance. In a simulation study the confidence coeffecients for these two intervals are compared with the confidence coefficients of two other commonly used confidence intervals. There the confidence interval derived here yields confidence coefficiends which are always greater than the prescriped level.     

Confidence intervals and tests on the variance ratio in random models with two variance components

The LM test is modified to test any value of the ratio of two variance components in a mixed effects linear model with two variance components. The test is exact, so it can be used to construct exact confidence intervals on this ratio.Exact Neyman-Pearson (NP) tests on the variance ratio are described.Their powers provide attainable upper bounds on powers of tests on the variance ratio.Efficiencies of LM tests, which include ANOVA tests, and NP tests are compared for unbalanced, random, one-way ANOVA models.Confidence intervals corresponding to LM tests and NP tests are described.     

Counterexamples to a result of broemeling on simultaneous inferences for variance ratios of some mixed linear models

In a recent paper5 Broemeling (1978) extended his earlier work on one-sided confidence regions for the variance ratios of balanced random-effects models to the two-sided case. The extension depends on a probability Inequality which was claimed to be tru We show here that it is false, hence the proof of the main result given in Ms parer is in error W also show Lhat the ntatement of his result remains true in certain special cases.     

Approximate confidence bounds for ratios of variance components in two-way unbalanced crossed models with interactions

Consider the general unbalanced two-factor crossed components-of-variance model with interaction given by Y_ijk: = μ+A_i: +B_j: + C_ij: +E_ijk: (i = 1,2, … a; j = 1,…,b; k = 1,…,.n_ij:=0) A_i:,B_j:, C_ij: and E_ijk: are independent unobservable random variables. Also A_i:sim; N(0,σ² _A),B_j: ～ N(0,σ² _B), C_ij:～N(0,s² _C:) and E_ijk:～N(0,s² _E:). In this paper approximate confidence bounds are obtained for ρ_A: = ρ² _A/² and ρ_B: = ρ² _B:/ρ² (where σ² = σ² _A:+ σ² _B+σ² _Cσ² _E) for special cases of the above model. The balanced incomplete block model is studied as a special case.     

Analysis of generalized linear mixed models via a stochastic approximation algorithm with Markov chain Monte-Carlo method

In recent years much effort has been devoted to maximum likelihood estimation of generalized linear mixed models. Most of the existing methods use the EM algorithm, with various techniques in handling the intractable E-step. In this paper, a new implementation of a stochastic approximation algorithm with Markov chain Monte Carlo method is investigated. The proposed algorithm is computationally straightforward and its convergence is guaranteed. A simulation and three real data sets, including the challenging salamander data, are used to illustrate the procedure and to compare it with some existing methods. The results indicate that the proposed algorithm is an attractive alternative for problems with a large number of random effects or with high dimensional intractable integrals in the likelihood function.     

Bayesian inference for the variance components in general mixed linear models

The general mixed linear model, containing both the fixed and random effects, is considered. Using gamma priors for the variance components, the conditional posterior distributions of the fixed effects and the variance components, conditional on the random effects, are obtained. Using the normal approximation for the multiple t distribution, approximations are obtained for the posterior distributions of the variance components in infinite series form. The same approximation Is used to obtain closed expressions for the moments of the variance components. An example is considered to illustrate the procedure and a numerical study examines the closeness of the approximations.     

Invariant methods for estimating variance components in mixed linear models 2

The subject of this contribution is to present a survey on new methods for variance component estimation, which appeared in the literature in recent years. Starting from mixed models treated in analysis of variance research work on this field turned over to a more general approach in which the covariance matrix of the vector of observations is assumed to be a unknown linear combination of known symmetric matrices. Much interest has been shown in developing some kinds op optimal estimators for the unknown parameters and most results were obtained for estimators being invariant with respect to a certain group of translations. Therefore we restrict attention to this class of estimates. We will deal with minimum variance unbiased estimators, least squared errors estimators, maximum likelihood estimators. Bayes quadratic estimators and show some relations to the mimimum norm quadratic unbiased estimation principle (MINQUE) introduced by C. R. Rao [20]. We do not mention the original motivation of MINQUE since the otion of minimum norm depends on a measure that is not accepted by all statisticians. Also we do‘nt deal with other approaches like the BAYEsian and fiducial methods which were successfully applied by S. Portnoy [18], P. Rusolph [22], G. C. Tiao, W. Y. Tan [28], M. J. K. Healy [9] and others, although in very special situations, only. Additionally we add some new results and also new insight in the properties of known estimators. We give a new characterization of MINQUE in the class of all estimators, extend explicite expressions for locally optimal quadratic estimators given by C. R. Rao [22] to a slightly more general situation and prove complete class theorems useful for the computation of BAYES quadratic estimators. We also investigate situations in which BAYES quadratic unbiased estimators do'nt change if the distribution of the error terms differ from the normal distribution.