Pseudo-empirical Bayes estimation of small area means under a nested error linear regression model with functional measurement errors

Small area estimation is studied under a nested error linear regression model with area level covariate subject to measurement error. Ghosh and Sinha (2007) obtained a pseudo-Bayes (PB) predictor of a small area mean and a corresponding pseudo-empirical Bayes (PEB) predictor, using the sample means of the observed covariate values to estimate the true covariate values. In this paper, we first derive an efficient PB predictor by using all the available data to estimate true covariate values. We then obtain a corresponding PEB predictor and show that it is asymptotically “optimal”. In addition, we employ a jackknife method to estimate the mean squared prediction error (MSPE) of the PEB predictor. Finally, we report the results of a simulation study on the performance of our PEB predictor and associated jackknife MSPE estimator. Our results show that the proposed PEB predictor can lead to significant gain in efficiency over the previously proposed PEB predictor. Area level models are also studied.     

Empirical Bayes Estimation of Small Area Means under a Nested Error Linear Regression Model with Measurement Errors in the Covariates

Abstract.  Previously, small area estimation under a nested error linear regression model was studied with area level covariates subject to measurement error. However, the information on observed covariates was not used in finding the Bayes predictor of a small area mean. In this paper, we first derive the fully efficient Bayes predictor by utilizing all the available data. We then estimate the regression and variance component parameters in the model to get an empirical Bayes (EB) predictor and show that the EB predictor is asymptotically optimal. In addition, we employ the jackknife method to obtain an estimator of mean squared prediction error (MSPE) of the EB predictor. Finally, we report the results of a simulation study on the performance of our EB predictor and associated jackknife MSPE estimators. Our results show that the proposed EB predictor can lead to significant gain in efficiency over the previously proposed EB predictor.     

A pseudo‐empirical best linear unbiased prediction approach to small area estimation using survey weights

The authors develop a small area estimation method using a nested error linear regression model and survey weights. In particular, they propose a pseudo‐empirical best linear unbiased prediction (pseudo‐EBLUP) estimator to estimate small area means. This estimator borrows strength across areas through the model and makes use of the survey weights to preserve the design consistency as the area sample size increases. The proposed estimator also has a nice self‐benchmarking property. The authors also obtain an approximation to the model mean squared error (MSE) of the proposed estimator and a nearly unbiased estimator of MSE. Finally, they compare the proposed estimator with the EBLUP estimator and the pseudo‐EBLUP estimator proposed by Prasad & Rao (1999), using data analyzed earlier by Battese, Harter & Fuller (1988).     

On Mean Squared Prediction Error Estimation in Small Area Estimation Problems

For a general linear mixed normal model, a new linearized weighted jackknife method is proposed to estimate the mean squared prediction error (MSPE) of an empirical best linear unbiased predictor (EBLUP) of a general mixed effect. Different MSPE estimators are compared using a Monte Carlo simulation study.     

Bayesian Estimators for Small Area Models when Auxiliary Information is Measured with Error

Small area estimators in linear models are typically expressed as a convex combination of direct estimators and synthetic estimators from a suitable model. When auxiliary information used in the model is measured with error, a new estimator, accounting for the measurement error in the covariates, has been proposed in the literature. Recently, for area‐level model, Ybarra & Lohr (Biometrika, 95, 2008, 919) suggested a suitable modification to the estimates of small area means based on Fay & Herriot (J. Am. Stat. Assoc., 74, 1979, 269) model where some of the covariates are measured with error. They used a frequentist approach based on the method of moments. Adopting a Bayesian approach, we propose to rewrite the measurement error model as a hierarchical model; we use improper non‐informative priors on the model parameters and show, under a mild condition, that the joint posterior distribution is proper and the marginal posterior distributions of the model parameters have finite variances. We conduct a simulation study exploring different scenarios. The Bayesian predictors we propose show smaller empirical mean squared errors than the frequentist predictors of Ybarra & Lohr (Biometrika, 95, 2008, 919), and they seem also to be more stable in terms of variability and bias. We apply the proposed methodology to two real examples.     

Mean squared error estimators of small area means using survey weights

Using survey weights, You & Rao [You and Rao, The Canadian Journal of Statistics 2002; 30, 431–439] proposed a pseudo‐empirical best linear unbiased prediction (pseudo‐EBLUP) estimator of a small area mean under a nested error linear regression model. This estimator borrows strength across areas through a linking model, and makes use of survey weights to ensure design consistency and preserve benchmarking property in the sense that the estimators add up to a reliable direct estimator of the mean of a large area covering the small areas. In this article, a second‐order approximation to the mean squared error (MSE) of the pseudo‐EBLUP estimator of a small area mean is derived. Using this approximation, an estimator of MSE that is nearly unbiased is derived; the MSE estimator of You & Rao [You and Rao, The Canadian Journal of Statistics 2002; 30, 431–439] ignored cross‐product terms in the MSE and hence it is biased. Empirical results on the performance of the proposed MSE estimator are also presented. The Canadian Journal of Statistics 38: 598–608; 2010 © 2010 Statistical Society of Canada     

Prediction in multilevel generalized linear models

Summary.  We discuss prediction of random effects and of expected responses in multilevel generalized linear models. Prediction of random effects is useful for instance in small area estimation and disease mapping, effectiveness studies and model diagnostics. Prediction of expected responses is useful for planning, model interpretation and diagnostics. For prediction of random effects, we concentrate on empirical Bayes prediction and discuss three different kinds of standard errors; the posterior standard deviation and the marginal prediction error standard deviation (comparative standard errors) and the marginal sampling standard deviation (diagnostic standard error). Analytical expressions are available only for linear models and are provided in an appendix . For other multilevel generalized linear models we present approximations and suggest using parametric bootstrapping to obtain standard errors. We also discuss prediction of expectations of responses or probabilities for a new unit in a hypothetical cluster, or in a new (randomly sampled) cluster or in an existing cluster. The methods are implemented in gllamm and illustrated by applying them to survey data on reading proficiency of children nested in schools. Simulations are used to assess the performance of various predictions and associated standard errors for logistic random-intercept models under a range of conditions.     

MODEL‐BASED DIRECT ESTIMATION OF SMALL‐AREA DISTRIBUTIONS

Much of the small‐area estimation literature focuses on population totals and means. However, users of survey data are often interested in the finite‐population distribution of a survey variable and in the measures (e.g. medians, quartiles, percentiles) that characterize the shape of this distribution at the small‐area level. In this paper we propose a model‐based direct estimator (MBDE, Chandra and Chambers) of the small‐area distribution function. The MBDE is defined as a weighted sum of sample data from the area of interest, with weights derived from the calibrated spline‐based estimate of the finite‐population distribution function introduced by Harms and Duchesne, under an appropriately specified regression model with random area effects. We also discuss the mean squared error estimation of the MBDE. Monte Carlo simulations based on both simulated and real data sets show that the proposed MBDE and its associated mean squared error estimator perform well when compared with alternative estimators of the area‐specific finite‐population distribution function.     

Benchmarked linear shrinkage prediction in the Fay–Herriot small area model

The empirical best linear unbiased predictor (EBLUP) is a linear shrinkage of the direct estimate toward the regression estimate and useful for the small area estimation in the sense of increasing precision of estimation of small area means. However, one potential difficulty of EBLUP is that the overall estimate for a larger geographical area based on a sum of EBLUP is not necessarily identical to the corresponding direct estimate like the overall sample mean. To fix this problem, the paper suggests a new method for benchmarking EBLUP in the Fay–Herriot model without assuming normality of random effects and sampling errors. The resulting benchmarked empirical linear shrinkage (BELS) predictor has novelty in the sense that coefficients for benchmarking are adjusted based on the data from each area. To measure the uncertainty of BELS, the second-order unbiased estimator of the mean squared error is derived.     

The effects of model mis-specifications in linear measurement error models

In the literature, there are many results on the consequences of mis-specified models for linear models with error in the response only, see, e.g., Seber(1977). There are also discussions of estimation for the model writh errors both in the response and in the predictor variables (called measurement error models; see, e.g., Fuller(1987)). In this paper, we consider the problem of model mis-specification for measurement error models. Only a few special cases have been tackled in the past (Edland, 1996; Carroll and Ruppert, 1996 and Lakshminarayanan Amp; Gunst, 1984); we deal with the situation here in some generality. Results have been obtained as follows: (a) When a model is under-fitted, the estimate of the variance of the measurement error will be asymptotically biased, as will the regression coefficients, and the asymptotic biases in the estimates of the regression coefficients will always exist for under-fitted models. Even orthogonality of the variables in the model will not make the biases vanish. (b)For over-fitting, the estimates of the variances of measurement errors and of the regression coefficients are asymptotically unbiased. However, the variance of the estimated regression coefficients will increase. Over-fitting will cause larger changes in the variances of the estimated parameters in measurement error models than in no measurement error models.     

Modal non‐linear regression in the presence of Laplace measurement error

In this paper, we propose a robust estimation procedure for a class of non‐linear regression models when the covariates are contaminated with Laplace measurement error, aiming at constructing an estimation procedure for the regression parameters which are less affected by the possible outliers, and heavy‐tailed underlying distribution, as well as reducing the bias introduced by the measurement error. Starting with the modal regression procedure developed for the measurement error‐free case, a non‐trivial modification is made so that the modified version can effectively correct the potential bias caused by measurement error. Large sample properties of the proposed estimate, such as the convergence rate and the asymptotic normality, are thoroughly investigated. A simulation study and real data application are conducted to illustrate the satisfying finite sample performance of the proposed estimation procedure.     

A risk set calibration method for failure time regression by using a covariate reliability sample

Regression parameter estimation in the Cox failure time model is considered when regression variables are subject to measurement error. Assuming that repeat regression vector measurements adhere to a classical measurement model, we can consider an ordinary regression calibration approach in which the unobserved covariates are replaced by an estimate of their conditional expectation given available covariate measurements. However, since the rate of withdrawal from the risk set across the time axis, due to failure or censoring, will typically depend on covariates, we may improve the regression parameter estimator by recalibrating within each risk set. The asymptotic and small sample properties of such a risk set regression calibration estimator are studied. A simple estimator based on a least squares calibration in each risk set appears able to eliminate much of the bias that attends the ordinary regression calibration estimator under extreme measurement error circumstances. Corresponding asymptotic distribution theory is developed, small sample properties are studied using computer simulations and an illustration is provided.     

Assessing different uncertainty measures of EBLUP: a resampling-based approach

The empirical best linear unbiased prediction approach is a popular method for the estimation of small area parameters. However, the estimation of reliable mean squared prediction error (MSPE) of the estimated best linear unbiased predictors (EBLUP) is a complicated process. In this paper we study the use of resampling methods for MSPE estimation of the EBLUP. A cross-sectional and time-series stationary small area model is used to provide estimates in small areas. Under this model, a parametric bootstrap procedure and a weighted jackknife method are introduced. A Monte Carlo simulation study is conducted in order to compare the performance of different resampling-based measures of uncertainty of the EBLUP with the analytical approximation. Our empirical results show that the proposed resampling-based approaches performed better than the analytical approximation in several situations, although in some cases they tend to underestimate the true MSPE of the EBLUP in a higher number of small areas.     

Small area estimation via heteroscedastic nested‐error regression

We show that the maximum likelihood estimators (MLEs) of the fixed effects and within‐cluster correlation are consistent in a heteroscedastic nested‐error regression (HNER) model with completely unknown within‐cluster variances under mild conditions. The result implies that the empirical best linear unbiased prediction (EBLUP) method for small area estimation is valid in such a case. We also show that ignoring the heteroscedasticity can lead to inconsistent estimation of the within‐cluster correlation and inferior predictive performance. A jackknife measure of uncertainty for the EBLUP is developed under the HNER model. Simulation studies are carried out to investigate the finite‐sample performance of the EBLUP and MLE under the HNER model, with comparisons to those under the nested‐error regression model in various situations, as well as that of the jackknife measure of uncertainty. The well‐known Iowa crops data is used for illustration. The Canadian Journal of Statistics 40: 588–603; 2012 © 2012 Statistical Society of Canada     

A Bayesian predictive inference for small area means incorporating covariates and sampling weights

The main goal in small area estimation is to use models to ‘borrow strength’ from the ensemble because the direct estimates of small area parameters are generally unreliable. However, model-based estimates from the small areas do not usually match the value of the single estimate for the large area. Benchmarking is done by applying a constraint, internally or externally, to ensure that the ‘total’ of the small areas matches the ‘grand total’. This is particularly useful because it is difficult to check model assumptions owing to the sparseness of the data. We use a Bayesian nested error regression model, which incorporates unit-level covariates and sampling weights, to develop a method to internally benchmark the finite population means of small areas. We use two examples to illustrate our method. We also perform a simulation study to further assess the properties of our method.     

A unified approach to estimation of nonlinear mixed effects and Berkson measurement error models

Mixed effects models and Berkson measurement error models are widely used. They share features which the author uses to develop a unified estimation framework. He deals with models in which the random effects (or measurement errors) have a general parametric distribution, whereas the random regression coefficients (or unobserved predictor variables) and error terms have nonparametric distributions. He proposes a second-order least squares estimator and a simulation-based estimator based on the first two moments of the conditional response variable given the observed covariates. He shows that both estimators are consistent and asymptotically normally distributed under fairly general conditions. The author also reports Monte Carlo simulation studies showing that the proposed estimators perform satisfactorily for relatively small sample sizes. Compared to the likelihood approach, the proposed methods are computationally feasible and do not rely on the normality assumption for random effects or other variables in the model.     

A simulation study of estimators for generalized linear measurement error models

The purpose of this paper is to examine the properties of several bias-corrected estimators for generalized linear measurement error models, along with the naive estimator, in some special settings. In particular, we consider logistic regression, poisson regression and exponential-gamma models where the covariates are subject to measurement error. Monte Carlo experiments are conducted to compare the relative performance of the estimators in terms of several criteria. The results indicate that the naive estimator of slope is biased towards zero by a factor increasing with the magnitude of slope and measurement error as well as the sample size. It is found that none of the biased-corrected estimators always outperforms the others, and that their small sample properties typically depend on the underlying model assumptions.     

Bias corrected estimation for generalized probit regression with covariate measurement error and censored responses

In this paper, we propose a bias corrected estimate of the regression coefficient for the generalized probit regression model when the covariates are subject to measurement error and the responses are subject to interval censoring. The main improvement of our method is that it reduces most of the bias that the naive estimates have. The great advantage of our method is that it is baseline and censoring distribution free, in a sense that the investigator does not need to calculate the baseline or the censoring distribution to obtain the estimator of the regression coefficient, an important property of Cox regression model. A sandwich estimator for the variance is also proposed. Our procedure can be generalized to general measurement error distribution as long as the first four moments of the measurement error are known. The results of extensive simulations show that our approach is very effective in eliminating the bias when the measurement error is not too large relative to the error term of the regression model.     

Analysis of cointegrated models with measurement errors

We study the asymptotic properties of the reduced-rank estimator of error correction models of vector processes observed with measurement errors. Although it is well known that there is no asymptotic measurement error bias when predictor variables are integrated processes in regression models [Phillips BCB, Durlauf SN. Multiple time series regression with integrated processes. Rev Econom Stud. 1986;53:473–495], we systematically investigate the effects of the measurement errors (in the dependent variables as well as in the predictor variables) on the estimation of not only cointegrating vectors but also the speed of the adjustment matrix. Furthermore, we present the asymptotic properties of the estimators. We also obtain the asymptotic distribution of the likelihood ratio test for the cointegrating ranks. We investigate the effects of the measurement errors on estimation and test through a Monte Carlo simulation study.     

SIMEX method for censored quantile regression with measurement error

Censored quantile regression serves as an important supplement to the Cox proportional hazards model in survival analysis. In addition to being exposed to censoring, some covariates may subject to measurement error. This leads to substantially biased estimate without taking this error into account. The SIMulation-EXtrapolation (SIMEX) method is an effective tool to handle the measurement error issue. We extend the SIMEX approach to the censored quantile regression with covariate measurement error. The algorithm is assessed via extensive simulations. A lung cancer study is analyzed to verify the validation of the proposed method.