Longitudinal profiles of bounded outcome scores as predictors for disease activity in rheumatoid arthritis patients: a joint modeling approach

A variety of statistical approaches have been suggested in the literature for the analysis of bounded outcome scores (BOS). In this paper, we suggest a statistical approach when BOSs are repeatedly measured over time and used as predictors in a regression model. Instead of directly using the BOS as a predictor, we propose to extend the approaches suggested in [16 E. Lesaffre, D. Rizopoulos, and R. Tsonaka, The logistics-transform for bounded outcome scores, Biostatistics 8 (2007), pp. 72–85. doi: 10.1093/biostatistics/kxj034[Crossref], [PubMed], [Web of Science ®] , [Google Scholar],21 M. Molas and E. Lesaffre, A comparison of the three random effects approaches to analyse repeated bounded outcome scores with an application in a stroke revalidation study, Stat. Med. 27 (2008), pp. 6612–6633. doi: 10.1002/sim.3432[Crossref], [PubMed], [Web of Science ®] , [Google Scholar],28 R. Tsonaka, D. Rizopoulos, and E. Lesaffre, Power and sample size calculations for discrete bounded outcome scores, Stat. Med. 25 (2006), pp. 4241–4252. doi: 10.1002/sim.2679[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]] to a joint modeling setting. Our approach is illustrated on longitudinal profiles of multiple patients’ reported outcomes to predict the current clinical status of rheumatoid arthritis patients by a disease activities score of 28 joints (DAS28). Both a maximum likelihood as well as a Bayesian approach is developed.     

Weighting variables in Kohonen competitive learning algorithms

This paper presents a new variable weight method, called the singular value decomposition (SVD) approach, for Kohonen competitive learning (KCL) algorithms based on the concept of Varshavsky et al. [18 R. Varshavsky, A. Gottlieb, M. Linial, and D. Horn, Novel unsupervised feature filtering of bilogical data, Bioinformatics 22 (2006), pp. 507–513.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]]. Integrating the weighted fuzzy c-means (FCM) algorithm with KCL, in this paper, we propose a weighted fuzzy KCL (WFKCL) algorithm. The goal of the proposed WFKCL algorithm is to reduce the clustering error rate when data contain some noise variables. Compared with the k-means, FCM and KCL with existing variable-weight methods, the proposed WFKCL algorithm with the proposed SVD's weight method provides a better clustering performance based on the error rate criterion. Furthermore, the complexity of the proposed SVD's approach is less than Pal et al. [17 S.K. Pal, R.K. De, and J. Basak, Unsupervised feature evaluation: a neuro-fuzzy approach, IEEE. Trans. Neural Netw. 11 (2000), pp. 366–376.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]], Wang et al. [19 X.Z. Wang, Y.D. Wang, and L.J. Wang, Improving fuzzy c-means clustering based on feature-weight learning, Pattern Recognit. Lett. 25 (2004), pp. 1123–1132.[Crossref], [Web of Science ®] , [Google Scholar]] and Hung et al. [9 W. -L. Hung, M. -S. Yang, and D. -H. Chen, Bootstrapping approach to feature-weight selection in fuzzy c-means algorithms with an application in color image segmentation, Pattern Recognit. Lett. 29 (2008), pp. 1317–1325.[Crossref], [Web of Science ®] , [Google Scholar]].     

Local influence diagnostics for generalized linear mixed models with overdispersion

Since the seminal paper by Cook and Weisberg [9 R.D. Cook and S. Weisberg, Residuals and Influence in Regression, Chapman &; Hall, London, 1982. [Google Scholar]], local influence, next to case deletion, has gained popularity as a tool to detect influential subjects and measurements for a variety of statistical models. For the linear mixed model the approach leads to easily interpretable and computationally convenient expressions, not only highlighting influential subjects, but also which aspect of their profile leads to undue influence on the model's fit [17 E. Lesaffre and G. Verbeke, Local influence in linear mixed models, Biometrics 54 (1998), pp. 570–582. doi: 10.2307/3109764[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]]. Ouwens et al. [24 M.J.N.M. Ouwens, F.E.S. Tan, and M.P.F. Berger, Local influence to detect influential data structures for generalized linear mixed models, Biometrics 57 (2001), pp. 1166–1172. doi: 10.1111/j.0006-341X.2001.01166.x[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]] applied the method to the Poisson-normal generalized linear mixed model (GLMM). Given the model's nonlinear structure, these authors did not derive interpretable components but rather focused on a graphical depiction of influence. In this paper, we consider GLMMs for binary, count, and time-to-event data, with the additional feature of accommodating overdispersion whenever necessary. For each situation, three approaches are considered, based on: (1) purely numerical derivations; (2) using a closed-form expression of the marginal likelihood function; and (3) using an integral representation of this likelihood. Unlike when case deletion is used, this leads to interpretable components, allowing not only to identify influential subjects, but also to study the cause thereof. The methodology is illustrated in case studies that range over the three data types mentioned.     

Random Effects,Fixed Effects and Hausman's Test for the Generalized Mixed Regressive Spatial Autoregressive Panel Data Model

This article suggests random and fixed effects spatial two-stage least squares estimators for the generalized mixed regressive spatial autoregressive panel data model. This extends the generalized spatial panel model of Baltagi et al. (2013 Baltagi, B. H., Egger, P., Pfaffermayr, M. (2013). A generalized spatial panel data model with random effects. Econometric Reviews 32:650–685.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) by the inclusion of a spatial lag term. The estimation method utilizes the Generalized Moments method suggested by Kapoor et al. (2007 Kapoor, M., Kelejian, H. H., Prucha, I. R. (2007). Panel data models with spatially correlated error components. Journal of Econometrics 127(1):97–130.[Crossref], [Web of Science ®] , [Google Scholar]) for a spatial autoregressive panel data model. We derive the asymptotic distributions of these estimators and suggest a Hausman test a la Mutl and Pfaffermayr (2011 Mutl, J., Pfaffermayr, M. (2011). The Hausman test in a Cliff and Ord panel model. Econometrics Journal 14:48–76.[Crossref], [Web of Science ®] , [Google Scholar]) based on the difference between these estimators. Monte Carlo experiments are performed to investigate the performance of these estimators as well as the corresponding Hausman test.     

Testing for sphericity in a two-way error components panel data model

This article is concerned with sphericity test for the two-way error components panel data model. It is found that the John statistic and the bias-corrected LM statistic recently developed by Baltagi et al. (2011 Baltagi, B. H., Feng, Q., Kao, C. (2011). Testing for sphericity in a fixed effects panel data model. Econometrics Journal 14:25–47.[Crossref], [Web of Science ®] , [Google Scholar])Baltagi et al. (2012 Baltagi, B. H., Feng, Q., Kao, C. (2012). A Lagrange multiplier test for cross-sectional dependence in a fixed effects panel data model. Journal of Econometrics 170:164–177.[Crossref], [Web of Science ®] , [Google Scholar], which are based on the within residuals, are not helpful under the present circumstances even though they are in the one-way fixed effects model. However, we prove that when the within residuals are properly transformed, the resulting residuals can serve to construct useful statistics that are similar to those of Baltagi et al. (2011 Baltagi, B. H., Feng, Q., Kao, C. (2011). Testing for sphericity in a fixed effects panel data model. Econometrics Journal 14:25–47.[Crossref], [Web of Science ®] , [Google Scholar])Baltagi et al. (2012 Baltagi, B. H., Feng, Q., Kao, C. (2012). A Lagrange multiplier test for cross-sectional dependence in a fixed effects panel data model. Journal of Econometrics 170:164–177.[Crossref], [Web of Science ®] , [Google Scholar]). Simulation results show that the newly proposed statistics perform well under the null hypothesis and several typical alternatives.     

Analysis of discrete lifetime data under middle-censoring and in the presence of covariates

‘Middle censoring’ is a very general censoring scheme where the actual value of an observation in the data becomes unobservable if it falls inside a random interval (L, R) and includes both left and right censoring. In this paper, we consider discrete lifetime data that follow a geometric distribution that is subject to middle censoring. Two major innovations in this paper, compared to the earlier work of Davarzani and Parsian [3 N. Davarzani and A. Parsian, Statistical inference for discrete middle-censored data, J. Statist. Plan. Inference 141 (2011), pp. 1455–1462. doi: 10.1016/j.jspi.2010.10.012[Crossref], [Web of Science ®] , [Google Scholar]], include (i) an extension and generalization to the case where covariates are present along with the data and (ii) an alternate approach and proofs which exploit the simple relationship between the geometric and the exponential distributions, so that the theory is more in line with the work of Iyer et al. [6 S.K. Iyer, S.R. Jammalamadaka, and D. Kundu, Analysis of middle censored data with exponential lifetime distributions, J. Statist. Plan. Inference 138 (2008), pp. 3550–3560. doi: 10.1016/j.jspi.2007.03.062[Crossref], [Web of Science ®] , [Google Scholar]]. It is also demonstrated that this kind of discretization of life times gives results that are close to the original data involving exponential life times. Maximum likelihood estimation of the parameters is studied for this middle-censoring scheme with covariates and their large sample distributions discussed. Simulation results indicate how well the proposed estimation methods work and an illustrative example using time-to-pregnancy data from Baird and Wilcox [1 D.D. Baird and A.J. Wilcox, Cigarette smoking associated with delayed conception, J, Am. Med. Assoc. 253 (1985), pp. 2979–2983. doi: 10.1001/jama.1985.03350440057031[Crossref], [Web of Science ®] , [Google Scholar]] is included.     

A comparison of alternative methods to construct confidence intervals for the estimate of a break date in linear regression models

This article considers constructing confidence intervals for the date of a structural break in linear regression models. Using extensive simulations, we compare the performance of various procedures in terms of exact coverage rates and lengths of the confidence intervals. These include the procedures of Bai (1997 Bai, J. (1997). Estimation of a change point in multiple regressions. Review of Economics and Statistics 79:551–563.[Crossref], [Web of Science ®] , [Google Scholar]) based on the asymptotic distribution under a shrinking shift framework, Elliott and Müller (2007 Elliott, G., Müller, U. (2007). Confidence sets for the date of a single break in linear time series regressions. Journal of Econometrics 141:1196–1218.[Crossref], [Web of Science ®] , [Google Scholar]) based on inverting a test locally invariant to the magnitude of break, Eo and Morley (2015 Eo, Y., Morley, J. (2015). Likelihood-ratio-based confidence sets for the timing of structural breaks. Quantitative Economics 6:463–497.[Crossref], [Web of Science ®] , [Google Scholar]) based on inverting a likelihood ratio test, and various bootstrap procedures. On the basis of achieving an exact coverage rate that is closest to the nominal level, Elliott and Müller's (2007 Elliott, G., Müller, U. (2007). Confidence sets for the date of a single break in linear time series regressions. Journal of Econometrics 141:1196–1218.[Crossref], [Web of Science ®] , [Google Scholar]) approach is by far the best one. However, this comes with a very high cost in terms of the length of the confidence intervals. When the errors are serially correlated and dealing with a change in intercept or a change in the coefficient of a stationary regressor with a high signal-to-noise ratio, the length of the confidence interval increases and approaches the whole sample as the magnitude of the change increases. The same problem occurs in models with a lagged dependent variable, a common case in practice. This drawback is not present for the other methods, which have similar properties. Theoretical results are provided to explain the drawbacks of Elliott and Müller's (2007 Elliott, G., Müller, U. (2007). Confidence sets for the date of a single break in linear time series regressions. Journal of Econometrics 141:1196–1218.[Crossref], [Web of Science ®] , [Google Scholar]) method.     

Buffered Autoregressive Models With Conditional Heteroscedasticity: An Application to Exchange Rates

This article introduces a new model called the buffered autoregressive model with generalized autoregressive conditional heteroscedasticity (BAR-GARCH). The proposed model, as an extension of the BAR model in Li et al. (2015 Li, G.D., Guan, B., Li, W.K., and Yu, P. L.H. (2015), “Hysteretic Autoregressive Time Series Models,” Biometrika, 102, 717–723.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), can capture the buffering phenomena of time series in both the conditional mean and variance. Thus, it provides us a new way to study the nonlinearity of time series. Compared with the existing AR-GARCH and threshold AR-GARCH models, an application to several exchange rates highlights the importance of the BAR-GARCH model.     

Robust estimation for non-homogeneous data and the selection of the optimal tuning parameter: the density power divergence approach

The density power divergence (DPD) measure, defined in terms of a single parameter α, has proved to be a popular tool in the area of robust estimation [1 A. Basu, I.R. Harris, N.L. Hjort and M.C. Jones, Robust and efficient estimation by minimizing a density power divergence, Biometrika 85 (1998), pp. 549–559. doi: 10.1093/biomet/85.3.549[Crossref], [Web of Science ®] , [Google Scholar]]. Recently, Ghosh and Basu [5 A. Ghosh and A. Basu, Robust estimation for independent non-homogeneous observations using density power divergence with applications to linear regression, Electron. J. Stat. 7 (2013), pp. 2420–2456. doi: 10.1214/13-EJS847[Crossref], [Web of Science ®] , [Google Scholar]] rigorously established the asymptotic properties of the MDPDEs in case of independent non-homogeneous observations. In this paper, we present an extensive numerical study to describe the performance of the method in the case of linear regression, the most common setup under the case of non-homogeneous data. In addition, we extend the existing methods for the selection of the optimal robustness tuning parameter from the case of independent and identically distributed (i.i.d.) data to the case of non-homogeneous observations. Proper selection of the tuning parameter is critical to the appropriateness of the resulting analysis. The selection of the optimal robustness tuning parameter is explored in the context of the linear regression problem with an extensive numerical study involving real and simulated data.     

Optimal network design for Bayesian spatial prediction of multivariate non-Gaussian environmental data

This paper deals with the problem of increasing air pollution monitoring stations in Tehran city for efficient spatial prediction. As the data are multivariate and skewed, we introduce two multivariate skew models through developing the univariate skew Gaussian random field proposed by Zareifard and Jafari Khaledi [21 H. Zareifard and M. Jafari Khaledi, Non-Gaussian modeling of spatial data using scale mixing of a unified skew Gaussian process, J. Multivariate Anal. 114 (2013), pp. 16–28. doi: 10.1016/j.jmva.2012.07.003[Crossref], [Web of Science ®] , [Google Scholar]]. These models provide extensions of the linear model of coregionalization for non-Gaussian data. In the Bayesian framework, the optimal network design is found based on the maximum entropy criterion. A Markov chain Monte Carlo algorithm is developed to implement posterior inference. Finally, the applicability of two proposed models is demonstrated by analyzing an air pollution data set.     

Bayesian Inference in Dynamic Disequilibrium Models: An Application to the Polish Credit Market

We propose a Bayesian approach for inference in a dynamic disequilibrium model. To circumvent the difficulties raised by the Maddala and Nelson (1974 Maddala , G. , Nelson , F. ( 1974 ). Maximum likelihood methods for models of markets in disequilibrium . Econometrica 42 ( 6 ): 1013 – 1030 .[Crossref], [Web of Science ®] , [Google Scholar]) specification in the dynamic case, we analyze a dynamic extended version of the disequilibrium model of Ginsburgh et al. (1980 Ginsburgh , V. , Tishler , A. , Zang , I. ( 1980 ). Alternative estimation methods for two regime models . European Economic Review 13 : 207 – 228 .[Crossref], [Web of Science ®] , [Google Scholar]). We develop a Gibbs sampler based on the simulation of the missing observations. The feasibility of the approach is illustrated by an empirical analysis of the Polish credit market, for which we conduct a specification search using the posterior deviance criterion of Spiegelhalter et al. (2002 Spiegelhalter , D. J. , Best , N. G. , Carlin , B. P. , Van Der Linde , A. ( 2002 ). Bayesian measures of complexity and fit . Journal of the Royal Statistical Society, Ser. B 64 : 583 – 639 .[Crossref] , [Google Scholar]).     

Evaluating the relative merits of competing models based on empirical likelihood ratio test

Competing models arise naturally in many research fields, such as survival analysis and economics, when the same phenomenon of interest is explained by different researcher using different theories or according to different experiences. The model selection problem is therefore remarkably important because of its great importance to the subsequent inference; Inference under a misspecified or inappropriate model will be risky. Existing model selection tests such as Vuong's tests [26 Q.H. Vuong, Likelihood ratio test for model selection and non-nested hypothesis, Econometrica 57 (1989), pp. 307–333. doi: 10.2307/1912557[Crossref], [Web of Science ®] , [Google Scholar]] and Shi's non-degenerate tests [21 X. Shi, A non-degenerate Vuong test, Quant. Econ. 6 (2015), pp. 85–121. doi: 10.3982/QE382[Crossref], [Web of Science ®] , [Google Scholar]] suffer from the variance estimation and the departure of the normality of the likelihood ratios. To circumvent these dilemmas, we propose in this paper an empirical likelihood ratio (ELR) tests for model selection. Following Shi [21 X. Shi, A non-degenerate Vuong test, Quant. Econ. 6 (2015), pp. 85–121. doi: 10.3982/QE382[Crossref], [Web of Science ®] , [Google Scholar]], a bias correction method is proposed for the ELR tests to enhance its performance. A simulation study and a real-data analysis are provided to illustrate the performance of the proposed ELR tests.     

Automatic clustering algorithm for fuzzy data

Coppi et al. [7 R. Coppi, P. D'Urso, and P. Giordani, Fuzzy and possibilistic clustering for fuzzy data, Comput. Stat. Data Anal. 56 (2012), pp. 915–927. doi: 10.1016/j.csda.2010.09.013[Crossref], [Web of Science ®] , [Google Scholar]] applied Yang and Wu's [20 M.-S. Yang and K.-L. Wu, Unsupervised possibilistic clustering, Pattern Recognit. 30 (2006), pp. 5–21. doi: 10.1016/j.patcog.2005.07.005[Crossref], [Web of Science ®] , [Google Scholar]] idea to propose a possibilistic k-means (PkM) clustering algorithm for LR-type fuzzy numbers. The memberships in the objective function of PkM no longer need to satisfy the constraint in fuzzy k-means that of a data point across classes sum to one. However, the clustering performance of PkM depends on the initializations and weighting exponent. In this paper, we propose a robust clustering method based on a self-updating procedure. The proposed algorithm not only solves the initialization problems but also obtains a good clustering result. Several numerical examples also demonstrate the effectiveness and accuracy of the proposed clustering method, especially the robustness to initial values and noise. Finally, three real fuzzy data sets are used to illustrate the superiority of this proposed algorithm.     

Unified multivariate survival model with a surviving fraction: an application to a Brazilian customer churn data

In this paper we propose a new lifetime model for multivariate survival data in presence of surviving fractions and examine some of its properties. Its genesis is based on situations in which there are m types of unobservable competing causes, where each cause is related to a time of occurrence of an event of interest. Our model is a multivariate extension of the univariate survival cure rate model proposed by Rodrigues et al. [37 J. Rodrigues, V.G. Cancho, M. de Castro, and F. Louzada-Neto, On the unification of long-term survival models, Statist. Probab. Lett. 79 (2009), pp. 753–759. doi: 10.1016/j.spl.2008.10.029[Crossref], [Web of Science ®] , [Google Scholar]]. The inferential approach exploits the maximum likelihood tools. We perform a simulation study in order to verify the asymptotic properties of the maximum likelihood estimators. The simulation study also focus on size and power of the likelihood ratio test. The methodology is illustrated on a real data set on customer churn data.     

A Comparison of Procedures for Controlling the False Discovery Rate in the Presence of Small Variance Genes: A Simulation Study

The Significance Analysis of Microarrays (SAM; Tusher et al., 2001 Tusher , V. G. , Tibshirani , R. , Chu , G. ( 2001 ). Significance analysis of microarrys applied to the ionizing radiation response . Proceedings of the National Academy of Sciences 98 : 5116 – 5121 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) method is widely used in analyzing gene expression data while controlling the FDR by using resampling-based procedure in the microarray setting. One of the main components of the SAM procedure is the adjustment of the test statistic. The introduction of the fudge factor to the test statistic aims at deflating the large value of test statistics due to the small standard error of gene-expression. Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801 – 823 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) pointed out that the fudge factor does not effectively improve the power and the control of the FDR as compared to the SAM procedure without the fudge factor in the presence of small variance genes. Motivated by the simulation results presented in Lin et al. (2008 Lin , D. , Shkedy , Z. , Burzykowski , T. , Göhlmann , H. W. H. , De Bondt , A. , Perera , T. , Geerts , T. , Bijnens , L. ( 2008 ). Significance analysis of microarray (SAM) for comparisons of several treatments with one control . Biometric Journal, MCP 50 ( 5 ): 801 – 823 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), in this article, we extend our study to compare several methods for choosing the fudge factor in the modified t-type test statistics and use simulation studies to investigate the power and the control of the FDR of the considered methods.     

First difference transformation in panel VAR models: Robustness,estimation, and inference

This article considers estimation of Panel Vector Autoregressive Models of order 1 (PVAR(1)) with focus on fixed T consistent estimation methods in First Differences (FD) with additional strictly exogenous regressors. Additional results for the Panel FD ordinary least squares (OLS) estimator and the FDLS type estimator of Han and Phillips (2010 Han, C., Phillips, P. C. B. (2010). Gmm estimation for dynamic panels with fixed effects and strong instruments at unity. Econometric Theory 26:119–151.[Crossref], [Web of Science ®] , [Google Scholar]) are provided. Furthermore, we simplify the analysis of Binder et al. (2005 Binder, M., Hsiao, C., Pesaran, M. H. (2005). Estimation and inference in short panel vector autoregressions with unit root and cointegration. Econometric Theory 21:795–837.[Crossref], [Web of Science ®] , [Google Scholar]) by providing additional analytical results and extend the original model by taking into account possible cross-sectional heteroscedasticity and presence of strictly exogenous regressors. We show that in the three wave panel the log-likelihood function of the unrestricted Transformed Maximum Likelihood (TML) estimator might violate the global identification assumption. The finite-sample performance of the analyzed methods is investigated in a Monte Carlo study.     

An intuitive clustering algorithm for spherical data with application to extrasolar planets

This paper proposes an intuitive clustering algorithm capable of automatically self-organizing data groups based on the original data structure. Comparisons between the propopsed algorithm and EM [1 A. Banerjee, I.S. Dhillon, J. Ghosh, and S. Sra, Clustering on the unit hypersphere using von Mises–Fisher distribution, J. Mach. Learn. Res. 6 (2005), pp. 1–39. [Google Scholar]] and spherical k-means [7 I.S. Dhillon and D.S. Modha, Concept decompositions for large sparse text data using clustering, Mach. Learn. 42 (2001), pp. 143–175. doi: 10.1023/A:1007612920971[Crossref], [Web of Science ®] , [Google Scholar]] algorithms are given. These numerical results show the effectiveness of the proposed algorithm, using the correct classification rate and the adjusted Rand index as evaluation criteria [5 J.-M. Chiou and P.-L. Li, Functional clustering and identifying substructures of longitudinal data, J. R. Statist. Soc. Ser. B. 69 (2007), pp. 679–699. doi: 10.1111/j.1467-9868.2007.00605.x[Crossref] , [Google Scholar],6 J.-M. Chiou and P.-L. Li, Correlation-based functional clustering via subspace projection, J. Am. Statist. Assoc. 103 (2008), pp. 1684–1692. doi: 10.1198/016214508000000814[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]]. In 1995, Mayor and Queloz announced the detection of the first extrasolar planet (exoplanet) around a Sun-like star. Since then, observational efforts of astronomers have led to the detection of more than 1000 exoplanets. These discoveries may provide important information for understanding the formation and evolution of planetary systems. The proposed clustering algorithm is therefore used to study the data gathered on exoplanets. Two main implications are also suggested: (1) there are three major clusters, which correspond to the exoplanets in the regimes of disc, ongoing tidal and tidal interactions, respectively, and (2) the stellar metallicity does not play a key role in exoplanet migration.     

Flexible parametric modelling of the hazard function in breast cancer studies

In cancer research, study of the hazard function provides useful insights into disease dynamics, as it describes the way in which the (conditional) probability of death changes with time. The widely utilized Cox proportional hazard model uses a stepwise nonparametric estimator for the baseline hazard function, and therefore has a limited utility. The use of parametric models and/or other approaches that enables direct estimation of the hazard function is often invoked. A recent work by Cox et al. [6 Cox, C., Chu, H., Schneider, M. F. and Munoz, A. 2007. Parametric survival analysis and taxonomy of hazard functions for the generalized gamma distribution. Stat. Med., 26: 4352–4374. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]] has stimulated the use of the flexible parametric model based on the Generalized Gamma (GG) distribution, supported by the development of optimization software. The GG distribution allows estimation of different hazard shapes in a single framework. We use the GG model to investigate the shape of the hazard function in early breast cancer patients. The flexible approach based on a piecewise exponential model and the nonparametric additive hazards model are also considered.     

Empirical Likelihood in Causal Inference

This paper discusses the estimation of average treatment effects in observational causal inferences. By employing a working propensity score and two working regression models for treatment and control groups, Robins et al. (1994 Robins , J. M. , Rotnitzky , A. , Zhao , L. P. ( 1994 ). Estimation of regression coefficients when some regressors are not always observed . Journal of the American Statistical Association 89 : 846 – 866 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar], 1995 Robins , J. M. , Rotnitzky , A. , Zhao , L. P. ( 1995 ). Analysis of semiparametric regression models for repeated outcomes in the presence of missing data . Journal of the American Statistical Association 90 : 106 – 121 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) introduced the augmented inverse probability weighting (AIPW) method for estimation of average treatment effects, which extends the inverse probability weighting (IPW) method of Horvitz and Thompson (1952 Horvitz , D. G. , Thompson , D. J. ( 1952 ). A generalization of sampling without replacement from a finite universe . Journal of the American Statistical Association 47 : 663 – 685 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]); the AIPW estimators are locally efficient and doubly robust. In this paper, we study a hybrid of the empirical likelihood method and the method of moments by employing three estimating functions, which can generate estimators for average treatment effects that are locally efficient and doubly robust. The proposed estimators of average treatment effects are efficient for the given choice of three estimating functions when the working propensity score is correctly specified, and thus are more efficient than the AIPW estimators. In addition, we consider a regression method for estimation of the average treatment effects when working regression models for both the treatment and control groups are correctly specified; the asymptotic variance of the resulting estimator is no greater than the semiparametric variance bound characterized by the theory of Robins et al. (1994 Robins , J. M. , Rotnitzky , A. , Zhao , L. P. ( 1994 ). Estimation of regression coefficients when some regressors are not always observed . Journal of the American Statistical Association 89 : 846 – 866 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar], 1995 Robins , J. M. , Rotnitzky , A. , Zhao , L. P. ( 1995 ). Analysis of semiparametric regression models for repeated outcomes in the presence of missing data . Journal of the American Statistical Association 90 : 106 – 121 .[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]). Finally, we present a simulation study to compare the finite-sample performance of various methods with respect to bias, efficiency, and robustness to model misspecification.     

Multivariate Bayesian U-type asymmetric designs for non parametric response surface prediction under correlated errors

The objective of this paper is to study U-type designs for Bayesian non parametric response surface prediction under correlated errors. The asymptotic Bayes criterion is developed in terms of the asymptotic approach of Mitchell et al. (1994 Mitchell, T., Sacks, J., Ylvisaker, D. (1994). Asymptotic Bayes criteria for nonparametric response surface design. Ann. Stat. 22:634–651.[Crossref], [Web of Science ®] , [Google Scholar]) for a more general covariance kernel proposed by Chatterjee and Qin (2011 Chatterjee, K., Qin, H. (2011). Generalized discrete discrepancy and its applications in experimental designs. J. Stat. Plann. Inference 141:951–960.[Crossref], [Web of Science ®] , [Google Scholar]). A relationship between the asymptotic Bayes criterion and other criteria, such as orthogonality and aberration, is then developed. A lower bound for the criterion is also obtained, and numerical results show that this lower bound is tight. The established results generalize those of Yue et al. (2011 Yue, R.X., Qin, H., Chatterjee, K. (2011). Optimal U-type design for Bayesian nonparametric multiresponse prediction. J. Stat. Plann. Inference 141:2472–2479.[Crossref], [Web of Science ®] , [Google Scholar]) from symmetrical case to asymmetrical U-type designs.