Extensions of empirical likelihood and chi-squared-based tests for ordered alternatives

Several methods for comparing k populations have been proposed in the literature. These methods assess the same null hypothesis of equal distributions but differ in the alternative hypothesis they consider. We focus on two important alternative hypotheses: monotone and umbrella ordering. Two new families of test statistics are proposed, including two known tests, as well as two new powerful tests under monotone ordering. Furthermore, these families are adapted for testing umbrella ordering. We compare some members of the families with respect to power and Type I errors under different simulation scenarios. Finally, the methods are illustrated in several applications to real data.     

A class of k-sample distribution-free tests for location against ordered alternatives

This paper introduces a new class of distribution-free tests for testing the homogeneity of several location parameters against ordered alternatives. The proposed class of test statistics is based on a linear combination of two-sample U-statistics based on subsample extremes. The mean and variance of the test statistic are obtained under the null hypothesis as well as under the sequence of local alternatives. The optimal weights are also determined. It is shown via Pitman ARE comparisons that the proposed class of test statistics performs better than its competitor tests in case of heavy-tailed and long-tailed distributions     

Some useful nonparametric tests for ordered alternatives in randomized block experiments

Testing for ordered alternatives in randomized block designs has been a problem of interest for almost three decades (Jonckheere (1954)). Three classes of rank tests have evolved—tests based on “within-blocks” rankings (W-tests), tests based on “ranking after alignment” within blocks (RAA-tests), and tests based on “among-blocks” rankings (A-Tests). This paper focuses on the latter. A simplified version of the Skillings-Wolfe generalized Purl test (1977) is suggested and two very useful A-tests—a generalized Johnson-Mehrotra “Optimal contrast” procedure and a generalized Tryon-Hettmansperger rank test—are developed. These procedures are compared and contrasted with other recent competitors presented by Skllllngs and Wolfe (1978) and by Salama and Quade (1981).     

Union-intersection rank tests for ordered alternatives in some simple linear models

The theory of locally most powerful rank tests and the union intersection principle are incorporated in the formulation of some distribution-free rank tests for ordered alternatives in some simple linear models (including the classical one-way layout as a special case). Some approximations for the null-hypothesis distributions of the test statistics ( for finite sample sizes) are considered, and the theory is supplemented by some numerical and simulation results.     

Linear rank tests for homogeneity against ordered alternatives in anova and anocova

A unified method of constructing rank tests for homogeneity against ordered alternatives in unbalanced analysis of variance and analysis of covariance is considered. The relationship between these tests with some of the existing methods are studied. The normal theory likelihood ratio tests are also derived and the asymptotic relative efficiency comparisons, in Pitman sense, of the rank tests with respect to the likelihood ratio tests are carried out.     

A study of several useful tests for ordered alternatives in the randomized block design

This study investigates the small sample powers of several tests designed against ordered location alternatives in randomized block experiments. The results are intended to aid the researcher in the selection process. Toward this end the small sample powers of three classes of rank tests — tests based on ‘within-blocks’ rankings (W-tests), ‘among-b locks’ rankings (A-tests), and ‘ranking after alignment’ within blocks (RAA-tests)— are compared and contrasted with the asymptotic properties given by Pirie (1974) as well as with the empirical powers of competing parametric procedures.     

Exact inference for multivariate ordered alternatives

In this paper we discuss three types of ordered alternatives ordered location, stochastic ordering and quadrant dependence. We prove that quadrant dependence is the more general among the three. Then we consider a conditional tests for the equality of c distributions against quadrant dependence in a multivariate setup. An exact simultaneous testing procedure based on dependent conditional tests is presented. Two applications to real data are also given.     

A rank test for stochastically ordered alternatives

A rank test based on the number of ‘near-matches’ among within-block rankings is proposed for stochastically ordered alternatives in a randomized block design with t treatments and b blocks. The asymptotic relative efficiency of this test with respect to the Page test is computed as number of blocks increases to infinity. A sequential analog of the above test procedure is also considered. A repeated significance test procedure is developed and average sample number is computed asymptotically under the null hypothesis as well as under a sequence of contiguous alternatives.     

Distribution-free tests for umbrella alternatives

In this paper we propose distribution-free teots ebi ujabreiia aAiuatives based on the decomposition of umbrella alternatives into a union of simple order alternatives, The proposed tests are shown to have more balanced power performances, Tables of critical points for the proposed tests are provided.     

Multivariate generalizations of jonckheere's test for ordered alternatives

In many dose-response studies, each of several independent groups of animals is treated with a different dose of a substance. Many response variables are then measured on each animal. The distributions of the response variables may be nonnormal, and Jonckheere's (1954) test for ordered alternatives in the one-way layout is sometimes used to test whether the level of a single variable increases with increasing dose. In some applications, however, it is important to consider a set of response variables simultaneously. For instance, an increase in each of certain enzymes in the blood serum may suggest liver damage. To test whether these enzyme levels increase with increasing dose, it may be preferable to consider these enzymes as a group, rather than individually.

I propose two multivariate generalizations of Jonckheere's univariate test. Each multivariate test statistic is a function of coordinate-wise Jonckheere statistics—one a sum, the other a quadratic form. The sum statistic can be used to test the alternative hypothesis that each variable is stochastically increasing with increasing dose. The quadratic form statistic is designed for the more general alternative hypothesis that each variable is stochastically ordered with increasing dose.

For each of these two alternatives, I also propose a multivariate generalization of a normal theory test described by Puri (1965). I examine the asymptotic distributions of the four test statistics under the null hypothesis and under translation alternatives and compare each distribution-free test to the corresponding normal theory test in terms of asymptotic relative efficiency.

The multivariate Jonckheere tests are illustrated using does-response data from a subchronic toxicology study carried out by the National Toxicology Program. Four groups of ten male rats each were treated with increasing doses of vinylidene flouride, and the serum enzymes SDH, SGOT, and SGPT were measured. A comparison of univariate Jonckheere tests on each variable, bivariate tests on SDH and SGOT, and multivariate tests on all three variables gives insight into the behavior of the various procedures.     

Bootstrap tests for multivariate directional alternatives

Tests on multivariate means that are hypothesized to be in a specified direction have received attention from both theoretical and applied points of view. One of the most common procedures used to test this cone alternative is the likelihood ratio test (LRT) assuming a multivariate normal model for the data. However, the resulting test for an ordered alternative is biased in that the only usable critical values are bounds on the null distribution. The present paper provides empirical evidence that bootstrapping the null distribution of the likelihood ratio statistic results in a bootstrap test (BT) with comparable power properties without the additional burden of assuming multivariate normality. Additionally, the tests based on the LRT statistic can reject the null hypothesis in favor of the alternative even though the true means are far from the alternative region. The BT also has similar properties for normal and nonnormal data. This anomalous behavior is due to the formulation of the null hypothesis and a possible remedy is to reformulate the null to be the complement of the alternative hypothesis. We discuss properties of a BT for the modified set of hypotheses (MBT) based on a simulation study. The resulting test is conservative in general and in some specific cases has power estimates comparable to those for existing methods. The BT has higher sensitivity but relatively lower specificity, whereas the MBT has higher specificity but relatively lower sensitivity.     

Assessing multiple endpoints with ordered alternatives

Nonparametric approaches to the analysis of multiple endpoints in clinical studies can be of particular value when the endpoints are heterogeneous or distributional assumptions are suspect. We describe a multivariate Terpstra-Jonckheere U-statistic for assessing multiple endpoints with ordered alternatives, and illustrate its use with data arising from a recent clinical study.     

A test for zero point triserial correlation coefficient and its relationship with tests for homogeneity of means with ordered alternatives

The point triserial correlation coefficient is defined and, under appropriate order restrictions, an exact test that this correlation coefficient equals zero is developed. The power function of that test is derived and partially tabulated. The general problem of testing for homogeneity of means under ordered alternatives is discussed. The available procedures for performing such tests are considered, are seen to provide alternative approaches to the test developed herein, and are compared with that test. An exact test for the equality of dependent point triserial correlation coefficients is described through application of a procedure suggested by Wolfe ‘1976’     

Nonparametric tests of hypotheses for umbrella alternatives

The author proposes a general method for constructing nonparametric tests of hypotheses for umbrella alternatives. Such alternatives are relevant when the treatment effect changes in direction after reaching a peak. The author's class of tests is based on the ranks of the observations. His general approach consists of defining two sets of rankings: the first is induced by the alternative and the other by the data itself. His test statistic measures the distance between the two sets. The author determines the asymptotic distribution for some special cases of distances under both the null and the alternative hypothesis when the location of the peak is known or unknown. He shows the good power of his tests through a limited simulation study     

Semiparametric tests for change-points with epidemic alternatives

The empirical likelihood ratio-based semiparametric tests of change-points with epidemic alternatives are constructed and are proved to have the same limiting null distributions as some well-known tests. The maximum empirical likelihood estimates of the change-points and the epidemic duration are shown to be consistent. Data-based model tests are also provided. The method is applied to a stock market price data and the Nile river data.     

Testing for ordered alternatives by combining independent distribution-free block statistics

A class of distribution-free tests for ordered alternatives in a block design is presented. On each block a distribution-free statistic is selected, and a weighted sum of these statistics is then formed. A procedure for selecting the weighting constants which maximize the asymptotic relative efficiency is presented. The improvement in the efficiency of the weighted sum of block statistics over the unweighted sum is considered and proves interesting. Some attention is also given to the idea of using different types of statistics on different blocks.     

Precedence tests and Lehmann alternatives

G = F ^k (k > 1); G = 1 − (1−F) ^k (k < 1); G = F ^k (k < 1); and G = 1 − (1−F) ^k (k > 1), where F and G are two continuous cumulative distribution functions. If an optimal precedence test (one with the maximal power) is determined for one of these four classes, the optimal tests for the other classes of alternatives can be derived. Application of this is given using the results of Lin and Sukhatme (1992) who derived the best precedence test for testing the null hypothesis that the lifetimes of two types of items on test have the same distibution. The test has maximum power for fixed κ in the class of alternatives G = 1 − (1−F) ^k , with k < 1. Best precedence tests for the other three classes of Lehmann-type alternatives are derived using their results. Finally, a comparison of precedence tests with Wilcoxon's two-sample test is presented. Received: February 22, 1999; revised version: June 7, 2000     

Weighted combinations of rank tests for location-scale alternatives

All existing location-scale rank tests use equal weights for the components. We advocate the use of weighted combinations of statistics. This approach can partly be substantiated by the theory of locally most powerful tests. We specifically investi= gate a Wilcoxon-Mood combination. We give exact critical values for a range of weights. The asymptotic normality of the test statistic is proved under a general hypothesis and Chernoff-Savage conditions. The asymptotic relative efficiency of this test with respect to unweighted combinations shows that a careful choice of weights results in a gain in efficiency.     

Testing parallelism of regression lines against ordered alternatives

For the problem of testing the equality of slopes of several regression lines against the alternative that the slopes are in increasing (decreasing) order of magnitude, two types of tests are proposed. These are the likelihood ratio test and a test that depends on suitable linear combination of one group statistics. Rank analogues of the two tests are also examined.     

Rank tests for the k-sample problem with restricted alternatives

An asymptotically maximin most powerful rank test among somewhere asymptotically most powerful linear rank tests with scores generating function cf> is derived for each of the simple order alternative, the simple loop alternative and the simple tree alternative in the k-sample problem. The comparisons of the tests obtained with the rank analogues of the Bartholomew's xv tests are made in terms of local asymptotic relative efficiency. It is found that our tests are better than the rank analogues of the xk tests. Furthermore, the asymptotic equivalence of the ranking by the pooled sample to the ranking in pairs are discuss¬ed and the tests which are asymptotically equivalent to ours are given.