A note on ranked-set sampling using a covariate

Ranked-set sampling (RSS) and judgment post-stratification (JPS) use ranking information to obtain more efficient inference than is possible using simple random sampling. Both methods were developed with subjective, judgment-based rankings in mind, but the idea of ranking using a covariate has received a lot of attention. We provide evidence here that when rankings are done using a covariate, the standard RSS and JPS mean estimators no longer make efficient use of the available information. We first show that when rankings are done using a covariate, the standard nonparametric mean estimators in JPS and unbalanced RSS are inadmissible under squared error loss. We then show that when rankings are done using a covariate, nonparametric regression techniques yield mean estimators that tend to be significantly more efficient than the standard RSS and JPS mean estimators. We conclude that the standard estimators are best reserved for settings where only subjective, judgment-based rankings are available.     

A class of partially linear transformation models for recurrent gap times

In this article, we propose a general class of partially linear transformation models for recurrent gap time data, which extends the linear transformation models by incorporating non linear covariate effects and includes the partially linear proportional hazards and the partially linear proportional odds models as special cases. Both global and local estimating equations are developed to estimate the parametric and non parametric covariate effects, and the asymptotic properties of the resulting estimators are established. The finite-sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a clinic study on chronic granulomatous disease is provided.     

Estimators based on ranks for arma models

In this paper we introduce a new family of robust estimators for ARMA models. These estimators are defined by replacing the residual sample autocovariances in the least squares equations by autocovariances based on ranks. The asymptotic normality of the proposed estimators is provided. The efficiency and robustness properties of these estimators are studied. An adequate choice of the score functions gives estimators which have high efficiency under normality and robustness in the presence of outliers. The score functions can also be chosen so that the resulting estimators are asymptotically as efficient as the maximum likelihood estimators for a given distribution.     

A Class of Weighted Estimating Equations for Semiparametric Transformation Models with Missing Covariates

In survival analysis, covariate measurements often contain missing observations; ignoring this feature can lead to invalid inference. We propose a class of weighted estimating equations for right‐censored data with missing covariates under semiparametric transformation models. Time‐specific and subject‐specific weights are accommodated in the formulation of the weighted estimating equations. We establish unified results for estimating missingness probabilities that cover both parametric and non‐parametric modelling schemes. To improve estimation efficiency, the weighted estimating equations are augmented by a new set of unbiased estimating equations. The resultant estimator has the so‐called ‘double robustness’ property and is optimal within a class of consistent estimators.     

Bootstrapping the conditional copula

This paper is concerned with inference about the dependence or association between two random variables conditionally upon the given value of a covariate. A way to describe such a conditional dependence is via a conditional copula function. Nonparametric estimators for a conditional copula then lead to nonparametric estimates of conditional association measures such as a conditional Kendall's tau. The limiting distributions of nonparametric conditional copula estimators are rather involved. In this paper we propose a bootstrap procedure for approximating these distributions and their characteristics, and establish its consistency. We apply the proposed bootstrap procedure for constructing confidence intervals for conditional association measures, such as a conditional Blomqvist beta and a conditional Kendall's tau. The performances of the proposed methods are investigated via a simulation study involving a variety of models, ranging from models in which the dependence (weak or strong) on the covariate is only through the copula and not through the marginals, to models in which this dependence appears in both the copula and the marginal distributions. As a conclusion we provide practical recommendations for constructing bootstrap-based confidence intervals for the discussed conditional association measures.     

Efficient estimation for case‐cohort studies

The author considers time‐to‐event data from case‐cohort designs. As existing methods are either inefficient or based on restrictive assumptions concerning the censoring mechanism, he proposes a semi‐parametrically efficient estimator under the usual assumptions for Cox regression models. The estimator in question is obtained by a one‐step Newton‐Raphson approximation that solves the efficient score equations with initial value obtained from an existing method. The author proves that the estimator is consistent, asymptotically efficient and normally distributed in the limit. He also resorts to simulations to show that the proposed estimator performs well in finite samples and that it considerably improves the efficiency of existing pseudo‐likelihood estimators when a correlate of the missing covariate is available. Although he focuses on the situation where covariates are discrete, the author also explores how the method can be applied to models with continuous covariates.     

Variance bounds for estimators in autoregressive models with constraints

We consider nonlinear and heteroscedastic autoregressive models whose residuals are martingale increments with conditional distributions that fulfil certain constraints. We treat two classes of constraints: residuals depending on the past through some function of the past observations only, and residuals that are invariant under some finite group of transformations. We determine the efficient influence function for estimators of the autoregressive parameter in such models, calculate variance bounds, discuss information gains, and suggest how to construct efficient estimators. Without constraints, efficient estimators can be given by weighted least squares estimators. With the constraints considered here, efficient estimators are obtained differently, as one-step improvements of some initial estimator, similarly as in autoregressive models with independent increments.     

Statistical Analysis of ‘Probabilities of Causation’ Using Co‐variate Information

Abstract. This article deals with two problems concering the probabilities of causation defined by Pearl (Causality: models, reasoning, and inference, 2nd edn, 2009, Cambridge University Press, New York) namely, the probability that one observed event was a necessary (or sufficient, or both) cause of another; one is to derive new bounds, and the other is to provide the covariate selection criteria. Tian & Pearl (Ann. Math. Artif. Intell., 28, 2000, 287–313) showed how to bound the probabilities of causation using information from experimental and observational studies, with minimal assumptions about the data‐generating process, and identifiable conditions for these probabilities. In this article, we derive narrower bounds using covariate information that is available from those studies. In addition, we propose the conditional monotonicity assumption so as to further narrow the bounds. Moreover, we discuss the covariate selection problem from the viewpoint of the estimation accuracy, and show that selecting a covariate that has a direct effect on an outcome variable cannot always improve the estimation accuracy, which is contrary to the situation in linear regression models. These results provide more accurate information for public policy, legal determination of responsibility and personal decision making.     

Correcting for non-compliance in randomized trials using rank preserving structural failure time models

We propose correcting for non-compliance in randomized trials by estimating the parameters of a class of semi-parametric failure time models, the rank preserving structural failure time models, using a class of rank estimators. These models are the structural or strong version of the “accelerated failure time model with time-dependent covariates” of Cox and Oakes (1984). In this paper we develop a large sample theory for these estimators, derive the optimal estimator within this class, and briefly consider the construction of “partially adaptive” estimators whose efficiency may approach that of the optimal estimator. We show that in the absence of censoring the optimal estimator attains the semiparametric efficiency bound for the model.     

Additive risk model with case-cohort sampled current status data

Two-phase stratified sampling has been extensively used in large epidemiologic studies as a way of reducing costs associated with assembling covariate histories and enlarging relative sample sizes of the most informative subgroups. In this article, we investigate case-cohort sampled current status data under the additive risk model assumption. We describe a class of estimating equations, each depending on a different prevalence ratio estimate. Asymptotic properties of the proposed estimators and inference based on the “m out of n” nonparametric bootstrap are investigated. A small simulation study is employed to evaluate the finite sample performance and relative efficiency of the proposed estimators.     

Efficient M-estimators with auxiliary information

This paper introduces a new class of M-estimators based on generalised empirical likelihood (GEL) estimation with some auxiliary information available in the sample. The resulting class of estimators is efficient in the sense that it achieves the same asymptotic lower bound as that of the efficient generalised method of moment (GMM) estimator with the same auxiliary information. The paper also shows that in case of smooth estimating equations the proposed estimators enjoy a small second order bias property compared to both efficient GMM and full GEL estimators. Analytical formulae to obtain bias corrected estimators are also provided. Simulations show that with correctly specified auxiliary information the proposed estimators and in particular those based on empirical likelihood outperform standard M and efficient GMM estimators both in terms of finite sample bias and efficiency. On the other hand with moderately misspecified auxiliary information estimators based on the nonparametric tilting method are typically characterised by the best finite sample properties.     

Nonparametric covariate adjustment for receiver operating characteristic curves

The accuracy of a diagnostic test is typically characterized using the receiver operating characteristic (ROC) curve. Summarizing indexes such as the area under the ROC curve (AUC) are used to compare different tests as well as to measure the difference between two populations. Often additional information is available on some of the covariates which are known to influence the accuracy of such measures. The authors propose nonparametric methods for covariate adjustment of the AUC. Models with normal errors and possibly non‐normal errors are discussed and analyzed separately. Nonparametric regression is used for estimating mean and variance functions in both scenarios. In the model that relaxes the assumption of normality, the authors propose a covariate‐adjusted Mann–Whitney estimator for AUC estimation which effectively uses available data to construct working samples at any covariate value of interest and is computationally efficient for implementation. This provides a generalization of the Mann–Whitney approach for comparing two populations by taking covariate effects into account. The authors derive asymptotic properties for the AUC estimators in both settings, including asymptotic normality, optimal strong uniform convergence rates and mean squared error (MSE) consistency. The MSE of the AUC estimators was also assessed in smaller samples by simulation. Data from an agricultural study were used to illustrate the methods of analysis. The Canadian Journal of Statistics 38:27–46; 2010 © 2009 Statistical Society of Canada     

Cox regression for mixed case interval-censored data with covariate errors

Covariate measurement error problems have been extensively studied in the context of right-censored data but less so for interval-censored data. Motivated by the AIDS Clinical Trial Group 175 study, where the occurrence time of AIDS was examined only at intermittent clinic visits and the baseline covariate CD4 count was measured with error, we describe a semiparametric maximum likelihood method for analyzing mixed case interval-censored data with mismeasured covariates under the proportional hazards model. We show that the estimator of the regression coefficient is asymptotically normal and efficient and provide a very stable and efficient algorithm for computing the estimators. We evaluate the method through simulation studies and illustrate it with AIDS data.     

Reweighting approximate GM estimators: Asymptotics and residual-based graphics

The iterative weighted least squares algorithm is handy for solving generalized estimating equations. In some situations it may be desirable to limit the number of iterations to a fixed finite number, for instance, to keep the breakdown point under control. Such a scheme is called reweighting. Usually reweighting leads to a different large sample theory than full iteration, and the reweighted estimator may inherit deficiencies of the starting value. When might the reweighting scheme work? To answer this question we define a broad class of estimators, namely, approximate GM estimators, and we show that reweighting leads to the same large sample theory as full iteration within this class. As an example, we provide conditions under which one-step Newton-Raphson estimators are approximate GM estimators. We then use the reweighting to construct residual-based graphics for approximate GM estimates, adapting weighted residual plots that have been proposed previously, and developing new plots to provide complementary views of the data.     

Generalized ratio-type and ratio-exponential-type estimators for population mean under modified Horvitz-Thompson estimator in adaptive cluster sampling

In the present article, we propose the generalized ratio-type and generalized ratio-exponential-type estimators for population mean in adaptive cluster sampling (ACS) under modified Horvitz-Thompson estimator. The proposed estimators utilize the auxiliary information in combination of conventional measures (coefficient of skewness, coefficient of variation, correlation coefficient, covariance, coefficient of kurtosis) and robust measures (tri-mean, Hodges-Lehmann, mid-range) to increase the efficiency of the estimators. Properties of the proposed estimators are discussed using the first order of approximation. The simulation study is conducted to evaluate the performances of the estimators. The results reveal that the proposed estimators are more efficient than competing estimators for population mean in ACS under both modified Hansen-Hurwitz and Horvitz-Thompson estimators.     

Investigating dependence between frequency and severity via simple generalized linear models

Recently, a body of literature proposed new models relaxing a widely-used but controversial assumption of independence between claim frequency and severity in non-life insurance rate making. This paper critically reviews a generalized linear model approach, where a dependence between claim frequency and severity is introduced by treating frequency as a covariate in a regression model for severity. As an extension of this approach, we propose a dispersion model for severity. For this model, the information loss caused by using average severity rather than individual severity is examined in detail and the parameter estimators suffering from low efficiency are identified. We also provide analytical solutions for the aggregate sum to help rate making. We show that the simple functional form used in current research may not properly reflect the real underlying dependence structure. A real data analysis is given to explain our analytical findings.     

Maximum Likelihood Estimators in Regression Models for Error‐prone Group Testing Data

Since Dorfman's seminal work on the subject, group testing has been widely adopted in epidemiological studies. In Dorfman's context of detecting syphilis, group testing entails pooling blood samples and testing the pools, as opposed to testing individual samples. A negative pool indicates all individuals in the pool free of syphilis antigen, whereas a positive pool suggests one or more individuals carry the antigen. With covariate information collected, researchers have considered regression models that allow one to estimate covariate‐adjusted disease probability. We study maximum likelihood estimators of covariate effects in these regression models when the group testing response is prone to error. We show that, when compared with inference drawn from individual testing data, inference based on group testing data can be more resilient to response misclassification in terms of bias and efficiency. We provide valuable guidance on designing the group composition to alleviate adverse effects of misclassification on statistical inference.     

Model averaging procedure for varying-coefficient partially linear models with missing responses

This paper is concerned with model averaging procedure for varying-coefficient partially linear models with missing responses. The profile least-squares estimation process and inverse probability weighted method are employed to estimate regression coefficients of the partially restricted models, in which the propensity score is estimated by the covariate balancing propensity score method. The estimators of the linear parameters are shown to be asymptotically normal. Then we develop the focused information criterion, formulate the frequentist model averaging estimators and construct the corresponding confidence intervals. Some simulation studies are conducted to examine the finite sample performance of the proposed methods. We find that the covariate balancing propensity score improves the performance of the inverse probability weighted estimator. We also demonstrate the superiority of the proposed model averaging estimators over those of existing strategies in terms of mean squared error and coverage probability. Finally, our approach is further applied to a real data example.     

Case-cohort analysis with semiparametric transformation models

Semiparametric transformation models provide flexible regression models for survival analysis, including the Cox proportional hazards and the proportional odds models as special cases. We consider the application of semiparametric transformation models in case-cohort studies, where the covariate data are observed only on cases and on a subcohort randomly sampled from the full cohort. We first propose an approximate profile likelihood approach with full-cohort data, which amounts to the pseudo-partial likelihood approach of Zucker [2005. A pseudo-partial likelihood method for semiparametric survival regression with covariate errors. J. Amer. Statist. Assoc. 100, 1264–1277]. Simulation results show that our proposal is almost as efficient as the nonparametric maximum likelihood estimator. We then extend this approach to the case-cohort design, applying the Horvitz–Thompson weighting method to the estimating equations from the approximated profile likelihood. Two levels of weights can be utilized to achieve unbiasedness and to gain efficiency. The resulting estimator has a closed-form asymptotic covariance matrix, and is found in simulations to be substantially more efficient than the estimator based on martingale estimating equations. The extension to left-truncated data will be discussed. We illustrate the proposed method on data from a cardiovascular risk factor study conducted in Taiwan.     

Consistency of semiparametric maximum likelihood estimators for two‐phase sampling

Semiparametric maximum likelihood estimators have recently been proposed for a class of two‐phase, outcome‐dependent sampling models. All of them were “restricted” maximum likelihood estimators, in the sense that the maximization is carried out only over distributions concentrated on the observed values of the covariate vectors. In this paper, the authors give conditions for consistency of these restricted maximum likelihood estimators. They also consider the corresponding unrestricted maximization problems, in which the “absolute” maximum likelihood estimators may then have support on additional points in the covariate space. Their main consistency result also covers these unrestricted maximum likelihood estimators, when they exist for all sample sizes.