The role of mitochondria in conserved mechanisms of aging

The European research project MiMage, supported by the European Community's Sixth Framework for Research and Technological Development, focuses on elucidating the role of mitochondria in conserved mechanisms of aging. This Perspective summarizes a selection of talks presented in April 2006 at the second MiMage symposium by members from participating laboratories and invited speakers.     

T-CIA: investigating T cells in aging

Over the past few decades it has become clear that the immune system and especially T cells are instrumental in achieving a long and healthy life. The European Union (EU) previously supported several pan-European research projects coordinated from Tuebingen, Germany, aimed at providing a better understanding of immunosenescence. For 3 years, until the end of 2005, the EU is supporting a project called T cells in aging (T-CIA). The aim of T-CIA is to spy out and combine current efforts in immunology, molecular biology, and gerontology for a better understanding of why the elderly often have dysregulated immune responses and are more susceptible to infections and cancer.     

Meeting report: 4th European Congress of Biogerontology

The 4th European Congress of Biogerontology took place in Newcastle upon Tyne in November 2004. Leading figures in the biology of aging presented their recent work, providing new insights into fundamental mechanisms of aging as it occurs in organisms ranging from yeast to the human species. Highlights of these presentations are presented here.     

Moving images: world cities,connections and projects in Sydney's TV production industry

World city research concerned with connectivity has tended to focus on advanced producer service firms and on selected North American and European cities; the prevailing methodology has been quantitative. In this article I answer the call to ‘go beyond counting’ by bringing together a project‐based enquiry — on a TV mini‐series Mary Bryant— with a more conventional assessment of network connectivity. The inclusion of a practice‐centred approach to this case study adds the performative data to the network, highlighting the actions and processes of those involved in maintaining the city networks. Furthermore, I demonstrate how this method of analysis is more suited to the study of project‐based cultural industries and highlight the role of Sydney in the global television industry — a city hitherto under‐explored in world city literature.     

Economic hardship and depression across the life course: the impact of welfare state regimes

Previous research in the United States suggests that depression related to economic hardship decreases with age. We test whether this pattern can be generalized to other developed nations. Based on data from 23 countries in the European Social Survey (2006--2007), multilevel analyses show that the moderating role of age depends on the socio-political context. While the hardship--depression link is not significantly different across the life course in Nordic and Bismarckian regimes, the hardship--depression link increases with age in Southern and Eastern European countries and decreases with age in strength in Anglo-Saxon welfare states. Our findings suggest that welfare state regimes play a significant role in attenuating, boosting, or even reversing the health effects of social experiences such as economic hardship on aging. Health knowledge gained through research that ignores the socio-political context may be limited in terms of generalization.     

Mitochondrial genetics of aging: intergenomic conflict resolution

Mitochondria are the organelles of aerobic respiration. They consume the oxygen we breathe to stay alive and generate energy for cells to function. But oxygen can be dangerous. Indeed, mitochondria generate the majority of reactive oxygen species that are prime suspects among the causes of aging. Mitochondria have been influential elements of evolving eukaryotic cells for perhaps 2 billion years, since a eubacterium fused with an archaebacterium. The picture that has emerged from this long history of genomic fusion is that of a complex network of nuclear-mitochondrial cross-talk. Here, we discuss the biochemical and genetic conflicts between mitochondria and nucleus, which have shaped the role of mitochondria in aging, and point to new paths for further investigations.     

New pathways in the evaluation of programmes for men who perpetrate violence against their female partners

Today, evaluation research in the field of intervention programmes for men who perpetrate violence against their female partners still makes a fragmentary impression. Across Europe various evaluation studies have been performed. However, the methodologies applied are too heterogeneous to allow the combination of the results in a meta-analytical way. In this paper we propose a future pathway for organising outcome evaluation studies of domestic violence perpetrator programmes in community settings, so that today’s problems in this field can be overcome. In a pragmatic framework that acknowledges the limited pre-conditions for evaluation studies in the area of domestic violence perpetrator programmes as it is today, feasible approaches for outcome evaluation are outlined, with recent developments in the field taken as starting points. The framework for organising future evaluation studies of work with perpetrators of domestic violence is presented together with a strategy to promote this framework. International networks of practitioners and researchers play a central role in this strategy through upskilling the area of practical work, preparing the ground for evaluation research and improving cooperation between practitioners and researchers. This paper is based on the results of the European funded project IMPACT (under the Daphne-III-funding programme of the European Commission).     

An eco-social approach to tackling social exclusion in European cities: A new comparative research project in progress

In this article we would like to introduce a three-year Research Project called 'New Local Policies against Social Exclusion in European Cities', financed by the Targeted Socio-Economic Research Program (TSER) of the European Union. We will briefly highlight the entire research project that aims to make a contribution to European debate about social exclusion within social work (see also Washington and Paylor 1998), as well as social work's theoretical knowledge and field projects. The specific emphasis is on analysing the significance of the eco-social environment and citizen participation in disadvantaged residential areas, but related work aims to develop new kinds of action models and research methods. The project started in January 1998 in Finland, Germany, and Great Britain, and it will be completed by the end of 2000. Our research is a unique kind of cross-national comparative case-context research, based on classic ideas of action research and comparative research. Overall, the project aims through a European exchange to develop innovative models of local policies, particularly within community-based social work.     

Time and aging--mechanisms and meanings

A recent European Molecular Biology Laboratory Conference on Science and Society entitled "Time & Aging--Mechanisms & Meanings" fascinated scientists from different research areas as well as nonscientists. Topics discussed included not only the biological aging process but also the psychological effects of aging and social influences that affect this process.     

Error catastrophe in mutant mitochondria

The error catastrophe theory of aging, proposed by Orgel in 1963, predicted a decrease in the fidelity of information transfer that accelerated as aging progressed, until properly functioning macromolecules could no longer be reliably made. The theory was extensively tested by comparing DNA polymerases, transfer RNAs, and proteins derived from aging versus young animals, but it did not prove to have general applicability to the process of aging. Recently, the heritable eye disorder progressive external ophthalmoplegia has been found to result from mutation of the gene encoding DNA polymerase gamma, which replicates mitochondrial DNA. The mutant form of the polymerase replicates DNA less accurately than the wild-type enzyme, providing an explanation for the accumulation of mutations in the mitochondrial DNA of patients with this disorder. The affected mitochondria appear to exhibit an age-dependent error catastrophe. It is possible that other genetic diseases might result in error catastrophes in mitochondria as well.     

The LINC Project

Abstract

The Linking Intergenerational Networks in Communities (LINC) Project, a statewide, collaborative, intergenerational program, funded in 1995 by the V. Kann Rasmussen Foundation, included Clemson University, the Bureau of Senior Services for South Carolina, the South Carolina Department of Education, and the United Way of South Carolina. In this paper, the author focuses on what the partnering groups learned during the five-year project about the process of creating and implementing a collaborative statewide intergenerational program that included a public university, the state offices of aging and education, and a private fundraising and public service agency. The author, who during part of the project was the evaluator at Generations Together at the University of Pittsburgh and who consulted with the LINC project on the project evaluation from 1998 to 2000, uses the literature on collaboration to describe how the four partners worked together to form an intergenerational collaborative organization in South Carolina.     

Towards an agenda for disability research in Europe: learning from disabled people’s organisations

This paper addresses the challenges of building capacity for collaborative participatory research with disabled people’s organisations in European countries. The paper presents initial findings from the project ‘European Research Agendas for Disability Equality’ (EuRADE), which seeks to build the capacity of civil society organisations to participate in future research collaborations in partnership with academic institutions. The findings draw on survey data identifying the research capacity, needs and priorities of 68 organisations in 25 countries and focuses, in particular, on responses from national or European level representative organisations of disabled people. The findings demonstrate a high degree of motivation and readiness for collaboration in academic research but raise concerns about the readiness of academic institutions to engage disabled people as equal partners within social model and rights‐based approaches. Respondent organisations identified a wide range of research needs that raise challenges for collaborative responses from the academic community. In this way, the findings provide a basis for developing user‐led agendas for European funded research within the emancipatory paradigm, and indentify important opportunities for new international research collaborations between activists and academics.     

Children in poverty in germany: reflections on recent social work research

This project focuses on children growing up in impoverished life circumstances, originating from an increasing level of poverty in Germany. There are two perspectives in social work research on children living in poverty: first, current research on childhood recognises that children are social agents in their own practices of life; second, research on poverty draws attention to the issue of social inequality, and broaches the question of the structural constraints and limitations of daily life. We report on current German research on children living in poverty, and focus on the role of peer relationships in coping with discrimination. This research is substantiated with the results of our own research project. We find that children develop strategies to mitigate the effects of poverty. The family can also help by providing the child with an interpretation of their poverty, and through daily coping mechanisms. Additionally, children can gain support from their peers. However, bridging social capital and gaining access to other social milieus is seldom successful. We conclude with a discussion of strategies that point the way out of child poverty. Such an optimistic goal, however, would require an alliance of practice, research and policy in the field of social work.     

Aging in the Era of Regenerative Medicine: Analysis of Aging‐Related Representations among Canadian Researchers

Explicitly aimed at understanding and controlling molecular and cellular processes at the root of senescence and biological aging, regenerative medicine aspires to artificially reproduce the biological processes that enable the body to regenerate itself. This no longer involves conserving the body's state of balance by combating disease, as in clinical medicine, but rather fighting degeneration itself. From stem cell research to gene therapy to the production of replacement tissues, regenerative medicine perfectly corresponds to the logic of biomedicalization specific to postmodern society. Based on a series of 18 interviews conducted with Canadian researchers and clinicians in the field of regenerative medicine, this article seeks to understand representations of the aging body among researchers in this field. Seen from a strictly negative angle, aging is assimilated by researchers to an inevitable catastrophe that nevertheless must be combated. More closely observing the theoretical model of regenerative biology and the types of treatments developed, it can be observed, however, that this medicine of the future does not target the elderly, but rather promises youth the ability to regenerate themselves to avoid aging.     

On the definition of public relations: a European view

The article confronts a U.S.-based definition of public relations as relationship management with a European view that besides a relational, argues also for a reflective paradigm that is concerned with publics and the public sphere; not only with relational (which can in principle be private), but also with public consequences of organizational behavior. The article is based on a three year research project on the European Public Relations Body of Knowledge and it reflects on the consequence of that project for definitional activities in the US practitioner and academic communities.     

European Communication Monitor: Current developments,issues and tendencies of the professional practice of public relations in Europe

The European Communication Monitor (ECM) research explores the current developments for communications disciplines, practices and instruments. It is an extensive research project to monitor trends in communication management, analyse the changing framework for the profession driven by European integration and evaluate specific topics of relevance to public relations practice. Specifically, the 2008 ECM edition is focused on aspects such as: strategy and control, interactive channels, corporate social responsibility, intercultural challenges, influence on management decision making, cooperation with agencies, and future budgets.     

The social field of the European corporate elite: a network analysis of interlocking directorates among Europe's largest corporate boards

In this article I investigate the emerging patterns of the European corporate elite network as an example of a European social field, as described by Fligstein. The findings confirm that interlocking directorates form a European corporate network. However, the intercorporate network rests on a very small group of European corporate elite members: it remains the playground of a select few pan‐European ‘big linkers’. Although financial institutions and bankers appear in the upper echelons of the network, they do not occupy crucial positions. Rather, (former) CEOs of Europe's largest big non‐financial businesses knit together the network of interlocking directorates. The network rests on a coalescence of finance and industry, rather than on the dominance of the one over the other. Although the project of European unification has been quite successful in organizing the formal institutional structures, it has not yet led to reproduction of a European business community reminiscent of the national communities.     

Meeting report--44th Annual Drosophila Research Conference

The ability to compare the genetics of aging in multiple model organisms is a powerful tool to dissect the biology of aging. Although the fruit fly has only about half again as many genes as the nematode worm, its tissue organization is much more complex. The emerging importance of tissue specificity and endocrine signaling in aging makes the fly a natural choice for many researchers interested in unraveling the next level of complexity of the aging process. This Perspective provides an overview of research related to aging that was described at the annual Drosophila conference held in Chicago in March 2003.