Research of stroke combined hyperlipidemia-induced erectile dysfunction in rat model

Abstract

Objective: The study was aimed to evaluate the influences of erectile dysfunction (ED) in a rat model of stroke combined with hyperlipidemia (HLP).

Methods: Male Sprague–Dawley rats were divided into control and hyperlipidemia (HLP) groups. HLP model was constructed by feeding with high-fat and cholesterol diets. Serum levels of total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG), and non-HDL were identified to check the model was success. Stroke model was established by FeCl₃. ICP/MAP value was detected to evaluate the erectile function of rats. Serum level of lipoproteins and the expressions of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) were detected by ELISA. Hematoxylin–eosin (HE) staining of corpus cavernosum and measurement of penis length were utilized to assessment erectile function. Western blot was used.

Results: TC, TG, LDL, and non-HDL-C in serum were up-regulated, while HDL level was attenuated. After treatment, the serum lipid level recovered. From the ICP/MAP values, the erectile function of both two treatment groups recovered. The expression of PDE5A was up-regulated, while the levels of eNOS and cGMP were suppressed after surgery. The length of penis was decreased, and corpus cavernosum was damaged following HLP and stroke. However, the erectile function was recovered after treatment.

Conclusion: Stroke combined HLP caused ED through NO-cGMP-PDE5 pathway.     

Devalued, deskilled and diversified: explaining the proliferation of the strip industry in the UK

This paper looks beyond the debates that focus on the objectification of the female body to examine the question as to why strip clubs have proliferated and found a permanent place in the night-time economy in the UK. Using empirical qualitative and quantitative data from the largest study into the strip industry in the UK to date, we challenge the common assumption that 'demand' is responsible for the rise in erotic dance. Instead, we argue that the proliferation of strip clubs is largely due to the internal economic structures of the industry which have developed partly in response to the financial crisis beginning in 2008. First, we argue that clubs profit from individual dancers through an exploitative system of fees and fines, rendering a strip club business a low cost investment with high returns and little risk to club owners. Second, we note that the last decade has seen diversification of the industry accompanied by deskilling and devaluing of dancing and dancers' labour. Third, we demonstrate that despite the negative effects of these changes on workers, there has been an expansion of the industry as the ability to make profit, even during a financial crisis was ensured through the transferral of risk to workers. Overall, we suggest that far from proliferating as a response to demand, the industry has maintained its market presence due to its ability to establish highly financially exploitation employment relationships with dancers at a time of economic fragility.     

论中国当代城市化的基本特征

对城市化的本质和内涵进行剖析,通过对比发达国家的城市化和发展中国家的城市化,就中国城市化的基本特征进行分析,认为当代中国城市化的发展背景远比西方发达国家城市化高潮时期以及大多数发展中国家面临的状态和问题更加错综复杂,因此需要根据中国国情,探索中国特色的城市化道路,尤其是赋予中国城市化的城市生活方式转变的内涵,而不是片面地追求城市化率的提高。     

Correlates of Alcohol Use Likelihood for Latino Immigrant Youth in an Emerging Context

Using a three-wave prospective longitudinal design spanning 3 years, we assessed alcohol use likelihood trajectories and their correlates among a community sample of Latino immigrant adolescents in the emerging immigrant context of Western Oregon. Results from growth mixture modeling revealed two distinct classes: lower risk youth who reported little likelihood of alcohol use but whose trajectory was increasing, and higher risk youth who reported higher likelihood of alcohol use and whose trajectory was stable. We found significant differences between the two classes such that lower risk youth reported greater levels of Latino cultural orientation and parental monitoring, whereas higher risk youth reported greater levels of family cultural stress and delinquency. Results are discussed in terms of prior research and theory.     

The development of sexology as a discipline∗

The founding of the SSSS in 1957 was perhaps one portent of the sexual revolution of the sixties, which would break some of the power of the antisex forces. At the time, the Society had no competititon, whereas now there are various splinter groups. It would be better had sexologists kept united in the common cause of founding a new academic discipline of sexology. Meantime, there is no department of sexology in any medical school or teaching hospital in the Western hemisphere. Sexology, because human beings are a sexually dimorphic species, deals basically with a partnership, not an indivisual. It has four branches: experimental and investigative; clinical and therapeutic; education and training; and standards and certification. The SSSS and the JOSR can contribute to a more systematic and less laissez faire growth of sexology as an academic discipline.     

Migrants' regular army of labour: gender dimensions of the impact of the global economic crisis on migrant labor in Western Europe

The purpose of this article is to remedy the lack of explanatory endeavours concerning the positive performance of female migrant workers during the recent economic crisis in Western Europe. This phenomenon both interrogates the established association between economic downturns and their negative impact on migrant labour in low‐skilled jobs and enriches the theory of the reserve army of labour, which has been applied to understanding the fragile status of migrant workers in Western economies. Secondary analysis of Labor Force Survey (LFS) and OECD data concerning the impact of the crisis on migrant labour shows that women employed in the care‐domestic sector have been affected significantly less than men employed in manufacture and constructions. To explain this evidence, the article proposes a theoretical framework that draws on key concepts and debates in different strands of sociology: the increasing demand for paid care‐domestic work due to the ageing population and the growth of native‐born women's rates of activity; the commodification of care and the state management of migration; the affectivity and spatial fixity of care‐domestic labour. All these factors contribute to configure female migrant labour, mostly employed in the reproductive sector, as a ‘regular’ rather than a reserve army of labour.     

Why Do Political Elites Fracture? The Unusual Case of the Yugoslav Communist Elite

After World War II, Yugoslavia as a state was reconstituted by a small communist elite. Since this was an ideocratic rule, ideology was taken seriously by the elite and treated enthusiastically. One of the elite’s initial goals was to speedily develop Yugoslavia, so that a Western level of economic development be achieved. Economic disparities among regions were also to have been overcome. For various reasons, this objective was never close to being achieved, although in certain periods economic development was strong. The elite tried to speed up growth by various incentives, including worker self-management. Failure to achieve this goal and various economic troubles first precipitated mutual acrimony within the elite along national lines, while at the next stage, it brought about ethnic segmentation of the elite itself. By 1972, the elite had dissolved into national, although still communist, elites. The major reasons for this process are found in the very failure to achieve the developmental goal, in the consociational nature of the political system, and in the nature of the political elites, which were national ones. Elite segmentation sheds important light on the dissolution of the Yugoslav state.     

Functional outcomes and complications following B-TURP versus HoLEP for the treatment of benign prostatic hyperplasia: a review of the literature and Meta-analysis

Objective: To conduct a systematic review and Meta-analysis of the literature on the efficacy and safety of B-TURP versus HoLEP for the treatment of benign prostatic hyperplasia (BPH) in terms of demographic and clinical baseline characteristics, peri-operative variables, and postoperative outcomes and complications.

Methods: Trials comparing B-TURP and HoLEP were identified systematically using Pubmed, Embase, CNKI, Web of Science and the Cochrane Library. Primary outcomes were the peak urinary flow rate (Q_max), post-void residual volume (PVR) and international prostate symptom score (IPSS). Secondary outcomes were operation time, irrigation duration, catheterization duration, resected tissue and complications.

Results: Four trials assessing B-TURP and HoLEP were considered eligible for Meta-analysis, including three randomized controlled trials (RCTs) and one retrospective study. There was no statistically significant difference between B-TURP and HoLEP in terms of Q_max, IPSS, PVR at 3–6?months follow-up, operation duration, catheterization duration, resected tissue and complications (p?>?0.05). HoLEP was associated with a significantly shorter irrigation time as compared with B-TURP (p?Conclusion: Both B-TURP and HoLEP are safe and minimally invasive techniques that are similar in terms of symptomatic relief, although these findings need further validation in larger RCTs involving larger numbers of patients and over a longer follow-up duration for B-TURP or HoLEP before a new gold standard procedure emerges for surgical treatment of BPH.     

An Analysis of Atlanta's Ordinance Prohibiting Urban Camping: Passage and Early Implementation

In November 1996, the Atlanta City Council passed an ordinance to prohibit certain Urban Camping behaviors on public lands. This paper analyzes the development, passage, and early implementation of Atlanta's Urban Camping and Improper Use of Public Places ordinance. The ordinance prohibits lying down, sleeping, regular meal preparation, and storing belongings on public property. The ordinance is controversial because it criminalizes behaviors of homeless individuals who have no private property and therefore no choice but to perform tasks necessary to life on public lands. The ordinance's passage in Atlanta is at least partly the result of a post Olympic private sector growth in power that capitalized on growing concerns about public safety and urban economic vitality. During its first year, the ordinance disproportionately impacted homeless persons. Arrests occurred primarily in parks and during daytime, summer hours. Arrests trends reflect continuing tension between Atlanta's various users of public space.     

Children's Pictures of a Good and Desirable Meal in Kindergarten — A Participatory Visual Approach

In kindergarten, meals are framed and regulated by the adults and ideas within the institution. However, by inviting children to visualise their ideas, they can be included when trying to understand as well as develop the meals. The purpose was to explore children's pictures of good and desirable meals in kindergarten by using a visual, participatory approach together with children four to six years. The children related to various aspects of the meal, emphasising the importance of food, table artefacts and context, defined as platescape, tablescape and roomscape. The result further highlighted the complexity of listening to the plurality of children's voices.