An approximation to cluster size distribution of two Gaussian random fields conjunction with application to FMRI data

In brain mapping, the regions of the brain that are ‘activated’ by a task or external stimulus are detected by thresholding an image of test statistics. Often the experiment is repeated on several different subjects or for several different stimuli on the same subject, and the researcher is interested in the common points in the brain where ‘activation’ occurs in all test statistic images. The conjunction is thus defined as those points in the brain that show ‘activation’ in all images. We are interested in which parts of the conjunction are noise, and which show true activation in all test statistic images. We would expect truly activated regions to be larger than usual, so our test statistic is based on the volume of clusters (connected components) of the conjunction. Our main result is an approximate P-value for this in the case of the conjunction of two Gaussian test statistic images. The results are applied to a functional magnetic resonance experiment in pain perception.     

A class of multivariate distribution-free tests of independence based on graphs

A class of distribution-free tests is proposed for the independence of two subsets of response coordinates. The tests are based on the pairwise distances across subjects within each subset of the response. A complete graph is induced by each subset of response coordinates, with the sample points as nodes and the pairwise distances as the edge weights. The proposed test statistic depends only on the rank order of edges in these complete graphs. The response vector may be of any dimensions. In particular, the number of samples may be smaller than the dimensions of the response. The test statistic is shown to have a normal limiting distribution with known expectation and variance under the null hypothesis of independence. The exact distribution free null distribution of the test statistic is given for a sample of size 14, and its Monte-Carlo approximation is considered for larger sample sizes. We demonstrate in simulations that this new class of tests has good power properties for very general alternatives.     

Test for homogeneity in Hardy–Weinberg normal mixture model

The phenotype of a quantitative trait locus (QTL) is often modeled by a finite mixture of normal distributions. If the QTL effect depends on the number of copies of a specific allele one carries, then the mixture model has three components. In this case, the mixing proportions have a binomial structure according to the Hardy–Weinberg equilibrium. In the search for QTL, a significance test of homogeneity against the Hardy–Weinberg normal mixture model alternative is an important first step. The LOD score method, a likelihood ratio test used in genetics, is a favored choice. However, there is not yet a general theory for the limiting distribution of the likelihood ratio statistic in the presence of unknown variance. This paper derives the limiting distribution of the likelihood ratio statistic, which can be described by the supremum of a quadratic form of a Gaussian process. Further, the result implies that the distribution of the modified likelihood ratio statistic is well approximated by a chi-squared distribution. Simulation results show that the approximation has satisfactory precision for the cases considered. We also give a real-data example.     

Likelihood Based Inference in Non-linear Regression Models Using the p* and R* Approach

We develop second order asymptotic results for likelihood-based inference in Gaussian non-linear regression models. We provide an approximation to the conditional density of the maximum likelihood estimator given an approximate ancillary statistic (the affine ancillary). From this approximation, we derive a statistic to test an hypothesis on one component of the parameter. This test statistic is an adjustment of the signed log-likelihood ratio statistic. The distributional approximations (for the maximum likelihood estimator and for the test statistic) are of second order in large deviation regions.     

Asymptotic behaviour of a test statistic for detection of change in mean of vectors

The paper gives an asymptotic distribution of a test statistic for detecting a change in a mean of random vectors with dependent components. The studied test statistic has a form of a maximum of a square Euclidean norms of vectors with components being standardized partial cumulative sums of deviations from means. The limit distribution was obtained using a result of Piterbarg [1994. High deviations for multidimensional stationary Gaussian processes with independent components. In: Zolotarev, V.M. (Ed.), Stability Problems for Stochastic Models, pp. 197–210].     

The likelihood ratio test for homogeneity in finite mixture models

The authors study the asymptotic behaviour of the likelihood ratio statistic for testing homogeneity in the finite mixture models of a general parametric distribution family. They prove that the limiting distribution of this statistic is the squared supremum of a truncated standard Gaussian process. The autocorrelation function of the Gaussian process is explicitly presented. A re‐sampling procedure is recommended to obtain the asymptotic p‐value. Three kernel functions, normal, binomial and Poisson, are used in a simulation study which illustrates the procedure.     

Balanced Confidence Regions Based on Tukey's Depth and the Bootstrap

We propose and study the bootstrap confidence regions for multivariate parameters based on Tukey's depth. The bootstrap is based on the normalized or Studentized statistic formed from an independent and identically distributed random sample obtained from some unknown distribution in R ^q . The bootstrap points are deleted on the basis of Tukey's depth until the desired confidence level is reached. The proposed confidence regions are shown to be second order balanced in the context discussed by Beran. We also study the asymptotic consistency of Tukey's depth-based bootstrap confidence regions. The applicability of the method proposed is demonstrated in a simulation study.     

On the use of priors in goodness‐of‐fit tests

Priors are introduced into goodness‐of‐fit tests, both for unknown parameters in the tested distribution and on the alternative density. Neyman–Pearson theory leads to the test with the highest expected power. To make the test practical, we seek priors that make it likely a priori that the power will be larger than the level of the test but not too close to one. As a result, priors are sample size dependent. We explore this procedure in particular for priors that are defined via a Gaussian process approximation for the logarithm of the alternative density. In the case of testing for the uniform distribution, we show that the optimal test is of the U‐statistic type and establish limiting distributions for the optimal test statistic, both under the null hypothesis and averaged over the alternative hypotheses. The optimal test statistic is shown to be of the Cramér–von Mises type for specific choices of the Gaussian process involved. The methodology when parameters in the tested distribution are unknown is discussed and illustrated in the case of testing for the von Mises distribution. The Canadian Journal of Statistics 47: 560–579; 2019 © 2019 Statistical Society of Canada     

Generalized portmanteau statistics and tests of randomness

This paper considers the problem of testing the randomness of Gaussian and non–Gaussian time series. A general class of parametric portmanteau statistics, which include the Box–Pierce and the Ljung–Box statistics, is introduced. Using the exact first and second moments of the sample autocorrelations when the observations are i.i.d. normal with unknown mean, the exact expected value of any portmanteau statistics is obtained for this case. Two new portmanteau statistics, which exploit the exact moments of the sample autocorrelations, are studied. For the nonparametric case, a rank portmanteau statistic is introduced. The latter has the same distribution for any series of exchangeable random variables and uses the exact moments of the rank autocorrelations. We show that its asymptotic distribution is chi–squate. Simulation results indicate that the new portmanteau statistics are better approximated by the chi–square asymptotic distribution than the Ljung–Box statistics. Several analytical results presented in the paper were derived by usig a symbolic manipulation program.     

Goodness of fit for the inverse Gaussian distribution

For testing the fit of the inverse Gaussian distribution with unknown parameters, the empirical distribution-function statistic A² is studied. Two procedures are followed in constructing the test statistic; they yield the same asymptotic distribution. In the first procedure the parameters in the distribution function are directly estimated, and in the second the distribution function is estimated by its Rao-Blackwell distribution estimator. A table is given for the asymptotic critical points of A². These are shown to depend only on the ratio of the unknown parameters. An analysis is provided of the effect of estimating the ratio to enter the table for A². This analysis enables the proposal of the complete operating procedure, which is sustained by a Monte Carlo study.     

Likelihood ratio test for univariate Gaussian mixture

We consider Gaussian mixtures and particularly the problem of testing homogeneity, that is testing no mixture, against a mixture with two components. Seven distinct cases are addressed, corresponding to the possible restrictions on the parameters. For each case, we give a statistic that we claim to be the likelihood ratio test statistic. The proof is given in a simple case. With the help of a bound for the maximum of a Gaussian process we calculate the percentile points. The results are illustrated by simulation.     

Alternative posterior consistency results in nonparametric binary regression using Gaussian process priors

We establish consistency of posterior distribution when a Gaussian process prior is used as a prior distribution for the unknown binary regression function. Specifically, we take the work of Ghosal and Roy [2006. Posterior consistency of Gaussian process prior for nonparametric binary regression. Ann. Statist. 34, 2413–2429] as our starting point, and then weaken their assumptions on the smoothness of the Gaussian process kernel while retaining a stronger yet applicable condition about design points. Furthermore, we extend their results to multi-dimensional covariates under a weaker smoothness condition on the Gaussian process. Finally, we study the extent to which posterior consistency can be achieved under a general model where, when additional hyperparameters in the covariance function of a Gaussian process are involved.     

A modified Kolmogorov-Smirnov test for the inverse gaussian density with unknown parameters

The Kolmogorov-Smirnov (KS) test is an empirical distribution function (EDF) based goodness-of-fit test that requires the underlying hypothesized density to be continuous and completely specified. When the parameters are unknown and must be estimated from the data, standard tables of the KS test statistic are not valid. Approximate upper tail percentage points of the KS statistic for the inverse Gaussian (IG) distribution with unknown parameters are tabled in this paper.

A study of the power of the KS test for the IG distribution indicates that the test is able todiscriminate between the IG distribution and distributions such as the uniform and exponentialdistributions that are very different in shape, but is relatively unable to discriminate between the IG distribution and distributions that are similar in shape such as the lognormal and Weibull distributions. In modeling settings the former distinction is typically more important to make than the latter distinction.     

Multi - sample test of equal gamma distribution scale parameters in presence of unknown common shape parameter

Shiue and Bain proposed an approximate F statistic for testing equality of two gamma distribution scale parameters in presence of a common and unknown shape parameter. By generalizing Shiue and Bain's statistic we develop a new statistic for testing equality of L >= 2 gamma distribution scale parameters. We derive the distribution of the new statistic ESP for L = 2 and equal sample size situation. For other situations distribution of ESP is not known and test based on the ESP statistic has to be performed by using simulated critical values. We also derive a C(α) statistic CML and develop a likelihood ratio statistic, LR, two modified likelihood ratio statistics M and MLB and a quadratic statistic Q. The distribution of each of the statistics CML, LR, M, MLB and Q is asymptotically chi-square with L - 1 degrees of freedom. We then conducted a monte-carlo simulation study to compare the perfor- mance of the statistics ESP, LR, M, MLB, CML and Q in terms of size and power. The statistics LR, M, MLB and Q are in general liberal and do not show power advantage over other statistics. The statistic CML, based on its asymptotic chi-square distribution, in general, holds nominal level well. It is most powerful or nearly most powerful in most situations and is simple to use. Hence, we recommend the statistic CML for use in general. For better power the statistic ESP, based on its empirical distribution, is recommended for the special situation for which there is evidence in the data that λ₁ < … < λ_L and n₁ < … < n_L, where λ₁ …, λ_L are the scale parameters and n₁,…, n_L are the sample sizes.     

Many-to-one comparison of nonlinear growth curves for Washington's Red Delicious apple

In this article, we are interested in comparing growth curves for the Red Delicious apple in several locations to that of a reference site. Although such multiple comparisons are common for linear models, statistical techniques for nonlinear models are not prolific. We theoretically derive a test statistic, considering the issues of sample size and design points. Under equal sample sizes and same design points, our test statistic is based on the maximum of an equi-correlated multivariate chi-square distribution. Under unequal sample sizes and design points, we derive a general correlation structure, and then utilize the multivariate normal distribution to numerically compute critical points for the maximum of the multivariate chi-square. We apply this statistical technique to compare the growth of Red Delicious apples at six locations to a reference site in the state of Washington in 2009. Finally, we perform simulations to verify the performance of our proposed procedure for Type I error and marginal power. Our proposed method performs well in regard to both.     

The conditional level of confidence intervals for the normal variance and applications

Suppose we observe two independent random vectors each having a multivariate normal distribution with covariance matrix known up to an unknown scale factor σ . The first random vector has a known mean vector while the second has an unknown mean vector. Interest centers around finding confidence intervals for σ² with confidence coefficient 1 ? α. Standard results show that, when we only observe the first random vector, an optimal (i.e., smallest length) confidence interval C, based on the well-known chi- squared statistic, can be constructed for σ² . When we additionally observe the second random vector, the confidence interval C is no longer optimal for estimating σ². One criterion useful for detecting the non-optimality of a confidence interval C concerns whether C admits positively or negatively biased relevant subsets. This criterion has recently received a good deal of attention. It is shown here that under some conditions the confidence interval C admits positively biased relevant subsets.

Applications of this result to the construction of ‘better‘ unconditional confidence intervals for σ² are presented. Some simulation results are given to indicate the typical extent of improvement attained.     

Tests for outliers in the inverse Gaussian distribution,with application to first hitting time models

The inverse Gaussian (IG) distribution is often applied in statistical modelling, especially with lifetime data. We present tests for outlying values of the parameters (μ, λ) of this distribution when data are available from a sample of independent units and possibly with more than one event per unit. Outlier tests are constructed from likelihood ratio tests for equality of parameters. The test for an outlying value of λ is based on an F-distributed statistic that is transformed to an approximate normal statistic when there are unequal numbers of events per unit. Simulation studies are used to confirm that Bonferroni tests have accurate size and to examine the powers of the tests. The application to first hitting time models, where the IG distribution is derived from an underlying Wiener process, is described. The tests are illustrated on data concerning the strength of different lots of insulating material.     

On testing structure of mean vector of compound symmetric gaussian model

In this paper the moments of the likelihood ratio statistic for testing the structure of mean vector of a compound symmetric Gaussian model, have been derived by using the orthogonal transformation of variables. Then the distribution of the test statistic is studied.     

Asymptotic Likelihood Based Inference for Co-integrated Homogenous Gaussian Diffusions

In this paper we consider inference for a multivariate Gaussian homogenous diffusion which is co-integrated, i.e. admits a representation in terms of stable relations (ergodic diffusions) plus Brownian motions. We show that inference on co-integration rank (the number of stable relations) in continuous time can be based on existing asymptotic distributions from discrete time co-integration analysis. Likewise the asymptotic distributions of the co-integration parameters are shown to be mixed Gaussian. Special attention is given to the parametrization of the drift terms. It is shown that the asymptotic distribution of the co-integration rank test statistic does not depend on the level of the process as a result of the chosen parametrization.     

An elliptically symmetric angular Gaussian distribution

We define a distribution on the unit sphere \(\mathbb {S}^{d-1}\) called the elliptically symmetric angular Gaussian distribution. This distribution, which to our knowledge has not been studied before, is a subfamily of the angular Gaussian distribution closely analogous to the Kent subfamily of the general Fisher–Bingham distribution. Like the Kent distribution, it has ellipse-like contours, enabling modelling of rotational asymmetry about the mean direction, but it has the additional advantages of being simple and fast to simulate from, and having a density and hence likelihood that is easy and very quick to compute exactly. These advantages are especially beneficial for computationally intensive statistical methods, one example of which is a parametric bootstrap procedure for inference for the directional mean that we describe.