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1.
In this article, we consider two different shared frailty regression models under the assumption of Gompertz as baseline distribution. Mostly assumption of gamma distribution is considered for frailty distribution. To compare the results with gamma frailty model, we consider the inverse Gaussian shared frailty model also. We compare these two models to a real life bivariate survival data set of acute leukemia remission times (Freireich et al., 1963). Analysis is performed using Markov Chain Monte Carlo methods. Model comparison is made using Bayesian model selection criterion and a well-fitted model is suggested for the acute leukemia data. 相似文献
2.
Classification and regression tree has been useful in medical research to construct algorithms for disease diagnosis or prognostic prediction. Jin et al. 7 developed a robust and cost-saving tree (RACT) algorithm with application in classification of hip fracture risk after 5-year follow-up based on the data from the Study of Osteoporotic Fractures (SOF). Although conventional recursive partitioning algorithms have been well developed, they still have some limitations. Binary splits may generate a big tree with many layers, but trinary splits may produce too many nodes. In this paper, we propose a classification approach combining trinary splits and binary splits to generate a trinary–binary tree. A new non-inferiority test of entropy is used to select the binary or trinary splits. We apply the modified method in SOF to construct a trinary–binary classification rule for predicting risk of osteoporotic hip fracture. Our new classification tree has good statistical utility: it is statistically non-inferior to the optimum binary tree and the RACT based on the testing sample and is also cost-saving. It may be useful in clinical applications: femoral neck bone mineral density, age, height loss and weight gain since age 25 can identify subjects with elevated 5-year hip fracture risk without loss of statistical efficiency. 相似文献
3.
The Significance Analysis of Microarrays (SAM; Tusher et al., 2001) method is widely used in analyzing gene expression data while controlling the FDR by using resampling-based procedure in the microarray setting. One of the main components of the SAM procedure is the adjustment of the test statistic. The introduction of the fudge factor to the test statistic aims at deflating the large value of test statistics due to the small standard error of gene-expression. Lin et al. (2008) pointed out that the fudge factor does not effectively improve the power and the control of the FDR as compared to the SAM procedure without the fudge factor in the presence of small variance genes. Motivated by the simulation results presented in Lin et al. (2008), in this article, we extend our study to compare several methods for choosing the fudge factor in the modified t-type test statistics and use simulation studies to investigate the power and the control of the FDR of the considered methods. 相似文献
4.
There is an emerging consensus in empirical finance that realized volatility series typically display long range dependence with a memory parameter (d) around 0.4 (Andersen et al., 2001; Martens et al., 2004). The present article provides some illustrative analysis of how long memory may arise from the accumulative process underlying realized volatility. The article also uses results in Lieberman and Phillips (2004, 2005) to refine statistical inference about d by higher order theory. Standard asymptotic theory has an O(n ?1/2) error rate for error rejection probabilities, and the theory used here refines the approximation to an error rate of o(n ?1/2). The new formula is independent of unknown parameters, is simple to calculate and user-friendly. The method is applied to test whether the reported long memory parameter estimates of Andersen et al. (2001) and Martens et al. (2004) differ significantly from the lower boundary (d = 0.5) of nonstationary long memory, and generally confirms earlier findings. 相似文献
5.
Shesh N. Rai Jianmin Pan Xiaobin Yuan Jianguo Sun Melissa M. Hudson Deo K. Srivastava 《统计学通讯:理论与方法》2013,42(17):3117-3133
New drug discovery in the pediatrics has dramatically improved survival, but with long- term adverse events. This motivates the examination of adverse outcomes such as long-term toxicity in a phase IV trial. An ideal approach to monitor long-term toxicity is to systematically follow the survivors, which is generally not feasible. Instead, cross-sectional surveys are conducted in Hudson et al. (2007), with one of the objectives to estimate the cumulative incidence rates along with specific interest in fixed-term (5 or 10 year) rates. We present inference procedures based on current status data to our motivating example with very interesting findings. 相似文献
6.
When a sufficient correlation between the study variable and the auxiliary variable exists, the ranks of the auxiliary variable are also correlated with the study variable, and thus, these ranks can be used as an effective tool in increasing the precision of an estimator. In this paper, we propose a new improved estimator of the finite population mean that incorporates the supplementary information in forms of: (i) the auxiliary variable and (ii) ranks of the auxiliary variable. Mathematical expressions for the bias and the mean-squared error of the proposed estimator are derived under the first order of approximation. The theoretical and empirical studies reveal that the proposed estimator always performs better than the usual mean, ratio, product, exponential-ratio and -product, classical regression estimators, and Rao (1991), Singh et al. (2009), Shabbir and Gupta (2010), Grover and Kaur (2011, 2014) estimators. 相似文献
7.
8.
We propose a new ratio type estimator for estimating the finite population mean using two auxiliary variables in stratified two-phase sampling. Expressions for bias and mean squared error of the proposed estimator are derived up to the first order of approximation. The proposed estimator is more efficient than the usual stratified sample mean estimator, traditional stratified ratio estimator and some other stratified estimators including Bahl and Tuteja (1991), Chami et al. (2012), Chand (1975), Choudhury and Singh (2012), Hamad et al. (2013), Vishwakarma and Gangele (2014), Sanaullah et al. (2014), and Chanu and Singh (2014). 相似文献
9.
This paper is based on the application of a Bayesian model to a clinical trial study to determine a more effective treatment to lower mortality rates and consequently to increase survival times among patients with lung cancer. In this study, Qian et al. [13] strived to determine if a Weibull survival model can be used to decide whether to stop a clinical trial. The traditional Gibbs sampler was used to estimate the model parameters. This paper proposes to use the independent steady-state Gibbs sampling (ISSGS) approach, introduced by Dunbar et al. [3], to improve the original Gibbs sampler in multidimensional problems. It is demonstrated that ISSGS provides accuracy with unbiased estimation and improves the performance and convergence of the Gibbs sampler in this application. 相似文献
10.
Based on the recursions in Huffer (1988) and Huffer and Lin (2001), we present a two-stage algorithm and two specialized methods for evaluating the probabilities involving linear combination of spacings of special forms. The two-stage algorithm combines the advantages of marking algorithm in Huffer and Lin (1997) and general algorithm in Huffer and Lin (2001). The proposed methods can analytically derive the exact expressions for some specific problems, and efficiently handle problems such as the distribution of the circular scan statistic and multiple coverage probabilities. 相似文献
11.
Repeated measurement designs are widely used in medicine, pharmacology, animal sciences, and psychology. In this paper the works of Iqbal and Tahir (2009) and Iqbal, Tahir, and Ghazali (2010) are generalized for the construction of circular-balanced and circular strongly balanced repeated measurements designs through the method of cyclic shifts for three periods. 相似文献
12.
Housila P. Singh 《统计学通讯:理论与方法》2013,42(23):4222-4238
This article considers some classes of estimators of the population median of the study variable using information on an auxiliary variable with their properties under large sample approximation. Asymptotic optimum estimator (AOE) in each class of estimators has been investigated along with the approximate mean square error formulae. It has been shown that the proposed classes of estimators are better than these considered by Gross (1980), Kuk and Mak (1989), Singh et al. (2003a), and Al and Cingi (2009). An empirical study is carried out to judge the merits of the suggested class of estimators over other existing estimators. 相似文献
13.
A Bottom-Up Dynamic Model of Portfolio Credit Risk with Stochastic Intensities and Random Recoveries
Tomasz R. Bielecki Areski Cousin Stéphane Crépey Alexander Herbertsson 《统计学通讯:理论与方法》2014,43(7):1362-1389
In Bielecki et al. (2014a), the authors introduced a Markov copula model of portfolio credit risk where pricing and hedging can be done in a sound theoretical and practical way. Further theoretical backgrounds and practical details are developed in Bielecki et al. (2014b,c) where numerical illustrations assumed deterministic intensities and constant recoveries. In the present paper, we show how to incorporate stochastic default intensities and random recoveries in the bottom-up modeling framework of Bielecki et al. (2014a) while preserving numerical tractability. These two features are of primary importance for applications like CVA computations on credit derivatives (Assefa et al., 2011; Bielecki et al., 2012), as CVA is sensitive to the stochastic nature of credit spreads and random recoveries allow to achieve satisfactory calibration even for “badly behaved” data sets. This article is thus a complement to Bielecki et al. (2014a), Bielecki et al. (2014b) and Bielecki et al. (2014c). 相似文献
14.
Viswanathan Ramakrishnan 《统计学通讯:模拟与计算》2013,42(3):405-418
In many genetic analyses of dichotomous twin data, odds ratios have been used to test hypotheses on heritability and shared common environment effects of a given disease (Lichtenstein et al., 2000; Ahlbom et al., 1997; Ramakrishnan et al., 1992, 4). However, estimates of these two effects have not been dealt with in the literature. In epidemiology, the attributable fraction (AF), a function of the odds ratio and the prevalence of the risk factor has been used to describe the contribution of a risk factor to a disease in a given population (Leviton, 1973). In this article, we adapt the AF to quantify the heritability and the shared common environment. Twin data on cancer, gallstone disease and phobia are used to illustrate the applicability of the AF estimate as a measure of heritability. 相似文献
15.
Gabriel Rodríguez 《统计学通讯:模拟与计算》2016,45(1):207-221
In recent articles, Fajardo et al. (2009) and Reisen and Fajardo (2012) propose an alternative semiparametric estimator of the fractional parameter in ARFIMA models which is robust to the presence of additive outliers. The results are very interesting, however, they use samples of 300 or 800 observations which are rarely found in macroeconomics. In order to perform a comparison, I estimate the fractional parameter using the procedure of Geweke and Porter-Hudak (1983) augmented with dummy variables associated with the (previously) detected outliers using the statistic τd suggested by Perron and Rodríguez (2003). Comparing with Fajardo et al. (2009) and Reisen and Fajardo (2012), I found better results for the mean and bias of the fractional parameter when T = 100 and the results in terms of the standard deviation and the MSE are very similar. However, for higher sample sizes such as 300 or 800, the robust procedure performs better. Empirical applications for seven monthly Latin-American inflation series with very small sample sizes contaminated by additive outliers are discussed. 相似文献
16.
Sanaullah et al. (2014) have suggested generalized exponential chain ratio estimators under stratified two-phase sampling scheme for estimating the finite population mean. However, the bias and mean square error (MSE) expressions presented in that work need some corrections, and consequently the study based on efficiency comparison also requires corrections. In this article, we revisit Sanaullah et al. (2014) estimator and provide the correct bias and MSE expressions of their estimator. We also propose an estimator which is more efficient than several competing estimators including the classes of estimators in Sanaullah et al. (2014). Three real datasets are used for efficiency comparisons. 相似文献
17.
Here, we apply the smoothing technique proposed by Chaubey et al. (2007) for the empirical survival function studied in Bagai and Prakasa Rao (1991) for a sequence of stationary non-negative associated random variables.The derivative of this estimator in turn is used to propose a nonparametric density estimator. The asymptotic properties of the resulting estimators are studied and contrasted with some other competing estimators. A simulation study is carried out comparing the recent estimator based on the Poisson weights (Chaubey et al., 2011) showing that the two estimators have comparable finite sample global as well as local behavior. 相似文献
18.
M. Pilar Alonso Asunción Beamonte Manuel Salvador 《Journal of applied statistics》2015,42(5):1043-1063
In this paper a methodology for the delineation of local labour markets (LLMs) using evolutionary algorithms is proposed. This procedure, based on that in Flórez-Revuelta et al. [13,14], introduces three modifications. First, initial groups of municipalities with a minimum size requirement are built using the travel time between them. Second, a not fully random initiation algorithm is proposed. And third, as a final stage of the procedure, a contiguity step is implemented. These modifications significantly decrease the computational times of the algorithm (up to a 99%) without any deterioration of the quality of the solutions. The optimization algorithm may give a set of potential solutions with very similar values with respect to the objective function what would lead to different partitions, both in terms of number of markets and their composition. In order to capture their common aspects an algorithm based on a cluster partitioning of k-means type is presented. This stage of the procedure also provides a ranking of LLMs foci useful for planners and administrations in decision-making processes on issues related to labour activities. Finally, to evaluate the performance of the algorithm a toy example with artificial data is analysed. The full methodology is illustrated through a real commuting data set of the region of Aragón (Spain). 相似文献
19.
Tony Vangeneugden Geert Molenberghs Geert Verbeke Clarice G.B. Demétrio 《统计学通讯:理论与方法》2014,43(19):4164-4178
In hierarchical data settings, be it of a longitudinal, spatial, multi-level, clustered, or otherwise repeated nature, often the association between repeated measurements attracts at least part of the scientific interest. Quantifying the association frequently takes the form of a correlation function, including but not limited to intraclass correlation. Vangeneugden et al. (2010) derived approximate correlation functions for longitudinal sequences of general data type, Gaussian and non-Gaussian, based on generalized linear mixed-effects models. Here, we consider the extended model family proposed by Molenberghs et al. (2010). This family flexibly accommodates data hierarchies, intra-sequence correlation, and overdispersion. The family allows for closed-form means, variance functions, and correlation function, for a variety of outcome types and link functions. Unfortunately, for binary data with logit link, closed forms cannot be obtained. This is in contrast with the probit link, for which such closed forms can be derived. It is therefore that we concentrate on the probit case. It is of interest, not only in its own right, but also as an instrument to approximate the logit case, thanks to the well-known probit-logit ‘conversion.’ Next to the general situation, some important special cases such as exchangeable clustered outcomes receive attention because they produce insightful expressions. The closed-form expressions are contrasted with the generic approximate expressions of Vangeneugden et al. (2010) and with approximations derived for the so-called logistic-beta-normal combined model. A simulation study explores performance of the method proposed. Data from a schizophrenia trial are analyzed and correlation functions derived. 相似文献
20.
Soo Hak Sung 《统计学通讯:理论与方法》2013,42(9):1663-1674
A complete convergence theorem for an array of rowwise independent random variables was established by Sung et al. (2005). This result has been generalized and extended by Kruglov et al. (2006) and Chen et al. (2007). In this article, we extend the results of Sung et al. (2005), Kruglov et al. (2006), and Chen et al. (2007) to an array of dependent random variables satisfying Hoffmann-Jørgensen type inequalities. 相似文献