Fitting parametric frailty and mixture models under biased sampling

Biased sampling from an underlying distribution with p.d.f. f(t), t>0, implies that observations follow the weighted distribution with p.d.f. f ^w (t)=w(t)f(t)/E[w(T)] for a known weight function w. In particular, the function w(t)=t ^α has important applications, including length-biased sampling (α=1) and area-biased sampling (α=2). We first consider here the maximum likelihood estimation of the parameters of a distribution f(t) under biased sampling from a censored population in a proportional hazards frailty model where a baseline distribution (e.g. Weibull) is mixed with a continuous frailty distribution (e.g. Gamma). A right-censored observation contributes a term proportional to w(t)S(t) to the likelihood; this is not the same as S ^w (t), so the problem of fitting the model does not simply reduce to fitting the weighted distribution. We present results on the distribution of frailty in the weighted distribution and develop an EM algorithm for estimating the parameters of the model in the important Weibull–Gamma case. We also give results for the case where f(t) is a finite mixture distribution. Results are presented for uncensored data and for Type I right censoring. Simulation results are presented, and the methods are illustrated on a set of lifetime data.     

APPROXIMATION OF EXCEEDANCE PROCESSES IN LARGE POPULATIONS

We consider a population of n individuals. Each of these individuals generates a discrete time branching stochastic process. We study the number of ancestors S(n,t) whose offspring at time t exceeds level θ(t), where θ(t) is some positive valued function. It is proved that S(n,t) may be approximated as t → ∞ and n → ∞ by some stochastic processes with independent increments.

     

Tests of regression coefficients under ridge regression models

This paper investigates two “non-exact” t-type tests, t( k₂) and t(k₂), of the individual coefficients of a linear regression model, based on two ordinary ridge estimators. The reported results are built on a simulation study covering 84 different models. For models with large standard errors, the ridge-based t-tests have correct levels with considerable gain in powers over those of the least squares t-test, t(0). For models with small standard errors, t(k₁) is found to be liberal and is not safe to use while, t(k₂) is found to slightly exceed the nominal level in few cases. When tie two ridge tests art: not winners, the results indicate that they don't loose much against t(0).     

ON TRANSITION PROBABILITIES OF SKIP-FREE MARKOV CHAINS

Consider an ergodic Markov chain X(t) in continuous time with an infinitesimal matrix Q = (q_ij) defined on a finite state space {0, 1,…, N}. In this note, we prove that if X(t) is skip-free positive (negative, respectively), i.e., q_ij, = 0 for j > i+ 1 (i > j+ 1), then the transition probability p_ij(t) = Pr[X(t)=j | X(0) =i] can be represented as a linear combination of p_0N(t) (p^(m)_(N0)(t)), 0 ≤ m ≤N, where f^(m)(t) denotes the mth derivative of a function f(t) with f⁽⁰⁾(t) =f(t). If X(t) is a birth-death process, then p_ij(t) is represented as a linear combination of p_0N^(m)(t), 0 ≤m≤N - |i-j|.     

Heine process as a q-analog of the Poisson process—waiting and interarrival times

In this study, we introduce the Heine process, {X_q(t), t > 0}, 0 < q < 1, where the random variable X_q(t), for every t > 0, represents the number of events (occurrences or arrivals) during a time interval (0, t]. The Heine process is introduced as a q-analog of the basic Poisson process. Also, in this study, we prove that the distribution of the waiting time W_{ν, q}, ν ? 1, up to the νth arrival, is a q-Erlang distribution and the interarrival times T_{k, q} = W_{k, q} ? W_{k ? 1, q},?k = 1, 2, …, ν with W_{0, q} = 0 are independent and equidistributed with a q-Exponential distribution.     

Strassen type limit points for moving averages of a wiener process

Let {W(s); 8 ≥ 0} be a standard Wiener process, and let β_N = (2a_N (log (N/a_N) + log log N)^-1/2, 0 < α_N ≤ N < ∞, where α_N↑ and α_N/N is a non-increasing function of N, and define γ_N(t) = β_N[W(n_N + ta_N) ? W(n_N)), 0 ≥ t ≥ 1, with n_N = N – a_N. Let K = {x ? C[0,1]: x is absolutely continuous, x(0) = 0 and }. We prove that, with probability one, the sequence of functions {γ_N(t), t ? [0,1]} is relatively compact in C[0,1] with respect to the sup norm ||·||, and its set of limit points is K. With a_N = N, our result reduces to Strassen's well-known theorem. Our method of proof follows Strassen's original, direct approach. The latter, however, contains an oversight which, in turn, renders his proof invalid. Strassen's theorem is true, of course, and his proof can also be rectified. We do this in a somewhat more general context than that of his original theorem. Applications to partial sums of independent identically distributed random variables are also considered.     

An explanation of generalized profile likelihoods

Let X, T, Y be random vectors such that the distribution of Y conditional on covariates partitioned into the vectors X = x and T = t is given by f(y; x, ), where = (, (t)). Here is a parameter vector and (t) is a smooth, real–valued function of t. The joint distribution of X and T is assumed to be independent of and . This semiparametric model is called conditionally parametric because the conditional distribution f(y; x, ) of Y given X = x, T = t is parameterized by a finite dimensional parameter = (, (t)). Severini and Wong (1992. Annals of Statistics 20: 1768–1802) show how to estimate and (·) using generalized profile likelihoods, and they also provide a review of the literature on generalized profile likelihoods. Under specified regularity conditions, they derive an asymptotically efficient estimator of and a uniformly consistent estimator of (·). The purpose of this paper is to provide a short tutorial for this method of estimation under a likelihood–based model, reviewing results from Stein (1956. Proceedings of the Third Berkeley Symposium on Mathematical Statistics and Probability, vol. 1, University of California Press, Berkeley, pp. 187–196), Severini (1987. Ph.D Thesis, The University of Chicago, Department of Statistics, Chicago, Illinois), and Severini and Wong (op. cit.).     

Estimation for semi-Markov models with partial observations via self-consistency equations

Nonparametric estimators of the survival function S(t) = P(T ≥ t) for a partially observed time variable T have been defined by several methods, in particular, by integral self-consistency equations. The author establishes explicit expressions of the estimators in an additive form and extend this approach to several cases: a left-truncated and right-censored variable and the left-censored or left-truncated sojourn times of a right-censored semi-Markov process. These estimators are always identical to the product-limit estimators if hazard functions may be defined.     

A New Test for New Better Than Used in Expectation Lifetimes

The mean residual life of a non negative random variable X with a finite mean is defined by M(t) = E[X ? t|X > t] for t ? 0. A popular nonparametric model of aging is new better than used in expectation (NBUE), when M(t) ? M(0) for all t ? 0. The exponential distribution lies at the boundary. There is a large literature on testing exponentiality against NBUE alternatives. However, comparisons of tests have been made only for alternatives much stronger than NBUE. We show that a new Kolmogorov-Smirnov type test is much more powerful than its competitors in most cases.     

FIRST-EXIT TIMES FOR POISSON SHOT NOISE

For a shot-noise process X(t) with Poisson arrival times and exponentially diminishing shocks of i.i.d. sizes, we consider the first time T _b at which a given level b > 0 is exceeded. An integral equation for the joint density of T _b and X(T _b ) is derived and, for the case of exponential jumps, solved explicitly in terms of Laplace transforms (LTs). In the general case we determine the ordinary LT of the function ? P(T _b > t) in terms of certain LTs derived from the distribution function H(x; t) = P(X(t) ≤ x), considered as a function of both variables x and t. Moreover, for G(t, u) = P(T _b > t, X(t) < u), that is the joint distribution function of sup_{0 ≤ s ≤ t} X(s) and X(t), an integro-differential equation is presented, whose unique solution is G(t, u).     

A lower bound for the transition density function of a stochastic differential equation

Let W_t be a one-dimensional Brownian motion on the probability space (Ω,F,P), and let dx_t = a(x_t)dt + b(x_t)dw_t, b²(x) > 0, be a one-dimensional Ito stochastic differential equation. For a(x) = a₀ + a₁x + … + a_nxⁿ on a bounded interval we obtain a lower bound for p(t,x,y), the transition density function of the homogeneous Markov process x_t, depending directly on the coefficients a₀,a₁, …, a_n, and b(x).     

A probablistic analysis for an optimal screening problem

Summary We consider a lotL formed byN apparently similar unitsW ₁,…,W _N, where each of theW _i may come from one of two different populationsP ₁ andP ₂;T ₁,…,T _N denote the corresponding lifetimes. The units fromP _i undergo a failure of kindi and their survival function isS _i (t). We assume that the failure rate function are known and that the units fromP ₁ are ?substandard?: λ ₁ (t)≥λ ₂ (t), ∀t≥0. We want to putW ₁,…,W _N under a pre-operational test (burn-in test) in order to eliminate at least a great part of the substandard units and we face the problem of obtaining a rule for stopping the test under the assumption that, with the failure of a unit, it is possible to recognize the population from which the unit comes. Such a problem will be formalized as an optimal stopping problem for a suitably defined Markov process. Our study shall evidentiate some fundamental aspects of the problem and the role of the prior distribution of the (random) numberM ₀ of those units inL coming fromP ₁ (substandard). The latter distribution has a great influence on the form of the solution. This research was supported by the C.N.R. Project ?Statistica Bayesiana e Simulazione in Affidalità e Modellistica Biologica?.     

On hypothesis tests in misspecified change-point problems for a Poisson process

Consider an inhomogeneous Poisson process X on [0, T] whose unk-nown intensity function “switches” from a lower function g_* to an upper function h_* at some unknown point ?_* that has to be identified. We consider two known continuous functions g and h such that g_*(t) ? g(t) < h(t) ? h_*(t) for 0 ? t ? T. We describe the behavior of the generalized likelihood ratio and Wald’s tests constructed on the basis of a misspecified model in the asymptotics of large samples. The power functions are studied under local alternatives and compared numerically with help of simulations. We also show the following robustness result: the Type I error rate is preserved even though a misspecified model is used to construct tests.     

Optimal Designs for Approximating a Stochastic Process with Respect to a Minimax Criterion

We study the problem of approximating a stochastic process Y = {Y(t: t ∈ T} with known and continuous covariance function R on the basis of finitely many observations Y(t ₁,), …, Y(t _n ). Dependent on the knowledge about the mean function, we use different approximations ? and measure their performance by the corresponding maximum mean squared error sub _t∈T E(Y(t) ? ?(t))². For a compact T ? ? ^p we prove sufficient conditions for the existence of optimal designs. For the class of covariance functions on T ² = [0, 1]² which satisfy generalized Sacks/Ylvisaker regularity conditions of order zero or are of product type, we construct sequences of designs for which the proposed approximations perform asymptotically optimal.     

Estimators for the Drift of Subfractional Brownian Motion

In this paper, we consider, using technique based on Girsanov theorem, the problem of efficient estimation for the drift of subfractional Brownian motion S^H ? (S^H_t)_{t ∈ [0, T]}. We also construct a class of biased estimators of James-Stein type which dominate, under the usual quadratic risk, the natural maximum likelihood estimator.     

Locking the Wiener Process to its Level-Crossing Time

We consider the specific transformation of a Wiener process {X(t), t ≥ 0} in the presence of an absorbing barrier a that results when this process is “time-locked” with respect to its first passage time T _a through a criterion level a, and the evolution of X(t) is considered backwards (retrospectively) from T _a . Formally, we study the random variables defined by Y(t) ≡ X(T _a  ? t) and derive explicit results for their density and mean, and also for their asymptotic forms. We discuss how our results can aid interpretations of time series “response-locked” to their times of crossing a criterion level.     

Nonparametric two‐step regression estimation when regressors and error are dependent

This paper considers estimation of the function g in the model Y_t = g(X_t ) + ?_t when E(?_t|Xt) ≠ 0 with nonzero probability. We assume the existence of an instrumental variable Z_t that is independent of ?_t, and of an innovation ηt = X_t — E(X_t|Z_t). We use a nonparametric regression of X_t on Z_t to obtain residuals η_t, which in turn are used to obtain a consistent estimator of g. The estimator was first analyzed by Newey, Powell & Vella (1999) under the assumption that the observations are independent and identically distributed. Here we derive a sample mean‐squared‐error convergence result for independent identically distributed observations as well as a uniform‐convergence result under time‐series dependence.     

First-exit times for compound poisson processes for some types of positive and negative jumps

We consider the one-sided and the two-sided first-exit problem for a compound Poisson process with linear deterministic decrease between positive and negative jumps. This process (X(t)) _t≥0 occurs as the workload process of a single-server queueing system with random workload removal, which we denote by M/G _u /G _d /1, where G _u (G _d ) stands for the distribution of the upward (downward) jumps; other applications are to cash management, dams, and several related fields. Under various conditions on G _u and G _d (assuming e.g. that one of them is hyperexponential, Erlang or Coxian), we derive the joint distribution of τ _y =inf{t≥0|X(t)?(0,y)}, y>0, and X(τ _y ) as well as that of T=inf{t≥0|X(t)≤0} and X(T). We also determine the distribution of sup{X(t)|0≤t≤T}.     

Estimated Generalized Least Squares for a Heteroscedastic Regression Model

This paper considers the general linear regression model yc = X₁β+u_t under the heteroscedastic structure E(u_t) = 0, E(u²) =σ²- (X_tβ)², E(u_t u_s) = 0, tæs, t, s= 1, T. It is shown that any estimated GLS estimator for β is asymptotically equivalent to the GLS estimator under some regularity conditions. A three-step GLS estimator, which calls upon the assumption E(u_t²) =s?²(X,β)² for the estimation of the disturbance covariance matrix, is considered.