Generalised Rank Regression Estimator with Standard Error Adjusted Lasso

One of the standard variable selection procedures in multiple linear regression is to use a penalisation technique in least‐squares (LS) analysis. In this setting, many different types of penalties have been introduced to achieve variable selection. It is well known that LS analysis is sensitive to outliers, and consequently outliers can present serious problems for the classical variable selection procedures. Since rank‐based procedures have desirable robustness properties compared to LS procedures, we propose a rank‐based adaptive lasso‐type penalised regression estimator and a corresponding variable selection procedure for linear regression models. The proposed estimator and variable selection procedure are robust against outliers in both response and predictor space. Furthermore, since rank regression can yield unstable estimators in the presence of multicollinearity, in order to provide inference that is robust against multicollinearity, we adjust the penalty term in the adaptive lasso function by incorporating the standard errors of the rank estimator. The theoretical properties of the proposed procedures are established and their performances are investigated by means of simulations. Finally, the estimator and variable selection procedure are applied to the Plasma Beta‐Carotene Level data set.     

A Bayesian Approach for Selecting the Best Exponential Population with Interval Censored Samples

In this article, we study the problem of selecting the best population from among several exponential populations based on interval censored samples using a Bayesian approach. A Bayes selection procedure and a curtailed Bayes selection procedure are derived. We show that these two Bayes selection procedures are equivalent. A numerical example is provided to illustrate the application of the two selection procedure. We also use Monte Carlo simulation to study performance of the two selection procedures. The numerical results of the simulation study demonstrate that the curtailed Bayes selection procedure has good performance because it can substantially reduce the duration time of life test experiment.     

A Class of Two-Stage Selection Procedures Using L-Statistics

Summary: A class of selection procedures for selecting the least dispersive distribution from k available distributions has been proposed. This problem finds applications in reliability and engineering. In engineering, for example, the goal of the experimenter is to select a firm whose components have least dispersive distribution from the available set of competing firms manufacturing the components of the desired specifications meant for the same purpose. The proposed procedures can be used even when the underlying distributions belong to different families. Applications of the proposed selection procedures are discussed by taking exponential, gamma and Lehmann type distributions. Performance of the proposed selection procedures is assessed through simulation study. Implementation of the proposed selection procedure is illustrated through an example. * The authors are very grateful to the editor and referees for their valuable comments.     

Conditional probability of correct selection under the continuum partition with applications

The problem of selecting the best population from among a finite number of populations in the presence of uncertainty is a problem one faces in many scientific investigations, and has been studied extensively, Many selection procedures have been derived for different selection goals. However, most of these selection procedures, being frequentist in nature, don't tell how to incorporate the information in a particular sample to give a data-dependent measure of correct selection achieved for this particular sample. They often assign the same decision and probability of correct selection for two different sample values, one of which actually seems intuitively much more conclusive than the other. The methodology of conditional inference offers an approach which achieves both frequentist interpret ability and a data-dependent measure of conclusiveness. By partitioning the sample space into a family of subsets, the achieved probability of correct selection is computed by conditioning on which subset the sample falls in. In this paper, the partition considered is the so called continuum partition, while the selection rules are both the fixed-size and random-size subset selection rules. Under the distributional assumption of being monotone likelihood ratio, results on least favourable configuration and alpha-correct selection are established. These re-sults are not only useful in themselves, but also are used to design a new sequential procedure with elimination for selecting the best of k Binomial populations. Comparisons between this new procedure and some other se-quential selection procedures with regard to total expected sample size and some risk functions are carried out by simulations.     

Fitting E(max) models to clinical trial dose-response data

We consider fitting Emax models to the primary endpoint for a parallel group dose–response clinical trial. Such models can be difficult to fit using Maximum Likelihood if the data give little information about the maximum possible response. Consequently, we consider alternative models that can be derived as limiting cases, which can usually be fitted. Furthermore we propose two model selection procedures for choosing between the different models. These model selection procedures are compared with two model selection procedures which have previously been used. In a simulation study we find that the model selection procedure that performs best depends on the underlying true situation. One of the new model selection procedures gives what may be regarded as the most robust of the procedures.     

Equal probability of correct selection for bernoulli selection procedures

The problem of selecting the Bernoulli population which has the highest "success" probability is considered. It has been noted in several articles that the probability of a correct selection is the same, uniformly in the Bernoulli p-vector (P1,P2,….,Pk), for two or more different selection procedures. We give a general theorem which explains this phenomenon.

An application of particular interest arises when "strong" curtailment of a single-stage procedure (as introduced by Bechhofer and Kulkarni (1982a) )is employed; the corresponding result for "weak" curtailment of a single-stage procedure needs no proof. The use of strong curtailment in place of weak curtailment requires no more (and usually many less) observations to achieve the same.     

Control-variate methods for comparison with a standard

Comparison with a standard is a general multiple comparison problem, where each system is required to be compared with a single system, referred to as a ‘standard’, as well as with other alternative systems. Screening procedures specially designed to be used for comparison with a standard have been proposed to find a subset that includes all the systems better than the standard in terms of the expected performance. Selection procedures are derived to determine the best system among a number of systems that are better than the standard, or to select the standard when it is equal to or better than the other alternatives. We develop new procedures for screening and selection through the use of two variance reduction techniques, common random numbers and control variates, which are particularly useful in the context of simulation experiments. Empirical results and a realistic example are also provided to compare our procedures with the existing ones.     

A combination multiple comparisons and subset selection procedure to identify treatments that are strictly inferior to the best

This paper considers the problem of identifying which treatments are strictly worse than the best treatment or treatments in a one-way layout, which has many important applications in screening trials for new product development. A procedure is proposed that selects a subset of the treatments containing only treatments that are known to be strictly worse than the best treatment or treatments. In addition, simultaneous confidence intervals are obtained which provide upper bounds on how inferior the treatments are compared with these best treatments. In this way, the new procedure shares the characteristics of both subset selection procedures and multiple comparison procedures. Some tables of critical points are provided for implementing the new procedure, and some examples of its use are given.     

Selection procedures in linear models

Many authors have studied variable selection in multiple linear regression models. In this paper, we derive some generalized selection procedures for the linear models. An approximation of noncentral F distribution has also been obtained.     

Selection of the best with a preliminary test for two-parameter exponential distributions

This paper deals with the problem of selecting the best population from among k(≥ 2) two-parameter exponential populations. New selection procedures are proposed for selecting the unique best. The procedures include preliminary tests which allow the xperimenter to have an option to not select if the statistical evidence is not significant. Two probabilities, the probability to make a selection and the probability of a correct selection, are controlled by these selection procedures. Comparisons between the proposed selection procedures and certain earlier existing procedures are also made. The results show the superiority of the proposed selection procedures in terms of the required sample size.     

The Ubiquity of Statistics

The use of biased estimation in data analysis and model building is discussed. A review of the theory of ridge regression and its relation to generalized inverse regression is presented along with the results of a simulation experiment and three examples of the use of ridge regression in practice. Comments on variable selection procedures, model validation, and ridge and generalized inverse regression computation procedures are included. The examples studied here show that when the predictor variables are highly correlated, ridge regression produces coefficients which predict and extrapolate better than least squares and is a safe procedure for selecting variables.     

Selecting all treatments better than a control using existing tables

In this paper subset selection procedures for selecting all treatment populations with means larger than a control population are proposed. The treatments and control are assumed to have a multivariate normal distribution. Various covariance structures are considered. All of the proposed procedures are easily implemented using existing tables of the multivariate normal and multivariate t distributions. Some other procedures which have been proposed require extensive and unavailable tables for their implementation     

Bayesian model-averaged regularization for Gaussian graphical models

The graphical lasso has now become a useful tool to estimate high-dimensional Gaussian graphical models, but its practical applications suffer from the problem of choosing regularization parameters in a data-dependent way. In this article, we propose a model-averaged method for estimating sparse inverse covariance matrices for Gaussian graphical models. We consider the graphical lasso regularization path as the model space for Bayesian model averaging and use Markov chain Monte Carlo techniques for the regularization path point selection. Numerical performance of our method is investigated using both simulated and real datasets, in comparison with some state-of-art model selection procedures.     

On selecting from k finite populations the population with the largest α -quantile

Several procedures for ranking populations according to the quantile of a given order have been discussed in the literature. These procedures deal with continuous distributions. This paper deals with the problem of selecting a population with the largest α-quantile from k ≥ 2 finite populatins, where the size of each population is known. A selection rule is given based on the sample quantiles, where he samples are drawn without replacement. A formula for the minimum probability of a correct selection for the given rule, for a certain configuration of the population α-quantiles, is given in terms of the sample numbers.     

Idle thoughts of a ‘well‐calibrated’ Bayesian in clinical drug development

The use of Bayesian approaches in the regulated world of pharmaceutical drug development has not been without its difficulties or its critics. The recent Food and Drug Administration regulatory guidance on the use of Bayesian approaches in device submissions has mandated an investigation into the operating characteristics of Bayesian approaches and has suggested how to make adjustments in order that the proposed approaches are in a sense calibrated. In this paper, I present examples of frequentist calibration of Bayesian procedures and argue that we need not necessarily aim for perfect calibration but should be allowed to use procedures, which are well‐calibrated, a position supported by the guidance. Copyright © 2016 John Wiley & Sons, Ltd.     

Handling co-dependence issues in resampling-based variable selection procedures: a simulation study

If a number of candidate variables are available, variable selection is a key task aiming to identify those candidates which influence the outcome of interest. Methods as backward elimination, forward selection, etc. are often implemented, despite their drawbacks. One of these drawbacks is the instability of their results with respect to small perturbations in the data. To handle this issue, resampling-based procedures have been introduced; using a resampling technique, e.g. bootstrap, these procedures generate several pseudo-samples that are used to compute the inclusion frequency of each variable, i.e. the proportion of pseudo-samples in which the variable is selected. Based on the inclusion frequencies, it is possible to discriminate between relevant and irrelevant variables. These procedures may fail in case of correlated variables. To deal with this issue, two procedures based on 2×2 tables of inclusion frequencies have been developed in the literature. In this paper we analyse the behaviours of these two procedures and the role of their tuning parameters in an extensive simulation study.     

Selecting the best normal population better than a standard under unequal variances

In this article we consider a problem of selecting the best normal population that is better than a standard when the variances are unequal. Single-stage selection procedures are proposed when the variances are known. Wilcox (1984) and Taneja and Dudewicz (1992) proposed two-stage selection procedures when the variances are unknown. In addition to these procedures, we propose a two-stage selection procedure based on the method of Lam (1988). Comparisons are made between these selection procedures in terms of the sample sizes.     

Sequential selectiok procedures based on confidence sequences for normal populations

In this paper confidence sequences are used to construct sequential procedures for selecting the population with the a common variance. These procedures are shown to provide substantial saving, particularly in the expected samplw sizes of the inferior populations,over various procedures in the literature. A new “indifference zone” formulation is given for the correct selection probability requirement, and confidence sequences are also applied to construct sequential procedures for this new selection goal.     

Bandwidth selection for kernel density estimation with length-biased data

Length-biased data are a particular case of weighted data, which arise in many situations: biomedicine, quality control or epidemiology among others. In this paper we study the theoretical properties of kernel density estimation in the context of length-biased data, proposing two consistent bootstrap methods that we use for bandwidth selection. Apart from the bootstrap bandwidth selectors we suggest a rule-of-thumb. These bandwidth selection proposals are compared with a least-squares cross-validation method. A simulation study is accomplished to understand the behaviour of the procedures in finite samples.     

Designing selection experiments with bernoulli populations

This paper is concerned with a fixed size subset selection problem for Bernoulli populations in the framework of the indifference zone approach. The goal is to select s populationswhich contain at least c of those with the t largest success probabilities. In order to control the probability of correct selection over the preference zone extensive tables of exact minimum sample sizes have been prepared to implement the single-stage procedure generalized from the well-known Sobel-Huyett procedure. It is shown how the tables can also be employed to design certain closedsequential procedures. These procedures curtail the sampling process of the single-stage procedureand may differ in their sampling rules. Two procedures working with play-the-winner rules are described in detail