Bayes estimators of the average failure rates

In the present paper we have proposed a Bayesian approach for making inferences from accelerated life tests which do not require distributional assumptions     

Asymptotic expansions and the reliability of tests in accelerated failure time models

This paper gives matrix formilae for the O(n^-1 ) cerrecti0n applicable to asymptotically efficient conditional moment tests. These formulae only require expectations of functions involving, at most, second order derivatives of the log-likelihood; unlike those previously providcd by Ferrari and Corddro(1994). The correction is used to assess the reliability of first order asymptotic theory for arbitrary residual-based diagnostics in a class of accelerated failure time models: this correction is always parameter free, depending only on the number of included covariates in the regression design. For all but one of the tests considered, first order theory is found to be extremely unreliable, even in quite large samples, although this may not be widely appreciated by applied workers.     

Optimal bounds for the mean of the total time on test for distributions with decreasing generalized failure rate

During any life test experiment it is of interest to study potential costs (or profits) of performing the test to the very end. Assuming that these costs are proportional to lifetimes of analysed items the experimenter needs to know the remaining total time on test, having just observed successive failure in the test. We derive sharp upper bounds on the expectation of the remaining total time on test statistic when the underlying distributions have decreasing generalized failure rate with respect to generalized Pareto distributions. In particular we obtain the bounds valid for distributions with decreasing density or failure rate. The results are illustrated with numerical examples.     

Sharp bounds for the mean of the total time on test for distributions with increasing generalized failure rate

The results of this paper are the continuation of the research presented by Bieniek [Optimal bounds for the mean of the total time on test for distributions with decreasing generalized failure rate. Statistics. 2016;50:1206–1220]. We consider the remaining total time on test after a given failure in a life test experiment. We derive sharp upper bounds on the mean of the total time on test optimal in the class of distributions with increasing generalized failure rate with respect to generalized Pareto distributions. Specific results are obtained for distributions with increasing density and increasing failure rate. We also provide exemplary numerical values of the obtained bounds and we compare them with the corresponding bounds for distributions with decreasing generalized failure rate.     

On gehan's wilcoxon and the accelerated failure time model

A proof is provided to show that Gehan's 1965 generalization of the two sample Wilcoxon test lies outside the class of efficient score procedures for right censored data (Prentice 1978).     

The gamma-linear failure rate distribution: theory and applications

For any continuous baseline G distribution, Zografos and Balakrishnan [On families of beta- and generalized gamma-generated distributions and associated inference. Statist Methodol. 2009;6:344–362] introduced the generalized gamma-generated distribution with an extra positive parameter. A new three-parameter continuous model called the gamma-linear failure rate (LFR) distribution, which extends the LFR model, is proposed and studied. Various structural properties of the new distribution are derived, including some explicit expressions for ordinary and incomplete moments, generating function, probability-weighted moments, mean deviations and Rényi and Shannon entropies. We estimate the model parameters by maximum likelihood and obtain the observed information matrix. The new model is modified to cope with possible long-term survivors in lifetime data. We illustrate the usefulness of the proposed model by means of two applications to real data.     

On the increasing failure rate criteria

We introduce the t₀ -increasing failure rate (IFR-t₀) class, where the failure rate at age x+t₀is greater then or equal to the failure rate at age x for x≥0. The dual class of t₀- decreasing failure rate (DER-t₀) is defined analogoualy.The relation between the IFR -t₀class and other classes of life distributions is studied. Preservation and nonpreservation properties of the IFR-t₀ and the DFR-t₀ classes under various reliablity operation are presented. The concet of stochastic comparison is utilized to cheracterized the IFR-t ₀ class and to suggest other classes of life distributions for aging.     

Two-Sample Statistics for Testing the Equality of Survival Functions Against Improper Semi-parametric Accelerated Failure Time Alternatives: An Application to the Analysis of a Breast Cancer Clinical Trial

This paper presents two-sample statistics suited for testing equality of survival functions against improper semi-parametric accelerated failure time alternatives. These tests are designed for comparing either the short- or the long-term effect of a prognostic factor, or both. These statistics are obtained as partial likelihood score statistics from a time-dependent Cox model. As a consequence, the proposed tests can be very easily implemented using widely available software. A breast cancer clinical trial is presented as an example to demonstrate the utility of the proposed tests.     

Mixture cure rate models with accelerated failures and nonparametric form of covariate effects

Two-component mixture cure rate model is popular in cure rate data analysis with the proportional hazards and accelerated failure time (AFT) models being the major competitors for modelling the latency component. [Wang, L., Du, P., and Liang, H. (2012), ‘Two-Component Mixture Cure Rate Model with Spline Estimated Nonparametric Components’, Biometrics, 68, 726–735] first proposed a nonparametric mixture cure rate model where the latency component assumes proportional hazards with nonparametric covariate effects in the relative risk. Here we consider a mixture cure rate model where the latency component assumes AFTs with nonparametric covariate effects in the acceleration factor. Besides the more direct physical interpretation than the proportional hazards, our model has an additional scalar parameter which adds more complication to the computational algorithm as well as the asymptotic theory. We develop a penalised EM algorithm for estimation together with confidence intervals derived from the Louis formula. Asymptotic convergence rates of the parameter estimates are established. Simulations and the application to a melanoma study shows the advantages of our new method.     

Optimal step-stress accelerated degradation test plans for inverse Gaussian process based on proportional degradation rate model

The purpose of this paper is to address the optimal design of the step-stress accelerated degradation test (SSADT) issue when the degradation process of a product follows the inverse Gaussian (IG) process. For this design problem, an important task is to construct a link model to connect the degradation magnitudes at different stress levels. In this paper, a proportional degradation rate model is proposed to link the degradation paths of the SSADT with stress levels, in which the average degradation rate is proportional to an exponential function of the stress level. Two optimization problems about the asymptotic variances of the lifetime characteristics' estimators are investigated. The optimal settings including sample size, measurement frequency and the number of measurements for each stress level are determined by minimizing the two objective functions within a given budget constraint. As an example, the sliding metal wear data are used to illustrate the proposed model.     

Bayesian parametric accelerated failure time spatial model and its application to prostate cancer

Prostate cancer (PrCA) is the most common cancer diagnosed in American men and the second leading cause of death from malignancies. There are large geographical variation and racial disparities existing in the survival rate of PrCA. Much work on the spatial survival model is based on the proportional hazards (PH) model, but few focused on the accelerated failure time (AFT) model. In this paper, we investigate the PrCA data of Louisiana from the Surveillance, Epidemiology, and End Results program and the violation of the PH assumption suggests that the spatial survival model based on the AFT model is more appropriate for this data set. To account for the possible extra-variation, we consider spatially referenced independent or dependent spatial structures. The deviance information criterion is used to select a best-fitting model within the Bayesian frame work. The results from our study indicate that age, race, stage, and geographical distribution are significant in evaluating PrCA survival.     

On Parameter Inference for Step-Stress Accelerated Life Test with Geometric Distribution

In this article, we present the parameter inference in step-stress accelerated life tests under the tampered failure rate model with geometric distribution. We deal with Type-II censoring scheme involved in experimental data, and provide the maximum likelihood estimate and confidence interval of the parameters of interest. With the help of the Monte-Carlo simulation technique, a comparison of precision of the confidence limits is demonstrated for our method, the Bootstrap method, and the large-sample based procedure. The application of two industrial real datasets shows the proposed method efficiency and feasibility.     

Tests of independence for censored bivariate failure time data

Bivariate failure time data is widely used in survival analysis, for example, in twins study. This article presents a class of chi2-type tests for independence between pairs of failure times after adjusting for covariates. A bivariate accelerated failure time model is proposed for the joint distribution of bivariate failure times while leaving the dependence structures for related failure times completely unspecified. Theoretical properties of the proposed tests are derived and variance estimates of the test statistics are obtained using a resampling technique. Simulation studies show that the proposed tests are appropriate for practical use. Two examples including the study of infection in catheters for patients on dialysis and the diabetic retinopathy study are also given to illustrate the methodology.     

Estimation of the failure rate-a survey of nonparametric methods Part I: Non-Bayesian Methods

In this paper several nonparametric, non-Bayesian methods for estimating the failure rate function on which no monotonicity conditions have been imposed are surveyed. The survey attempts to consolidate and synthesize literature from several diverse areas of application, and endeavors to be as up-to-date as is feasible.     

On the asymptotic distribution of an estimate of the change point in a failure rate

The failure rate r(t) is assumed to have the shape of the"first"part of the"bathtub"model, i.e.r(t) is non-increasing for t<r and is constant for t> r. Asymptotic distribution of one of the estimates proposed earlier has been investigated in this paper. This leads to a test for the hypothesis HQ r<r ₀ vs H :r>r (where TQ > 0). Asymptotic expression for the power of this test under Pitman alternatives is derived. Some simulations are reported.     

Multiple step-stress accelerated life test: the tampered failure rate model

Battacharyya and Soejoeti (1989) proposed the tampered failure rate model for step-stress accelerated life testing. In this note, their model is generalized from the simple (2-step) step-stress setting to the multiple (k-step, k > 2) setting. For the parametric setting where the life distribution under constant stress is Weibull, maximum likelihood estimation is investigated and the situation where the different stress levels are equispaced is looked at.     

On bootstrap testing inference in cure rate models

Survival models deal with the time until the occurrence of an event of interest. However, in some situations the event may not occur in part of the studied population. The fraction of the population that will never experience the event of interest is generally called cure rate. Models that consider this fact (cure rate models) have been extensively studied in the literature. Hypothesis testing on the parameters of these models can be performed based on likelihood ratio, gradient, score or Wald statistics. Critical values of these tests are obtained through approximations that are valid in large samples and may result in size distortion in small or moderate sample sizes. In this sense, this paper proposes bootstrap corrections to the four mentioned tests and bootstrap Bartlett correction for the likelihood ratio statistic in the Weibull promotion time model. Besides, we present an algorithm for bootstrap resampling when the data presents cure fraction and right censoring time (random and non-informative). Simulation studies are conducted to compare the finite sample performances of the corrected tests. The numerical evidence favours the corrected tests we propose. We also present an application in an actual data set.     

Empirical likelihood method for the multivariate accelerated failure time models

In applications, multivariate failure time data appears when each study subject may potentially experience several types of failures or recurrences of a certain phenomenon, or failure times may be clustered. Three types of marginal accelerated failure time models dealing with multiple events data, recurrent events data and clustered events data are considered. We propose a unified empirical likelihood inferential procedure for the three types of models based on rank estimation method. The resulting log-empirical likelihood ratios are shown to possess chi-squared limiting distributions. The properties can be applied to do tests and construct confidence regions without the need to solve the rank estimating equations nor to estimate the limiting variance-covariance matrices. The related computation is easy to implement. The proposed method is illustrated by extensive simulation studies and a real example.     

Improving the bridge structure by using linear failure rate distribution

In this paper, a system of five components is studied; one of these components is a bridge network component. Each of these components has a non-constant failure rate. The system components have linear failure rate lifetime distribution. The given system is improved by using three methods: reduction, warm standby with perfect switch and warm standby with imperfect switch. The reliability equivalence factors of the bridge structure system are obtained. The γ-fractiles are obtained to compare the original system with these improved systems. Finally, we present numerical results to show the difference between these methods.