A self-consistent estimator of marginal survival functions based on dependent competing risk data and an assumed copula

When the time to death, X, and the time to censoring, Y, are associated some additional information is need to identify the marginal survival functions. A natural function which provides this additional information is the copula of X and Y. Assuming that the copula is known, we use the notion of self consistency to construct an estimator of the marginal survival functions based on dependent competing risk data. Results of a small simulation study are shown to compare this estimator to other estimators of the marginal survival function based on an assumed copula.     

Tests of Fit for Exponentiality based on the Empirical Laplace Transform

The Laplace transform \psi(t)=E[{\rm exp}(-tX)] of a random variable X with exponential density u exp( m u x ), x S 0, satisfies the equation (\lambda+t)\psi(t)-\lambda=0 , t S 0. We study the behavior of a class of consistent tests for exponentiality based on a suitably weighted integral of [({\hat\lambda}_n+t)\psi_n(t)-{\hat\lambda}_n]^2 , where {\hat\lambda}_n is the maximum-likelihood estimate of u , and é n is the empirical Laplace transform, each based on an i.i.d. sample X 1 , …, X n . As the decay of the weight function tends to infinity, the test statistic approaches the square of the first nonzero component of Neyman's smooth test for exponentiality. The new tests are compared with other omnibus tests for exponentiality.     

Improved Predictive Inference for Responses Based on Location Parameter Median from the Rayleigh Model Given a Doubly Censored Sample

The purpose of this article is to investigate the predictive inference for responses from the location parameter mean as well as from the median given a doubly censored sample from the two-parameter Rayleigh model. The predictive results by Khan et al. (2010 Khan , H. M. R. , Provost , S. B. , Ashima , S. ( 2010 ). Predictive Inference from a Two-Parameter Rayleigh Life Model Given a Doubly Censored Sample . Commun. Statist. Theor. Meth. 39 ( 7 ): 1237 – 1246 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) are used to obtain the predictive inference for responses from the median, where Khan et al. (2010 Khan , H. M. R. , Provost , S. B. , Ashima , S. ( 2010 ). Predictive Inference from a Two-Parameter Rayleigh Life Model Given a Doubly Censored Sample . Commun. Statist. Theor. Meth. 39 ( 7 ): 1237 – 1246 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) obtained the future estimates from the mean. A numerical example representing 66 liver cancer patients is used for predictive analysis. It is concluded that the predictive inference from the median gives precise results as compared with the location parameter mean.     

A proportional hazards model for the analysis of doubly censored competing risks data

ABSTRACT

Competing risks data are common in medical research in which lifetime of individuals can be classified in terms of causes of failure. In survival or reliability studies, it is common that the patients (objects) are subjected to both left censoring and right censoring, which is refereed as double censoring. The analysis of doubly censored competing risks data in presence of covariates is the objective of this study. We propose a proportional hazards model for the analysis of doubly censored competing risks data, using the hazard rate functions of Gray (1988 Gray, R.J. (1988). A class of k-sample tests for comparing the cumulative incidence of a competing risk. Ann. Statist. 16:1141–1154.[Crossref], [Web of Science ®] , [Google Scholar]), while focusing upon one major cause of failure. We derive estimators for regression parameter vector and cumulative baseline cause specific hazard rate function. Asymptotic properties of the estimators are discussed. A simulation study is conducted to assess the finite sample behavior of the proposed estimators. We illustrate the method using a real life doubly censored competing risks data.     

A Statistical Model for Shelf Life Estimation Using Sensory Evaluations Scores

Abstract

This article focuses on the problem of estimating the shelf life of food products by modeling the results coming from sensory evaluations. In such studies, trained panelists are asked to judge food attributes by reference to a scale of numbers (scores varying often from 0 to 6). The usual statistical approach for data analysis is to fit a regression line relating the scores and the time of evaluation. The estimate of the shelf life is obtained by solving the regression equation and replacing the score by a cut-off point (which indicates product “failure”) previously chosen by the food company. The procedure used in these sensory evaluations is such that one never knows the exact “time to failure”. Consequently, data arising from these studies are either right or left censored. We propose a model which incorporates these informations and assumes a Weibull for the underlying distribution of the failure time. Simulation studies were implemented. The approach was used in a real data set coming from sensory evaluations of a dehydrated food product.     

Kolmogorov–Smirnov test for life test data with hybrid censoring

This work considers goodness-of-fit for the life test data with hybrid censoring. An alternative representation of the Kolmogorov–Smirnov (KS) statistics is provided under Type-I censoring. The alternative representation leads us to approximate the limiting distributions of the KS statistic as a functional of the Brownian bridge for Type-II, Type-I hybrid, and Type-II hybrid censored data. The approximated distributions are used to obtain the critical values of the tests in this context. We found that the proposed KS test procedure for Type-II censoring has more power than the available one(s) in literature.     

Approximate Identifiability, Moments and Censored Data

It is well known that the joint distribution of a pair of random variables ( X,Y ) is not identifiable on the basis of the joint distribution of the function (min ( X,Y ), 1[ X < Y ]). This paper introduces the concept of approximate identifiability and studies its relevance to the function (min ( X,Y ), Y ). It shows that the distribution of ( X,Y ) is approximately identifiable on the basis of the distribution of (min ( X,Y ), Y ). The identification is explicitly executed by a method of moments. The method is applied to the analysis of censored distributions arising in the theory of clinical trials and is compared to the standard method of Kaplan and Meier.     

Calculating nonparametric confidence intervals for quantiles using fractional order statistics

In this paper, we provide an easy-to-program algorithm for constructing the preselected 100(1 - alpha)% nonparametric confidence interval for an arbitrary quantile, such as the median or quartile, by approximating the distribution of the linear interpolation estimator of the quantile function Q L ( u ) = (1 - epsilon) X \[ n u ] + epsilon X \[ n u ] + 1 with the distribution of the fractional order statistic Q I ( u ) = Xn u , as defined by Stigler, where n = n + 1 and \[ . ] denotes the floor function. A simulation study verifies the accuracy of the coverage probabilities. An application to the extreme-value problem in flood data analysis in hydrology is illustrated.     

Bayesian Estimation of Survival Functions under Stochastic Precedence

When estimating the distributions of two random variables, X and Y, investigators often have prior information that Y tends to be bigger than X. To formalize this prior belief, one could potentially assume stochastic ordering between X and Y, which implies Pr(X < or = z) > or = Pr(Y < or = z) for all z in the domain of X and Y. Stochastic ordering is quite restrictive, though, and this article focuses instead on Bayesian estimation of the distribution functions of X and Y under the weaker stochastic precedence constraint, Pr(X < or = Y) > or = 0.5. We consider the case where both X and Y are categorical variables with common support and develop a Gibbs sampling algorithm for posterior computation. The method is then generalized to the case where X and Y are survival times. The proposed approach is illustrated using data on survival after tumor removal for patients with malignant melanoma.     

Simplified estimation of the parameters of exponential distribution from samples censored in the middle

This paper presents the small sample optimum choice of k ≤n + r₁ ? r₂ + 1) order statistics for the best linear unbiased estimates (BLUES) of the parameters μ and σ or σ alone ( μ known) when the sample is Type II censored in the middle retaining only r₁ lower and n - r₂ + 1 upper order statistics. For n = 3(1)10, k = 2(1)4, r₁ = O(1) (n?2) and r₂ = (r₁ +2) (l)n, the optimum ranks, the coefficients of the BLUEs have been presented in Table I     

Logistic regression with a partially observed covariate

We present results of a Monte Carlo study comparing four methods of estimating the parameters of the logistic model logit (pr (Y = 1 | X, Z)) = α₀ + α ₁ X + α ₂ Z where X and Z are continuous covariates and X is always observed but Z is sometimes missing. The four methods examined are 1) logistic regression using complete cases, 2) logistic regression with filled-in values of Z obtained from the regression of Z on X and Y, 3) logistic regression with filled-in values of Z and random error added, and 4) maximum likelihood estimation assuming the distribution of Z given X and Y is normal. Effects of different percent missing for Z and different missing value mechanisms on the bias and mean absolute deviation of the estimators are examined for data sets of N = 200 and N = 400.     

Estimating population size with truncated sampling

Let X₁, X₂,…,X_n be independent, indentically distributed random variables with density f(x,θ) with respect to a σ-finite measure μ. Let R be a measurable set in the sample space X. The value of X is observable if X ? (X?R) and not otherwise. The number J of observable X’s is binomial, N, Q, Q = 1?P(X ? R). On the basis of J observations, it is desired to estimate N and θ. Estimators considered are conditional and unconditional maximum likelihood and modified maximum likelihood using a prior weight function to modify the likelihood before maximizing. Asymptotic expansions are developed for the [Ncirc]’s of the form [Ncirc] = N + α√N + β + o_p(1), where α and β are random variables. All estimators have the same α, which has mean 0, variance σ² (a function of θ) and is asymptotically normal. Hence all are asymptotically equivalent by the usual limit distributional theory. The β’s differ and Eβ can be considered an “asymptotic bias”. Formulas are developed to compare the asymptotic biases of the various estimators. For a scale parameter family of absolutely continuous distributions with X = (0,∞) and R = (T,∞), special formuli are developed and a best estimator is found.     

Fisher’s observed information matrix for location and scale parameters under type i censoring

An expression for Fisher's observed information matrix is given under type I censoring for any location-scale distribution under mild requirements. It is illustrated on a data set which has been analyzed by several authors.     

Non parametric Bayesian analysis of the two-sample problem with censoring

Testing for differences between two groups is a fundamental problem in statistics, and due to developments in Bayesian non parametrics and semiparametrics there has been renewed interest in approaches to this problem. Here we describe a new approach to developing such tests and introduce a class of such tests that take advantage of developments in Bayesian non parametric computing. This class of tests uses the connection between the Dirichlet process (DP) prior and the Wilcoxon rank sum test but extends this idea to the DP mixture prior. Here tests are developed that have appropriate frequentist sampling procedures for large samples but have the potential to outperform the usual frequentist tests. Extensions to interval and right censoring are considered and an application to a high-dimensional data set obtained from an RNA-Seq investigation demonstrates the practical utility of the method.     

Estimating Incidence Rate on Current Status Data with Application to a Phase IV Cancer Trial

New drug discovery in the pediatrics has dramatically improved survival, but with long- term adverse events. This motivates the examination of adverse outcomes such as long-term toxicity in a phase IV trial. An ideal approach to monitor long-term toxicity is to systematically follow the survivors, which is generally not feasible. Instead, cross-sectional surveys are conducted in Hudson et al. (2007 Hudson , M. M. , Rai , S. N. , Nunez , C. , Merchant , T. E. , Marina , N. M. , Zalamea , N. , Cox , C. , Phipps , S. , Pompeu , R. , Rosenthal , D. ( 2007 ). Noninvasive evaluation of late anthracycline cardiac toxicity in childhood cancer survivors . J. Clin. Oncol. 25 : 3635 – 3643 .[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]), with one of the objectives to estimate the cumulative incidence rates along with specific interest in fixed-term (5 or 10 year) rates. We present inference procedures based on current status data to our motivating example with very interesting findings.     

Parameter Estimation for Bivariate Shock Models with Singular Distribution for Censored Data with Concomitant Order Statistics

When two‐component parallel systems are tested, the data consist of Type‐II censored data X_(i), i= 1, n, from one component, and their concomitants Y _[i] randomly censored at X_(r), the stopping time of the experiment. Marshall & Olkin's (1967) bivariate exponential distribution is used to illustrate statistical inference procedures developed for this data type. Although this data type is motivated practically, the likelihood is complicated, and maximum likelihood estimation is difficult, especially in the case where the parameter space is a non‐open set. An iterative algorithm is proposed for finding maximum likelihood estimates. This article derives several properties of the maximum likelihood estimator (MLE) including existence, uniqueness, strong consistency and asymptotic distribution. It also develops an alternative estimation method with closed‐form expressions based on marginal distributions, and derives its asymptotic properties. Compared with variances of the MLEs in the finite and large sample situations, the alternative estimator performs very well, especially when the correlation between X and Y is small.     

Location estimators based on linear combinations of modified order statistics

Let Xj,…, X be i.i.d random variables with common distribution function F(x-0), and let a(u) be a function defined on [0,1], For each t$$$R define the t-order statistics as: X. (t) = X. if there in k exist exactly (i- 1) X. !s such that |X.-t|greater|X.-t| and define the variable T (t) = n 2. , a(i/n) X, (t) . We consider estimates of 8 defined as solutions of the eauaticn T (8) =6 , and     

Estimation of Survivorship Function Based on Doubly Censored Data with Application to HIV/AIDS

Left censoring concept has been defined in different ways in statistical applications. Turnbull (1974 Turnbull , B. W. ( 1974 ). Nonparametric estimation of a survivorship function with doubly censored data . J. Amer. Statist. Assoc. 69 : 169 – 173 .[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) defines it in a particular way. Whereas in recent literature, especially in epidemiological studies, it has been defined in another way. This difference between the two approaches is the main reason that despite simplicity, Turnbull method cannot be applicable in all cases of doubly censored data. In this article we present a modified Turnbull method for analysis of doubly censored data adequate with recent definition. Comparison has been done with other statistical methods, including imputation estimator, full likelihood-based and conditional likelihood-based approach using Iranian HIV data.     

A modified multiple comparisons with a control for exponential location parameters based on doubly censored sample under heteroscedasticity

ABSTRACT

In this paper, a modified one-stage multiple comparison procedures with a control for exponential location parameters based on the doubly censored sample under heteroscedasticity is proposed. A simulation study is done and the results show that the proposed procedures have shorter confidence length with coverage probabilities closer to the nominal ones compared with the one proposed in Wu (2017 Wu, S. F. 2017. Multiple comparisons of exponential location parameters with a control based on doubly censored sample under heteroscedasticity. Communications in Statistics: Simulation and Computation 46 (3):1858–1870. doi: 10.1080/03610918.2015.1017582.[Taylor & Francis Online] , [Google Scholar]). At last, an example of comparing the duration of remission for four drugs as the treatment of leukemia is given to demonstrate the proposed procedures.     

Rejoinder: "Comment on 'a new Statistic for Testing Suspected Outliers'"

The values of the power of Tiku's (1975) T statistic for testing outliers in normal samples are evaluated. The statistic T is shown to be more powerful than other comparable statistics under Tiku's outlier model, although slightly less powerful under Dixon's (1950) contamination model.