Nonparametric tests for right-censored data with biased sampling

Testing the equality of two survival distributions can be difficult in a prevalent cohort study when non random sampling of subjects is involved. Due to the biased sampling scheme, independent censoring assumption is often violated. Although the issues about biased inference caused by length-biased sampling have been widely recognized in statistical, epidemiological and economical literature, there is no satisfactory solution for efficient two-sample testing. We propose an asymptotic most efficient nonparametric test by properly adjusting for length-biased sampling. The test statistic is derived from a full likelihood function, and can be generalized from the two-sample test to a k-sample test. The asymptotic properties of the test statistic under the null hypothesis are derived using its asymptotic independent and identically distributed representation. We conduct extensive Monte Carlo simulations to evaluate the performance of the proposed test statistics and compare them with the conditional test and the standard logrank test for different biased sampling schemes and right-censoring mechanisms. For length-biased data, empirical studies demonstrated that the proposed test is substantially more powerful than the existing methods. For general left-truncated data, the proposed test is robust, still maintains accurate control of type I error rate, and is also more powerful than the existing methods, if the truncation patterns and right-censoring patterns are the same between the groups. We illustrate the methods using two real data examples.     

Tests for noncorrelation of two multivariate ARMA time series

In many situations, we want to verify the existence of a relationship between multivariate time series. In this paper, we generalize the procedure developed by Haugh (1976) for univariate time series in order to test the hypothesis of noncorrelation between two multivariate stationary ARMA series. The test statistics are based on residual cross-correlation matrices. Under the null hypothesis of noncorrelation, we show that an arbitrary vector of residual cross-correlations asymptotically follows the same distribution as the corresponding vector of cross-correlations between the two innovation series. From this result, it follows that the test statistics considered are asymptotically distributed as chi-square random variables. Two test procedures are described. The first one is based on the residual cross-correlation matrix at a particular lag, whilst the second one is based on a portmanteau type statistic that generalizes Haugh's statistic. We also discuss how the procedures for testing noncorrelation can be adapted to determine the directions of causality in the sense of Granger (1969) between the two series. An advantage of the proposed procedures is that their application does not require the estimation of a global model for the two series. The finite-sample properties of the statistics introduced were studied by simulation under the null hypothesis. It led to modified statistics whose upper quantiles are much better approximated by those of the corresponding chi-square distribution. Finally, the procedures developed are applied to two different sets of economic data.     

Confidence interval estimation and hypothesis testing for a common correlation coefficient

Several procedures have been proposed for testing the hypothesis that all off-diagonal elements of the correlation matrix of a multivariate normal distribution are equal. If the hypothesis of equal correlation can be accepted, it is then of interest to estimate and perhaps test hypotheses for the common correlation. In this paper, two versions of five different test statistics are compared via simulation in terms of adequacy of the normal approximation, coverage probabilities of confidence intervals, control of Type I error, and power. The results indicate that two test statistics based on the average of the Fisher z-transforms of the sample correlations should be used in most cases. A statistic based on the sample eigenvalues also gives reasonable results for confidence intervals and lower-tailed tests.     

TESTS FOR DETECTING MORE NBU-NESS AT A SPECIFIC AGE

This paper proposes a class of non‐parametric test procedures for testing the null hypothesis that two distributions, F and G, are equal versus the alternative hypothesis that F is ‘more NBU (new better than used) at specified age t₀’ than G. Using Hoeffding's two‐sample U‐statistic theorem, it establishes the asymptotic normality of the test statistics and produces a class of asymptotically distribution‐free tests. Pitman asymptotic efficacies of the proposed tests are calculated with respect to the location and shape parameters. A numerical example is provided for illustrative purposes.     

Optimal tests for carcinogenicity in a model with fatal and incidental tumours

In a recent paper Heimann and Neuhaus (Biometrika 88 (2001) 435) studied the combined test of Peto et al. (Long Term and Short Term Screening Assays for Carcinogens: A Critical Appraisal, IARC Monograph on the evaluation of the carcinogenic risk of chemicals to humans, Annex to supplement 2, WHO, Geneva, pp. 311–426) for the two sample testing problem. This test is an ad hoc test adding the log rank test statistic for the random censorship model and the Mantel Haenszel test statistic for the interval censored data model. Heimann and Neuhaus (Biometrika 88 (2001) 435) also introduced an appropriate statistical model combining randomly censored and interval censored data, to handle lethal and incidental tumours jointly.In the present paper we will derive asymptotically optimal tests for this model in a systematic way. The optimal test statistic is decomposed into two orthogonal parts, representing the fatal and incidental components. This will allow to use well known results from the literature for the fatal part, to estimate unknown quantities for the incidental part, and last but not least to compare with Peto's combined test.Moreover, we introduce conditional permutation versions of our tests which are finite sample distribution free under the null hypothesis with equal censoring and are asymptotically equivalent to their unconditional counterparts even under locally unequal censoring. Crucial for these results is a conditional limit theorem for the test statistics under local alternatives which follows from results of Strasser and Weber (Math. Methods Statist. 2 (1999) 220).     

A monte carlo investigation of a statistic for a bivariate missing data problem

Testing the equal means hypothesis of a bivariate normal distribution with homoscedastic varlates when the data are incomplete is considered. If the correlational parameter, ρ, is known, the well-known theory of the general linear model is easily employed to construct the likelihood ratio test for the two sided alternative. A statistic, T, for the case of ρ unknown is proposed by direct analogy to the likelihood ratio statistic when ρ is known. The null and nonnull distribution of T is investigated by Monte Carlo techniques. It is concluded that T may be compared to the conventional t distribution for testing the null hypothesis and that this procedure results in a substantial increase in power-efficiency over the procedure based on the paired t test which ignores the incomplete data. A Monte Carlo comparison to two statistics proposed by Lin and Stivers (1974) suggests that the test based on T is more conservative than either of their statistics.     

Iso‐chi‐squared testing of 2 × k: ordered tables

The Pearson chi‐squared statistic for testing the equality of two multinomial populations when the categories are nominal is much less appropriate for ordinal categories. Test statistics typically used in this context are based on scorings of the ordinal levels, but the results of these tests are highly dependent on the choice of scores. The authors propose a test which naturally modifies the Pearson chi‐squared statistic to incorporate the ordinal information. The proposed test statistic does not depend on the scores and under the null hypothesis of equality of populations, it is asymptotically equivalent to the likelihood ratio test against the alternative of two‐sided likelihood ratio ordering.     

A modification of the kruskal-wallis statistic for the generalized behrens-fisher problem

The problem of testing the equality of the medians of several populations is considered. Standard distribution-free procedures for this problem require that the populations have the same shape in order to maintain their nominal significance level, ever asymptotically, under the null hypothesis of equal medians , A modification of the Kruskal-Wallis test statistic is proposed which is exactly distribution-free under the usual nonparanetric asswnption that the continuous populations are identical with any shape. It is asymptotically distribution-free when the Continuous populations are asswned to be syrmnetric with equal medians.     

Empirical phi-divergence test statistics for testing simple and composite null hypotheses

The main purpose of this paper is to introduce first a new family of empirical test statistics for testing a simple null hypothesis when the vector of parameters of interest is defined through a specific set of unbiased estimating functions. This family of test statistics is based on a distance between two probability vectors, with the first probability vector obtained by maximizing the empirical likelihood (EL) on the vector of parameters, and the second vector defined from the fixed vector of parameters under the simple null hypothesis. The distance considered for this purpose is the phi-divergence measure. The asymptotic distribution is then derived for this family of test statistics. The proposed methodology is illustrated through the well-known data of Newcomb's measurements on the passage time for light. A simulation study is carried out to compare its performance with that of the EL ratio test when confidence intervals are constructed based on the respective statistics for small sample sizes. The results suggest that the ‘empirical modified likelihood ratio test statistic’ provides a competitive alternative to the EL ratio test statistic, and is also more robust than the EL ratio test statistic in the presence of contamination in the data. Finally, we propose empirical phi-divergence test statistics for testing a composite null hypothesis and present some asymptotic as well as simulation results for evaluating the performance of these test procedures.     

Some Properties of the Pivotal Statistic Based on the Asymptotically Distribution-Free Theory in Structural Equation Modeling

For normally distributed data, the asymptotic bias and skewness of the pivotal statistic Studentized by the asymptotically distribution-free standard error are shown to be the same as those given by the normal theory in structural equation modeling. This gives the same asymptotic null distributions of the two pivotal statistics up to the next order beyond the usual normal approximation under normality. With an alternative hypothesis, the asymptotic variances of the two statistics under normality/non normality are also derived. It is, however, shown that the asymptotic variances of the non null distributions of the statistics are generally different even under normality.     

Omnibus test of normality using the Q statistic

A new statistical procedure for testing normality is proposed. The Q statistic is derived as the ratio of two linear combinations of the ordered random observations. The coefficients of the linear combinations are utilizing the expected values of the order statistics from the standard normal distribution. This test is omnibus to detect the deviations from normality that result from either skewness or kurtosis. The statistic is independent of the origin and the scale under the null hypothesis of normality, and the null distribution of Q can be very well approximated by the Cornish-Fisher expansion. The powers for various alternative distributions were compared with several other test statistics by simulations.     

Robust tests for the common principal components model

When dealing with several populations, the common principal components (CPC) model assumes equal principal axes but different variances along them. In this paper, a robust log-likelihood ratio statistic allowing to test the null hypothesis of a CPC model versus no restrictions on the scatter matrices is introduced. The proposal plugs into the classical log-likelihood ratio statistic robust scatter estimators. Using the same idea, a robust log-likelihood ratio and a robust Wald-type statistic for testing proportionality against a CPC model are considered. Their asymptotic distributions under the null hypothesis and their partial influence functions are derived. A small simulation study allows to compare the behavior of the classical and robust tests, under normal and contaminated data.     

Behrens-fisher problem under the assumption of homogeneous coefficients of variation

The powers of the likelihood ratio (LR) test and an “asymptotically (in some sense) optimum” invariant test are examined and compared by simulation techniques with those of several other relevant tests for the problem of testing the equality of two univariate normal population means under the assumption of heterogeneous variances but homogeneous coefficients of variation. It is seen that the LR test is highly satisfactory for all values of the coefficient of variation and the “asymptotically optimum” invariant test, which is computationally much simpler than the LR test, is a reasonably good competitor for cases where the value of the coefficient of variation is greater than or equal to 3. Also, a     

Correlation type gogdness-of-fit statistics with censored sampling

Some comments are made concerning the possible forms of a correlation coefficient type goodness-of-fit statistic, and their relationship with other goodness-of-fit statistics, Critical values for a correlation goodness-of-fit statistic and for the Cramer-von Mises statistic are provided for testing a completely-specified null hypothesis for both complete and censored sampling, Critical values for a correlation test statistic are provided for complete and censored sampling for testing the hypothesis of normality, two parameter exponentiality, Weibull (or, extreme value) and an exponential-power distribution, respectively. Critical values are also provided for a test of one-parameter exponentiality based on the Cramer-von Mises statistic     

Rényi statistics for testing composite hypotheses in general exponential models

We introduce a family of Rényi statistics of orders r?∈?R for testing composite hypotheses in general exponential models, as alternatives to the previously considered generalized likelihood ratio (GLR) statistic and generalized Wald statistic. If appropriately normalized exponential models converge in a specific sense when the sample size (observation window) tends to infinity, and if the hypothesis is regular, then these statistics are shown to be χ²-distributed under the hypothesis. The corresponding Rényi tests are shown to be consistent. The exact sizes and powers of asymptotically α-size Rényi, GLR and generalized Wald tests are evaluated for a concrete hypothesis about a bivariate Lévy process and moderate observation windows. In this concrete situation the exact sizes of the Rényi test of the order r?=?2 practically coincide with those of the GLR and generalized Wald tests but the exact powers of the Rényi test are on average somewhat better.     

Hypothesis Testing in Functional Comparative Calibration Models

The purpose of this article is to investigate hypothesis testing in functional comparative calibration models. Wald type statistics are considered which are asymptotically distributed according to the chi-square distribution. The statistics are based on maximum likelihood, corrected score approach, and method of moment estimators of the model parameters, which are shown to be consistent and asymptotically normally distributed. Results of analytical and simulation studies seem to indicate that the Wald statistics based on the method of moment estimators and the corrected score estimators are, as expected, less efficient than the Wald type statistic based on the maximum likelihood estimators for small n. Wald statistic based on moment estimators are simpler to compute than the other Wald statistics tests and their performance improves significantly as n increases. Comparisons with an alternative F statistics proposed in the literature are also reported.     

A new goodness of fit test for the equality of multinomial cell probabilities versus trend alternatives

In this paper, a new test statistic is presented for testing the null hypothesis of equal multinomial cell probabilities versus various trend alternatives. Exact asymptotic critical values are obtained, The power of the test is compared with several other statistics considered by Choulakian et al (1995), The test is shown to have better power for certain trend alternatives.     

Asymptotocally nonparametric tests with censored paired data

A class of asymptotically nonparametric test with contains a test proposed by Wei(1980), is considered for testing the equality of two continuous distribution funcitons when paired observations are subject to arbitrary right censorship. It is shown that under the null hypothesis each test statistic converges in distribution to the standard normal random variable. Furthermore. the Monte Carlo simulation results indicate that some tests in this class are more powerful than Wei's test. A generalization to incomplete censored paired data is also included.     

A GOODNESS OF FIT TEST BASED ON THE LINKED LINE CHART1

In this paper, we propose a graphical representation of data and a test statistic based on it for testing the goodness of fit of a completely specified null distribution. The graph is constructed as a linked line chart given by vectors which reflect the pattern of order statistics. The test statistic is defined as an area defined by our chart and its asymptotic distribution is derived under the null hypothesis. Computer simulations performed to study the power properties of our chart indicate that the test is powerful for scale alternatives. Furthermore, it is shown that our test is closely related to the Watson test.     

Nonparametric multiple comparison procedures for unbalanced one-way factorial designs

In this paper, we present several nonparametric multiple comparison (MC) procedures for unbalanced one-way factorial designs. The nonparametric hypotheses are formulated by using normalized distribution functions and the comparisons are carried out on the basis of the relative treatment effects. The proposed test statistics take the form of linear pseudo rank statistics and the asymptotic joint distribution of the pseudo rank statistics for testing treatments versus control satisfies the multivariate totally positive of order two condition irrespective of the correlations among the rank statistics. Therefore, in the context of MCs of treatments versus control, the nonparametric Simes test is validated for the global testing of the intersection hypothesis. For simultaneous testing of individual hypotheses, the nonparametric Hochberg stepup procedure strongly controls the familywise type I error rate asymptotically. With regard to all pairwise comparisons, we generalize various single-step and stagewise procedures to perform comparisons on the relative treatment effects. To further compare with normal theory counterparts, the asymptotic relative efficiencies of the nonparametric MC procedures with respect to the parametric MC procedures are derived under a sequence of Pitman alternatives in a nonparametric location shift model for unbalanced one-way layouts. Monte Carlo simulations are conducted to demonstrate the validity and power of the proposed nonparametric MC procedures.