Optimal Circular Block Designs for Neighbouring Competition Effects

Competition or interference occurs when the responses to treatments in experimental units are affected by the treatments in neighbouring units. This may contribute to variability in experimental results and lead to substantial losses in efficiency. The study of a competing situation needs designs in which the competing units appear in a predetermined pattern. This paper deals with optimality aspects of circular block designs for studying the competition among treatments applied to neighbouring experimental units. The model considered is a four-way classified model consisting of direct effect of the treatment applied to a particular plot, the effect of those treatments applied to the immediate left and right neighbouring units and the block effect. Conditions have been obtained for the block design to be universally optimal for estimating direct and neighbour effects. Some classes of balanced and strongly balanced complete block designs have been identified to be universally optimal for the estimation of direct, left and right neighbour effects and a list of universally optimal designs for v<20 and r<100 has been prepared.     

Optimal Block Designs With Interference Effects From Neighboring Units Under a Non Additive Model

Here, the optimality of block design with interference effect from neighboring unit under a general non additive model is investigated, which allows for the presence of interactions among the treatments applied in the adjacent plots. A non additive model with interference × direct effects of treatments is considered as these effects contribute significantly to the response. A class of complete block designs balanced for interference effects from left neighboring unit is shown to be universally optimal for the estimation of direct and interference effects of treatments and two such series of designs have been constructed. Furthermore, considering direct treatment × block non additivity with interference effects, the optimality is studied and the optimal designs are obtained.     

Optimal block designs with non additive mixed effects interference

This paper deals with optimality aspects of block designs balanced for interference effects from neighboring units on both sides under a general non additive model along with random block effects. Here, a class of complete, circular block designs strongly balanced for interference effects has been shown to be universally optimal for the estimation of direct effects and interference effects (left and right) of treatments under a non additive mixed effects model.     

Optimal Allocation of Observations for Inference on k Ordered Normal Population Means

The optimal allocation of observations when there is a natural ordering in the k normal population means is discussed. It is shown that the design which minimizes the total mean square error of the maximum likelihood estimators in the null case allocates half the observations to each of the two extreme populations. The design is obviously optimal for testing the homogeneity of means against the simple ordered alternative. It is, however, hardly acceptable for the estimation in the nonnull case. It is, therefore, shown that the observations could be allocated to the non-extreme populations according to weights which are proportional to the absolute values of the Abelson and Tukey scores at the same time keeping the minimum local power for testing the simple ordered alternative to be maximal. The design gives also the maximum minimum power, not local, for the alternative in the class of linear tests. It, of course, suffers from a small loss of efficiency for the estimation under the null case but is much better under the nonnull case than the extreme design which allocates half the observations to each of the two extreme populations. Some numerical comparisons of the mean square errors are given.     

A characterization of a universally optimal design within a class of block designs

It is shown that within the class of connected binary designs with arbitrary block sizes and arbitrary replications only a symmetic balanced incomplete block design produces a completely symmetric information matrix for the treatment effects whenever the number of blocks is equal to the number of treatments and the number of experimental units is an integer multiple of the number of treatments. Such a design is known to be universally optimal.     

Universal optimality of experimental designs: Definitions and a criterion

Several definitions of universal optimality of experimental designs are found in the Literature; we discuss the interrelations of these definitions using a recent characterization due to Friedland of convex functions of matrices. An easily checked criterion is given for a design to satisfy the main definition of universal optimality; this criterion says that a certain set of linear functions of the eigenvalues of the information matrix is maximized by the information matrix of a design if and only if that design is universally optimal. Examples are given; in particular we show that any universally optimal design is (M, S)-optimal in the sense of K. Shah.     

Optimum Mixture Design for the Detection of Synergistic Effects

In mixture experiments, optimal designs for the estimation of parameters, both linear and non-linear, have been discussed by several authors. Optimal designs for the estimation of a subset of parameters have also been investigated. However, designs for testing the effects of certain factors and interactions have been studied only in the context of response surface models. In this article, we attempt to find the optimum design for testing the presence of synergistic effects in a mixture model. The classical F-test has been considered and the optimum design has been obtained so as to maximize the power of the test. It is observed that the barycenters are necessarily the support points of the trace-optimal design.     

Some adjusted orthogonal,variance balanced,multidimensional block designs

A multidimensional block design (MBD) is an experimental design with d > 1 blocking criteria geometrically represented as a d-dimensional lattice with treatment varieties assigned to some or all nodes of the lattice. Intrablock analysis of variance tables for some special classes of two- and three-dimensional block designs with some empty nodes are given. Design plans and efficiencies for 31 two-dimensional designs, each universally optimal in defined classes of designs, and 7 three-dimensional designs, each nearly optimal in defined classes of designs, are listed in the appendices. A need for such designs is apparent when the blocking criteria are implemented successively and empty nodes do not represent wasted experimental units.     

Block designs robust against the presence of positional effects

The problem considered is to find optimum designs for treatment effects in a block design (BD) setup, when positional effects are also present besides treatment and block effects, but they are ignored while formulating the model. In the class of symmetric balanced incomplete block designs, the Youden square design is shown to be optimal in the sense of minimizing the bias term in the mean squared error (MSE) of the best linear unbiased estimators of the full set of orthonormal treatment contrasts, irrespective of the value of the positional effects.     

Optimal predictive design augmentation for spatial generalised linear mixed models

A typical model for geostatistical data when the observations are counts is the spatial generalised linear mixed model. We present a criterion for optimal sampling design under this framework which aims to minimise the error in the prediction of the underlying spatial random effects. The proposed criterion is derived by performing an asymptotic expansion to the conditional prediction variance. We argue that the mean of the spatial process needs to be taken into account in the construction of the predictive design, which we demonstrate through a simulation study where we compare the proposed criterion against the widely used space-filling design. Furthermore, our results are applied to the Norway precipitation data and the rhizoctonia disease data.     

ITERATIVE ANALYSIS OF GENERALIZED LATTICE DESIGNS

Generalized lattice designs are defined. They include as special cases the square and rectangular lattice designs, and the α-designs defined by Patterson and Williams (1976). An iterative procedure is given for the combined estimation of variety effects in generalized lattice designs with optimal or near optimal efficiency factors. This procedure, together with an approximate variance matrix, enables the analysis of efficient generalized lattice designs to be carried out on mini computers.     

Optimality in the presence of two factor interactions among the nuisance factors

Here we consider an m way heterogeneity settingin the presence of two factor interactions among the heterogeneity directions . The set of experimental units considered do not exhaust all possible level combinations of the heterogeneity directions ; but the set is such that all heterogeneity effects assumed i n the model are orthogonally estmable.In such a setting , calleda doubly balanced m-way setting , the C-matrix of the reduced normal equations for the treatment effects is derived . Universally optimal designs are obtained in the cases where the settingis (i) Completely regular or (ii) partly regular of a special type . An interesting observation is that there are situations where the universally optimal designsin the present setting are totally different from the designs known t o be universally optimal when there is no interaction effect among the heterogeneity directions. This indicates that the usual optimality criteria are sensitive to validity or otherwise of the usual assumptions of lack of interactions among heterogeneity directions.     

An approximate Bayesian up-down method for estimating a percentage point on a dose-response curve

While the up-down method for estimating a percentage point on a dose-response curve has received considerable attention, a general Bayesian solution to the up-down design and estimation has never been presented, probably due to its computational complexity both in design and use. This paper presents a theoretical approach for up-down experimental designs with unknown location and slope parameters, and a practical approach for their use. The simplex method is used to find the optimal starting dose level and step sizes that minimize the expected root mean square error for a fixed number of observations and a reduced number of step sizes. The Bayesian estimate is then approximated by a polynomial formula. The coefficients of the formula are also chosen using simplex minimization. Two example solutions are given with uniform-uniform and normal-gamma joint prior distributions, showing that the simplifying assumptions make the method far easier to use with only a marginal increase in expected root mean square error. We show how to adapt these prior distributions to a wide range of frequently encountered applications.     

An example of applying the asymptotic quasi-likelihood to dimension estimation for random spatial patterns

With reference to a specific example of a random spatial fractal and the modified box-counting method of dimension estimation, this paper aims to examine firstly the estimation of pointwise dimension via modification of the box-counting procedure, secondly the regression inspired estimation procedure, including generalised least squares and, finally, to develop a new estimation procedure – the asymptotic quasi-likelihood method – for the estimation of pointwise dimension. The main focus is on practicality – to arrive at an estimation method which is easy to use and robust.     

Optimal robust parameter designs with qualitative and quantitative factors

Robust parameter design is an effective methodology for reducing variance and improving the quality of a product and a process. Recent work has mainly concentrated on two‐level robust parameter designs. We consider general robust parameter designs with factors having two or more or mixed levels these levels being either qualitative or quantitative. We propose a methodology and develop a generalised minimum aberration optimality criterion for selecting optimal robust parameter designs. A catalogue of 18‐run optimal designs is constructed and tabulated.     

Optimal B-robust estimators for the parameters of the Burr XII distribution

The Burr XII distribution offers a flexible alternative to the distributions that play important role for modelling data in reliability, risk and process capability. However, estimating the shape parameters of the Burr XII distribution is a challenging problem. The classical estimation methods such as maximum likelihood and least squares are often used to estimate the parameters of the Burr XII distribution, but these methods are very sensitive to the outliers in the data. Thus, a robust estimation method alternative to the classical methods is needed to find robust estimators that are less sensitive to the outliers in the data. The purpose of this paper is to use the optimal B-robust estimation method [Hampel FR, Ronchetti EM, Rousseeuw PJ, Stahel WA. Robust statistics: the approach based on influence functions. New York: Wiley; 1986] to obtain robust estimators for the shape parameters of the Burr XII distribution. The simulation results show that the optimal B-robust estimators generally outperform the classical estimators in terms of the bias and root mean square errors when there are outliers in data.     

Error misspecification and properties of the simple ridge estimator

This paper gives necessary and sufficient conditions for the ridge estimator applied to an error misspecified regression model to dominate the generalised least squares estimator. It is shown that the requirements for mean square error dominance are more stringent than in the correct specification case.     

Stepwise estimators for three-phase sampling of categorical variables

Three-phase sampling can be a very effective design for the estimation of regional and national forest cover type frequencies. Simultaneous estimation of frequencies and sampling variances require estimation of a large number of parameters; often so many that consistency and robustness of results becomes an issue. A new stepwise estimation model, in which bias in phase one and two is corrected sequentially instead of simultaneously, requires fewer parameters. Simulated three-phase sampling tested the new model with 144 settings of sample sizes, the number of classes and classification accuracy. Relative mean absolute deviations and root mean square errors were, in most cases, about 8% lower with the stepwise method than with a simultaneous approach. Differences were a function of design parameters. Average expected relative root mean square errors, derived from the assumption of a Dirichlet distribution of cover-type frequencies, tracked the empirical root mean square errors obtained from repeated sampling with ±10%. Resampling results indicate that the relative bias of the most frequent cover types was slightly inflated by the stepwise method. For the least common cover type, the simultaneous method produced the largest relative bias.     

Bayesian optimal blocking of factorial designs

The presence of block effects makes the optimal selection of fractional factorial designs a difficult task. The existing frequentist methods try to combine treatment and block wordlength patterns and apply minimum aberration criterion to find the optimal design. However, ambiguities exist in combining the two wordlength patterns and therefore, the optimality of such designs can be challenged. Here we propose a Bayesian approach to overcome this problem. The main technique is to postulate a model and a prior distribution to satisfy the common assumptions in blocking and then, to develop an optimal design criterion for the efficient estimation of treatment effects. We apply our method to develop regular, nonregular, and mixed-level blocked designs. Several examples are presented to illustrate the advantages of the proposed method.     

Optimal design for the proportional odds model

The authors construct locally optimal designs for the proportional odds model for ordinal data. While they investigate the standard D‐optimal design, they also investigate optimality criteria for the simultaneous estimation of multiple quantiles, namely D_A ‐optimality and the omnibus criterion. The design of experiments for the simultaneous estimation of multiple quantiles is important in both toxic and effective dose studies in medicine. As with c‐optimality in the binary response problem, the authors find that there are distinct phase changes when exploring extreme quantiles that require additional design points. The authors also investigate relative efficiencies of the criteria.