Revisiting retesting in the estimation of proportions by group testing

In the estimation of a proportion p by group testing (pooled testing), retesting of units within positive groups has received little attention due to the minimal gain in precision compared to testing additional units. If acquisition of additional units is impractical or too expensive, and testing is not destructive, we show that retesting can be a useful option. We propose the retesting of a random grouping of units from positive groups, and compare it with nested halving procedures suggested by others. We develop an estimator of p for our proposed method, and examine its variance properties. Using simulation we compare retesting methods across a range of group testing situations, and show that for most realistic scenarios, our method is more efficient.     

Estimation of proportions by group testing with retesting of positive groups

Abstract

When estimating a proportion p by group testing, and it is desired to increase precision, it is sometimes impractical to obtain additional individuals but it is possible to retest groups formed from the individuals within the groups that test positive at the first stage. Hepworth and Watson assessed four methods of retesting, and recommended a random regrouping of individuals from the first stage. They developed an estimator of p for their proposed method, and, because of the analytic complexity, used simulation to examine its variance properties. We now provide an analytical solution to the variance of the estimator, and compare its performance with the earlier simulated results. We show that our solution gives an acceptable approximation in a reasonable range of circumstances.     

Point estimation after early stopping in a repeated measures trial

When the individual measurements are statistically independent, the maximum likelihood estimator calculated at the end of a sequential procedure overestimates the underlying effect. There are many clinical trials in which we are interested in comparing changes in responses between two treatment groups sequentially. Lee and DeMets (1991, JASA 86, 757–762) proposed a group sequential method for comparing rates of change when a response variable is measured for eaeh patient at successive follow-up visits. They assumed that the response follows the linear mixed effects model and derived the asymptotic joint distribution of the sequentially computed statistics. In this article, we consider the maximum likelihood estimator (MLE), the median unbiased estimator (MUE) and the midpoint of a 100(1-α)% confidence interval as point estimators for the rate of change in the linear mixed effects model, and investigate their properties by Monte Carlo simulation.     

Testing the homogeneity of risk differences with sparse count data

ABSTRACT

In this paper, we consider testing the homogeneity of risk differences in independent binomial distributions especially when data are sparse. We point out some drawback of existing tests in either controlling a nominal size or obtaining powers through theoretical and numerical studies. The proposed test is designed to avoid the drawbacks of existing tests. We present the asymptotic null distribution and asymptotic power function for the proposed test. We also provide numerical studies including simulations and real data examples showing the proposed test has reliable results compared to existing testing procedures.     

Statistical Analysis of Non Linear Least Squares Estimation for Harmonic Signals in Multiplicative and Additive Noise

Abstract

This article concerns the stochastically constrained linear model under a biased assumption. We propose a quasi-stochastically constrained least squares estimator. Furthermore, we provide the expectation of this estimator, demonstrate its consistency and asymptotic normality. In the end of the article, the simulation study of the new estimator shows that it is superior to the least squares estimator, ridge estimator, and the linear constrained estimators under certain conditions by comparing the mean squared errors of these estimators.     

Robust procedures for multi-sample location problems with unequal group variances

Robust procedures are proposed for testing the equality of several group means without assuming the equality of group variances. These statistics are obtained by modifying Welch's W and Brown-Forsythe's F^* using a trimmed mean and a sine-wave M estimator.Approximate distributions of these new statistics are obtained under normality. Their performances are evaluated by Monte Carlo sampling experiments under various long-tailed symmetric distributions     

Optimal group sequential designs constrained on both overall and stage one error rates

Abstract

Optimized group sequential designs proposed in the literature have designs minimizing average sample size with respect to a prior distribution of treatment effect with overall type I and type II error rates well-controlled (i.e., at final stage). The optimized asymmetric group sequential designs that we present here additionally consider constrains on stopping probabilities at stage one: probability of stopping for futility at stage one when no drug effect exists as well as the probability of rejection when the maximum effect size is true at stage one so that accountability of group sequential design is ensured from the first stage throughout.     

Asymptotic properties of the bootstrap unit root test statistic under possibly infinite variance

ABSTRACT

In this article, the unit root test for the AR(1) model is discussed, under the condition that the innovations of the model are in the domain of attraction of the normal law with possibly infinite variances. By using residual bootstrap with sample size m < n (n being the size of the original sample), we bootstrap the least-squares estimator of the autoregressive parameter. Under some mild assumptions, we prove that the null distribution of the unit root test statistic based on the least-square estimator of the autoregressive parameter can be approximated by using residual bootstrap.     

Efficient regression modeling for correlated and overdispersed count data

Abstract

The objective of this paper is to propose an efficient estimation procedure in a marginal mean regression model for longitudinal count data and to develop a hypothesis test for detecting the presence of overdispersion. We extend the matrix expansion idea of quadratic inference functions to the negative binomial regression framework that entails accommodating both the within-subject correlation and overdispersion issue. Theoretical and numerical results show that the proposed procedure yields a more efficient estimator asymptotically than the one ignoring either the within-subject correlation or overdispersion. When the overdispersion is absent in data, the proposed method might hinder the estimation efficiency in practice, yet the Poisson regression based regression model is fitted to the data sufficiently well. Therefore, we construct the hypothesis test that recommends an appropriate model for the analysis of the correlated count data. Extensive simulation studies indicate that the proposed test can identify the effective model consistently. The proposed procedure is also applied to a transportation safety study and recommends the proposed negative binomial regression model.     

Generation of pseudo random numbers and estimation under Cox models with time-dependent covariates

ABSTRACT

We study the method for generating pseudo random numbers under various special cases of the Cox model with time-dependent covariates when the baseline hazard function may not be constant and the random variable may equal infinity with a positive probability. During our simulation studies in computing the partial likelihood estimates, in between 3% and 20% of the time with a moderate sample size, it happens that the partial likelihood estimate of the regression coefficient is ∞ for the data from the Cox model. We propose a semi-parametric estimator as a modification for such a case. We present simulation results on the asymptotic properties of the semi-parametric estimator.     

An estimator of population total in multiple characteristics and its robustness to product moment correlation coefficient

We developed an alternative estimator for the probability proportional to size with replacement sampling scheme when certain characteristics under study have low correlation with the size measured used for sample selection. The performance of the proposed estimator has been studied with other related alternative estimators by comparing biases and the variances of respective alternative estimators. Most of the alternative estimators assume the knowledge of the product moment correlation coefficient. Therefore an empirical study, with the help of wide variety of populations, has been carried out to study their respective efficiency when correlation coefficient is departed from its true value.     

A model with long-term survivors: negative binomial Birnbaum-Saunders

Abstract

We propose a cure rate survival model by assuming that the number of competing causes of the event of interest follows the negative binomial distribution and the time to the event of interest has the Birnbaum-Saunders distribution. Further, the new model includes as special cases some well-known cure rate models published recently. We consider a frequentist analysis for parameter estimation of the negative binomial Birnbaum-Saunders model with cure rate. Then, we derive the appropriate matrices for assessing local influence on the parameter estimates under different perturbation schemes. We illustrate the usefulness of the proposed model in the analysis of a real data set from the medical area.     

Superiority of the r-k class estimator over some estimators in a misspecified linear model

ABSTRACT

In this article, we discuss the superiority of r-k class estimator over some estimators in a misspecified linear model. We derive the necessary and sufficient conditions for the superiority of the r-k class estimator over each of these estimators under the Mahalanobis loss function by the average loss criterion in the misspecified linear model.     

Bias correction of estimated proportions using inverse binomial group testing

Group testing, in which individuals are pooled together and tested as a group, can be combined with inverse sampling to estimate the prevalence of a disease. Alternatives to the MLE are desirable because of its severe bias. We propose an estimator based on the bias correction method of Firth (1993), which is almost unbiased across the range of prevalences consistent with the group testing design. For equal group sizes, this estimator is shown to be equivalent to that derived by applying the correction method of Burrows (1987), and better than existing methods. For unequal group sizes, the problem has some intractable elements, but under some circumstances our proposed estimator can be found, and we show it to be almost unbiased. Calculation of the bias requires computer‐intensive approximation because of the infinite number of possible outcomes.     

Confidence intervals for a population proportion using group testing in the presence of misclassification

In this study, we consider the construction of the confidence interval for the population proportion while using group testing with misclassification. We propose two confidence intervals based on Cornish-Fisher expansion and a modified Wilson’s interval based on a newly developed estimator. We investigate the performance of these intervals extensively and also apply the methods to real datasets. Our newly derived methods have competitive performance compared with existing methods.     

The Bayes rule of the parameter in (0,1) under Zhang’s loss function with an application to the beta-binomial model

Abstract

For the restricted parameter space (0,1), we propose Zhang’s loss function which satisfies all the 7 properties for a good loss function on (0,1). We then calculate the Bayes rule (estimator), the posterior expectation, the integrated risk, and the Bayes risk of the parameter in (0,1) under Zhang’s loss function. We also calculate the usual Bayes estimator under the squared error loss function, and the Bayes estimator has been proved to underestimate the Bayes estimator under Zhang’s loss function. Finally, the numerical simulations and a real data example of some monthly magazine exposure data exemplify our theoretical studies of two size relationships about the Bayes estimators and the Posterior Expected Zhang’s Losses (PEZLs).     

Improved Empirical Bayes Estimation in Group Testing Procedure for Small Proportions

Group testing has been long recognized as an efficient method to classify all the experimental units into two mutually exclusive categories: defective or not defective. In recent years, more attention has been brought to the estimation of the population prevalence rate p of a disease, or of some property, using group testing. In this article, we propose two scaled squared-error loss functions, which improve the Bayesian approach to estimating p in terms of minimizing the mean squared error (MSE) of the Bayes estimators of p for small p. We show that the new estimators are preferred over the estimator from the usual squared-error loss function and the maximum likelihood estimator (MLE) for small p.     

A Conditionally Unbiased Estimator for the Equal-Catchability Model

ABSTRACT

In this article we reconsider an estimator of population size previously advocated for use when sampling from a population subdivided into different types. We show that it may be usefully adopted in the simple equal-catchability model used in mark-recapture. Unlike the commonly used maximum likelihood estimator, this conditionally unbiased estimator is always finite-valued. Except in situations in which the data contain little relevant information, its performance, in terms of bias and precision, is seen to be at least as good as that of the maximum likelihood estimator. Two estimators of the standard deviation of the conditionally unbiased estimator are considered.     

Describing extra-binomial variation with partially correlated models

Data in the form of proportions are often analyzed under a binomial model. However, because genuine random sampling is often infeasible, the subjects in the sample may be collected in clumps and the variances of the observed proportions may be considerably larger than those corresponding to the binomial model. A set of data from a study of the proportion of subjects testing positive to the disease toxoplasmosis is used in this article to motivate partially correlated binomial models capable of describing data observed in practical situations where clumped sampling is likely to appear, According to these models, the extra-binomial variance of the observed frequencies may range from a linear to a quadratic function of the sample size. An efficient algorithm for the evaluation of the resulting probability mass function is given.     

An improved and efficient biased estimation technique in logistic regression model

Abstract

In this article, we propose a new improved and efficient biased estimation method which is a modified restricted Liu-type estimator satisfying some sub-space linear restrictions in the binary logistic regression model. We study the properties of the new estimator under the mean squared error matrix criterion and our results show that under certain conditions the new estimator is superior to some other estimators. Moreover, a Monte Carlo simulation study is conducted to show the performance of the new estimator in the simulated mean squared error and predictive median squared errors sense. Finally, a real application is considered.