Asymptotically optimal Berry-Esseen-type bounds for distributions with an absolutely continuous part

Recursive and closed form upper bounds are offered for the Kolmogorov and the total variation distance between the standard normal distribution and the distribution of a standardized sum of n independent and identically distributed random variables. The method employed is a modification of the method of compositions along with Zolotarev's ideal metric. The approximation error in the CLT obtained vanishes at a rate O(n^−k/2+1), provided that the common distribution of the summands possesses an absolutely continuous part, and shares the same k−1 (k?3) first moments with the standard normal distribution. Moreover, for the first time, these new uniform Berry-Esseen-type bounds are asymptotically optimal, that is, the ratio of the true distance to the respective bound converges to unity for a large class of distributions of the summands. Thus, apart from the correct rate, the proposed error estimates incorporate an optimal asymptotic constant (factor). Finally, three illustrative examples are presented along with numerical comparisons revealing that the new bounds are sharp enough even to be used in practical statistical applications.     

Estimation of the error distribution in a varying coefficient regression model

This paper deals with the estimation of the error distribution function in a varying coefficient regression model. We propose two estimators and study their asymptotic properties by obtaining uniform stochastic expansions. The first estimator is a residual-based empirical distribution function. We study this estimator when the varying coefficients are estimated by under-smoothed local quadratic smoothers. Our second estimator which exploits the fact that the error distribution has mean zero is a weighted residual-based empirical distribution whose weights are chosen to achieve the mean zero property using empirical likelihood methods. The second estimator improves on the first estimator. Bootstrap confidence bands based on the two estimators are also discussed.     

Asymptotic distribution in affiliation finite discrete weighted networks with an increasing degree sequence

Abstract

The asymptotic normality of a fixed number of the maximum likelihood estimators (MLEs) in the affiliation finite discrete weighted networks with an increasing degree sequence has been established recently. In this article, we further derive a central limit theorem for a linear combination of all the MLEs with an increasing dimension. Simulation studies are provided to illustrate the asymptotic results.     

Asymptotic normality of numbers of observations in random regions determined by order statistics

In this paper, we study the joint limiting behaviour of numbers of observations that fall into regions determined by order statistics and Borel sets. We show that suitably centred and normed versions of these numbers are asymptotically multivariate normal under some conditions. We consider two cases: one where the population distribution function is discontinuous and the other where it is continuous and the order statistics are extreme. Finally, we compare results obtained for the two cases with their analogues for absolutely continuous distribution function and central-order statistics.     

Testing,Estimation in GMM and CUE with Nearly-Weak Identification

In this article, we analyze Generalized Method of Moments (GMM) and Continuous Updating Estimator (CUE) with strong, nearly-weak, and weak identification. We show that with this mixed system, the limits of the estimators are nonstandard. In the subcase of GMM estimator with only nearly-weak instruments, the correlation between the instruments and the first order conditions decline at a slower rate than root T. We find an important difference between the nearly-weak case and the weak case. Inference with point estimates is possible with the Wald, likelihood ratio (LR), and Lagrange multiplier (LM) tests in GMM estimator with only nearly-weak instruments present in the system. The limit is the standard χ² limit. This is important from an applied perspective, since tests on the weak case do depend on the true value and can only test simple null. We also show this in the more realistic case of mixed type of strong, weak, and nearly-weak instruments, Anderson and Rubin (1949 Anderson , T. W. , Rubin , H. ( 1949 ). Estimation of the parameters of a single equation in a complete system of stochastic equations . Annals of Mathematical Statistics 20 : 46 – 63 .[Crossref] , [Google Scholar]) and Kleibergen (2005 Kleibergen , F. ( 2005 ). Testing parameters in GMM without assuming that they are identified . Econometrica Forthcoming . [Google Scholar]) type of tests are asymptotically pivotal and have χ² limit.     

An exact upper limit for the variance bias in a carry-over model with correlated errors

The analysis of crossover designs assuming i.i.d. errors leads to biased variance estimates whenever the true covariance structure is not spherical. As a result, the OLS F-test for the equality of the direct effects of the treatments is not valid. Bellavance et al. [1996. Biometrics 52, 607–612] use simulations to show that a modified F-test based on an estimate of the within subjects covariance matrix allows for nearly unbiased tests. Kunert and Utzig [1993. JRSS B 55, 919–927] propose an alternative test that does not need an estimate of the covariance matrix. Instead, they correct the F-statistic by multiplying by a constant based on the worst-case scenario. However, for designs with more than three observations per subject, Kunert and Utzig (1993) only give a rough upper bound for the worst-case variance bias. This may lead to overly conservative tests. In this paper we derive an exact upper limit for the variance bias due to carry-over for an arbitrary number of observations per subject. The result holds for a certain class of highly efficient balanced crossover designs.     

Joint analysis of occurrence and time to stability after entrance into the Italian labour market: an approach based on a Bayesian cure model with structured stochastic search variable selection

Precarious employment is a serious social problem, especially in those countries, such as Italy, where there are limited benefits from social security. We investigate this phenomenon by analysing the initial part of the career of employees starting with unstable contracts for a panel of Italian workers. Our aim is to estimate the probability of getting a stable job and to detect factors influencing both this probability and the duration of precariousness. To answer these questions, we use an ad hoc mixture cure rate model in a Bayesian framework.     

Analysing direct effects in randomized trials with secondary interventions: an application to human immunodeficiency virus prevention trials

Summary.  The 'Methods for improving reproductive health in Africa' trial is a recently completed randomized trial that investigated the effect of diaphragm and lubricant gel use in reducing infection by the human immunodeficiency virus (HIV) among susceptible women. 5045 women were randomly assigned to either the active treatment arm or not. Additionally, all subjects in both arms received intensive condom counselling and provision, the 'gold standard' HIV prevention barrier method. There was much lower reported use of condoms in the intervention arm than in the control arm, making it difficult to answer important public health questions based solely on the intention-to-treat analysis. We adapt an analysis technique from causal inference to estimate the 'direct effects' of assignment to the diaphragm arm, adjusting for use of condoms in an appropriate sense. Issues raised in the trial apply to other trials of HIV prevention methods, some of which are currently being conducted or designed.     

Accounting for informative non‐compliance with a bivariate exponential model in the design of endpoint trials

Failure to adjust for informative non‐compliance, a common phenomenon in endpoint trials, can lead to a considerably underpowered study. However, standard methods for sample size calculation assume that non‐compliance is non‐informative. One existing method to account for informative non‐compliance, based on a two‐subpopulation model, is limited with respect to the degree of association between the risk of non‐compliance and the risk of a study endpoint that can be modelled, and with respect to the maximum allowable rates of non‐compliance and endpoints. In this paper, we introduce a new method that largely overcomes these limitations. This method is based on a model in which time to non‐compliance and time to endpoint are assumed to follow a bivariate exponential distribution. Parameters of the distribution are obtained by equating them with the study design parameters. The impact of informative non‐compliance is investigated across a wide range of conditions, and the method is illustrated by recalculating the sample size of a published clinical trial. Copyright © 2005 John Wiley & Sons, Ltd.     

A hierarchical modelling approach to analysing longitudinal data with drop-out and non-compliance, with application to an equivalence trial in paediatric acquired immune deficiency syndrome

Longitudinal clinical trials with long follow-up periods almost invariably suffer from a loss to follow-up and non-compliance with the assigned therapy. An example is protocol 128 of the AIDS Clinical Trials Group, a 5-year equivalency trial comparing reduced dose zidovudine with the standard dose for treatment of paediatric acquired immune deficiency syndrome patients. This study compared responses to treatment by using both clinical and cognitive outcomes. The cognitive outcomes are of particular interest because the effects of human immunodeficiency virus infection of the central nervous system can be more acute in children than in adults. We formulate and apply a Bayesian hierarchical model to estimate both the intent-to-treat effect and the average causal effect of reducing the prescribed dose of zidovudine by 50%. The intent-to-treat effect quantifies the causal effect of assigning the lower dose, whereas the average causal effect represents the causal effect of actually taking the lower dose. We adopt a potential outcomes framework where, for each individual, we assume the existence of a different potential outcomes process at each level of time spent on treatment. The joint distribution of the potential outcomes and the time spent on assigned treatment is formulated using a hierarchical model: the potential outcomes distribution is given at the first level, and dependence between the outcomes and time on treatment is specified at the second level by linking the time on treatment to subject-specific effects that characterize the potential outcomes processes. Several distributional and structural assumptions are used to identify the model from observed data, and these are described in detail. A detailed analysis of AIDS Clinical Trials Group protocol 128 is given; inference about both the intent-to-treat effect and average causal effect indicate a high probability of dose equivalence with respect to cognitive functioning.