Renovating inverval-censored responses

In this note we provide a general framework for describing interval-censored samples including estimation of the magnitude and rank positions of data that have been interval-censored so as to counteract the effect of censoring. This process of sample adjustment, or renovation, allows samples to be compared graphically, using diagrams (such as boxplots) which are based on ranks. The renovation process is based on Buckley-James regression estimators for linear regression with censored data.     

For censored and truncated data

In this paper we develop nonparametric methods for regression analysis when the response variable is subject to censoring and/or truncation. The development is based on a data completion princple that enables us to apply, via an iterative scheme, nonparametric regression techniques to iteratively com¬pleted data from a given sample with censored and/or truncated observations. In particular, locally weighted regression smoothers and additive regression models are extended to left-truncated and right-censored data Nonparamet¬ric regression analysis is applied to the Stanford heart transplant data, which have been analyzed by previous authors using semiparametric regression meth¬ods. and provides new insights into the relationship between expected survival time after a heart transplant and explanatory variables.     

Asymptotic normality of kernel estimators based upon incomplete data

In this paper, we are concerned with nonparametric estimation of the density and the failure rate functions of a random variable X which is at risk of being censored. First, we establish the asymptotic normality of a kernel density estimator in a general censoring setup. Then, we apply our result in order to derive the asymptotic normality of both the density and the failure rate estimators in the cases of right, twice and doubly censored data. Finally, the performance and the asymptotic Gaussian behaviour of the studied estimators, based on either doubly or twice censored data, are illustrated through a simulation study.     

Bias From Censored Regressors

We study the bias that arises from using censored regressors in estimation of linear models. We present results on bias in ordinary least aquares (OLS) regression estimators with exogenous censoring and in instrumental variable (IV) estimators when the censored regressor is endogenous. Bound censoring such as top-coding results in expansion bias, or effects that are too large. Independent censoring results in bias that varies with the estimation method—attenuation bias in OLS estimators and expansion bias in IV estimators. Severe biases can result when there are several regressors and when a 0–1 variable is used in place of a continuous regressor.     

Progressive type II censored order statistics from exponential distributions

In the model of progressive type II censoring, point and interval estimation as well as relations for single and product moments are considered. Based on two-parameter exponential distributions, maximum likelihood estimators (MLEs), uniformly minimum variance unbiased estimators (UMVUEs) and best linear unbiased estimators (BLUEs) are derived for both location and scale parameters. Some properties of these estimators are shown. Moreover, results for single and product moments of progressive type II censored order statistics are presented to obtain recurrence relations from exponential and truncated exponential distributions. These relations may then be used to compute all the means, variances and covariances of progressive type II censored order statistics based on exponential distributions for arbitrary censoring schemes. The presented recurrence relations simplify those given by Aggarwala and Balakrishnan (1996)     

Estimation for Location-Scale Models with Censored Data

This article considers a class of estimators for the location and scale parameters in the location-scale model based on ‘synthetic data’ when the observations are randomly censored on the right. The asymptotic normality of the estimators is established using counting process and martingale techniques when the censoring distribution is known and unknown, respectively. In the case when the censoring distribution is known, we show that the asymptotic variances of this class of estimators depend on the data transformation and have a lower bound which is not achievable by this class of estimators. However, in the case that the censoring distribution is unknown and estimated by the Kaplan–Meier estimator, this class of estimators has the same asymptotic variance and attains the lower bound for variance for the case of known censoring distribution. This is different from censored regression analysis, where asymptotic variances depend on the data transformation. Our method has three valuable advantages over the method of maximum likelihood estimation. First, our estimators are available in a closed form and do not require an iterative algorithm. Second, simulation studies show that our estimators being moment-based are comparable to maximum likelihood estimators and outperform them when sample size is small and censoring rate is high. Third, our estimators are more robust to model misspecification than maximum likelihood estimators. Therefore, our method can serve as a competitive alternative to the method of maximum likelihood in estimation for location-scale models with censored data. A numerical example is presented to illustrate the proposed method.     

Heteroscedasticity and Distributional Assumptions in the Censored Regression Model

Data censoring causes ordinary least-square estimators of linear models to be biased and inconsistent. The Tobit estimator yields consistent estimators in the presence of data censoring if the errors are normally distributed. However, nonnormality or heteroscedasticity results in the Tobit estimators being inconsistent. Various estimators have been proposed for circumventing the normality assumption. Some of these estimators include censored least absolute deviations (CLAD), symmetrically censored least-square (SCLS), and partially adaptive estimators. CLAD and SCLS will be consistent in the presence of heteroscedasticity; however, SCLS performs poorly in the presence of asymmetric errors. This article extends the partially adaptive estimation approach to accommodate possible heteroscedasticity as well as nonnormality. A simulation study is used to investigate the estimators’ relative performance in these settings. The partially adaptive censored regression estimators have little efficiency loss for censored normal errors and appear to outperform the Tobit and semiparametric estimators for nonnormal error distributions and be less sensitive to the presence of heteroscedasticity. An empirical example is considered, which supports these results.     

Maximum likelihood estimation in a Weibull regression model with type-1 censoring: a Monte Carlo study

Results of the Monte Carlo study of the performance of a maximum likelihood estimation in a Weibull parametric regression model with two explanatory variables are presented. One simulation run contained 1000 samples censored on the average by the amount of 0-30%. Each simulatedsample was generated in a form of two-factor two-level balanced experiment. The confidence intervals were computed using the large-sample normal approximation via the matrix of observed information. For small sample sizes the estimates of the scale parameter b of the loglifetime were significantly negatively biased, which resulted in a poor quality of confidence intervals for b and the low-level quantiles. All estimators improved their quality when the nominal value of b decreased. A moderate amount of censoring improved the quality of point and confidence estimation. The reparametrization b 7 produced rather accurate confidence intervals. Exact confidence intervals for b in case of non-censoring were obtained using the pivotal quantity b/b.     

Semiparametric Quantile Regression Analysis of Right‐censored and Length‐biased Failure Time Data with Partially Linear Varying Effects

Right‐censored and length‐biased failure time data arise in many fields including cross‐sectional prevalent cohort studies, and their analysis has recently attracted a great deal of attention. It is well‐known that for regression analysis of failure time data, two commonly used approaches are hazard‐based and quantile‐based procedures, and most of the existing methods are the hazard‐based ones. In this paper, we consider quantile regression analysis of right‐censored and length‐biased data and present a semiparametric varying‐coefficient partially linear model. For estimation of regression parameters, a three‐stage procedure that makes use of the inverse probability weighted technique is developed, and the asymptotic properties of the resulting estimators are established. In addition, the approach allows the dependence of the censoring variable on covariates, while most of the existing methods assume the independence between censoring variables and covariates. A simulation study is conducted and suggests that the proposed approach works well in practical situations. Also, an illustrative example is provided.     

数据归并与连续自变量虚拟化

 本文基于数据双侧归并的一般化设定探讨了回归方程中包含归并数据时的参数估计问题。对于某些变量存在数据归并的线性模型,由于样本似然函数非常复杂,普通的一阶优化条件没有解析解,Newton-Raphson迭代也难以收敛。我们基于EM算法来计算参数的ML估计,推导了对应的参数迭代方程,给出了参数的一个闭式解。特别是,当数据双侧归并比例达到100%时,被归并的连续变量退化为虚拟变量的形式,对此,我们建议使用AIC或SC来识别回归方程中的虚拟变量是否为结构变化抑或是变量归并。     

Recurrence relations for single and product moments of progressively Type-II censored order statistics from generalized logistic distribution with applications to inference

In this article, we establish several recurrence relations for the single and product moments of progressively Type-II right censored order statistics from a generalized logistic distribution. The use of these relations in a systematic manner allow us to compute all the means, variances, and covariances of progressively Type-II right censored order statistics from the generalized logistic distribution for all sample sizes n, effective sample sizes m, and all progressive censoring schemes (R₁, …, R_m). These moments are then utilized to derive best linear unbiased estimators of the scale and location-scale parameters of the generalized logistic distribution. A comparison of these estimators with the maximum likelihood estimates is then made through Monte Carlo simulations. Finally, the best linear unbiased predictors of censored failure times is discussed briefly.     

Estimation and goodness-of-fit for the Cox model with various types of censored data

The currently existing estimation methods and goodness-of-fit tests for the Cox model mainly deal with right censored data, but they do not have direct extension to other complicated types of censored data, such as doubly censored data, interval censored data, partly interval-censored data, bivariate right censored data, etc. In this article, we apply the empirical likelihood approach to the Cox model with complete sample, derive the semiparametric maximum likelihood estimators (SPMLE) for the Cox regression parameter and the baseline distribution function, and establish the asymptotic consistency of the SPMLE. Via the functional plug-in method, these results are extended in a unified approach to doubly censored data, partly interval-censored data, and bivariate data under univariate or bivariate right censoring. For these types of censored data mentioned, the estimation procedures developed here naturally lead to Kolmogorov-Smirnov goodness-of-fit tests for the Cox model. Some simulation results are presented.     

Inference based on progressively censored sample from Pareto population

Abstract

In this paper, we assume that the lifetimes have a two-parameter Pareto distribution and discuss some results of progressive Type-II censored sample. We obtain maximum likelihood estimators and Bayes estimators of the unknown parameters under squared error loss and a precautionary loss functions in progressively Type-II censored sample. Robust Bayes estimation of unknown parameters over three different classes of priors under progressively Type-II censored sample, squared error loss, and precautionary loss functions are obtained. We discuss estimation of unknown parameters on competing risks progressive Type-II censoring. Finally, we consider the problem of estimating the common scale parameter of two Pareto distributions when samples are progressively Type-II censored.     

The log-odd log-logistic Weibull regression model: modelling,estimation, influence diagnostics and residual analysis

In applications of survival analysis, the failure rate function may frequently present a unimodal shape. In such cases, the log-normal and log-logistic distributions are used. In this paper, we shall be concerned only with parametric forms, so a location-scale regression model based on the odd log-logistic Weibull distribution is proposed for modelling data with a decreasing, increasing, unimodal and bathtub failure rate function as an alternative to the log-Weibull regression model. For censored data, we consider a classic method to estimate the parameters of the proposed model. We derive the appropriate matrices for assessing local influences on the parameter estimates under different perturbation schemes and present some ways to assess global influences. Further, for different parameter settings, sample sizes and censoring percentages, various simulations are performed. In addition, the empirical distribution of some modified residuals is determined and compared with the standard normal distribution. These studies suggest that the residual analysis usually performed in normal linear regression models can be extended to a modified deviance residual in the new regression model applied to censored data. We analyse a real data set using the log-odd log-logistic Weibull regression model.     

Information attainable in some randomly incomplete multivariate response models

In a general parametric setup, a multivariate regression model is considered when responses may be missing at random while the explanatory variables and covariates are completely observed. Asymptotic optimality properties of maximum likelihood estimators for such models are linked to the Fisher information matrix for the parameters. It is shown that the information matrix is well defined for the missing-at-random model and that it plays the same role as in the complete-data linear models. Applications of the methodologic developments in hypothesis-testing problems, without any imputation of missing data, are illustrated. Some simulation results comparing the proposed method with Rubin's multiple imputation method are presented.     

Statistical analysis of data from dilution assays with censored correlated counts

Frequently, count data obtained from dilution assays are subject to an upper detection limit, and as such, data obtained from these assays are usually censored. Also, counts from the same subject at different dilution levels are correlated. Ignoring the censoring and the correlation may provide unreliable and misleading results. Therefore, any meaningful data modeling requires that the censoring and the correlation be simultaneously addressed. Such comprehensive approaches of modeling censoring and correlation are not widely used in the analysis of dilution assays data. Traditionally, these data are analyzed using a general linear model on a logarithmic-transformed average count per subject. However, this traditional approach ignores the between-subject variability and risks, providing inconsistent results and unreliable conclusions. In this paper, we propose the use of a censored negative binomial model with normal random effects to analyze such data. This model addresses, in addition to the censoring and the correlation, any overdispersion that may be present in count data. The model is shown to be widely accessible through the use of several modern statistical software.     

Buckley–James Type Estimator for Censored Data with Covariates Missing by Design

Abstract. The Buckley–James estimator (BJE) is a well‐known estimator for linear regression models with censored data. Ritov has generalized the BJE to a semiparametric setting and demonstrated that his class of Buckley–James type estimators is asymptotically equivalent to the class of rank‐based estimators proposed by Tsiatis. In this article, we revisit such relationship in censored data with covariates missing by design. By exploring a similar relationship between our proposed class of Buckley–James type estimating functions to the class of rank‐based estimating functions recently generalized by Nan, Kalbfleisch and Yu, we establish asymptotic properties of our proposed estimators. We also conduct numerical studies to compare asymptotic efficiencies from various estimators.     

An Iterative Weighted Least Squares Algorithm and Simulation Study for Censored Data M-Estimates

A popular linear regression estimator for censored data is the one proposed by Buckley and James (1979). However, this estimator is not robust to outliers, which is not surprising since it is a modified version of the uncensored data least squares estimator. Lai and Ying (1994) have proposed an M-estimator for censored data that is a generalization of the Buckley- James estimator. In this paper we discuss a weighted least squares algorithm for computing these M-estimates and compare the performance of two Huber M-estimators with the Buckley-James estimator in a simulation study. We find that the Huber M-estimators perform more robustly for a broad range of censoring and error distributions.     

Aalen's linear model for doubly censored data

Double censoring often occurs in registry studies when left censoring is present in addition to right censoring. In this work, we examine estimation of Aalen's nonparametric regression coefficients based on doubly censored data. We propose two estimation techniques. The first type of estimators, including ordinary least squared (OLS) estimator and weighted least squared (WLS) estimators, are obtained using martingale arguments. The second type of estimator, the maximum likelihood estimator (MLE), is obtained via expectation-maximization (EM) algorithms that treat the survival times of left censored observations as missing. Asymptotic properties, including the uniform consistency and weak convergence, are established for the MLE. Simulation results demonstrate that the MLE is more efficient than the OLS and WLS estimators.     

Comparison of Regression Curves with Censored Responses

Abstract.  In this article, we introduce a procedure to test the equality of regression functions when the response variables are censored. The test is based on a comparison of Kaplan–Meier estimators of the distribution of the censored residuals. Kolmogorov–Smirnov- and Cramér–von Mises-type statistics are considered. Some asymptotic results are proved: weak convergence of the process of interest, convergence of the test statistics and behaviour of the process under local alternatives. We also describe a bootstrap procedure in order to approximate the critical values of the test. A simulation study and an application to a real data set conclude the paper.