E-Bayesian and hierarchical Bayesian estimations for the system reliability parameter based on asymmetric loss function

This paper explores properties of the E-Bayesian and hierarchical Bayesian estimations of the system reliability parameter. E-Bayesian estimation and hierarchical Bayesian estimation of Pascal distribution's parameter under two loss function, LINEX loss function and entropy loss function can be found. We obtained limits of that the E-Bayesian estimation and hierarchical Bayesian estimation are equal. A Monte Carlo simulation is used to compare performances of the two methods.     

Use of asymmetric loss functions in sequential estimation problems for multiple linear regression

When estimating in a practical situation, asymmetric loss functions are preferred over squared error loss functions, as the former is more appropriate than the latter in many estimation problems. We consider here the problem of fixed precision point estimation of a linear parametric function in beta for the multiple linear regression model using asymmetric loss functions. Due to the presence of nuissance parameters, the sample size for the estimation problem is not known beforehand and hence we take the recourse of adaptive multistage sampling methodologies. We discuss here some multistage sampling techniques and compare the performances of these methodologies using simulation runs. The implementation of the codes for our proposed models is accomplished utilizing MATLAB 7.0.1 program run on a Pentium IV machine. Finally, we highlight the significance of such asymmetric loss functions with few practical examples.     

Sequential estimation of exponential lacation parameter using an asymmetric loss function

For a two-parameter negative exponential population with both parameters unknown, the bounded risk sequential estimation problem of the location parameter is considered under an asymmetric linex loss funmction. Asymptotic second-order expansion of the risk function is derived for a general class of stopping variables. Some examples are include involving purely scquential and accelerated sequential sampling methodologies. A Monte-Carlo study is carried out to support the asymptotic results and to compare the performance of the different sampling methodologies.     

Bayes sequential estimation for a time-transformed exponential model

A problem of Bayesian sequential estimating an unknown parameter of a time-transformed exponential model is considered. It is supposed that the loss associated with the error of estimation is weighted squared or precautionary and the cost of observing the process is a function of time and the number of observations. Bayes sequential procedures for estimating the unknown parameter are presented.     

Estimating the exponential reliability function for a system in series with type II censored data

The problem of estimating the one parameter exponential reliability function for a system composed of l componentes in series is considered. Under the type II censoring scheme, the Bayes nature of the minimum variance unbiased estimator is demonstrated and the admissibility of related generalized Bayes estimators is established. For the one component case, the best unbiased estimator is admissible.     

Optimal,nearly optimal and robust procedures for the exponential distribution with relative linear exponential loss

In this paper, the problem of sequentially estimating the mean of the exponential distribution with relative linear exponential loss and fixed cost for each observation is considered within the Bayesian framework. An optimal procedure with a deterministic stopping rule is derived. Since the corresponding value of the optimal deterministic stopping rule cannot be obtained directly, an approximate optimal deterministic stopping rule and an asymptotically pointwise optimal rule are proposed. In addition, we propose a robust procedure with a deterministic stopping rule, which does not depend on the parameters of the prior distribution. All of the proposed procedures are shown to be asymptotically optimal. Some numerical studies are conducted to investigate the performances of the proposed procedures. A real data set is provided to illustrate the use of the proposed procedures.     

Predictive analysis for joint progressive censoring plans: a Bayesian approach

Comparative lifetime experiments are of particular importance in production processes when one wishes to determine the relative merits of several competing products with regard to their reliability. This paper confines itself to the data obtained by running a joint progressive Type-II censoring plan on samples in a combined manner. The problem of Bayesian predicting failure times of surviving units is discussed in details when parent populations are exponential. Two real data sets are analyzed in order to illustrate all the inferential procedures developed here. When destructive experiments under a censoring scheme finished, the researchers are usually interested to estimate remaining lifetimes of surviving units for sequel experiments. Findings of this paper are useful for these purposes specially when samples are non-homogeneous such as those taken from industrial storages.     

Informing the selection of futility stopping thresholds: case study from a late-phase clinical trial

In an environment where (i) potential risks to subjects participating in clinical studies need to be managed carefully, (ii) trial costs are increasing, and (iii) there are limited research resources available, it is necessary to prioritize research projects and sometimes re-prioritize if early indications suggest that a trial has low probability of success. Futility designs allow this re-prioritization to take place. This paper reviews a number of possible futility methods available and presents a case study from a late-phase study of an HIV therapeutic, which utilized conditional power-based stopping thresholds. The two most challenging aspects of incorporating a futility interim analysis into a trial design are the selection of optimal stopping thresholds and the timing of the analysis, both of which require the balancing of various risks. The paper outlines a number of graphical aids that proved useful in explaining the statistical risks involved to the study team. Further, the paper outlines a decision analysis undertaken which combined expectations of drug performance with conditional power calculations in order to produce probabilities of different interim and final outcomes, and which ultimately led to the selection of the final stopping thresholds.     

Estimation of parameters of exponential distribution in the truncated space using asymmetric loss function

This paper is concerned with estimation of location and scale parameters of an exponential distribution when the location parameter is bounded above by a known constant. We propose estimators which are better than the standard estimators in the unrestricted case with respect to the suitable choice of LINEX loss. The admissibility of the modified Pitman estimators with respect to the LINEX loss is proved. Finally the theory developed is applied to the problem of estimating the location and scale parameters of two exponential distributions when the location parameters are ordered.     

A generalization of the compound rayleigh distribution: using a bayesian method on cancer survival times

In this paper the generalized compound Rayleigh model, exhibiting flexible hazard rate, is high¬lighted. This makes it attractive for modelling survival times of patients showing characteristics of a random hazard rate. The Bayes estimators are derived for the parameters of this model and some survival time parameters from a right censored sample. This is done with respect to conjugate and discrete priors on the parameters of this model, under the squared error loss function, Varian's asymmetric linear-exponential (linex) loss function and a weighted linex loss function. The future survival time of a patient is estimated under these loss functions. A Monte Carlo simu¬lation procedure is used where closed form expressions of the estimators cannot be obtained. An example illustrates the proposed estimators for this model.     

Assessing inter- and intra-agreement for dependent binary data: a Bayesian hierarchical correlation approach

Agreement measures are designed to assess consistency between different instruments rating measurements of interest. When the individual responses are correlated with multilevel structure of nestings and clusters, traditional approaches are not readily available to estimate the inter- and intra-agreement for such complex multilevel settings. Our research stems from conformity evaluation between optometric devices with measurements on both eyes, equality tests of agreement in high myopic status between monozygous twins and dizygous twins, and assessment of reliability for different pathologists in dysplasia. In this paper, we focus on applying a Bayesian hierarchical correlation model incorporating adjustment for explanatory variables and nesting correlation structures to assess the inter- and intra-agreement through correlations of random effects for various sources. This Bayesian generalized linear mixed-effects model (GLMM) is further compared with the approximate intra-class correlation coefficients and kappa measures by the traditional Cohen’s kappa statistic and the generalized estimating equations (GEE) approach. The results of comparison studies reveal that the Bayesian GLMM provides a reliable and stable procedure in estimating inter- and intra-agreement simultaneously after adjusting for covariates and correlation structures, in marked contrast to Cohen’s kappa and the GEE approach.     

Selecting the best geometric distribution based on type-I censored data: a Bayesian approach

This paper considers the statistical reliability on discrete failure data and the selection of the best geometric distribution having the smallest failure probability from among several competitors. Using the Bayesian approach a Bayes selection rule based on type-I censored data is derived and its associated monotonicity is also obtained. An early selection rule which allows us to make a selection possible earlier than the censoring time of the life testing experiment is proposed. This early selection rule can be shown to be equivalent to the Bayes selection rule. An illustrative example is given to demonstrate the use and the performance of the early selection rule.     

Stein rule prediction of the composite target function in a general linear regression model

This paper considers the problem of simultaneous prediction of the actual and average values of the dependent variable in a general linear regression model. Utilizing the philosophy of Stein rule procedure, a family of improved predictors for a linear function of the actual and expected value of the dependent variable for the forecast period has been proposed. An unbiased estimator for the mean squared error (MSE) matrix of the proposed family of predictors has been obtained and dominance of the family of Stein rule predictors over the best linear unbiased predictor (BLUP) has been established under a quadratic loss function.     

Evaluating estimators using stochastic dominance rules:the variance of a normal distribution

The paper presents an application of stochastic dominance approach to estimator evaluation. This new approach is general and applicable when a monetary loss function is defined over the deviation of a sample estimate from the appropriate parameter. The paper applies this approach to the evaluation of alternative estimators of the normal distribution variance     

Stochastic models for greenhouse gas emission rate estimation from hydroelectric reservoirs: a Bayesian hierarchical approach

Herein, we propose a fully Bayesian approach to the greenhouse gas emission problem. The goal of this work is to estimate the emission rate of polluting gases from the area flooded by hydroelectric reservoirs. We present models for gas concentration evolution in two ways: first, by proposing them from ordinary differential equation solutions and, second, by using stochastic differential equations with a discretization scheme. Finally, we present techniques to estimate the emission rate for the entire reservoir. In order to carry out the inference, we use the Bayesian framework with Monte Carlo via Markov Chain methods. Discretization schemes over continuous differential equations are used when necessary. These models applied to greenhouse gas emission and Bayesian inference for this purpose are completely new in statistical literature, as far as we know, and contribute to estimate the amount of polluting gases released from hydroelectric reservoirs in Brazil. The proposed models are applied in a real data set and results are presented.     

Pareto analysis for the lifetime performance index of products on the basis of progressively first-failure-censored batches under balanced symmetric and asymmetric loss functions

One of the most important topics in manufacturing industries is the evaluation of performance lifetimes of products. Based on a given lifetime performance index, this paper deals with evaluating the performance of a process subject to a given lower specification limit. We confine ourselves to the progressively first-failure-censored data coming from a common Pareto distribution. With both the Bayesian and the non-Bayesian approaches being investigated here, we pay more attention to Bayesian estimators under balanced type loss functions. The results are presented under the balanced versions of two well-known loss functions, namely the squared error loss and the Varian's linear-exponential (LINEX) loss. Moreover, based on the Bayesian and the non-Bayesian approaches, the problem of testing hypotheses on the lifetime performance index is studied. Also, a simulation study is performed to assess the obtained results. Finally, two illustrative examples are given.     

Evaluation of different statistical methods using SAS software: an in silico approach for analysis of real-time PCR data

Real-time polymerase chain reaction (PCR) is reliable quantitative technique in gene expression studies. The statistical analysis of real-time PCR data is quite crucial for results analysis and explanation. The statistical procedures of analyzing real-time PCR data try to determine the slope of regression line and calculate the reaction efficiency. Applications of mathematical functions have been used to calculate the target gene relative to the reference gene(s). Moreover, these statistical techniques compare C_t (threshold cycle) numbers between control and treatments group. There are many different procedures in SAS for real-time PCR data evaluation. In this study, the efficiency of calibrated model and delta delta C_t model have been statistically tested and explained. Several methods were tested to compare control with treatment means of C_t. The methods tested included t-test (parametric test), Wilcoxon test (non-parametric test) and multiple regression. Results showed that applied methods led to similar results and no significant difference was observed between results of gene expression measurement by the relative method.     

Regression models using the LINEX loss to predict lower bounds for the number of points for approximating planar contour shapes

Researchers in statistical shape analysis often analyze outlines of objects. Even though these contours are infinite-dimensional in theory, they must be discretized in practice. When discretizing, it is important to reduce the number of sampling points considerably to reduce computational costs, but to not use too few points so as to result in too much approximation error. Unfortunately, determining the minimum number of points needed to achieve sufficiently approximate the contours is computationally expensive. In this paper, we fit regression models to predict these lower bounds using characteristics of the contours that are computationally cheap as predictor variables. However, least squares regression is inadequate for this task because it treats overestimation and underestimation equally, but underestimation of lower bounds is far more serious. Instead, to fit the models, we use the LINEX loss function, which allows us to penalize underestimation at an exponential rate while penalizing overestimation only linearly. We present a novel approach to select the shape parameter of the loss function and tools for analyzing how well the model fits the data. Through validation methods, we show that the LINEX models work well for reducing the underestimation for the lower bounds.     

Bayesian item response model: a generalized approach for the abilities' distribution using mixtures

Traditional Item Response Theory models assume the distribution of the abilities of the population in study to be Gaussian. However, this may not always be a reasonable assumption, which motivates the development of more general models. This paper presents a generalized approach for the distribution of the abilities in dichotomous 3-parameter Item Response models. A mixture of normal distributions is considered, allowing for features like skewness, multimodality and heavy tails. A solution is proposed to deal with model identifiability issues without compromising the flexibility and practical interpretation of the model. Inference is carried out under the Bayesian Paradigm through a novel MCMC algorithm. The algorithm is designed in a way to favour good mixing and convergence properties and is also suitable for inference in traditional IRT models. The efficiency and applicability of our methodology is illustrated in simulated and real examples.