共查询到20条相似文献,搜索用时 31 毫秒
1.
Generally it is very difficult to construct robust slope-rotatable designs along axial directions. Present paper focuses on modified second-order slope-rotatable designs (SOSRDs) with correlated errors. Modified robust second-order slope-rotatability conditions are derived for a general variance–covariance structure of errors. These conditions get simplified for intraclass correlation structure. A few robust second-order slope-rotatable designs (over all directions, or with equal maximum directional variance slope, or D-optimal slope) are examined with respect to modified robust slope-rotatability. It is observed that robust second-order slope-rotatable designs over all directions, or with equal maximum directional variance slope, or D-optimal slope are not generally modified robust second-order slope-rotatable designs. 相似文献
2.
AbstractDesigns for the first order trigonometric regression model over an interval on the real line are considered for the situation where estimation of the slope of the response surface at various points in the factor space is of primary interest. Minimization of the variance of the estimated slope at a point maximized over all points in the region of interest is taken as the design criterion. Optimal designs under the minimax criterion are derived for the situation where the design region and the region of interest are identical and a symmetric “partial cycle”. Some comparisons of the minimax designs with the traditional D- and A-optimal designs are provided. Efficiencies of some exact designs under the minimax criterion are also investigated. 相似文献
3.
Fangrong Yan Huihong Zhu Junlin Liu Liyun Jiang Xuelin Huang 《Pharmaceutical statistics》2018,17(5):458-476
A bioequivalence test is to compare bioavailability parameters, such as the maximum observed concentration (Cmax) or the area under the concentration‐time curve, for a test drug and a reference drug. During the planning of a bioequivalence test, it requires an assumption about the variance of Cmax or area under the concentration‐time curve for the estimation of sample size. Since the variance is unknown, current 2‐stage designs use variance estimated from stage 1 data to determine the sample size for stage 2. However, the estimation of variance with the stage 1 data is unstable and may result in too large or too small sample size for stage 2. This problem is magnified in bioequivalence tests with a serial sampling schedule, by which only one sample is collected from each individual and thus the correct assumption of variance becomes even more difficult. To solve this problem, we propose 3‐stage designs. Our designs increase sample sizes over stages gradually, so that extremely large sample sizes will not happen. With one more stage of data, the power is increased. Moreover, the variance estimated using data from both stages 1 and 2 is more stable than that using data from stage 1 only in a 2‐stage design. These features of the proposed designs are demonstrated by simulations. Testing significance levels are adjusted to control the overall type I errors at the same level for all the multistage designs. 相似文献
4.
A measure for evaluating slope rotatability over all directions in response surface designs, is proposed. This measure is used to form slope variance dispersion graph evaluating the overall slope rotatability and the slope estimation capability of an experimental design throughout the region of interest. This graph allows for an easy comparison of competing designs. 相似文献
5.
Minimization of the variance of the estimated slope of a response surface maximized over all points in the factor space is taken as the design criterion. Optimal designs under the criterion are derived for second-order polynomial regression over hypercubic regions. 相似文献
6.
We obtain designs for linear regression models under two main departures from the classical assumptions: (1) the response is taken to be only approximately linear, and (2) the errors are not assumed to be independent, but to instead follow a first-order autoregressive process. These designs have the property that they minimize (a modification of) the maximum integrated mean squared error of the estimated response, with the maximum taken over a class of departures from strict linearity and over all autoregression parameters ρ,|ρ,| < 1, of fixed sign. Specific methods of implementation are discussed. We find that an asymptotically optimal procedure for AR(1) models consists of choosing points from that design measure which is optimal for uncorrelated errors, and then implementing them in an appropriate order. 相似文献
7.
The effects of missing observations in a designed experiment are reviewed. Conditions are determined for a design to retain equal information, i.e. the same generalized variance of unknown parameters, when either any single or any pair of observations is lost. Some examples of designs with this property are given. Although there are many designs which retain equal information for the loss of exactly t observations, where t = 1,2,3,…, it is shown that it is not possible to obtain any design which retains equal information when any one and any two and also any three observations are missing. 相似文献
8.
S. Huda 《统计学通讯:理论与方法》2013,42(6):1225-1231
Abstract A second-order model involving the intercept and only the pure quadratic terms is considered for regression over hypercubes. Minimization of the variance of the difference between estimated responses at two points, maximized over all pairs of points in the region of interest in factor space, is taken as the design criterion. Optimal design under the minimax criterion is derived and found to be the one which is also simultaneously A-, D-, and E-optimal for the parameters excluding the intercept. The minimax design is compared with other standard designs and is found to perform extremely well. 相似文献
9.
John J. Borkowski 《统计学通讯:理论与方法》2013,42(8):2041-2058
For quadratic regression on the hypercube, G—efficiencies are often used in the selection process of an experimental design. To calculate a design's G—efficiency, it is necessary to maximize the prediction variance over the experimental design region. However, it is common to approximate a G—efficiency. This is achieved by calculating the prediction variances generated from a subset of points in the design space and taking the maximum to estimate the maximum prediction variance. This estimate is then applied to approximate the G—efficiency. In this paper, it will be shown that over the class of central composite designs (CCDs) on the hypercube. the prediction variance can be expressed in a closed-form. An exact value of the maximum prediction variance can then be determined by evaluating this closed-form expression over a finite subset of barycentric points. Tables of exact G—efficiencies will be presented. Design optimality criteria, quadratic regression on the hypercube, and the structures of the design matrix X, X'X, and (X'X)?1 for any CCD will be discussed. 相似文献
10.
Slope rotatability over all directions designs 总被引:1,自引:1,他引:0
Lisa H. Ying Friedrich Pukelsheim Norman R. Draper 《Journal of applied statistics》1995,22(3):331-341
Slope rotatability over all directions (SROAD)is a useful concept when the slope of a second-order response is to be studied. SROAD designs ensure that knowledge of the slope is acquired symmetrically, whatever direction later becomes of more interest as the data are analyzed. Some standard second-order designs are SROAD,but here we explore designs for two and three dimensions, which do not have the full symmetries of such standard designs but which still possess the SROAD property. 相似文献
11.
Douglas P. Wiens 《Revue canadienne de statistique》1996,24(1):67-79
We consider the problem of the sequential choice of design points in an approximately linear model. It is assumed that the fitted linear model is only approximately correct, in that the true response function contains a nonrandom, unknown term orthogonal to the fitted response. We also assume that the parameters are estimated by M-estimation. The goal is to choose the next design point in such a way as to minimize the resulting integrated squared bias of the estimated response, to order n-1. Explicit applications to analysis of variance and regression are given. In a simulation study the sequential designs compare favourably with some fixed-sample-size designs which are optimal for the true response to which the sequential designs must adapt. 相似文献
12.
Lisa H. Ying Friedrich Pukelsheim Norman R. Draper 《Journal of applied statistics》1995,22(3):343-354
Slope rotatability over all directions (SROAD) is a useful concept when the slope of a second-order response is to be studied. SROAD designs ensure that knowledge jof the slope is acquired symmetrically, whatever direction later becomes of more interest as the data are analyzed. In a prior paper, we explored designs for k=2 and 3 dimensions, which do not have the full symmetries of second-order designs but which still possess the SROAD property.Here, we discuss designs in higher dimensions.The introductory sections 1 and 2 are essentially identical to those of the prior paper. 相似文献
13.
Douglas P. Wiens 《Statistics and Computing》2013,23(3):391-401
We study designs, optimal up to and including terms that are O(n ?1), for weighted least squares regression, when the weights are intended to be inversely proportional to the variances but are estimated with random error. We take a finite, but arbitrarily large, design space from which the support points are to be chosen, and obtain the optimal proportions of observations to be assigned to each point. Specific examples of D- and I-optimal design for polynomial responses are studied. In some cases the same designs that are optimal under homoscedasticity remain so for a range of variance functions; in others there tend to be more support points than are required in the homoscedastic case. We also exhibit minimax designs, that minimize the maximum, over finite classes of variance functions, value of the loss. These also tend to have more support points, often resulting from the breaking down of replicates into clusters. 相似文献
14.
Candel MJ 《Pharmaceutical statistics》2012,11(2):97-106
When examining the effect of treatment A versus B, there may be a choice between a parallel group design, an AA/BB design, an AB/BA cross‐over and Balaam's design. In case of a linear mixed effects regression, it is examined, starting from a flexible function of the costs involved and allowing for subject dropout, which design is most efficient in estimating this effect. For no carry‐over, the AB/BA cross‐over design is most efficient as long as the dropout rate at the second measurement does not exceed 2ρ/(1 + ρ), ρ being the intraclass correlation. For steady‐state carry‐over, depending on the costs involved, the dropout rate and ρ, either a parallel design or an AA/BB design is most efficient. For types of carry‐over that allow for self carry‐over, interest is in the direct treatment effect plus the self carry‐over effect, with either an AA/BB or Balaam's design being most efficient. In case of insufficient knowledge on the dropout rate or ρ, a maximin strategy is devised: choose the design that minimizes the maximum variance of the treatment estimator. Such maximin designs are derived for each type of carry‐over. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
15.
《Journal of Statistical Computation and Simulation》2012,82(8):1582-1604
In the optimal experimental design literature, the G-optimality is defined as minimizing the maximum prediction variance over the entire experimental design space. Although the G-optimality is a highly desirable property in many applications, there are few computer algorithms developed for constructing G-optimal designs. Some existing methods employ an exhaustive search over all candidate designs, which is time-consuming and inefficient. In this paper, a new algorithm for constructing G-optimal experimental designs is developed for both linear and generalized linear models. The new algorithm is made based on the clustering of candidate or evaluation points over the design space and it is a combination of point exchange algorithm and coordinate exchange algorithm. In addition, a robust design algorithm is proposed for generalized linear models with modification of an existing method. The proposed algorithm are compared with the methods proposed by Rodriguez et al. [Generating and assessing exact G-optimal designs. J. Qual. Technol. 2010;42(1):3–20] and Borkowski [Using a genetic algorithm to generate small exact response surface designs. J. Prob. Stat. Sci. 2003;1(1):65–88] for linear models and with the simulated annealing method and the genetic algorithm for generalized linear models through several examples in terms of the G-efficiency and computation time. The result shows that the proposed algorithm can obtain a design with higher G-efficiency in a much shorter time. Moreover, the computation time of the proposed algorithm only increases polynomially when the size of model increases. 相似文献
16.
Hader and Park (1978) introduced second order slope rotatability in axial directions. Park (1987) introduced second order slope rotatabilty over all directions. It is shown that these designs have the additional properly that the sum of the variances of estimates of slopes in all directions at any point is a function of the distance of the point from the design origin. 相似文献
17.
Holger Dette 《Revue canadienne de statistique》1997,25(4):531-543
For regression models with quantitative factors it is illustrated that the E-optimal design can be extremely inefficient in the sense that it degenerates to a design which takes all observations at only one point. This phenomenon is caused by the different size of the elements in the covariance matrix of the least-squares estimator for the unknown parameters. For these reasons we propose to replace the E-criterion by a corresponding standardized version. The advantage of this approach is demonstrated for the polynomial regression on a nonnegative interval, where the classical and standardized E-optimal designs can be found explicitly. The described phenomena are not restricted to the E-criterion but appear for nearly all optimality criteria proposed in the literature. Therefore standardization is recommended for optimal experimental design in regression models with quantitative factors. The optimal designs with respect to the new standardized criteria satisfy a similar invariance property as the famous D-optimal designs, which allows an easy calculation of standardized optimal designs on many linearly transformed design spaces. 相似文献
18.
The problem considered is that of finding D-optimal design for the estimation of covariate parameters and the treatment and block contrasts in a block design set up in the presence of non stochastic controllable covariates, when N = 2(mod 4), N being the total number of observations. It is clear that when N ≠ 0 (mod 4), it is not possible to find designs attaining minimum variance for the estimated covariate parameters. Conditions for D-optimum designs for the estimation of covariate parameters were established when each of the covariates belongs to the interval [?1, 1]. Some constructions of D-optimal design have been provided for symmetric balanced incomplete block design (SBIBD) with parameters b = v, r = k = v ? 1, λ =v ? 2 when k = 2 (mod 4) and b is an odd integer. 相似文献
19.
Ester Samuel-Cahn 《The American statistician》2013,67(3):156-157
Three sampling designs are considered for estimating the sum of k population means by the sum of the corresponding sample means. These are (a) the optimal design; (b) equal sample sizes from all populations; and (c) sample sizes that render equal variances to all sample means. Designs (b) and (c) are equally inefficient, and may yield a variance up to k times as large as that of (a). Similar results are true when the cost of sampling is introduced, and they depend on the population sampled. 相似文献