On testing homogeneity of t normal means against ordered alternatives in r groups

Given k=rt normal populations with a common but unknown variance consisting of t treatments applied to r different groups of units, and supposing that in each group the means are monoto-nically non-decreasing (or non-increasing), then the likelihood ratio test of homogeneity of the means in each group against the simple order alternative is considered. Critical values are provided when one observation is drawn from each of the k populations.     

A rank test for stochastically ordered alternatives

A rank test based on the number of ‘near-matches’ among within-block rankings is proposed for stochastically ordered alternatives in a randomized block design with t treatments and b blocks. The asymptotic relative efficiency of this test with respect to the Page test is computed as number of blocks increases to infinity. A sequential analog of the above test procedure is also considered. A repeated significance test procedure is developed and average sample number is computed asymptotically under the null hypothesis as well as under a sequence of contiguous alternatives.     

A test of simultaneous homogeneity against ordered alternatives in multifactorial design

A test of simultaneous homogeneity of main effects of several factors against an alternative hypothesis with simple order restrictions in main effects of more than one factor in a multifactorial design is considered. This can be regarded as an extension of Shorack's (1967) work where the alternative hypo t hqaLs involves simple order restriction in main effects of one faetor. We derive the likelihood ratio test statistic, E^-2 , and its null hypothesis distribution which involves the convolutions of PIrobabilities P(l,k) used in the statistical inference under order restriction , The powers of the E^-2 test and the usual F test are compar-ed by simulation.     

A class of k-sample distribution-free tests for location against ordered alternatives

This paper introduces a new class of distribution-free tests for testing the homogeneity of several location parameters against ordered alternatives. The proposed class of test statistics is based on a linear combination of two-sample U-statistics based on subsample extremes. The mean and variance of the test statistic are obtained under the null hypothesis as well as under the sequence of local alternatives. The optimal weights are also determined. It is shown via Pitman ARE comparisons that the proposed class of test statistics performs better than its competitor tests in case of heavy-tailed and long-tailed distributions     

Union-intersection rank tests for ordered alternatives in some simple linear models

The theory of locally most powerful rank tests and the union intersection principle are incorporated in the formulation of some distribution-free rank tests for ordered alternatives in some simple linear models (including the classical one-way layout as a special case). Some approximations for the null-hypothesis distributions of the test statistics ( for finite sample sizes) are considered, and the theory is supplemented by some numerical and simulation results.     

Testing homogeneity against trend based on rank in one-way layout

In this paper, we are concerned with testing homogeneity against trend. Parsons (1979) considered the exact distribution of the test statistic based on the Wilcoxon type scores. We extend his result to the case of the general scores. Then we give a table of significance probabilities for the Fisher-Yates normal scores. We also study the asymptotic distribution of the test statis-tic based on the general scores under the null hypothesis, and the asymptotic relative efficiency against Bartholomew's likelihood ratio test assuming normality     

Testing parallelism of regression lines against ordered alternatives

For the problem of testing the equality of slopes of several regression lines against the alternative that the slopes are in increasing (decreasing) order of magnitude, two types of tests are proposed. These are the likelihood ratio test and a test that depends on suitable linear combination of one group statistics. Rank analogues of the two tests are also examined.     

Linear signed rank tests for hultivariate location

Previously proposed linear signed rank tests for multivariate location are not invariant under linear transformations of the observations, The asymptotic relative efficiencies of the tests 2 with respect to Hotelling's T²test depend on the direction of shift and the covariance matrix of the alternative distributions. For distributions with highly correlated components, the efficiencies of some of these tests can be arbitrarily low; they approach zero for certain multivariate normal alternatives, This article proposes a transformation of the data to be performed prior to standard linear signed rank tests, The resulting procedures have attractive power and efficiency properties compared to the original tests, In particular, for elliptically symmetric contiguous alternafives, the efficiencies of the new tests equal those of corresponding univariate linear signed rank tests with respect to the t test.     

Optimal testing in a three way anova model

We consider likelihood ratio, score and Wald tests for a three-way random effects ANOVA model. Competitor tests are compared using criteria such as small sample power, asymptotic relative efficiency, and convenient null distribution. The final choice is between a new test and two tests long used in practice.     

Testing for ordered alternatives by combining independent distribution-free block statistics

A class of distribution-free tests for ordered alternatives in a block design is presented. On each block a distribution-free statistic is selected, and a weighted sum of these statistics is then formed. A procedure for selecting the weighting constants which maximize the asymptotic relative efficiency is presented. The improvement in the efficiency of the weighted sum of block statistics over the unweighted sum is considered and proves interesting. Some attention is also given to the idea of using different types of statistics on different blocks.     

Multivariate generalizations of jonckheere's test for ordered alternatives

In many dose-response studies, each of several independent groups of animals is treated with a different dose of a substance. Many response variables are then measured on each animal. The distributions of the response variables may be nonnormal, and Jonckheere's (1954) test for ordered alternatives in the one-way layout is sometimes used to test whether the level of a single variable increases with increasing dose. In some applications, however, it is important to consider a set of response variables simultaneously. For instance, an increase in each of certain enzymes in the blood serum may suggest liver damage. To test whether these enzyme levels increase with increasing dose, it may be preferable to consider these enzymes as a group, rather than individually.

I propose two multivariate generalizations of Jonckheere's univariate test. Each multivariate test statistic is a function of coordinate-wise Jonckheere statistics—one a sum, the other a quadratic form. The sum statistic can be used to test the alternative hypothesis that each variable is stochastically increasing with increasing dose. The quadratic form statistic is designed for the more general alternative hypothesis that each variable is stochastically ordered with increasing dose.

For each of these two alternatives, I also propose a multivariate generalization of a normal theory test described by Puri (1965). I examine the asymptotic distributions of the four test statistics under the null hypothesis and under translation alternatives and compare each distribution-free test to the corresponding normal theory test in terms of asymptotic relative efficiency.

The multivariate Jonckheere tests are illustrated using does-response data from a subchronic toxicology study carried out by the National Toxicology Program. Four groups of ten male rats each were treated with increasing doses of vinylidene flouride, and the serum enzymes SDH, SGOT, and SGPT were measured. A comparison of univariate Jonckheere tests on each variable, bivariate tests on SDH and SGOT, and multivariate tests on all three variables gives insight into the behavior of the various procedures.     

Simultaneous rank tests for detecting differentially expressed genes

Rank tests are known to be robust to outliers and violation of distributional assumptions. Two major issues besetting microarray data are violation of the normality assumption and contamination by outliers. In this article, we formulate the normal theory simultaneous tests and their aligned rank transformation (ART) analog for detecting differentially expressed genes. These tests are based on the least-squares estimates of the effects when data follow a linear model. Application of the two methods are then demonstrated on a real data set. To evaluate the performance of the aligned rank transform method with the corresponding normal theory method, data were simulated according to the characteristics of a real gene expression data. These simulated data are then used to compare the two methods with respect to their sensitivity to the distributional assumption and to outliers for controlling the family-wise Type I error rate, power, and false discovery rate. It is demonstrated that the ART generally possesses the robustness of validity property even for microarray data with small number of replications. Although these methods can be applied to more general designs, in this article the simulation study is carried out for a dye-swap design since this design is broadly used in cDNA microarray experiments.     

Multivariate signed rank statistics for shift alternatives

Let X ₁,X ₂,…,X _N be successive independent random P-vectors drawn from some continuous diagonally symmetric distribution. The problem of detecting a shift in level of the sequence at an unknown time point M, ≦M ≦ N-1, is studied. Test statistics based on multivariate analogues of the rank statistics derived by BHATTACHARYYA and JOHNSON (1888) are proposed, and their asymptotic properties are investigated.     

Extensions of empirical likelihood and chi-squared-based tests for ordered alternatives

Several methods for comparing k populations have been proposed in the literature. These methods assess the same null hypothesis of equal distributions but differ in the alternative hypothesis they consider. We focus on two important alternative hypotheses: monotone and umbrella ordering. Two new families of test statistics are proposed, including two known tests, as well as two new powerful tests under monotone ordering. Furthermore, these families are adapted for testing umbrella ordering. We compare some members of the families with respect to power and Type I errors under different simulation scenarios. Finally, the methods are illustrated in several applications to real data.     

Weighted combinations of rank tests for location-scale alternatives

All existing location-scale rank tests use equal weights for the components. We advocate the use of weighted combinations of statistics. This approach can partly be substantiated by the theory of locally most powerful tests. We specifically investi= gate a Wilcoxon-Mood combination. We give exact critical values for a range of weights. The asymptotic normality of the test statistic is proved under a general hypothesis and Chernoff-Savage conditions. The asymptotic relative efficiency of this test with respect to unweighted combinations shows that a careful choice of weights results in a gain in efficiency.     

Some linear and nonlinear rank tests for competing risks models

Using the methods of asymptotic decision theory asymptotically optimal for translation and scale families as well as for certian nonparmetric families. Moreover, two new classes of nonlinear rank tests are introduced. These tests are designed for detecting either “ omnibus alternatives ” or “ one sided alternatives of trend ”. Under the null hypothesis of randomness all tests are distribution - free. The asymptotic distributions of the test statistics are derived under contiguous alternatives.     

A class of tests for exponentiality against decreasing mean residual life alternatives

A class of tests is proposed for testing Exponentiality against the Decreasing Mean Residual Life (DMRL) class of non-exponential probability distributions. These tests are consistent and asymptotically unbiased against all continuous DMRL alternatives. They are U - statistics and hence asymptotically normally distributed. The asymptotic relative efficiency (ARE) with respect to other tests for DMRL are quite high. Small sample powers are also comparable with small sample powers of the competitors.     

Saddlepoint p-values for group of linear rank tests

Many nonparametric tests in one sample problem, matched pairs, and competingrisks under censoring have the same underlying permutation distribution. This article proposes a saddlepoint approximation to the exact p-values of these tests instead of the asymptotic approximations. The performance of the saddlepoint approximation is assessed by using simulation studies that show the superiority of the saddlepoint methods over the asymptotic approximations in several settings. The use of the saddlepoint to approximate the p-values of class of two sample tests under complete randomized design is also discussed.     

Smoothed alternatives of the two-sample median and Wilcoxon's rank sum tests

We discuss smoothed rank statistics for testing the location shift parameter of the two-sample problem. They are based on discrete test statistics – the median and Wilcoxon's rank sum tests. For the one-sample problem, Maesono et al. [Smoothed nonparametric tests and their properties. arXiv preprint. 2016; ArXiv:1610.02145] reported that some nonparametric discrete tests have a problem with their p-values because of their discreteness. The p-values of Wilcoxon's test are frequently smaller than those of the median test in the tail area. This leads to an arbitrary choice of the median and Wilcoxon's rank sum tests. To overcome this problem, we propose smoothed versions of those tests. The smoothed tests inherit the good properties of the original tests and are asymptotically equivalent to them. We study the significance probabilities and local asymptotic powers of the proposed tests.