On choosing between fixed and random block effects in some no-interaction models

The purpose of this article is to strengthen the understanding of the relationship between a fixed-blocks and random-blocks analysis in models that do not include interactions between treatments and blocks. Treating the block effects as random has been recommended in the literature for balanced incomplete block designs (BIBD) because it results in smaller variances of treatment contrasts. This reduction in variance is large if the block-to-block variation relative to the total variation is small. However, this analysis is also more complicated because it results in a subjective interpretation of results if the block variance component is non-positive. The probability of a non-positive variance component is large precisely in those situations where a random-blocks analysis is useful – that is, when the block-to-block variation, relative to the total variation, is small. In contrast, the analysis in which the block effects are fixed is computationally simpler and less subjective. The loss in power for some BIBD with a fixed effects analysis is trivial. In such cases, we recommend treating the block effects as fixed. For response surface experiments designed in blocks, however, an opposite recommendation is made. When block effects are fixed, the variance of the estimated response surface is not uniquely estimated, and in practice this variance is obtained by ignoring the block effect. It is argued that a more reasonable approach is to treat the block effects to be random than to ignore it.     

Rank-based analysis of repeated measures block designs

A rank-based inference is developed for repeated measures balanced incomplete block and randomized complete block designs using a suitable dispersion function. Asymptotic distributions of rank estimators are developed after establishing approximate linearity of the gradient vector of the dispersion function. Unlike available nonparametric procedures for those designs, estimation and testing are tied together. Three different test statistics are developed for testing the linear hypotheses. Friedman's (1937) statistic and Durbin's (1951) statistic are particular cases of one of the three proposed statistics. An estimate of a scale parameter which appears in the ARE expression as well as as in the variences and covariances of the rank estimators is discussed.     

On totally balanced block designs for competition effects

Competition between neighbouring units in field experiments is a serious source of bias. The study of a competing situation needs construction of an environment in which it can happen and the competing units have to appear in a predetermined pattern. This paper describes methods of constructing incomplete block designs balanced for neighbouring competition effects. The designs obtained are totally balanced in the sense that all the effects, direct and neighbours, are estimated with the same variance. The efficiency of these designs has been computed as compared to a complete block design balanced for neighbours and a catalogue has also been prepared.     

On construction of constant block-sum partially balanced incomplete block designs

Abstract

Constant block-sum designs are of interest in repeated measures experimentation where the treatments levels are quantitative and it is desired that at the end of the experiments, all units have been exposed to the same constant cumulative dose. It has been earlier shown that the constant block-sum balanced incomplete block designs do not exist. As the next choice, we, in this article, explore and construct several constant block-sum partially balanced incomplete block designs. A natural choice is to first explore these designs via magic squares and Parshvanath yantram is found to be especially useful in generating designs for block size 4. Using other techniques such as pair-sums and, circular and radial arrangements, we generate a large number of constant block-sum partially balanced incomplete block designs. Their relationship with mixture designs is explored. Finally, we explore the optimization issues when constant block-sum may not be possible for the class of designs with a given set of parameters.     

Near-Balanced Incomplete Block Designs,With an Application to Poster Competitions

Judging scholarly posters creates a challenge to assign the judges efficiently. If there are many posters and few reviews per judge, the commonly used balanced incomplete block design is not a feasible option. An additional challenge is an unknown number of judges before the event. We propose two connected near-balanced incomplete block designs that both satisfy the requirements of our setting: one that generates a connected assignment and balances the treatments and another one that further balances pairs of treatments. We describe both fixed and random effects models to estimate the population marginal means of the poster scores and rationalize the use of the random effects model. We evaluate the estimation accuracy and efficiency, especially the winning chance of the truly best posters, of the two designs in comparison with a random assignment via simulation studies. The two proposed designs both demonstrate accuracy and efficiency gain over the random assignment.     

Incomplete block designs for complete diallel crosses and their analysis

A large number of incomplete block designs for Griffing's complete diallel cross-systems I, II and III, involving from five to 12 lines, are suggested, using two-associate triangular partially balanced incomplete block designs. Analysis of incomplete block designs for complete diallel cross-systems has been carried out assuming the most appropriate model for genetic yield, as advocated by Hinklemnann. This includes estimation of the general combining ability, specific combining ability and reciprocal cross- effects. An illustration of the design for each system is presented.     

Balanced and partially balanced incomplete block designs with autocorrelation errors

The paper aims to find variance balanced and variance partially balanced incomplete block designs when observations within blocks are autocorrelated and we call them BIBAC and PBIBAC designs. Orthogonal arrays of type I and type II when used as BIBAC designs have smaller average variance of elementary contrasts of treatment effects compared to the corresponding Balanced Incomplete Block (BIB) designs with homoscedastic, uncorrelated errors. The relative efficiency of BIB designs compared to BIBAC designs depends on the block size k and the autocorrelation ρ and is independent of the number of treatments. Further this relative efficiency increases with increasing k. Partially balanced incomplete block designs with autocorrelated errors are introduced using partially balanced incomplete block designs and orthogonal arrays of type I and type II.     

Polygonal designs: some existence and non-existence results

Polygonal designs are introduced as a generalization of balanced incomplete block designs and as a specialization of partially balanced incomplete block designs. As in the case of balanced incomplete block designs, there is no hope of deciding the values of the parameters for which polygonal designs exist. We develop enough theory to reveal the structure, and thus, to resolve the existence problem for small polygonal designs, and derive necessary conditions for general cases. © 1998 Elsevier Science B.V. All rights reserved.     

Regular graph designs

In this survey paper, measures of optimality of experimental designs are discussed from a combinatorial viewpoint. The main vehicle for this discussion is the regular graph design. This family of designs was introduced in the hope that they would be ‘good’ designs in cases where no balanced incomplete block design can exist. Various properties of these designs are discussed.     

A note on the nonexistence of the constant block-sum balanced incomplete block designs

Abstract

Due to important practical applications and considerations in biomedical clinical trials, fixed block-sum designs are of interest. We show that in general, the constant block-sum balanced incomplete block designs do not exist.     

On linear statistical models of commutative quadratic type

By defining a special class of vector decompositions we consider linear statistical models of commutative quadratic type, which especially cover balanced complete and incomplete ANOVA models with fixed, random and mixed effects. Under the assumption of normal distribution we are concerned with distributions of general quadratic forms, with point and confidence region estimation as well as with hypothesis testing for fixed effects (including multiple comparisons) and variance components.     

On a class of variance balanced incomplete block designs

In this paper variance balanced incomplete block designs have been constructed for situations when suitable BIB designs do not exist for a given number of treatments, because of the contraints bk=vr, λ(v-1) = r(k-l). These variance balanced designs are in unequal block sizes and unequal replications.     

Mixture designs with orthogonal blocks

Constructions of blocked mixture designs are considered in situations where BLUEs of the block effect contrasts are orthogonal to the BLUEs of the regression coefficients. Orthogonal arrays (OA), Balanced Arrays (BAs), incidence matrices of balanced incomplete block designs (BIBDs), and partially balanced incomplete block designs (PBIBDs) are used. Designs with equal and unequal block sizes are considered. Also both cases where the constants involved in the orthogonality conditions depend and do not depend on the factors have been taken into account. Some standard (already available) designs can be obtained as particular cases of the designs proposed here.     

A generating algorithm for linear trend-free and nearly linear trend-free block designs

The theory and properties of trend-free (TF) and nearly trend-free (NTF) block designs are wel1 developed. Applications have been hampered because a methodology for design construction has not been available.

This article begins with a short review of concepts and properties of TF and NTF block designs. The major contribution is provision of an algorithm for the construction of linear and nearly linear TF block designs. The algorithm is incorporated in a computer program in FORTRAN 77 provided in an appendix for the IBM PC or compatible microcomputer, a program adaptable also to other computers. Three sets of block designs generated by the program are given as examples.

A numerical example of analysis of a linear trend-free balanced incomplete block design is provided.     

On the construction of group divisible incomplete block designs

In this paper a method of constructing group-divisible incomplete block designs has been suggested. A series of balanced incomplete block designs has also been obtained.     

Methods of constructing group divisible designs with k = 3 and 4

The paper provides methods of construction of group divisible designs with block sizes three and four through balanced incomplete block and partially balanced incomplete block designs of block sizes 3 and 4. Furthermore, four non-isomorphic solutions are given.     

SOME SERIES OF EFFICIENCY BALANCED DESIGNS

Two series of efficiency balanced designs with v*+ 1 treatments have been constructed using balanced incomplete block designs having v* treatments.     

Optimum covariate designs in partially balanced incomplete block (PBIB) design set-ups

The use of covariates in block designs is necessary when the covariates cannot be controlled like the blocking factor in the experiment. In this paper, we consider the situation where there is some flexibility for selection in the values of the covariates. The choice of values of the covariates for a given block design attaining minimum variance for estimation of each of the parameters has attracted attention in recent times. Optimum covariate designs in simple set-ups such as completely randomised design (CRD), randomised block design (RBD) and some series of balanced incomplete block design (BIBD) have already been considered. In this paper, optimum covariate designs have been considered for the more complex set-ups of different partially balanced incomplete block (PBIB) designs, which are popular among practitioners. The optimum covariate designs depend much on the methods of construction of the basic PBIB designs. Different combinatorial arrangements and tools such as orthogonal arrays, Hadamard matrices and different kinds of products of matrices viz. Khatri–Rao product, Kronecker product have been conveniently used to construct optimum covariate designs with as many covariates as possible.     

Harmonic mean approach to unbalanced mixed effects models under heteroscedastic variances

In this paper we consider unbalanced mixed models (Scheffe's model) under heteroscedastic variances. By using the harmonic mean approach, It is shown that the problems appear to be anologous to those problems from balanced mixed models under homoscedastic variance. Thus, by using harmonic mean approach, statistical inferences about fixed effects and variance components are derived by using those from balanced models under homoscedastic variance. Laguerre polynomial expansion is used Lo approximate sampling distributions of relevant statistics.     

Block designs robust against the presence of positional effects

The problem considered is to find optimum designs for treatment effects in a block design (BD) setup, when positional effects are also present besides treatment and block effects, but they are ignored while formulating the model. In the class of symmetric balanced incomplete block designs, the Youden square design is shown to be optimal in the sense of minimizing the bias term in the mean squared error (MSE) of the best linear unbiased estimators of the full set of orthonormal treatment contrasts, irrespective of the value of the positional effects.